Objective: To investigate the significance of cerbB2 and PCNA expression in adenocarcinoma. Methods: Expression of cerbB2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemi...Objective: To investigate the significance of cerbB2 and PCNA expression in adenocarcinoma. Methods: Expression of cerbB2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemistry. Results: The expression of cerbB2 was detected in 34 cases. The positive staining of cerbB2 was associated with increased lymph node metastasis (57.1% Vs 24.0%, P=0.041) and lower 5year survival rate (32.4% Vs 58.9%, P=0.008). The average PCNA labeling index (PCNA LI) was 40.6% (0.1% 91.4%). High PCNA LI was associated with lymph node metastasis (56.4% Vs 38.5%, P=0.016) and lower 5year survival rate (28.7% Vs 64.4%, P=0.005). Positive staining of cerbB2 were associated with high PCNA LI (44.7% Vs 34.6% P=0.003). Conclusions: cerbB2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical adenocarcinoma.展开更多
BACKGROUND The female genital tract is an uncommon site of involvement for extra-genital malignancies. Ovarian metastases have been described as disseminations of lung adenocarcinoma;rare cases of secondary localizati...BACKGROUND The female genital tract is an uncommon site of involvement for extra-genital malignancies. Ovarian metastases have been described as disseminations of lung adenocarcinoma;rare cases of secondary localizations in the cervix, adnexa, and vagina have also been reported in the literature. Here, we report two cases of advanced lung adenocarcinoma with female genital tract metastasis. CASE SUMMARY The first case was a 41-year-old woman with stage IV lung adenocarcinoma metastasizing to the cervix. Immunohistochemistry of the cervical biopsy specimen revealed thyroid transcription factor (TTF)-1(+), cytokeratin (CK)-7(+), and (CK)-20(-). Gene mutational analysis showed epidermal growth factor receptor (EGFR) L858R mutation in exon 21. She had a positive response to gefitinib, for both the pulmonary mass and cervical neoplasm. The second case was a 29-year-old woman who was diagnosed with stage IV lung adenocarcinoma with EGFR mutation. After 12 mo of treatment with icotinib, ovarian biopsy showed adenocarcinoma with CDX2(-), TTF-1(+++), PAX8(-), CK- 7(+++), CK-20(++), and Ki67(15%+), accompanied with EGFR 19-del mutation and T790M mutation. CONCLUSION Immunohistochemistry and gene mutational testing have greatly helped in locating the initial tumor site when both pulmonary and female genital tract neoplasms exist.展开更多
文摘Objective: To investigate the significance of cerbB2 and PCNA expression in adenocarcinoma. Methods: Expression of cerbB2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemistry. Results: The expression of cerbB2 was detected in 34 cases. The positive staining of cerbB2 was associated with increased lymph node metastasis (57.1% Vs 24.0%, P=0.041) and lower 5year survival rate (32.4% Vs 58.9%, P=0.008). The average PCNA labeling index (PCNA LI) was 40.6% (0.1% 91.4%). High PCNA LI was associated with lymph node metastasis (56.4% Vs 38.5%, P=0.016) and lower 5year survival rate (28.7% Vs 64.4%, P=0.005). Positive staining of cerbB2 were associated with high PCNA LI (44.7% Vs 34.6% P=0.003). Conclusions: cerbB2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical adenocarcinoma.
基金Supported by the National Natural Science Foundation of China,No.81670017
文摘BACKGROUND The female genital tract is an uncommon site of involvement for extra-genital malignancies. Ovarian metastases have been described as disseminations of lung adenocarcinoma;rare cases of secondary localizations in the cervix, adnexa, and vagina have also been reported in the literature. Here, we report two cases of advanced lung adenocarcinoma with female genital tract metastasis. CASE SUMMARY The first case was a 41-year-old woman with stage IV lung adenocarcinoma metastasizing to the cervix. Immunohistochemistry of the cervical biopsy specimen revealed thyroid transcription factor (TTF)-1(+), cytokeratin (CK)-7(+), and (CK)-20(-). Gene mutational analysis showed epidermal growth factor receptor (EGFR) L858R mutation in exon 21. She had a positive response to gefitinib, for both the pulmonary mass and cervical neoplasm. The second case was a 29-year-old woman who was diagnosed with stage IV lung adenocarcinoma with EGFR mutation. After 12 mo of treatment with icotinib, ovarian biopsy showed adenocarcinoma with CDX2(-), TTF-1(+++), PAX8(-), CK- 7(+++), CK-20(++), and Ki67(15%+), accompanied with EGFR 19-del mutation and T790M mutation. CONCLUSION Immunohistochemistry and gene mutational testing have greatly helped in locating the initial tumor site when both pulmonary and female genital tract neoplasms exist.
