BACKGROUND Acute cerebral infarction is a severe type of ischemic stroke that can be divided into anterior circulation cerebral infarction and posterior circulation cerebral infarction(PCCI).PCCI affects the structure...BACKGROUND Acute cerebral infarction is a severe type of ischemic stroke that can be divided into anterior circulation cerebral infarction and posterior circulation cerebral infarction(PCCI).PCCI affects the structure of the posterior circulation brain,because posterior part of the brain,which has more complex anatomical structures and more prone to posterior circulation vascular variation.Therefore,improving the prognosis of PCCI patients is necessary.AIM To explore the effect of medical care linkage-continuous management mode(MCLMM)on endovascular interventional therapy(EIT)for PCCI.METHODS Sixty-nine patients with PCCI who received EIT and conventional nursing intervention were selected as the control group,and 78 patients with PCCI who received EIT and MCLMM intervention were selected as the observation group.The incidence of postoperative complications,compliance and disease selfmanagement behavior after six months of intervention,modified Rankin scale(mRS)and Barthel index(BI)scores in the acute phase and after one year of intervention,and recurrence within one year were compared between the two groups.RESULTS The total incidence rate of postoperative complications in the observation group(7.69%)was lower than that in the control group(18.84%)(P<0.05).The scores for medical compliance behavior(regular medication,appropriate diet,and rehabilitation cooperation rates)and disease self-management behavior(self-will,disease knowledge,and self-care ability)in the observation group were higher than those in the control group(P<0.05).After one year of intervention,in the observation group,the mRS score was significantly lower,and the BI score was significantly higher than those in the control group(P<0.05).The recurrence rate within one year in the observation group(3.85%)was significantly lower than that in the control group(13.04%)(P<0.05).CONCLUSION MCLMM can reduce the incidence of complications after EIT for PCCI,improve patient compliance behavior and disease self-management ability,and promote the recovery of neurological function.展开更多
Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = ...Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = 50) and medication control group (n= 50). In the former group, penetration needling from Baihui (GV 20) to Qianding (GV 21) and from Shuaigu(GB 8) to Xuanli (GB 6) was performed, followed by conducting electroacupuncture (EA) stimulation; while in control group, intravenous drip of Ligustrazine injectio 120 mg plus 5% glucose solution 250 mL (once daily, with 14 days being a therapeutic course) was given in the first therapeutic course and then intravenous drip of Piracetum injectio (2 g plus 5% glucose or normal saline 250 mL, once daily, continuously for 14 days) conducted in the second therapeutic course. Results: After treatment, of the 50 cases in scalp acupuncture group, 26 (52%) were recovered basically, 15 (30%) had significant improvement, 7 (14%) had improvement and 2 (4%) failed in the treatment; while of the 50 cases in control group, 15 (30%) recovered basically, 17 (34%) had marked improvement, 16 (32%) had improvement and 2 (4%) failed in the treatment. The integral values of hemiplegia and aphasia of scalp acupuncture group were less than those of control group (P <0.01). It Indicates that the therapeutic effect of scalp acupuncture is superior to that of control group.展开更多
Heat-sensitive suspended moxibustion has a neuroprotective effect against focal cerebral ischemia/reperfusion injury, but the underly- ing mechanisms remain unclear. The duration of heat-sensitive suspended moxibusti...Heat-sensitive suspended moxibustion has a neuroprotective effect against focal cerebral ischemia/reperfusion injury, but the underly- ing mechanisms remain unclear. The duration of heat-sensitive suspended moxibustion （usually from 30 minutes to 1 hour） is longer than traditional suspended moxibustion （usually 15 minutes）. However, the effects of 15- and 35-minute suspended moxibustion in rats with cerebra/ischemia/reperfusion injury are poorly understood. In this study, we performed 15- or 35-minute suspended moxibustion at acupoint Dazhui （GV14） in an adult rat model of focal cerebral ischemia/reperfusion injury. Infarct volume was evaluated with the 2,3,5-triphenyltetrazolium chloride assay. Histopathological changes and neuronal apoptosis at the injury site were assessed by hematoxy- lin-eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Caspase-9 and caspase-3 expression at the in- jury site was detected using immunofluorescent staining. Bax and Bcl-2 expression at the injury site was assessed using western blot assay. In the 35-minute moxibustion group, infarct volume was decreased, neuronal apoptosis was reduced, caspase-9, caspase-3 and Bax expres- sion was lower, and Bcl-2 expression was increased, compared with the 15-minute moxibustion group. Our findings show that 35-minute moxibustion has a greater anti-apoptotic effect than 15-minute moxibustion after focal cerebral ischemia/reperfusion injury.展开更多
目的基于脑肠轴理论观察针刺治疗卒中后抑郁的临床疗效。方法选取74例卒中后抑郁患者,根据随机数字表法分为试验组和对照组,每组37例。两组均采用常规西药治疗,对照组采用醒脑开窍针刺法治疗,试验组在对照组基础上联合基于脑肠轴理论取...目的基于脑肠轴理论观察针刺治疗卒中后抑郁的临床疗效。方法选取74例卒中后抑郁患者,根据随机数字表法分为试验组和对照组,每组37例。两组均采用常规西药治疗,对照组采用醒脑开窍针刺法治疗,试验组在对照组基础上联合基于脑肠轴理论取穴的电针治疗。比较两组临床疗效,观察两组治疗前后中医主症积分、汉密顿抑郁量表(Hamilton depression scale,HAMD)评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分和日常生活能力量表(activity of daily living,ADL)评分的变化,比较两组治疗前后血清胃泌素(gastrin,GAS)、生长抑素(somatostatin,SS)、5-羟色胺(5-hydroxytryptamin,5-HT)和脑源性神经生长因子(brain-derived neuotrophyic factor,BDNF)水平的变化。结果试验组抑郁总有效率和中医证候总有效率均高于对照组(P<0.05)。两组治疗后中医主症积分、HAMD评分和NIHSS评分均较同组治疗前降低(P<0.05),ADL评分较同组治疗前升高(P<0.05);试验组治疗后上述评分均优于对照组(P<0.05)。两组治疗后血清SS水平均降低(P<0.05),血清GAS、5-HT和BDNF水平均升高(P<0.05);且试验组治疗后血清SS水平低于对照组(P<0.05),血清GAS、5-HT和BDNF水平高于对照组(P<0.05)。结论在常规西药治疗基础上,醒脑开窍针刺法联合基于脑肠轴理论取穴的电针治疗可更好地缓解卒中后抑郁患者的临床症状,改善神经功能和日常生活能力,提高临床疗效,这可能与调节血清SS、GAS、5-HT和BDNF水平有关。展开更多
目的观察电针联合归脾汤合血府逐瘀汤治疗脑梗死后抑郁的临床疗效及对患者神经功能和生活质量的影响。方法纳入102例脑梗死后抑郁患者,按随机数字表法分为观察组和对照组,每组51例。对照组采用口服归脾汤合血府逐瘀汤治疗,观察组在对照...目的观察电针联合归脾汤合血府逐瘀汤治疗脑梗死后抑郁的临床疗效及对患者神经功能和生活质量的影响。方法纳入102例脑梗死后抑郁患者,按随机数字表法分为观察组和对照组,每组51例。对照组采用口服归脾汤合血府逐瘀汤治疗,观察组在对照组治疗基础上联合电针治疗。比较两组临床疗效,比较两组治疗前后中医证候积分、17项汉密尔顿抑郁量表(Hamilton depression scale-17,HAMD-17)评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分和脑卒中专用生活质量量表(stroke-specific quality of life scale,SS-QOL)评分的变化,比较两组治疗前后血清5-羟色胺(5-hydroxytryptamine,5-HT)和去甲肾上腺素(norepinephrine,NE)水平的变化。结果观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。两组治疗后中医证候积分、HAMD-17评分和NIHSS评分均较治疗前降低(P<0.05),两组治疗后SS-QOL评分以及血清5-HT和NE水平均较治疗前升高(P<0.05)。观察组治疗后中医证候积分、HAMD-17评分和NIHSS评分均低于对照组(P<0.05),SS-QOL评分以及血清5-HT和NE水平均高于对照组(P<0.05)。结论电针联合归脾汤合血府逐瘀汤治疗脑梗死后抑郁可有效缓解症状,改善神经功能,提高生活质量,疗效优于单纯口服中药治疗。展开更多
目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Intern...目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Internet,CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)中医药(含中西医结合)治疗脑梗死的相关文献。完成筛选、建立数据库,在中医传承辅助平台(V3.0)上运用频数统计、聚类分析、关联规则分析等方法,统计药物使用频率、性味归经分布情况,分析药物配伍规律及关联、聚类效果。结果纳入文献共143篇,共整理出161首方剂,222味中药。四气中温(41.51%)、寒(27.55%)、平(25.89%)为主;五味以苦(34.17%)、甘(28.82%)、辛(24.45%)为主;归经以肝(26.68%)、心(17.96%)、脾(16.14%)三经为主;药物频次≥35次的中药共有13味,以活血化瘀类药物为主;药物组合中频次≥45次的有18组;将整理后的222味中药可分为3个聚类。结论脑梗死的治疗药物以温寒平、归心肝经者为多,治疗方法以活血化瘀、补益肝肾、平肝熄风为主,可为临床治疗提供一定借鉴。展开更多
文摘BACKGROUND Acute cerebral infarction is a severe type of ischemic stroke that can be divided into anterior circulation cerebral infarction and posterior circulation cerebral infarction(PCCI).PCCI affects the structure of the posterior circulation brain,because posterior part of the brain,which has more complex anatomical structures and more prone to posterior circulation vascular variation.Therefore,improving the prognosis of PCCI patients is necessary.AIM To explore the effect of medical care linkage-continuous management mode(MCLMM)on endovascular interventional therapy(EIT)for PCCI.METHODS Sixty-nine patients with PCCI who received EIT and conventional nursing intervention were selected as the control group,and 78 patients with PCCI who received EIT and MCLMM intervention were selected as the observation group.The incidence of postoperative complications,compliance and disease selfmanagement behavior after six months of intervention,modified Rankin scale(mRS)and Barthel index(BI)scores in the acute phase and after one year of intervention,and recurrence within one year were compared between the two groups.RESULTS The total incidence rate of postoperative complications in the observation group(7.69%)was lower than that in the control group(18.84%)(P<0.05).The scores for medical compliance behavior(regular medication,appropriate diet,and rehabilitation cooperation rates)and disease self-management behavior(self-will,disease knowledge,and self-care ability)in the observation group were higher than those in the control group(P<0.05).After one year of intervention,in the observation group,the mRS score was significantly lower,and the BI score was significantly higher than those in the control group(P<0.05).The recurrence rate within one year in the observation group(3.85%)was significantly lower than that in the control group(13.04%)(P<0.05).CONCLUSION MCLMM can reduce the incidence of complications after EIT for PCCI,improve patient compliance behavior and disease self-management ability,and promote the recovery of neurological function.
文摘Abstract: In the present paper, the authors report the findings of scalp-acupuncture treatment of 50 cases of acute cerebral Infarction. A total of 100 patients were randomly divided into scalp acupuncture group (n = 50) and medication control group (n= 50). In the former group, penetration needling from Baihui (GV 20) to Qianding (GV 21) and from Shuaigu(GB 8) to Xuanli (GB 6) was performed, followed by conducting electroacupuncture (EA) stimulation; while in control group, intravenous drip of Ligustrazine injectio 120 mg plus 5% glucose solution 250 mL (once daily, with 14 days being a therapeutic course) was given in the first therapeutic course and then intravenous drip of Piracetum injectio (2 g plus 5% glucose or normal saline 250 mL, once daily, continuously for 14 days) conducted in the second therapeutic course. Results: After treatment, of the 50 cases in scalp acupuncture group, 26 (52%) were recovered basically, 15 (30%) had significant improvement, 7 (14%) had improvement and 2 (4%) failed in the treatment; while of the 50 cases in control group, 15 (30%) recovered basically, 17 (34%) had marked improvement, 16 (32%) had improvement and 2 (4%) failed in the treatment. The integral values of hemiplegia and aphasia of scalp acupuncture group were less than those of control group (P <0.01). It Indicates that the therapeutic effect of scalp acupuncture is superior to that of control group.
基金supported by the National Natural Science Foundation of China,No.81060305&81660819the Natural Science Foundation of Jiangxi Province of China,No.2015BAB205068+2 种基金Key Program for Science and Technology Cooperation Projects of Jiangxi Province of China,No.20161BBH80053a grant from the Key Project of Health Commission of Jiangxi Province of China,No.2014Z003the Natural Science Foundation of Jiangxi University of Traditional Chinese Medicine of China,No.2014ZR018&2015jzzdxk024
文摘Heat-sensitive suspended moxibustion has a neuroprotective effect against focal cerebral ischemia/reperfusion injury, but the underly- ing mechanisms remain unclear. The duration of heat-sensitive suspended moxibustion （usually from 30 minutes to 1 hour） is longer than traditional suspended moxibustion （usually 15 minutes）. However, the effects of 15- and 35-minute suspended moxibustion in rats with cerebra/ischemia/reperfusion injury are poorly understood. In this study, we performed 15- or 35-minute suspended moxibustion at acupoint Dazhui （GV14） in an adult rat model of focal cerebral ischemia/reperfusion injury. Infarct volume was evaluated with the 2,3,5-triphenyltetrazolium chloride assay. Histopathological changes and neuronal apoptosis at the injury site were assessed by hematoxy- lin-eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Caspase-9 and caspase-3 expression at the in- jury site was detected using immunofluorescent staining. Bax and Bcl-2 expression at the injury site was assessed using western blot assay. In the 35-minute moxibustion group, infarct volume was decreased, neuronal apoptosis was reduced, caspase-9, caspase-3 and Bax expres- sion was lower, and Bcl-2 expression was increased, compared with the 15-minute moxibustion group. Our findings show that 35-minute moxibustion has a greater anti-apoptotic effect than 15-minute moxibustion after focal cerebral ischemia/reperfusion injury.
文摘目的基于脑肠轴理论观察针刺治疗卒中后抑郁的临床疗效。方法选取74例卒中后抑郁患者,根据随机数字表法分为试验组和对照组,每组37例。两组均采用常规西药治疗,对照组采用醒脑开窍针刺法治疗,试验组在对照组基础上联合基于脑肠轴理论取穴的电针治疗。比较两组临床疗效,观察两组治疗前后中医主症积分、汉密顿抑郁量表(Hamilton depression scale,HAMD)评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分和日常生活能力量表(activity of daily living,ADL)评分的变化,比较两组治疗前后血清胃泌素(gastrin,GAS)、生长抑素(somatostatin,SS)、5-羟色胺(5-hydroxytryptamin,5-HT)和脑源性神经生长因子(brain-derived neuotrophyic factor,BDNF)水平的变化。结果试验组抑郁总有效率和中医证候总有效率均高于对照组(P<0.05)。两组治疗后中医主症积分、HAMD评分和NIHSS评分均较同组治疗前降低(P<0.05),ADL评分较同组治疗前升高(P<0.05);试验组治疗后上述评分均优于对照组(P<0.05)。两组治疗后血清SS水平均降低(P<0.05),血清GAS、5-HT和BDNF水平均升高(P<0.05);且试验组治疗后血清SS水平低于对照组(P<0.05),血清GAS、5-HT和BDNF水平高于对照组(P<0.05)。结论在常规西药治疗基础上,醒脑开窍针刺法联合基于脑肠轴理论取穴的电针治疗可更好地缓解卒中后抑郁患者的临床症状,改善神经功能和日常生活能力,提高临床疗效,这可能与调节血清SS、GAS、5-HT和BDNF水平有关。
文摘目的观察电针联合归脾汤合血府逐瘀汤治疗脑梗死后抑郁的临床疗效及对患者神经功能和生活质量的影响。方法纳入102例脑梗死后抑郁患者,按随机数字表法分为观察组和对照组,每组51例。对照组采用口服归脾汤合血府逐瘀汤治疗,观察组在对照组治疗基础上联合电针治疗。比较两组临床疗效,比较两组治疗前后中医证候积分、17项汉密尔顿抑郁量表(Hamilton depression scale-17,HAMD-17)评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分和脑卒中专用生活质量量表(stroke-specific quality of life scale,SS-QOL)评分的变化,比较两组治疗前后血清5-羟色胺(5-hydroxytryptamine,5-HT)和去甲肾上腺素(norepinephrine,NE)水平的变化。结果观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。两组治疗后中医证候积分、HAMD-17评分和NIHSS评分均较治疗前降低(P<0.05),两组治疗后SS-QOL评分以及血清5-HT和NE水平均较治疗前升高(P<0.05)。观察组治疗后中医证候积分、HAMD-17评分和NIHSS评分均低于对照组(P<0.05),SS-QOL评分以及血清5-HT和NE水平均高于对照组(P<0.05)。结论电针联合归脾汤合血府逐瘀汤治疗脑梗死后抑郁可有效缓解症状,改善神经功能,提高生活质量,疗效优于单纯口服中药治疗。
文摘目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Internet,CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)中医药(含中西医结合)治疗脑梗死的相关文献。完成筛选、建立数据库,在中医传承辅助平台(V3.0)上运用频数统计、聚类分析、关联规则分析等方法,统计药物使用频率、性味归经分布情况,分析药物配伍规律及关联、聚类效果。结果纳入文献共143篇,共整理出161首方剂,222味中药。四气中温(41.51%)、寒(27.55%)、平(25.89%)为主;五味以苦(34.17%)、甘(28.82%)、辛(24.45%)为主;归经以肝(26.68%)、心(17.96%)、脾(16.14%)三经为主;药物频次≥35次的中药共有13味,以活血化瘀类药物为主;药物组合中频次≥45次的有18组;将整理后的222味中药可分为3个聚类。结论脑梗死的治疗药物以温寒平、归心肝经者为多,治疗方法以活血化瘀、补益肝肾、平肝熄风为主,可为临床治疗提供一定借鉴。
