Cerebral cavemous malformation （CCM） is a frequently occurring disease in Latin American populations, but little is known about the prevalence in China. This study enrolled one Chinese family with CCM, comprising 16...Cerebral cavemous malformation （CCM） is a frequently occurring disease in Latin American populations, but little is known about the prevalence in China. This study enrolled one Chinese family with CCM, comprising 16 members; four were diagnosed with CCM which corresponded with autosomal incomplete dominance inheritance. The main clinical manifestations included headache, focal neural dysfunction, and cerebral hemorrhage. The lesions were a mixture of hyperintensity and hypointensity signals on TlWl and T2Wl, with a black hypointensity ring on T2Wl. CCM cranial magnetic resonance imaging T2Wl revealed an iron ring as a result of hemosiderin deposition. Pathological findings of CCM revealed tightly packed and variably thickened vascular channels lacking smooth muscle or elastic tissue. Intralesional hyalinosis, calcification, or bleeding of different phases and perilesional glial hyperplasia were observed, as well as hemosiderin deposition within or around the lesions. These features of this family were consistent with specific genetic, imaging and pathological features of familial CCM. Pathological characteristics reveal repeated hemorrhage, as well as intralesional and perilesional hemosiderin deposition.展开更多
目的探究颈部血管彩超(CVUS)及颈部CT血管造影术(CTA)联合CT脑灌注成像(CTP)对急性脑梗死合并脑血管狭窄或闭塞的诊断价值。方法选取2018年1月至2019年4月在韩城市人民医院神经内科治疗的急性脑梗死患者54例作为研究对象,采用数字减影...目的探究颈部血管彩超(CVUS)及颈部CT血管造影术(CTA)联合CT脑灌注成像(CTP)对急性脑梗死合并脑血管狭窄或闭塞的诊断价值。方法选取2018年1月至2019年4月在韩城市人民医院神经内科治疗的急性脑梗死患者54例作为研究对象,采用数字减影血管造影(DSA)、CVUS、CTA、CTP检查(DSA为检查金标准),重建获取图像,比较病侧区、健侧对照区CTP参数脑灌注值、强化峰值(PE)、达峰时间(TTP)、脑血容量(CBV),并对比分析不同检查方法对脑血管狭窄或闭塞的诊断价值。结果 CTP检查结果显示,病侧区与健侧对照区的脑灌注值[(20.42±6.30) Hu vs (67.58±25.25) Hu]、PE [(4.38±0.53) Hu vs (7.81±0.50) Hu]、CBV [(2.20±0.34) mL/100 g vs (4.61±1.53) mL/100 g]比较,病侧区明显低于健侧对照区,TTP为(13.43±1.28) s,明显多于健侧对照区的(9.95±1.30) s,差异均有统计学意义(P<0.05);54例急性脑梗死患者应用DSA检查,均发现病灶同侧症状性脑动脉狭窄或闭塞,检出率为100%;应用CVUS检查,发现病灶同侧脑血管狭窄或闭塞者为42例,检出率为77.78%,CTA检查发现病灶同侧脑血管狭窄或闭塞41例,检出率为75.93%,CVUS和CTA的检出率明显低于DSA检出率,差异均有统计学意义(P<0.05);而CVUS+CTP检出者51例,检出率为94.44%,CTA+CTP检出者52例,检出率为96.30%,以上两者联合检查的检出率与DSA的检出率比较差异均无统计学意义(P>0.05)。结论 "CVUS+CT"与"CTA+CTP"检查均能够有效判断出急性脑梗死缺血范围,提高急性脑梗死合并症状性脑血管狭窄或闭塞的检出率,且与DSA相比差异不明显,值得推广使用。展开更多
基金the Medical Health Science and Tech-nology General Program of Guangzhou,No. 2009-YB-042
文摘Cerebral cavemous malformation （CCM） is a frequently occurring disease in Latin American populations, but little is known about the prevalence in China. This study enrolled one Chinese family with CCM, comprising 16 members; four were diagnosed with CCM which corresponded with autosomal incomplete dominance inheritance. The main clinical manifestations included headache, focal neural dysfunction, and cerebral hemorrhage. The lesions were a mixture of hyperintensity and hypointensity signals on TlWl and T2Wl, with a black hypointensity ring on T2Wl. CCM cranial magnetic resonance imaging T2Wl revealed an iron ring as a result of hemosiderin deposition. Pathological findings of CCM revealed tightly packed and variably thickened vascular channels lacking smooth muscle or elastic tissue. Intralesional hyalinosis, calcification, or bleeding of different phases and perilesional glial hyperplasia were observed, as well as hemosiderin deposition within or around the lesions. These features of this family were consistent with specific genetic, imaging and pathological features of familial CCM. Pathological characteristics reveal repeated hemorrhage, as well as intralesional and perilesional hemosiderin deposition.
文摘目的探究颈部血管彩超(CVUS)及颈部CT血管造影术(CTA)联合CT脑灌注成像(CTP)对急性脑梗死合并脑血管狭窄或闭塞的诊断价值。方法选取2018年1月至2019年4月在韩城市人民医院神经内科治疗的急性脑梗死患者54例作为研究对象,采用数字减影血管造影(DSA)、CVUS、CTA、CTP检查(DSA为检查金标准),重建获取图像,比较病侧区、健侧对照区CTP参数脑灌注值、强化峰值(PE)、达峰时间(TTP)、脑血容量(CBV),并对比分析不同检查方法对脑血管狭窄或闭塞的诊断价值。结果 CTP检查结果显示,病侧区与健侧对照区的脑灌注值[(20.42±6.30) Hu vs (67.58±25.25) Hu]、PE [(4.38±0.53) Hu vs (7.81±0.50) Hu]、CBV [(2.20±0.34) mL/100 g vs (4.61±1.53) mL/100 g]比较,病侧区明显低于健侧对照区,TTP为(13.43±1.28) s,明显多于健侧对照区的(9.95±1.30) s,差异均有统计学意义(P<0.05);54例急性脑梗死患者应用DSA检查,均发现病灶同侧症状性脑动脉狭窄或闭塞,检出率为100%;应用CVUS检查,发现病灶同侧脑血管狭窄或闭塞者为42例,检出率为77.78%,CTA检查发现病灶同侧脑血管狭窄或闭塞41例,检出率为75.93%,CVUS和CTA的检出率明显低于DSA检出率,差异均有统计学意义(P<0.05);而CVUS+CTP检出者51例,检出率为94.44%,CTA+CTP检出者52例,检出率为96.30%,以上两者联合检查的检出率与DSA的检出率比较差异均无统计学意义(P>0.05)。结论 "CVUS+CT"与"CTA+CTP"检查均能够有效判断出急性脑梗死缺血范围,提高急性脑梗死合并症状性脑血管狭窄或闭塞的检出率,且与DSA相比差异不明显,值得推广使用。
