Objective:To observe the clinical efficacy of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage and the effect on blood sugar an...Objective:To observe the clinical efficacy of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage and the effect on blood sugar and serum CRP.Methods:A total of 84 patients with hypertensive cerebral hemorrhage who were admitted in our hospital were included in the study and divided into the minimally invasive group (n=53) and the conservative group (n=31) according to different treatment protocols. The patients in the two groups were given routine drug treatments. The patients in the observation group were given urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle. The blood sugar and serum CRP levels before and after treatment in the two groups were compared. CT was performed to reexamine the cerebral hematoma and edema volume.Results: The serum CRP and blood sugar levels 3, 7 and 14 d after treatment in the minimally invasive group were significantly lower than those in the conservative group (P<0.05). The cerebral hematoma and edema volume 1, 3, 7, and 14 d after treatment in the minimally invasive group was significantly lower than that in the conservative group (P<0.05).Conclusions: Urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage can significantly alleviate the brain tissue injury, reduce the systemic inflammatory reaction and blood sugar level, and contribute to the rehabilitation.展开更多
Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We susp...Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude.展开更多
目的观察软通道穿刺引流术治疗中等量高血压脑出血的临床效果。方法选取2021年6月—2022年6月在福建省立医院进行手术治疗的300例中等量高血压脑出血患者,采用随机数字表法分为对照组与观察组,每组各150例。对照组采用开颅血肿清除术的...目的观察软通道穿刺引流术治疗中等量高血压脑出血的临床效果。方法选取2021年6月—2022年6月在福建省立医院进行手术治疗的300例中等量高血压脑出血患者,采用随机数字表法分为对照组与观察组,每组各150例。对照组采用开颅血肿清除术的方法为患者进行治疗,观察组采用软通道穿刺引流术为患者进行治疗,比较两组治疗效果。结果与对照组比较,观察组中等量高血压脑出血患者的救治成功率更高,治疗有效性更高,术后并发症发生率更低,且经过治疗后的临床神经功能缺损评分(national institute of health stroke scale,NIHSS)更低,生活质量和睡眠质量更高(P<0.05)。结论针对中等量高血压脑出血患者,采取软通道穿刺引流术的效果更优,患者的治疗有效性和神经功能状况得到改善,并发症情况较低,且患者治疗后生活质量和睡眠质量得到提升,治疗优势突出,可在临床大量推广。展开更多
文摘Objective:To observe the clinical efficacy of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage and the effect on blood sugar and serum CRP.Methods:A total of 84 patients with hypertensive cerebral hemorrhage who were admitted in our hospital were included in the study and divided into the minimally invasive group (n=53) and the conservative group (n=31) according to different treatment protocols. The patients in the two groups were given routine drug treatments. The patients in the observation group were given urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle. The blood sugar and serum CRP levels before and after treatment in the two groups were compared. CT was performed to reexamine the cerebral hematoma and edema volume.Results: The serum CRP and blood sugar levels 3, 7 and 14 d after treatment in the minimally invasive group were significantly lower than those in the conservative group (P<0.05). The cerebral hematoma and edema volume 1, 3, 7, and 14 d after treatment in the minimally invasive group was significantly lower than that in the conservative group (P<0.05).Conclusions: Urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage can significantly alleviate the brain tissue injury, reduce the systemic inflammatory reaction and blood sugar level, and contribute to the rehabilitation.
基金supported by Grant No.SWH2017JSZD07 from The First Affiliated Hospital of Army Medical University's"Science and Technology Innovation Program",Grant No.81571116 from the National Natural Science Foundation of China.
文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude.
文摘目的观察软通道穿刺引流术治疗中等量高血压脑出血的临床效果。方法选取2021年6月—2022年6月在福建省立医院进行手术治疗的300例中等量高血压脑出血患者,采用随机数字表法分为对照组与观察组,每组各150例。对照组采用开颅血肿清除术的方法为患者进行治疗,观察组采用软通道穿刺引流术为患者进行治疗,比较两组治疗效果。结果与对照组比较,观察组中等量高血压脑出血患者的救治成功率更高,治疗有效性更高,术后并发症发生率更低,且经过治疗后的临床神经功能缺损评分(national institute of health stroke scale,NIHSS)更低,生活质量和睡眠质量更高(P<0.05)。结论针对中等量高血压脑出血患者,采取软通道穿刺引流术的效果更优,患者的治疗有效性和神经功能状况得到改善,并发症情况较低,且患者治疗后生活质量和睡眠质量得到提升,治疗优势突出,可在临床大量推广。
文摘目的 探讨对高血压性脑出血采用微创软通道穿刺引流术治疗的效果。方法 选取2019年1月—2023年1月阜宁县人民医院收治的64例高血压性脑出血患者为研究对象,按照随机数表法分为对照组和观察组,每组32例。对照组采用开颅血肿清除术治疗,观察组采用微创软通道穿刺引流治疗,比较两组治疗效果、手术相关指标、术前、术后1个月、术后3个月的神经功能采用神经功能缺损(National Institute of Health Stroke Scale, NIHSS)评分与改良Barthel指数(Modified Barthel Index, MBI),另统计患者并发症率。结果 观察组总有效率(93.75%)高于对照组(75.00%),差异有统计学意义(χ^(2)=4.267,P<0.05);观察组并发症率(6.25%)低于对照组(28.13%),差异有统计学意义(χ^(2)=5.379,P<0.05)。观察组手术时间、血肿清除时间及住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。术后1个月和3个月,观察组的NIHSS评分均低于对照组,MBI评分高于对照组,差异有统计学意义(P<0.05)。结论 对高血压性脑出血者予微创软通道穿刺引流术治疗疗效确切,操作简单,患者术后恢复更快,有利于神经功能与日常生活能力的改善,且可降低并发症风险。
