genetic algorithm is proposed for maximum independent set problems. A specially designed mutation operato is adopted to search the solution space more efficienily, where adjacen relation of a graph is inte-grated. The...genetic algorithm is proposed for maximum independent set problems. A specially designed mutation operato is adopted to search the solution space more efficienily, where adjacen relation of a graph is inte-grated. The DIMACS benchmark graphs are used to test our algorithm, and the results show that the algorithm outper-forms our previous version. Moreover two new low bounds are found for graphs in DIMACS.展开更多
Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology...Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field.展开更多
文摘genetic algorithm is proposed for maximum independent set problems. A specially designed mutation operato is adopted to search the solution space more efficienily, where adjacen relation of a graph is inte-grated. The DIMACS benchmark graphs are used to test our algorithm, and the results show that the algorithm outper-forms our previous version. Moreover two new low bounds are found for graphs in DIMACS.
基金supported by the grant from the National Natural Science Foundation of China(No. 31670919 to H.W.)the 1000-Youth Elite Program of China to H.W
文摘Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field.
