期刊文献+
共找到683篇文章
< 1 2 35 >
每页显示 20 50 100
Development and characterization of the PolyU-1 lunar regolith simulant based on Chang’e-5 returned samples 被引量:1
1
作者 Yuan Zou Huanyu Wu +3 位作者 Shupeng Chai Wei Yang Renhao Ruan Qi Zhao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第9期1317-1326,共10页
Leading national space exploration agencies and private enterprises are actively engaged in lunar exploration initiatives to accomplish manned lunar landings and establish permanent lunar bases in the forthcoming year... Leading national space exploration agencies and private enterprises are actively engaged in lunar exploration initiatives to accomplish manned lunar landings and establish permanent lunar bases in the forthcoming years.With limited access to lunar surface materials on Earth,lunar regolith simulants are crucial for lunar exploration research.The Chang’e-5(CE-5)samples have been characterized by state-of-the-art laboratory equipment,providing a unique opportunity to develop a high-quality lunar regolith simulant.We have prepared a high-fidelity PolyU-1 simulant by pulverizing,desiccating,sieving,and blending natural mineral materials on Earth based on key physical,mineral,and chemical characteristics of CE-5 samples.The results showed that the simulant has a high degree of consistency with the CE-5 samples in terms of the particle morphology,mineral and chemical composition.Direct shear tests were conducted on the simulant,and the measured internal friction angle and cohesion values can serve as references for determining the mechanical properties of CE-5 lunar regolith.The PolyU-1 simulant can contribute to experimental studies involving lunar regolith,including the assessment of interaction between rovers and lunar regolith,as well as the development of in-situ resource utilization(ISRU)technologies. 展开更多
关键词 Lunar regolith Simulant Lunar soil mechanics change-5 ISRU Lunar exploration
下载PDF
祛瘀护膜法调控PI3K/Akt通路对反流性食管炎大鼠E-钙黏蛋白表达和食管黏膜修复的影响
2
作者 胡绍江 吴婷婷 +5 位作者 朱惠萍 梁国强 丁姮月 杨欣 王敏 孙宏文 《现代中西医结合杂志》 CAS 2024年第15期2066-2077,共12页
目的基于磷脂酰肌醇3-激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(Akt)信号通路调控E-钙黏蛋白(E-cadherin)的表达,探讨祛瘀护膜法对反流性食管炎(RE)大鼠食管黏膜损伤的影响,进一步明确其作用机制。方法取68只雄性SD大鼠,随机选择10只大鼠作为... 目的基于磷脂酰肌醇3-激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(Akt)信号通路调控E-钙黏蛋白(E-cadherin)的表达,探讨祛瘀护膜法对反流性食管炎(RE)大鼠食管黏膜损伤的影响,进一步明确其作用机制。方法取68只雄性SD大鼠,随机选择10只大鼠作为假手术组,剩余大鼠采用4.2 mm幽门夹+2/3胃底结扎术方法建立RE模型。将56只造模成功的大鼠随机分为7组,每组8只。雷贝拉唑组给予雷贝拉唑0.0018 g/kg灌胃,铝镁加组给予铝镁加混悬液0.0135 g/kg灌胃,雷贝拉唑+祛瘀护膜剂组给予雷贝拉唑0.0018 g/kg+祛瘀护膜剂1.62 g/kg灌胃,雷贝拉唑+加味祛瘀护膜剂组给予雷贝拉唑0.0018 g/kg+加味祛瘀护膜剂2.97 g/kg灌胃,祛瘀护膜剂组给予祛瘀护膜剂1.62 g/kg灌胃,加味祛瘀护膜剂组给予加味祛瘀护膜剂2.97 g/kg灌胃,假手术组和模型组给予蒸馏水+淀粉灌胃,均1次/d,连续灌胃14 d。观察大鼠一般情况,末次灌胃结束后取出全胃计算胃内色素残留率,HE染色观察食管组织病理形态,透射电镜观察食管组织Cajal间质细胞结构,RT-PCR法检测食管组织中E-cadherin、锌指转录因子(Slug)mRNA表达情况,Western blot法检测食管组织中E-cadherin、半胱氨酸蛋白酶-1(Caspase-1)、磷酸化PI3K(p-PI3K)、磷酸化Akt(p-Akt)、第10号染色体缺失的磷酸酶和张力蛋白同源基因(PTEN)、磷酸肌醇依赖性蛋白激酶-1(PDK1)蛋白表达情况,免疫组织化学法检测食管组织中E-cadherin、Caspase-1、PTEN、PDK1阳性表达情况,ELISA法检测血清中Caspase-1、白细胞介素-1β(IL-1β)、白细胞介素-17(IL-17)、白细胞介素-18(IL-18)、白细胞介素-23(IL-23)水平。结果与假手术组比较,模型组大鼠胃内色素残留率明显升高(P<0.05);食管组织可见炎性细胞浸润,黏膜层轻度增厚,Cajal间质细胞数量减少;食管组织中E-cadherin mRNA相对表达量和E-cadherin、PTEN蛋白相对表达量及E-cadherin、PTEN阳性表达面积率均明显降低(P均<0.05),Slug mRNA相对表达量和Caspase-1、p-PI3K、p-Akt、PDK1蛋白相对表达量及Caspase-1、PDK1阳性表达面积率均明显升高(P均<0.05);血清Caspase-1、IL-1β、IL-17、IL-18、IL-23水平均明显升高(P均<0.05)。与模型组比较,各药物组大鼠胃内色素残留率均明显降低(P均<0.05);食管组织损伤明显减轻;雷贝拉唑+祛瘀护膜剂组、雷贝拉唑+加味祛瘀护膜剂组食管组织中E-cadherin mRNA相对表达量和E-cadherin、PTEN蛋白相对表达量及E-cadherin、PTEN阳性表达面积率均明显升高(P均<0.05),Slug mRNA相对表达量和Caspase-1、p-PI3K、p-Akt、PDK1蛋白相对表达量及Caspase-1、PDK1阳性表达面积率均明显降低(P均<0.05);血清Caspase-1、IL-1β、IL-17、IL-18、IL-23水平均明显降低(P均<0.05)。与雷贝拉唑组比较,雷贝拉唑+祛瘀护膜剂组、雷贝拉唑+加味祛瘀护膜剂组食管组织中E-cadherin mRNA相对表达量和E-cadherin、PTEN蛋白相对表达量及E-cadherin、PTEN阳性表达面积率均明显升高(P均<0.05),Slug mRNA相对表达量和Caspase-1、p-PI3K、p-Akt蛋白相对表达量及Caspase-1、PDK1阳性表达面积率均明显降低(P均<0.05);雷贝拉唑+加味祛瘀护膜剂组食管组织中PDK1蛋白相对表达量和血清Caspase-1、IL-1β、IL-17、IL-18、IL-23水平均明显降低(P均<0.05)。雷贝拉唑+加味祛瘀护膜剂组食管组织中p-PI3K、p-Akt蛋白相对表达量和血清Caspase-1、IL-1β、IL-17、IL-18、IL-23水平均明显低于雷贝拉唑+祛瘀护膜剂组(P均<0.05)。结论祛瘀护膜法可通过抑制PI3K/Akt通路过度激活作用于E-cadherin、Slug转录因子,在下调Caspase-1、p-PI3K、p-Akt、PDK1蛋白表达的同时上调E-cadherin、PTEN蛋白的表达,进而降低血清中Caspase-1、IL-1β、IL-17、IL-18、IL-23水平,减轻上皮组织细胞的炎性病变和(或)抑制细胞的转移、浸润,促进食管黏膜损伤修复,其联合西药治疗效果更佳,且优化组方作用更明显。 展开更多
关键词 反流性食管炎 食管黏膜 祛瘀护膜法 磷脂酰肌醇3-激酶 丝氨酸-苏氨酸蛋白激酶 e-钙黏蛋白
下载PDF
Lunar Penetrating Radar onboard the Chang'e-3 mission 被引量:15
3
作者 Guang-You Fang Bin Zhou +11 位作者 Yi-Cai Ji Qun-Ying Zhang Shao-Xiang Shen Yu-Xi Li Hong-Fei Guan Chuan-Jun Tang Yun-Ze Gao Wei Lu Sheng-Bo Ye Hai-Dong Han Jin Zheng Shu-Zhi Wang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第12期1607-1622,共16页
Lunar Penetrating Radar (LPR) is one of the important scientific instru- ments onboard the Chang'e-3 spacecraft. Its scientific goals are the mapping of lunar regolith and detection of subsurface geologic structure... Lunar Penetrating Radar (LPR) is one of the important scientific instru- ments onboard the Chang'e-3 spacecraft. Its scientific goals are the mapping of lunar regolith and detection of subsurface geologic structures. This paper describes the goals of the mission, as well as the basic principles, design, composition and achievements of the LPR. Finally, experiments on a glacier and the lunar surface are analyzed. 展开更多
关键词 change-3 mission -- moon rover -- Lunar Penetrating Radar
下载PDF
Development and calibration of the Moon-based EUV camera for Chang'e-3 被引量:4
4
作者 Bo Chen Ke-Fei Song +31 位作者 Zhao-Hui Li Qing-Wen Wu Qi-Liang Ni Xiao-Dong Wang Jin-Jiang Xie Shi-Jie Liu Ling-Ping He Fei He Xiao-Guang Wang Bin Chen Hong-Ji Zhang Xiao-Dong Wang Hai-Feng Wang Xin Zheng Shu-Lin E Yong-Cheng Wang Tao Yu Liang Sun Jin-Ling Wang Zhi Wang Liang Yang Qing-Long Hu Ke Qiao Zhong-Su Wang Xian-Wei Yang Hai-Ming Bao Wen-Guang Liu Zhe Li Ya Chen Yang Gao Hui Sun Wen-Chang Chen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第12期1654-1663,共10页
The process of development and calibration for the first Moon-based ex- treme ultraviolet (EUV) camera to observe Earth's plasmasphere is introduced and the design, test and calibration results are presented. The E... The process of development and calibration for the first Moon-based ex- treme ultraviolet (EUV) camera to observe Earth's plasmasphere is introduced and the design, test and calibration results are presented. The EUV camera is composed of a multilayer film mirror, a thin film filter, a photon-counting imaging detector, a mech- anism that can adjust the direction in two dimensions, a protective cover, an electronic unit and a thermal control unit. The center wavelength of the EUV camera is 30.2 nm with a bandwidth of 4.6nm. The field of view is 14.7° with an angular resolution of 0.08°, and the sensitivity of the camera is 0.11 count s-1 Rayleigh-1. The geomet- ric calibration, the absolute photometric calibration and the relative photometric cal- ibration are carried out under different temperatures before launch to obtain a matrix that can correct geometric distortion and a matrix for relative photometric correction, which are used for in-orbit correction of the images to ensure their accuracy. 展开更多
关键词 change-3 -- EUV camera: development: calibration -- Earth's plas-masphere -- lunar exploration
下载PDF
Data processing and preliminary results of the Chang'e-3 VIS/NIR Imaging Spectrometer in-situ analysis 被引量:3
5
作者 Bin Liu Chun-Lai Li +7 位作者 Guang-Liang Zhang Rui Xu Jian-Jun Liu Xin Ren Xu Tan Xiao-Xia Zhang Wei Zuo Wei-Bin Wen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第12期1578-1594,共17页
The Chang'e-3 Visible and Near-infrared Imaging Spectrometer (VNIS) is one of the four payloads on the Yutu rover. After traversing the landing site during the first two lunar days, four different areas are detecte... The Chang'e-3 Visible and Near-infrared Imaging Spectrometer (VNIS) is one of the four payloads on the Yutu rover. After traversing the landing site during the first two lunar days, four different areas are detected, and Level 2A and 2B ra- diance data have been released to the scientific community. The released data have been processed by dark current subtraction, correction for the effect of temperature, radiometric calibration and geometric calibration. We emphasize approaches for re- flectance analysis and mineral identification for in-situ analysis with VNIS. Then the preliminary spectral and mineralogical results from the landing site are derived. After comparing spectral data from VNIS with data collected by the Ma instrument and samples of mare that were returned from the Apollo program, all the reflectance data have been found to have similar absorption features near 1000 nm except lunar sample 71061. In addition, there is also a weak absorption feature between 1750-2400nm on VNIS, but the slopes of VNIS and Ma reflectance at longer wavelengths are lower than data taken from samples of lunar mare. Spectral parameters such as Band Centers and Integrated Band Depth Ratios are used to analyze mineralogical features. The results show that detection points E and N205 are mixtures of high-Ca pyroxene and olivine, and the composition of olivineat point N205 is higher than that at point E, but the compositions of detection points S3 and N203 are mainly olivine-rich. Since there are no obvious absorption features near 1250 nm, plagioclase is not directly identified at the landing site. 展开更多
关键词 change-3 -- VNIS -- in-situ analysis -- data processing
下载PDF
Metallurgical performance evaluation of space-weathered Chang’e-5 lunar soil
6
作者 Chen Li Wenhui Ma +1 位作者 Yang Li Kuixian Wei 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第6期1241-1248,共8页
Space metallurgy is an interdisciplinary field that combines planetary space science and metallurgical engineering.It involves systematic and theoretical engineering technology for utilizing planetary resources in sit... Space metallurgy is an interdisciplinary field that combines planetary space science and metallurgical engineering.It involves systematic and theoretical engineering technology for utilizing planetary resources in situ.However,space metallurgy on the Moon is challenging because the lunar surface has experienced space weathering due to the lack of atmosphere and magnetic field,making the mi-crostructure of lunar soil differ from that of minerals on the Earth.In this study,scanning electron microscopy and transmission electron microscopy analyses were performed on Chang’e-5 powder lunar soil samples.The microstructural characteristics of the lunar soil may drastically change its metallurgical performance.The main special structure of lunar soil minerals include the nanophase iron formed by the impact of micrometeorites,the amorphous layer caused by solar wind injection,and radiation tracks modified by high-energy particle rays inside mineral crystals.The nanophase iron presents a wide distribution,which may have a great impact on the electromagnetic prop-erties of lunar soil.Hydrogen ions injected by solar wind may promote the hydrogen reduction process.The widely distributed amorph-ous layer and impact glass can promote the melting and diffusion process of lunar soil.Therefore,although high-energy events on the lun-ar surface transform the lunar soil,they also increase the chemical activity of the lunar soil.This is a property that earth samples and tradi-tional simulated lunar soil lack.The application of space metallurgy requires comprehensive consideration of the unique physical and chemical properties of lunar soil. 展开更多
关键词 space metallurgy change-5 lunar soil space weathering metallurgical performance
下载PDF
Preface: The Chang'e-3 lander and rover mission to the Moon 被引量:1
7
作者 Wing-Huen Ip Jun Yan +1 位作者 Chun-Lai Li Zi-Yuan Ouyang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第12期1511-1513,共3页
The Chang'e-3 (CE-3) lander and rover mission to the Moon was an in- termediate step in China's lunar exploration program, which will be followed by a sample return mission. The lander was equipped with a number o... The Chang'e-3 (CE-3) lander and rover mission to the Moon was an in- termediate step in China's lunar exploration program, which will be followed by a sample return mission. The lander was equipped with a number of remote-sensing instruments including a pair of cameras (Landing Camera and Terrain Camera) for recording the landing process and surveying terrain, an extreme ultraviolet camera for monitoring activities in the Earth's plasmasphere, and a first-ever Moon-based ultravi- olet telescope for astronomical observations. The Yutu rover successfully carried out close-up observations with the Panoramic Camera, mineralogical investigations with the VIS-NIR Imaging Spectrometer, study of elemental abundances with the Active Particle-induced X-ray Spectrometer, and pioneering measurements of the lunar sub- surface with Lunar Penetrating Radar. This special issue provides a collection of key information on the instrumental designs, calibration methods and data processing pro- cedures used by these experiments with a perspective of facilitating further analyses of scientific data from CE-3 in preparation for future missions. 展开更多
关键词 change-3 - Moon lander - rover - radar - lunar telescope
下载PDF
Correlations between plasmapause evolutions and auroral signatures during substorms observed by Chang'e-3 EUV Camera 被引量:2
8
作者 XiaoXin Zhang Fei He +2 位作者 Bo Chen Chao Shen HuaNing Wang 《Earth and Planetary Physics》 2017年第1期35-43,共9页
The plasmapause locations determined from the Chang'e-3(CE-3) Extreme Ultraviolet Camera(EUVC) images and the auroral boundaries determined from the Defense Meteorological Satellite Program(DMSP) Special Sensor Ul... The plasmapause locations determined from the Chang'e-3(CE-3) Extreme Ultraviolet Camera(EUVC) images and the auroral boundaries determined from the Defense Meteorological Satellite Program(DMSP) Special Sensor Ultraviolet Spectrographic Imager(SSUSI) images are used to investigate the plasmaspheric evolutions during substorms. The most important finding is a nightside pointing plasmaspheric plume observed at 23:05 UT on 21 April 2014 under quiet solar wind and geomagnetic conditions, which drifted from the dusk sector. High correlations between the plasmapause evolutions and the auroral signatures exist during substorms. After substorm onset, the plasmapause erosion and the equatorward expansion of the auroral oval occur almost simultaneously in both MLT and UT, and then both the erosion and the expansion propagate westward and eastward. It is suggested that the plasmaspheric erosion and its MLT propagations are induced by the enhanced earthward plasma convection during substorm period, and the substorm dipolarization causes pitch-angle scattering of plasma sheet electrons and the resulting precipitation excites aurora emissions at the same time. 展开更多
关键词 PLASMASPHERE change-3 EUVC minimum L Algorithm SUBSTORM
下载PDF
Deployment Reliability Test and Assessment for Landing Gear of Chang' E-3 Probe 被引量:1
9
作者 吴琼 杨建中 +2 位作者 傅惠民 徐青华 满剑锋 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期782-784,800,共4页
Chang'E-3 probe incorporates four landing gears to assure the soft-landing,which are stowed while launching and deployed after separated from rocket. Deployment reliability is quite crucial for this mission. The d... Chang'E-3 probe incorporates four landing gears to assure the soft-landing,which are stowed while launching and deployed after separated from rocket. Deployment reliability is quite crucial for this mission. The deployment reliability test( DRT) method and assessment method were developed in this paper. Then DRT was conducted and the deployment reliability estimate of Chang'E-3probe was used to verify the proposed methods. 展开更多
关键词 change-3 landing gear DEPLOYMENT RELIABILITY test ASSESSMENT
下载PDF
miR-30e-5p通过靶向PIK3CD介导PI3K/AKT/mTOR信号通路对肝癌细胞侵袭和迁移的影响
10
作者 郝云鹤 邹瑞 +1 位作者 赵晓彪 李铎 《中国现代普通外科进展》 CAS 2024年第1期19-24,共6页
目的:探讨mi R-30e-5p通过靶向磷酸肌醇-3-激酶催化亚基δ肽(PIK3CD)介导磷酸肌醇3激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路抑制肝癌细胞的侵袭、迁移的机制。方法:将Hep G2通过转染相应质粒后分为对照组、miR-... 目的:探讨mi R-30e-5p通过靶向磷酸肌醇-3-激酶催化亚基δ肽(PIK3CD)介导磷酸肌醇3激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路抑制肝癌细胞的侵袭、迁移的机制。方法:将Hep G2通过转染相应质粒后分为对照组、miR-30e-5p mimics组、PIK3CD敲低组、阴性对照组、miR-30e-5p mimics+PIK3CD过表达组,实时荧光定量PCR和免疫印迹检测细胞miR-30e-5p、PIK3CD与PI3K/AKT/mTOR信号通路表达;CCK-8法检测各组细胞增殖率;细胞划痕实验和Transwell侵袭实验分别检测各组细胞迁移、侵袭情况;以免疫印迹实验检测各组细胞基质金属蛋白酶(MMP)2、MMP9及E-cadherin、N-cadherin、Vimentin蛋白表达。采用双荧光素酶报告实验检测miR-30e-5p对PIK3CD的靶向调节。结果:与对照组相比,mi R-30e-5p mimics组、PIK3CD敲低组增殖率、迁移率、侵袭数、PIK3CD蛋白与mRNA表达、N-cadherin、MMP2、MMP9、磷酸化PI3K、磷酸化AKT、磷酸化m TOR蛋白表达降低(P<0.05),E-cadherin表达升高(P<0.05)。过表达PIK3CD减弱了miR-30e-5p mimics对肝癌细胞增殖、迁移、侵袭的抑制作用,并升高PI3K/AKT/mTOR通过相关蛋白表达。miR-30e-5p可靶向下调PIK3CD表达。结论:上调miR-30e-5p可通过降低PIK3CD表达而阻止PI3K/AKT/mTOR信号激活,从而抑制肝癌细胞增殖、迁移和侵袭。 展开更多
关键词 miR-30e-5p PIK3CD PI3K/AKT/MTOR 肝肿瘤 侵袭 迁移
下载PDF
The formation and evolutionary characteristics of organic matter and pyrites in the continental shales of the 3^(rd)submember of Chang 7 Member,Yanchang formation,Ordos Basin,China
11
作者 Ruikang Bian 《Energy Geoscience》 EI 2024年第2期31-39,共9页
Through microscopic analyses(e.g.,organic macerals,thin section observation,scanning electron microscope(SEM)imaging of fresh bedding planes via argon ion milling,and energy spectrum tests)combined with Rock-Eval anal... Through microscopic analyses(e.g.,organic macerals,thin section observation,scanning electron microscope(SEM)imaging of fresh bedding planes via argon ion milling,and energy spectrum tests)combined with Rock-Eval analyses,this study systematically investigated the organic matter and pyrites in the continental shales in the 3^(rd)submember of the Chang 7 Member(Chang 7^(3)submember)in the Yanchang Formation,Ordos Basin and determined their types and the formation and evolutionary characteristics.The results are as follows.The organic matter of the continental shales in the Chang 7^(3)submember is dominated by amorphous bituminites and migrabitumens,which have come into being since the early diagenetic stage and middle diagenetic stage A,respectively.The formation and transformation of organic matter is a prerequisite for the formation of pyrites.The Ordos Basin was a continental freshwater lacustrine basin and lacked sulphates in waters during the deposition of the Chang 7 Member.Therefore,the syndiagenetic stage did not witness the formation of large quantities of pyrites.Since the basin entered early diagenetic stage A,large quantities of sulfur ions were released as the primary organic matter got converted into bituminites and,accordingly,pyrites started to form.However,this stage featured poorer fluid and spatial conditions compared with the syndepositional stage due to withdraw of water,the partial formation of bituminites,and a certain degree of compaction.As a result,large quantities of pyrrhotite failed to transition into typical spherical framboidal pyrites but grew into euhedral monocrystal aggregates.In addition,pyrites are still visible in the migrabitumens in both microfractures and inorganic pores of mudstones and shales,indicating that the pyrite formation period can extend until the middle diagenetic stage A. 展开更多
关键词 Organic matter Pyrite Formation and evolution Continental shale chang 7^(3)submember Ordos Basin
下载PDF
Nomenclature for lunar features at the Chang'e-3 landing site
12
作者 Zhoubin Zhang Chunlai Li +1 位作者 Wei Zuo Xingguo Zeng 《Acta Geochimica》 EI CAS CSCD 2017年第2期213-223,共11页
Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstan... Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstanding contributions of academics,masters in various fields, and popularize the traditional cultures of ethnic groups all over the world, but also have a critical function of providing accurate indicative information on features with special morphology, origin, nature and scientific value. However, nomenclature for features at the Chang'e-3 landing site, which has a more arbitrary form without many constrains posed by a uniformed system, is unlike the features for other morphological units.This paper originated from the actual needs for the description of scientific exploration activities, interpretation of scientific research and dissemination of scientific results. Some prominent morphological units with great scientific importance and identification purpose were chosen from the images taken by the terrain camera, panorama cameras and landing camera onboard the Chang'e lander and Yutu rover. A nomenclature system was established under the three enclosures, four quadrants and twenty-eight lunar lodges' system of the Chinese ancient sky division method. Finally, a standard feature names set waspublished after some necessary approval procedures by the International Astronomical Union. 展开更多
关键词 MOON change-3 Landing site Lunarfeature nomenclature
下载PDF
Reliability Design for the Landing Gear of Chang'E-3 Probe
13
作者 杨建中 吴琼 +1 位作者 满剑锋 朱汪 《Journal of Donghua University(English Edition)》 EI CAS 2015年第6期1006-1010,共5页
Landing gear is one of the important components of Chang'E-3 Probe.The device was used to absorb the impact energy of Chang'E-3 Probe during the landing process.After landing on the moon,it can support the lan... Landing gear is one of the important components of Chang'E-3 Probe.The device was used to absorb the impact energy of Chang'E-3 Probe during the landing process.After landing on the moon,it can support the lander steadily for a long time.In order to assure the reliability of the landing gear and deal with the extremely severe landing conditions,many reliability measures were adopted in the design procedure,such as selection of cushion materials,optimization of mechanism configuration,design of deployment mode,allocation of buffer force and control of its variation.The successful landing on the moon of Chang'E-3 Probe has completely verified the high reliability of the landing gear. 展开更多
关键词 landing gear change-3 Probe RELIABILITY design material CONFIGURATION
下载PDF
Nitrogen-Induced Change of Magnetic Properties in Antiperovskite-Type Carbide:Mn3InC
14
作者 伊木然 孙莹 +3 位作者 邓司浩 史可文 胡鹏伟 王聪 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第6期159-163,共5页
The effects of N substitution on the magnetic properties of Mn3InC1-xNx (0.0≤ x ≤0.7) are investigated sys- tematically. Partial substitution of N for C leads to the monotonic reduction in both the Curie temperatu... The effects of N substitution on the magnetic properties of Mn3InC1-xNx (0.0≤ x ≤0.7) are investigated sys- tematically. Partial substitution of N for C leads to the monotonic reduction in both the Curie temperature Tc and saturated magnetization Ms. The final results obtained from thermo-magnetie curves demonstrate that Mn3InC1-xNx samples show a magnetic phase transition from a paramagnetic (PM) state to a ferrimagnetic (FIM) state consisting of ferromagnetic (FM) and antiferromagnetie (AFM) components. In addition, there is a competition between the AFM component and the FM component in the FIM state with the change of the N-doped content. Magnetic measurements of Mn3InC at 100 Oe and 5000 Oe indicate the metastability and the coexistence of different magnetic phases at lower temperature. The spans of FIM phase broaden gradually with further N doping. The mechanism for the induction of the complicated magnetic state is still in controversy. However, the results clearly show that the doping at the X site in antiperovskite Mn3AX materials is as useful as that of the A and Mn sites. 展开更多
关键词 Nitrogen-Induced change of Magnetic Properties in Antiperovskite-Type Carbide:Mn3InC FIM Mn AFM
下载PDF
Improvement in refractive-index change in LiNbO3:Ce:Cu by applying an external electric field
15
作者 戴翠霞 刘立人 +3 位作者 刘德安 周煜 柴志方 栾竹 《Chinese Physics B》 SCIE EI CAS CSCD 2005年第12期2491-2495,共5页
By jointly solving two-centre material equations with a nonzero external electric field and coupled-wave equations, we have numerically studied the dependence of the non-volatile holographic recording in LiNbO3:Ce:C... By jointly solving two-centre material equations with a nonzero external electric field and coupled-wave equations, we have numerically studied the dependence of the non-volatile holographic recording in LiNbO3:Ce:Cu crystals on the external electric field. The dominative photovoltaic effect of the non-volatile holographic recording in doubly doped LiNbO3 crystals is directly verified. And an external electric field that is applied in the positive direction along the c-axis (or a large one in the negative direction of the c-axis) in the recording phase and another one that is applied in the negative direction of the c-axis in the fixing phase are both proved to benefit strong photorefractive performances. Experimental verifications are given with a small electric field applied externally. 展开更多
关键词 non-volatile holographic recording external electric field refractive-index change LiNbO3:Ce:Cu crystals
下载PDF
E-64d对大鼠视网膜缺血再灌注损伤中Calpain和Caspase-3表达的调控作用 被引量:6
16
作者 陈芝清 姚克 +2 位作者 徐雯 章征 朱雅琴 《眼科研究》 CSCD 北大核心 2007年第1期44-48,共5页
目的探讨E-64d(半胱氨酸蛋白酶抑制剂及钙激活中性蛋白酶抑制剂)在大鼠视网膜缺血再灌注损伤(RIRI)中对Calpain/Caspase-3表达的调节作用。方法将80只SD大鼠随机分为正常组、视网膜缺血再灌注组、对照组和E-64d治疗组,并分为1、3、6、24... 目的探讨E-64d(半胱氨酸蛋白酶抑制剂及钙激活中性蛋白酶抑制剂)在大鼠视网膜缺血再灌注损伤(RIRI)中对Calpain/Caspase-3表达的调节作用。方法将80只SD大鼠随机分为正常组、视网膜缺血再灌注组、对照组和E-64d治疗组,并分为1、3、6、24、72h5个时间段。通过前房穿刺加压法制成RIRI动物模型,采用Western-blot以及RT-PCR方法测定在大鼠RIRI模型中的Calpian、Caspase-3蛋白和mRNA表达情况。结果缺血再灌注24hm-Calpain、Caspase-3蛋白的表达缺血再灌注组较正常组上升,而E-64d组表达与正常组相似,比缺血再灌注组下降。E-64d能下调视网膜缺血再灌注后m-Calpain/Calpastatin的mRNA比值,在24h与缺血组有显著统计学差异。结论E-64d能降低视网膜缺血再灌注时m-Calpain、Caspase-3蛋白的表达,调控m-Calpain和Calpastatin的mRNA比值。 展开更多
关键词 e-64d 视网膜缺血再灌注损伤 CALPAIN CASPASe-3
下载PDF
E-钙粘素介导的细胞粘附通过EGFR激活卵巢癌细胞PI3K-Akt信号通路 被引量:9
17
作者 刘联 张昕 +3 位作者 王秀问 黎莉 于学军 徐从高 《现代妇产科进展》 CSCD 北大核心 2007年第4期270-273,共4页
目的研究E-钙粘素介导的细胞粘附对卵巢癌细胞Akt及其上游的磷脂酰肌醇3-激酶(phosphatidylinositol 3-Kinase,PI3K)信号的激活及对卵巢癌细胞增殖的作用。方法基于卵巢癌细胞株CaOV-3构建Ca2+依赖性细胞粘附模型;Western blot和免疫沉... 目的研究E-钙粘素介导的细胞粘附对卵巢癌细胞Akt及其上游的磷脂酰肌醇3-激酶(phosphatidylinositol 3-Kinase,PI3K)信号的激活及对卵巢癌细胞增殖的作用。方法基于卵巢癌细胞株CaOV-3构建Ca2+依赖性细胞粘附模型;Western blot和免疫沉淀法检测E-钙粘素介导的细胞粘附通过表皮生长因子受体(epidermal growth factor recep-tor,EGFR)对PI3K-Akt的激活;同时通过阻断该通路的关键组分观察对卵巢癌细胞增殖的影响。结果(1)E-钙粘素介导的细胞粘附可激活卵巢癌细胞内部的EGFR-PI3K-Akt信号通路;(2)应用E-钙粘素抗体或PI3K抑制剂处理的CaOV-3细胞株表现出生长受阻的现象,72h时细胞生长抑制率分别达73.5%和78.8%。结论E-钙粘素激活卵巢癌细胞EGFR-PI3K-Akt相关的信号转导通路对肿瘤细胞的增殖有重要作用。干预该信号通路的关键组分显著抑制细胞生长,为卵巢癌的靶向治疗提供了新的有价值的干预靶点。 展开更多
关键词 卵巢肿瘤 e-钙粘素 磷脂酰肌醇3-激酶 受体 表皮生长因子 细胞粘附 信号转导
下载PDF
p-STAT3与E-cadherin在胰腺癌中的表达及其临床意义 被引量:4
18
作者 黄陈 裘正军 +5 位作者 胡宏惠 江弢 朱麟 张放 黄克俭 曹俊 《世界华人消化杂志》 CAS 北大核心 2007年第4期381-386,共6页
目的:观察信号传导和转录激活因子3 (STAT3)活化形式-磷酸化STAT3(p-STAT3)和上皮型-钙黏附素(E-cadherin)在胰腺癌组织及细胞中的表达及其临床意义,探讨STAT3信号通路在胰腺癌侵袭转移中的作用.方法:免疫组化检测34例胰腺癌和10例正... 目的:观察信号传导和转录激活因子3 (STAT3)活化形式-磷酸化STAT3(p-STAT3)和上皮型-钙黏附素(E-cadherin)在胰腺癌组织及细胞中的表达及其临床意义,探讨STAT3信号通路在胰腺癌侵袭转移中的作用.方法:免疫组化检测34例胰腺癌和10例正常胰腺组织中p-STAT3和E-cad的表达,并分析其与胰腺癌临床病理特征的关系.细胞侵袭测定试剂盒检测胰腺癌细胞株SW1990和CaPan-2侵袭能力:分别采用Western blot和电泳迁移率变迁实验(EMSA)检测2种细胞中p-STAT3蛋白表达及STAT3-DNA结合活性.结果:免疫组化发现p-STAT3在胰腺癌组织中存在高表达(64.7%),与临床分期及淋巴结转移有关(P=0.017,P=0.013);E-cad在胰腺癌组织中表达明显降低,与组织学分级(P= 0.002)、临床分期(P=0.034)及淋巴结转移(P=0.019)有关.在胰腺癌组织中,p-STAT3与E-cad的表达呈负相关(r=-0.537,P=0.001).体外侵袭实验发现SW1990细胞比CaPan-2细胞具有更高的侵袭能力(P<0.05).Western blot发现在胰腺癌高侵袭力细胞株SW1990中p-STAT3蛋白呈高表达,而在低侵袭力细胞株CaPan-2中呈低表达;EMSA实验亦证实SW1990细胞较CaPan-2细胞具有更高的STAT3-DNA结合活性(P<0.05).结论:p-STAT3与胰腺癌侵袭转移及E-cad异常表达密切相关;联合检测两种蛋白对于胰腺癌恶性潜能的判断具有一定的参考价值. 展开更多
关键词 胰腺癌 信号传导与转录激活因子3 e-钙黏附素 侵袭 转移
下载PDF
银杏叶提取物及其黄酮类单体对ChangLiver细胞中CYP3A4和CYP2C9的影响 被引量:8
19
作者 袁凤 王蓉 +1 位作者 王世明 原永芳 《中南药学》 CAS 2013年第11期801-806,共6页
目的研究银杏叶提取物(GBE)及其黄酮类单体槲皮素和山柰酚对Chang Liver细胞CYP3A4、CYP2C9表达的影响。方法 CCK-8法检测GBE、槲皮素、山柰酚对Chang Liver细胞增殖的抑制作用;RT-PCR方法检测其不同浓度对Chang Liver细胞中CYP3A4 mRNA... 目的研究银杏叶提取物(GBE)及其黄酮类单体槲皮素和山柰酚对Chang Liver细胞CYP3A4、CYP2C9表达的影响。方法 CCK-8法检测GBE、槲皮素、山柰酚对Chang Liver细胞增殖的抑制作用;RT-PCR方法检测其不同浓度对Chang Liver细胞中CYP3A4 mRNA、CYP2C9 mRNA表达的影响;Western blot方法测定CYP3A4、CYP2C9蛋白表达的相对含量。结果 GBE呈浓度依赖性地诱导CYP3A4 mRNA和蛋白的表达,对CYP2C9mRNA和蛋白的表达没有显著作用;槲皮素对CYP3A4 mRNA和蛋白的表达有较明显的诱导作用,呈浓度依赖性地抑制CYP2C9 mRNA和蛋白的表达;山柰酚呈浓度依赖性地抑制细胞中CYP3A4 mRNA和蛋白的表达,对CYP2C9 mRNA和蛋白的表达没有显著影响。结论 GBE、槲皮素、山柰酚对Chang Liver细胞中CYP3A4、CYP2C9的表达具有不同的影响作用,这些结果为GBE与其他药物相互作用提供理论基础,提高联合用药的有效性及安全性,为黄酮类单体新药开发提供参考信息和理论依据。 展开更多
关键词 银杏叶提取物 槲皮素 山柰酚 chang Liver细胞 CYP3A4 CYP2C9
下载PDF
2E-3-苯基丙烯酰氧基烃基膦酸二乙酯的合成与生物活性研究 被引量:2
20
作者 王涛 黄海金 +1 位作者 罗劲 周水桃 《江西师范大学学报(自然科学版)》 CAS 北大核心 2011年第1期15-20,共6页
设计、合成了系列新的2E-3-苯基丙烯酰氧基烃基膦酸酯衍生物4a^4m,它们的结构经元素分析、IR、1H NMR、31P NMR和MS测试而确定.初步的生物活性测试结果表明,部分标题化合物对小麦和油菜具有良好的抑制活性.
关键词 2e-3-苯基丙烯酰氧基烃基膦酸酯 合成 生物活性
下载PDF
上一页 1 2 35 下一页 到第
使用帮助 返回顶部