Objective: To observe the therapeutic effect of electroacupuncture (EA) on plasma angiotensin (Ang*.Ⅱ), aldosterone (ALD) and atrial natriuretic polypeptide (ANP) contents in experimental cerebral infarction rabbits ...Objective: To observe the therapeutic effect of electroacupuncture (EA) on plasma angiotensin (Ang*.Ⅱ), aldosterone (ALD) and atrial natriuretic polypeptide (ANP) contents in experimental cerebral infarction rabbits for analyzing the underlying mechanism of acupuncture in ameliorating blood supply of the brain tissue. Methods: A total of 80 rabbits were randomized into control (n=8), pseudo-operation (n=24), model (n=24) and EA (n=24) groups. Cerebral infarction model was established by infusion of self-thrombus into the carotid artery. EA (1 mA, 2 Hz) was applied to 'Baihui'(百会GV 20) and 'Shuigou'(水沟GV 26) for 30 min, once every 12 hours. Plasma Ang-II, ALD and ANP contents were detected with radioimmunoassay method. In the later 3 groups, blood samples were taken at 6 h, 24 h and 48 h after cerebral ischemia. Results: Compared with control and pseudo-operation groups, Ang-II and ALD contents of model group at 6 h, 24 h and 48 h after cerebral ischemia increased significantly while plasma ANP of the 3 time-courses of model group decreased considerably (P<0.01). In comparison with model group, results showed that Ang-II and ALD contents of EA group decreased significantly whereas ANP level of EA group increased strikingly (P<0.01). Conclusion: Electroacupuncture has the effects of raising plasma ANP level and lowering plasma Ang-II and ALD in cerebral infarction rabbits.展开更多
目的比较地氟醚和丙泊酚麻醉下颅内动脉瘤患者行夹闭术术中血管紧张素Ⅱ(AT-Ⅱ)、内皮素(ET)和降钙素基因相关肽(CGRP)的变化。方法择期开颅动脉瘤夹闭术患者88例,随机分为地氟醚组(n=45)和丙泊酚组(n=43),以吸入地氟醚或静注丙泊酚维...目的比较地氟醚和丙泊酚麻醉下颅内动脉瘤患者行夹闭术术中血管紧张素Ⅱ(AT-Ⅱ)、内皮素(ET)和降钙素基因相关肽(CGRP)的变化。方法择期开颅动脉瘤夹闭术患者88例,随机分为地氟醚组(n=45)和丙泊酚组(n=43),以吸入地氟醚或静注丙泊酚维持麻醉。分别于麻醉诱导前、剪硬膜、夹闭动脉瘤和动脉瘤夹闭后30 min采集动脉血,应用放免法检测血浆AT-Ⅱ、ET和CGRP的浓度。结果两组AT-Ⅱ四个时点间及组间比较差异均无显著意义;丙泊酚组夹闭动脉瘤时ET较剪硬膜时明显升高(P<0.05);组间比较,夹闭动脉瘤时丙泊酚组ET明显高于地氟醚组(P<0.05);两组剪硬膜、夹闭动脉瘤和动脉瘤夹闭后30 min CGRP较麻醉诱导前均有所降低。结论丙泊酚麻醉下夹闭动脉瘤时缩血管物质ET明显升高,而地氟醚麻醉下无此现象,提示丙泊酚麻醉中应注重扩血管治疗,以防急性脑血管痉挛的发生,地氟醚可能更适合应用于开颅动脉瘤夹闭术。展开更多
文摘Objective: To observe the therapeutic effect of electroacupuncture (EA) on plasma angiotensin (Ang*.Ⅱ), aldosterone (ALD) and atrial natriuretic polypeptide (ANP) contents in experimental cerebral infarction rabbits for analyzing the underlying mechanism of acupuncture in ameliorating blood supply of the brain tissue. Methods: A total of 80 rabbits were randomized into control (n=8), pseudo-operation (n=24), model (n=24) and EA (n=24) groups. Cerebral infarction model was established by infusion of self-thrombus into the carotid artery. EA (1 mA, 2 Hz) was applied to 'Baihui'(百会GV 20) and 'Shuigou'(水沟GV 26) for 30 min, once every 12 hours. Plasma Ang-II, ALD and ANP contents were detected with radioimmunoassay method. In the later 3 groups, blood samples were taken at 6 h, 24 h and 48 h after cerebral ischemia. Results: Compared with control and pseudo-operation groups, Ang-II and ALD contents of model group at 6 h, 24 h and 48 h after cerebral ischemia increased significantly while plasma ANP of the 3 time-courses of model group decreased considerably (P<0.01). In comparison with model group, results showed that Ang-II and ALD contents of EA group decreased significantly whereas ANP level of EA group increased strikingly (P<0.01). Conclusion: Electroacupuncture has the effects of raising plasma ANP level and lowering plasma Ang-II and ALD in cerebral infarction rabbits.
文摘目的比较地氟醚和丙泊酚麻醉下颅内动脉瘤患者行夹闭术术中血管紧张素Ⅱ(AT-Ⅱ)、内皮素(ET)和降钙素基因相关肽(CGRP)的变化。方法择期开颅动脉瘤夹闭术患者88例,随机分为地氟醚组(n=45)和丙泊酚组(n=43),以吸入地氟醚或静注丙泊酚维持麻醉。分别于麻醉诱导前、剪硬膜、夹闭动脉瘤和动脉瘤夹闭后30 min采集动脉血,应用放免法检测血浆AT-Ⅱ、ET和CGRP的浓度。结果两组AT-Ⅱ四个时点间及组间比较差异均无显著意义;丙泊酚组夹闭动脉瘤时ET较剪硬膜时明显升高(P<0.05);组间比较,夹闭动脉瘤时丙泊酚组ET明显高于地氟醚组(P<0.05);两组剪硬膜、夹闭动脉瘤和动脉瘤夹闭后30 min CGRP较麻醉诱导前均有所降低。结论丙泊酚麻醉下夹闭动脉瘤时缩血管物质ET明显升高,而地氟醚麻醉下无此现象,提示丙泊酚麻醉中应注重扩血管治疗,以防急性脑血管痉挛的发生,地氟醚可能更适合应用于开颅动脉瘤夹闭术。
