目的对比改良肩关节镜下双纽扣钢板动态固定与锁骨钩钢板切开复位内固定治疗RockwoodⅢ~Ⅴ型肩锁关节脱位的中期疗效。方法回顾性分析2015年1月至2019年12月华中科技大学同济医学院附属同济医院收治的51例RockwoodⅢ~Ⅴ型肩锁关节脱位...目的对比改良肩关节镜下双纽扣钢板动态固定与锁骨钩钢板切开复位内固定治疗RockwoodⅢ~Ⅴ型肩锁关节脱位的中期疗效。方法回顾性分析2015年1月至2019年12月华中科技大学同济医学院附属同济医院收治的51例RockwoodⅢ~Ⅴ型肩锁关节脱位患者资料,其中RockwoodⅢ型19例,Ⅳ型18例,Ⅴ型14例;男32例,女19例;年龄11~65岁,平均(38.6±17.2)岁。21例行改良肩关节镜下双纽扣钢板动态固定术(A组),30例行锁骨钩钢板切开复位内固定术(B组)。比较两组术中及术后住院情况,采用Constant-Murley评分、加利福尼亚大学洛杉矶分校(University of California at Los Angeles,UCLA)评分、疼痛视觉模拟评分(visual analogue scale,VAS)评估肩关节功能。结果患者术后随访24~29个月,平均(24.4±5.2)个月。相较于B组,A组术中出血量更少,住院时间更短,住院总费用更低,但手术时间更长,差异均有统计学意义(P<0.05)。术后3周、6周、12周,A组的Constant-Murley评分、UCLA评分和VAS均优于B组(P<0.05);末次随访时以上3项评价指标组间比较差异均无统计学意义(P>0.05)。两组Constant-Murley评分和UCLA评分术后生存率比较,术后早期A组明显优于B组,末次随访时两组差异无统计学意义。结论对于RockwoodⅢ~Ⅴ型肩锁关节脱位,术后早期(术后3周、6周、12周)关节镜下改良纽扣钢板动态固定更有优势,术后中期(术后24个月)两种方式的治疗效果差异无统计学意义。展开更多
BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity ...BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis.AIM To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in IBD.METHODS H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic activity.Subsequently,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic inflammation.The effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,respectively.Finally,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood biochemistry.RESULTS H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy mice.No significant damage to major organs was observed in healthy mice following H-CeO2 administration.CONCLUSION The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.展开更多
文摘目的对比改良肩关节镜下双纽扣钢板动态固定与锁骨钩钢板切开复位内固定治疗RockwoodⅢ~Ⅴ型肩锁关节脱位的中期疗效。方法回顾性分析2015年1月至2019年12月华中科技大学同济医学院附属同济医院收治的51例RockwoodⅢ~Ⅴ型肩锁关节脱位患者资料,其中RockwoodⅢ型19例,Ⅳ型18例,Ⅴ型14例;男32例,女19例;年龄11~65岁,平均(38.6±17.2)岁。21例行改良肩关节镜下双纽扣钢板动态固定术(A组),30例行锁骨钩钢板切开复位内固定术(B组)。比较两组术中及术后住院情况,采用Constant-Murley评分、加利福尼亚大学洛杉矶分校(University of California at Los Angeles,UCLA)评分、疼痛视觉模拟评分(visual analogue scale,VAS)评估肩关节功能。结果患者术后随访24~29个月,平均(24.4±5.2)个月。相较于B组,A组术中出血量更少,住院时间更短,住院总费用更低,但手术时间更长,差异均有统计学意义(P<0.05)。术后3周、6周、12周,A组的Constant-Murley评分、UCLA评分和VAS均优于B组(P<0.05);末次随访时以上3项评价指标组间比较差异均无统计学意义(P>0.05)。两组Constant-Murley评分和UCLA评分术后生存率比较,术后早期A组明显优于B组,末次随访时两组差异无统计学意义。结论对于RockwoodⅢ~Ⅴ型肩锁关节脱位,术后早期(术后3周、6周、12周)关节镜下改良纽扣钢板动态固定更有优势,术后中期(术后24个月)两种方式的治疗效果差异无统计学意义。
文摘BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory disease.High oxidative stress is a treatment target for IBD.Cerium oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis.AIM To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in IBD.METHODS H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic activity.Subsequently,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic inflammation.The effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,respectively.Finally,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood biochemistry.RESULTS H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy mice.No significant damage to major organs was observed in healthy mice following H-CeO2 administration.CONCLUSION The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.
