柔肝法治疗肝气郁结证溃疡性结肠炎的研究

本研究以柔肝为治疗组，健脾为对照组，对肝气郁结在溃疡性结肠炎（ＵＣ）发病学中的内在联系进行了临床及实验研究。结果：治疗组总有效率为９６％，对照组总有效率为８４．４％，两组比较有显著性差异（Ｐ＜０．０５）；Ｅ玫瑰花形成率、淋巴细胞转化率两组较治疗前均有显著增高，对调节植物神经功能的失调率治疗组明显优于对照组（Ｐ＜０．０１）。实验研究观察到大鼠ＵＣ模型肠管Ｐ物质和血管活性肠肽含量：模型组明显增高，治疗组较模型组含量明显降低（Ｐ＜０．０１），与对照组比较有显著性差异（Ｐ＜０．０１）。提示：柔肝药物胃肠宁具有调节神经──内分泌（胃肠激素）──免疫的作用。

肠胃宁药理作用研究

肠胃宁具有明显松弛肠平滑肌、对抗乙酰胆硷及组胺所致肠痉挛作用;能抑制大肠杆菌,痢疾杆菌及金葡菌生长;抑制Hcl所致小鼠腹腔毛细血管通透性亢进,并对抗巴豆油的致炎作用,尚能降低发热家兔体温。

胃肠宁胶囊治疗肝胃郁热型胃脘痛的临床观察——附:170例病例报告

对照观察了中药胃肠宁胶囊和三九胃泰治疗肝胃郁热型胃脘痛患者 170例的临床疗效。结果治疗组 (胃肠宁胶囊组 ) 10 4例 ,显效率为 75 .96% ;对照组 (三九胃泰组 ) 66例 ,显效率为 36.36% ,二者比较有高度统计学意义 (P <0 .0 1) ,表明胃肠宁胶囊治疗肝胃郁热型胃脘痛的疗效优于三九胃泰。通过治疗前后肝胃郁热主症及其引起的其它症状的比较及慢性浅表性胃炎病理诊断比较 ,结果表明 ,具有疏肝解郁、清热和胃降逆之功效的胃肠宁胶囊具有改善肝胃郁热所引起的脘胁满闷、灼热疼痛、口苦、口干等症的作用 ,且未发现不良反应 。

肠胃宁胶囊安全性评价研究

目的研究肠胃宁胶囊单次和重复给药的临床前安全性,为临床用药提供参考。方法 40只小鼠分为肠胃宁胶囊组和空白对照组,每组20只小鼠,肠胃宁胶囊给药剂量为32 g/kg,空白对照组给予同体积纯水,详细观察动物体征至药后14 d,剖检肉眼大体观察各脏器形态。120只大鼠分为肠胃宁胶囊9、3、1 g/kg剂量组和空白对照组,每组30只大鼠,连续灌胃给药13周,分别于给药13周和停药后4周时取部分大鼠进行血液学指标、血液生化学指标、病理组织学检查。结果肠胃宁胶囊以32 g/kg剂量单日灌胃给药,药后观察至第14天小鼠未见明显毒性反应。肠胃宁胶囊9、3、1 g/kg剂量连续灌胃给药13周,大鼠体重、血液学、血液生化学指标及组织病理学未见明显毒性反应。结论肠胃宁胶囊小鼠单次给药最大给药量为32 g/kg;大鼠重复给药13周最大无毒反应剂量大于9 g/kg。

Study on Treatment of Ulcerative Colitis with Liver-Qi Stagnation by Nourishing the Liver

Objective: To study the links between stagnation of the Liver-Qi and the pathogenesis of ulcerative colitis (UC) were studied clinically and experimentally. Methods: Using the principle of nourishing the Liver in the treated group and invigorating the Spleen in the control group. Results: The effective rate was 96%in the treated group and 82% in the control group, and the difference was significant (P < 0. 05); the formation rate of E rosettes and the transformation rate of lymphocytes were significantly raised in the two groups compared with the pre-treatment period, and the rate of adjusting dysfunction of vegetative nerve system in the treated group was evidently higher than that in the control group (P < 0. 01 ). The level of intestinal styrenated phenol (SP) and vasoactive intestinal polypeptide (VIP) of UC model were determined in rats, and results showed that the level of SP and VIP significantly increased in the UC model group. They were markedly lowered in the treated group compared with model group (P < 0. 01 ) and there was significant difference from the control group (P < 0. 01 ). Conclusion: Wei Chang Ning, a drug to nourish the Liver, had the action of regulating neurological-endocrinological (gastrointestinal hormone) -immunological system.