Objective To study the expression of interleukin-2(IL-2), soluble interleukin-2 receptor (sIL-2R), determine the alteration of erythrocytic immunity and T cell subgroup in the blood of outer circulation in patients wi...Objective To study the expression of interleukin-2(IL-2), soluble interleukin-2 receptor (sIL-2R), determine the alteration of erythrocytic immunity and T cell subgroup in the blood of outer circulation in patients with hypertensive cerebral hemorrhage so and to probe into the relationship between them, and to explore the clinical significance. Methods Enzyme linked immnunosorbent assay (ELISA) was used to determine the content of IL-2 and sIL-2R. The immunoadsorption was employed to examine the erythrocytic immune activity and its regulating function. Streptavidin-peroxidase(S-P) was used to determine the cell number of CD3 (cluster of differentiation3), CD4 and CD8. Results The content of IL-2 in the group with hypertensive cerebral hemorrhage was significantly lower than that in the control group (P<0.01), and the content of sIL-2R increased. Red blood cell C_ 3b receptor (RBC.C_ 3b R) and RBC immune adherence enhancing factor (RFEB) dropped greatly (P<0.01), while RBC immune complex rosette (RBC.ICR) and RBC immune adherence inhibiting factor (RFIR) increased greatly. The cell number of CD3 and CD4decreased (P<0.01) and there was no obvious change in CD8 (P<0.05). Conclusion The decrease of immune function was observed in patients with hypertensive cerebral hemorrhage. The determination of the content of IL-2, sIL-2R, erythrocytic immunity and the activity of T subgroup has an important clinical significance in the occurrence, development, treatment, and prognosis of hypertensive cerebral hemorrhage.展开更多
目的探讨高同型半胱氨酸血症的高血压（H型高血压）与高血压脑出血早期血肿扩大及3个月时临床转归和死亡的关系。方法纳入2013年1月至2014年12月本科住院的高血压原发性脑出血患者298例,记录其一般资料,在起病6h内及24h行CT扫描,同时检...目的探讨高同型半胱氨酸血症的高血压（H型高血压）与高血压脑出血早期血肿扩大及3个月时临床转归和死亡的关系。方法纳入2013年1月至2014年12月本科住院的高血压原发性脑出血患者298例,记录其一般资料,在起病6h内及24h行CT扫描,同时检测同型半胱氨酸（Hcy）、血糖、胆固醇、纤维蛋白原等及美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale,NIHSS）评分。随访3个月,记录改良Bathel（MBI）量评分及死亡例数。结果血浆Hcy水平升高[优势比（odds ratio,OR）=0.356,95%可信区间（confidence interval,CI）：0.131~0.826;P=0.021]和收缩压增高（OR=1.021,95%CI：1.002~1.028;P=0.045）是原发性脑出血患者血肿扩大的独立危险因素。血浆Hcy升高（OR=1.031,95%CI：1.021~1.278;P=0.035）和收缩压增高（OR=1.141,95%CI：1.011~1.072;P=0.034）是临床转归不良的独立危险因素。收缩压增高（OR=1.023,95%CI：1.007~1.051;P=0.021）、血糖高（OR=1.382,95%CI：1.221~1.673;P=0.004）、Hcy水平增高（OR=1.521,95%CI：1.025~8.096;P=0.023）是3个月内死亡的独立危险因素。结论 H型高血压是原发性脑出血早期血肿扩大及3个月时临床转归和死亡的独立预测因素。展开更多
文摘Objective To study the expression of interleukin-2(IL-2), soluble interleukin-2 receptor (sIL-2R), determine the alteration of erythrocytic immunity and T cell subgroup in the blood of outer circulation in patients with hypertensive cerebral hemorrhage so and to probe into the relationship between them, and to explore the clinical significance. Methods Enzyme linked immnunosorbent assay (ELISA) was used to determine the content of IL-2 and sIL-2R. The immunoadsorption was employed to examine the erythrocytic immune activity and its regulating function. Streptavidin-peroxidase(S-P) was used to determine the cell number of CD3 (cluster of differentiation3), CD4 and CD8. Results The content of IL-2 in the group with hypertensive cerebral hemorrhage was significantly lower than that in the control group (P<0.01), and the content of sIL-2R increased. Red blood cell C_ 3b receptor (RBC.C_ 3b R) and RBC immune adherence enhancing factor (RFEB) dropped greatly (P<0.01), while RBC immune complex rosette (RBC.ICR) and RBC immune adherence inhibiting factor (RFIR) increased greatly. The cell number of CD3 and CD4decreased (P<0.01) and there was no obvious change in CD8 (P<0.05). Conclusion The decrease of immune function was observed in patients with hypertensive cerebral hemorrhage. The determination of the content of IL-2, sIL-2R, erythrocytic immunity and the activity of T subgroup has an important clinical significance in the occurrence, development, treatment, and prognosis of hypertensive cerebral hemorrhage.
文摘目的探讨高同型半胱氨酸血症的高血压（H型高血压）与高血压脑出血早期血肿扩大及3个月时临床转归和死亡的关系。方法纳入2013年1月至2014年12月本科住院的高血压原发性脑出血患者298例,记录其一般资料,在起病6h内及24h行CT扫描,同时检测同型半胱氨酸（Hcy）、血糖、胆固醇、纤维蛋白原等及美国国立卫生研究院卒中量表（National Institute of Health Stroke Scale,NIHSS）评分。随访3个月,记录改良Bathel（MBI）量评分及死亡例数。结果血浆Hcy水平升高[优势比（odds ratio,OR）=0.356,95%可信区间（confidence interval,CI）：0.131~0.826;P=0.021]和收缩压增高（OR=1.021,95%CI：1.002~1.028;P=0.045）是原发性脑出血患者血肿扩大的独立危险因素。血浆Hcy升高（OR=1.031,95%CI：1.021~1.278;P=0.035）和收缩压增高（OR=1.141,95%CI：1.011~1.072;P=0.034）是临床转归不良的独立危险因素。收缩压增高（OR=1.023,95%CI：1.007~1.051;P=0.021）、血糖高（OR=1.382,95%CI：1.221~1.673;P=0.004）、Hcy水平增高（OR=1.521,95%CI：1.025~8.096;P=0.023）是3个月内死亡的独立危险因素。结论 H型高血压是原发性脑出血早期血肿扩大及3个月时临床转归和死亡的独立预测因素。
