Lymphocyte chalone was partially purified by ultrafiltration and chromatography onSep hadex G75 column.Its inhibitory effect on proliferation of T,B lymphoctes was demonstratedby[~3H]-TdR incorporation method.In mouse...Lymphocyte chalone was partially purified by ultrafiltration and chromatography onSep hadex G75 column.Its inhibitory effect on proliferation of T,B lymphoctes was demonstratedby[~3H]-TdR incorporation method.In mouse bone marrow transplantation model,the treatmentwith lymphocyte chalone in vivo and in vitro was found to have significantly improved the 30 daysurvival rate and mean survival time,suggesting its inhibitory effect on acute graft-versus-host dis-ease(GVHD)and the helpful effect on H-2 incompatible tone marrow transplantation in mice.展开更多
基金This projection was supported by the National Natural Science Fundation of China
文摘Lymphocyte chalone was partially purified by ultrafiltration and chromatography onSep hadex G75 column.Its inhibitory effect on proliferation of T,B lymphoctes was demonstratedby[~3H]-TdR incorporation method.In mouse bone marrow transplantation model,the treatmentwith lymphocyte chalone in vivo and in vitro was found to have significantly improved the 30 daysurvival rate and mean survival time,suggesting its inhibitory effect on acute graft-versus-host dis-ease(GVHD)and the helpful effect on H-2 incompatible tone marrow transplantation in mice.
