Objective： To investigate the relationship among plasma endothelin（ET）, calcitonin gene-related peptide（CGRP） and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo（CV） and to ass...Objective： To investigate the relationship among plasma endothelin（ET）, calcitonin gene-related peptide（CGRP） and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo（CV） and to assess the effect of ET and CGRP on the onset of CV. Methods：The concentration of ET and CGRP in 64 patients with CV and 30 controls was determined by radioimmunity method. The average blood flow velocity （Vm） of bilateral vertebral arteries was detected by Transcranial Doppler（TCD）. Results：Plasma concen- tration ofET（91.48 ± 9.08 pg/ml） and ET/CGRP ratio value（2.88 ± 0.52） in vertebrobasilar arteriospasm group were both higher than those in vertebrobasilar non-arteriospasm group and in controls, while CGRP concentration（30.66 ± 6.05 pg/ml） in vertebrobasilar arteriospasm group was lower than that in vertebrobasilar non-arteriospasm group and controls respectively. The Vm of bilateral verte- bral arteries in vertebrobasilar arteriospasm group（67.97 ± 11.64 cm/s ） was higher than that in vertebrobasilar non-arteriospasm group and controls respectively, having a positive correlation with ET concentration and ET/CGRP ratio value（r1=0.52, P 〈 0.05; r2=0.59, P 〈 0.05）, but a negative correlation with CGRP concentration（r3=-0.54, P 〈 0.05）. There was no significant difference in ET and CGRP concentration, ET/CGRP ratio value and the Vm of bilateral vertebral arteries between vertebrobasilar non-arteriospasm group and the control group. Conclusion： All the results indicate that ET and CGRP are possibly the most important substance factors at the onset of CV with vertebrobasilar arteriospasm, and their imbalance of regulating vertebrobasilar arterial contraction and relaxation may play an important role in the onset of CV with vertebrobasilar arteriospasm.展开更多
Objective:Through the real-world electronic medical record information system,the medical records of patients with cervical vertigo were sorted and statistically analyzed to explore the risk factors of patients with c...Objective:Through the real-world electronic medical record information system,the medical records of patients with cervical vertigo were sorted and statistically analyzed to explore the risk factors of patients with cervical vertigo.Method:Retrospective case-control study was adopted.The general status and accompanying symptoms,medical history,auxiliary examination and other medical records of the patients were subject to statistical analysis,and risk factors were determined from logistic regression analysis.Results:The results of imaging examination showed that the risk of vertigo in patients with abnormal cervical physiological curvature was 2.607 times higher than that in patients with normal cervical physiological curvature,and the risk of vertigo in patients with narrowed intervertebral space was 0.431 times higher than that in patients with normal intervertebral space.Conclusion:There were differences in gender,cervical physiological curvature,intervertebral space and other clinical indexes between patients with cervical vertigo and patients without cervical vertigo.Abnormal cervical physiological curvature and narrowing of intervertebral space were significantly correlated with vertigo.展开更多
文摘Objective： To investigate the relationship among plasma endothelin（ET）, calcitonin gene-related peptide（CGRP） and blood flow rate of bilateral vertebral arteries in patients with cervical vertigo（CV） and to assess the effect of ET and CGRP on the onset of CV. Methods：The concentration of ET and CGRP in 64 patients with CV and 30 controls was determined by radioimmunity method. The average blood flow velocity （Vm） of bilateral vertebral arteries was detected by Transcranial Doppler（TCD）. Results：Plasma concen- tration ofET（91.48 ± 9.08 pg/ml） and ET/CGRP ratio value（2.88 ± 0.52） in vertebrobasilar arteriospasm group were both higher than those in vertebrobasilar non-arteriospasm group and in controls, while CGRP concentration（30.66 ± 6.05 pg/ml） in vertebrobasilar arteriospasm group was lower than that in vertebrobasilar non-arteriospasm group and controls respectively. The Vm of bilateral verte- bral arteries in vertebrobasilar arteriospasm group（67.97 ± 11.64 cm/s ） was higher than that in vertebrobasilar non-arteriospasm group and controls respectively, having a positive correlation with ET concentration and ET/CGRP ratio value（r1=0.52, P 〈 0.05; r2=0.59, P 〈 0.05）, but a negative correlation with CGRP concentration（r3=-0.54, P 〈 0.05）. There was no significant difference in ET and CGRP concentration, ET/CGRP ratio value and the Vm of bilateral vertebral arteries between vertebrobasilar non-arteriospasm group and the control group. Conclusion： All the results indicate that ET and CGRP are possibly the most important substance factors at the onset of CV with vertebrobasilar arteriospasm, and their imbalance of regulating vertebrobasilar arterial contraction and relaxation may play an important role in the onset of CV with vertebrobasilar arteriospasm.
基金supported by Health Research Fund of Shaanxi Province(No.:2018D018).
文摘Objective:Through the real-world electronic medical record information system,the medical records of patients with cervical vertigo were sorted and statistically analyzed to explore the risk factors of patients with cervical vertigo.Method:Retrospective case-control study was adopted.The general status and accompanying symptoms,medical history,auxiliary examination and other medical records of the patients were subject to statistical analysis,and risk factors were determined from logistic regression analysis.Results:The results of imaging examination showed that the risk of vertigo in patients with abnormal cervical physiological curvature was 2.607 times higher than that in patients with normal cervical physiological curvature,and the risk of vertigo in patients with narrowed intervertebral space was 0.431 times higher than that in patients with normal intervertebral space.Conclusion:There were differences in gender,cervical physiological curvature,intervertebral space and other clinical indexes between patients with cervical vertigo and patients without cervical vertigo.Abnormal cervical physiological curvature and narrowing of intervertebral space were significantly correlated with vertigo.
