Analysis of feasibility of application of Beishu point acupressure therapy in treating gastroesophageal reflux disease via AMPK / ULK1 mediated autophagy pathway based on "adjusting central axis via pivot" theory

Gastroesophageal reflux disease(GERD)is a digestive system disease characterized by uncomfortable symptoms caused by reflux of gastric contents.It has increased sharply with the development of my country’s society and economy.If there is no reasonable and effective Prevention and treatment measures will inevitably increase the financial burden of patients,and also pose a major threat to the quality of life and health of patients.Cell signal transduction mediated by various receptors participates in the regulation mechanism of the body's various levels of biological functions.By inhibiting or activating its functions,the purpose of curing diseases can be achieved,and cell signal transduction has been used in traditional Chinese medicine.Studying.The theory of"adjusting the central axis"was explored by Professor Xie Sheng through decades of clinical experience.It has been proven in practice to treat GERD.It starts from the model of TCM viscera and expounds that the pathogenesis of GERD involves multiple viscera.Multi-system and multi-factor,explain the correlation of the disease with a variety of zang-fu syndromes,and use this as a basis to guide the clinical use of hidden prescriptions.The back-shu pointer therapy can prevent GERD by correcting the unbalanced state of the viscera and qi machine,and promoting the junction of the two channels of Ren and Du.Based on the theory of"adjusting the hub by the pivot",this article expounds the pathogenesis of GERD from the perspective of traditional Chinese medicine.By consulting the literature and combining with the previous research,it proposes to analyze the methods and methods of Backshu pointer therapy to prevent and treat GERD from the AMPK/ULK1 mediated autophagy pathway.

Distribution, features, and influence factors of the submarine topographic boundaries of the Okinawa Trough

Based on multiple types of data, the topographical features of the Okinawa Trough(OT) have been characterized and a computation method has been proposed to determine the break point of continental shelf(BOS), foot point of the continental slope(FOS), the central axial point, and the maximum depth point. A total of 48 topographical profiles that crosscut the continental slope have been used to determine the trends of the BOS and FOS(the BOS and FOS lines) in the East China Sea(ECS). The trend of central axial points in the OT has been similarly determined by analyzing 39 topographical profiles across the axis of the trough. The BOS line forms the boundary between the continental shelf and slope. In the ECS, the BOS line roughly follows the 200 m isobath, continuously in the northern and middle parts of the OT, but jumping about somewhat in the south. The FOS line is the boundary between the continental slope and the bottom of the trough. The depth of the FOS increases gradually from north to south in the OT. Intense incisions by canyons into the slope in the southern part of the trough have led to the complex distribution of FOS. Topographical profiles crosscutting the northern, middle, and southern parts of the OT exhibit features that include: a single W-shape, a composite W-shape, and a U-shape, respectively, which suggests that in the middle and northern parts of the trough the central axial points are always located on seamount peaks or ridges associated with linear seamounts, whereas in the south they are found in the center of en echelon depressions. The line formed by the central axial points is the east-west dividing line of the OT, which indicates that the trough is a natural gap that prevents the extension of ECS continental shelf to the east. The distributions of the BOS and FOS lines are influenced by fluctuation of sea levels and submarine canyons, whereas the distribution of axis lines is controlled by tectonics and deposition.