The basic rule of traditional Chinese medicine,different diseases treated in the same way,refers to the phenomenon that treating different diseases with the same pathogenesis by adopting the same method,which has cons...The basic rule of traditional Chinese medicine,different diseases treated in the same way,refers to the phenomenon that treating different diseases with the same pathogenesis by adopting the same method,which has considerable guiding significance in acupuncture at Changqiang（长强 GV 1） during clinical practices.In this study,by integrating distal end therapeutic effect of meridians and collaterals and acupoints,and yin-yang of traditional Chinese medicine and signal pathway and biological holographic law of western medicine,the mechanism of acupuncture at GV 1 in treatment of multiple cognitive disorderrelated diseases was analyzed,so as to expand the application of acupuncture at GV 1.展开更多
OBJECTIVE: To investigate the effect of catgut implantation at acupoints on the expressions of γ-amino butyric acid B receptor(GABAB ) and metabotropic glutamate receptor 1(mGluR1) in the brain stem of rats with spas...OBJECTIVE: To investigate the effect of catgut implantation at acupoints on the expressions of γ-amino butyric acid B receptor(GABAB ) and metabotropic glutamate receptor 1(mGluR1) in the brain stem of rats with spasticity after stroke.METHODS: In total, 60 male Sprague-Dawley rats were randomly divided into three groups: a sham group(n=10), a model group(n=25) and a treatment group(n=25). The rats in both the model group and the treatment group were subjected to middle cerebral artery occlusion to establish a model of focal cerebral ischemia. Rats with limb-spasm met the inclusion criteria. Only the left carotid artery was isolated in sham group rats. Three days after modeling, the treatment group was subjected to catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12). Neurological deficit symptoms were assessed with the Zea-Longa neurological deficit score. The Modified Ashworth Scale(MAS), and isolated muscle tone were used to evaluate spasticity before and after treatment. Immunohistochemistry was applied to determine the expression of GABAB and mGluR1 in the rat brain stem after treatment.RESULTS: After treatment, neural impairment symptoms had significantly improved in the treatment group when compared to the model group(P<0.05). Both MAS and isolated muscle tone in the treatment group were significantly decreased when compared with the model group(P<0.05),and were also lower than before treatment. GABAB expression was significantly higher and mGluR1 was lower in the treatment group when compared with the model group(P<0.01 and P<0.05, respectively).CONCLUSION: Catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12), can relieve limb spasticity by increasing the expression of GABAB and reducing the expression of mGluR1 in the brain stem of rats after stroke.展开更多
Objective To investigate the immunologic mechanism of acupuncture at Bǎihuì（百 会 GV 20） and Zúsānlǐ（足三里 ST 36） for treatment of depression. Methods Eighty-four cases of depression patients were ra...Objective To investigate the immunologic mechanism of acupuncture at Bǎihuì（百 会 GV 20） and Zúsānlǐ（足三里 ST 36） for treatment of depression. Methods Eighty-four cases of depression patients were randomly divided into an electroacupuncture observation group（group A）, an electroacupuncture control group（group B） and a medication control group（group C）, 28 cases in each group. Bǎihuì（百会 GV 20） and Zúsānlǐ（足三里 ST 36） were used in the group A; Tàichōng （太冲 LR 3）, Sānyīnjiāo （三阴交 SP 6）, Nèiguān （内关 PC 6） and Shénmén （神门 HT 7） were used in the group B; and the group C was treated with oral administration of Fluoxetine. The scores of Hamilton Depression Scale （HAMD） were tested and the level of serum interleukin 1（IL-1β）, interleukin 6 （IL-6）, and tumor necrosis factor α （TNF-α） were measured by Enzyme Linked Immunosorbent Assay （ELISA）before and after treatment. Results Their scores of HAMD were obviously decreased after treatment in three groups（all P0.01）. In the group A, 2 cases were cured, 19 cases were markedly effective, 5 cases were effective and 2 cases were failed. In the group B, 16 cases were markedly effective, 12 cases were effective. While in the group C, 1 case was cured, 17 cases were markedly effective, 7 cases were effective and 3 cases were failed. The grade distribution of clinical effect showed that the effect of group A was better （P0.05）. The levels of serum IL-1β and IL-6 in the three groups were obviously decreased after treatment （P0.05, P0.01）, while there was no significant difference between the level of serum TNF-α before and after treatment. Conclusion The effect of electroacupuncture observation group is superior to those of electroacupuncture control group and medication control group.All of these three methods can clear the inflammatory cytokines such as IL-1β and IL-6 away and improve the symptoms of depression.展开更多
Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Met...Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Methods： A total of 112 patients with primary insomnia were randomized into an acupuncture group and a medication group according to the visiting sequence, 56 cases in each group. The acupuncture group was intervened by acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）], and points selected based on syndrome differentiation, while the medication group was by oral intake of zopiclone tablet. The Pittsburgh sleep quality index（PSQI） was measured before and after treatment, and the clinical efficacy was compared after 1 month of treatment. Results： After treatment, subscales of PSQI and global score in the acupuncture group were improved, and intra-group comparisons showed statistical differences（all P〈0.05）; subscales of sleep quality, sleep latency, sleep duration and global score of PSQI in the medication group were improved, showing statistical differences（all P〈0.05）. Inter-group comparison of global and subscales scores of PSQI showed statistical differences（all P〈0.05）. The total effective rate in the acupuncture group was 92.9%, higher than 67.9% in the medication group, and between-group comparison showed a statistical difference（P〈0.05）. Conclusion： Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] as the main treatment method can produce a better effect than oral intake of zopiclone tablet.展开更多
基金National Natural Science Foundation of China:81373720Collaborative project of Institute of Acupuncture and Moxibustion of China Academy of Chinese Medical Sciences:zzkf08001
文摘The basic rule of traditional Chinese medicine,different diseases treated in the same way,refers to the phenomenon that treating different diseases with the same pathogenesis by adopting the same method,which has considerable guiding significance in acupuncture at Changqiang（长强 GV 1） during clinical practices.In this study,by integrating distal end therapeutic effect of meridians and collaterals and acupoints,and yin-yang of traditional Chinese medicine and signal pathway and biological holographic law of western medicine,the mechanism of acupuncture at GV 1 in treatment of multiple cognitive disorderrelated diseases was analyzed,so as to expand the application of acupuncture at GV 1.
基金Supported by Henan University of Traditional Chinese Medcine Innovation Team Projet(No.2011XCXTD05)
文摘OBJECTIVE: To investigate the effect of catgut implantation at acupoints on the expressions of γ-amino butyric acid B receptor(GABAB ) and metabotropic glutamate receptor 1(mGluR1) in the brain stem of rats with spasticity after stroke.METHODS: In total, 60 male Sprague-Dawley rats were randomly divided into three groups: a sham group(n=10), a model group(n=25) and a treatment group(n=25). The rats in both the model group and the treatment group were subjected to middle cerebral artery occlusion to establish a model of focal cerebral ischemia. Rats with limb-spasm met the inclusion criteria. Only the left carotid artery was isolated in sham group rats. Three days after modeling, the treatment group was subjected to catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12). Neurological deficit symptoms were assessed with the Zea-Longa neurological deficit score. The Modified Ashworth Scale(MAS), and isolated muscle tone were used to evaluate spasticity before and after treatment. Immunohistochemistry was applied to determine the expression of GABAB and mGluR1 in the rat brain stem after treatment.RESULTS: After treatment, neural impairment symptoms had significantly improved in the treatment group when compared to the model group(P<0.05). Both MAS and isolated muscle tone in the treatment group were significantly decreased when compared with the model group(P<0.05),and were also lower than before treatment. GABAB expression was significantly higher and mGluR1 was lower in the treatment group when compared with the model group(P<0.01 and P<0.05, respectively).CONCLUSION: Catgut implantation at Dazhui(GV 14), Guanyuan(CV 4), and Zhongwan(CV 12), can relieve limb spasticity by increasing the expression of GABAB and reducing the expression of mGluR1 in the brain stem of rats after stroke.
基金Supported by The Specific Chinese Medicine Project of Chinese Medical Science and Technology, The State Administration of Traditional Chinese Medicine: 04-05 LP 10
文摘Objective To investigate the immunologic mechanism of acupuncture at Bǎihuì（百 会 GV 20） and Zúsānlǐ（足三里 ST 36） for treatment of depression. Methods Eighty-four cases of depression patients were randomly divided into an electroacupuncture observation group（group A）, an electroacupuncture control group（group B） and a medication control group（group C）, 28 cases in each group. Bǎihuì（百会 GV 20） and Zúsānlǐ（足三里 ST 36） were used in the group A; Tàichōng （太冲 LR 3）, Sānyīnjiāo （三阴交 SP 6）, Nèiguān （内关 PC 6） and Shénmén （神门 HT 7） were used in the group B; and the group C was treated with oral administration of Fluoxetine. The scores of Hamilton Depression Scale （HAMD） were tested and the level of serum interleukin 1（IL-1β）, interleukin 6 （IL-6）, and tumor necrosis factor α （TNF-α） were measured by Enzyme Linked Immunosorbent Assay （ELISA）before and after treatment. Results Their scores of HAMD were obviously decreased after treatment in three groups（all P0.01）. In the group A, 2 cases were cured, 19 cases were markedly effective, 5 cases were effective and 2 cases were failed. In the group B, 16 cases were markedly effective, 12 cases were effective. While in the group C, 1 case was cured, 17 cases were markedly effective, 7 cases were effective and 3 cases were failed. The grade distribution of clinical effect showed that the effect of group A was better （P0.05）. The levels of serum IL-1β and IL-6 in the three groups were obviously decreased after treatment （P0.05, P0.01）, while there was no significant difference between the level of serum TNF-α before and after treatment. Conclusion The effect of electroacupuncture observation group is superior to those of electroacupuncture control group and medication control group.All of these three methods can clear the inflammatory cytokines such as IL-1β and IL-6 away and improve the symptoms of depression.
文摘Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Methods： A total of 112 patients with primary insomnia were randomized into an acupuncture group and a medication group according to the visiting sequence, 56 cases in each group. The acupuncture group was intervened by acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）], and points selected based on syndrome differentiation, while the medication group was by oral intake of zopiclone tablet. The Pittsburgh sleep quality index（PSQI） was measured before and after treatment, and the clinical efficacy was compared after 1 month of treatment. Results： After treatment, subscales of PSQI and global score in the acupuncture group were improved, and intra-group comparisons showed statistical differences（all P〈0.05）; subscales of sleep quality, sleep latency, sleep duration and global score of PSQI in the medication group were improved, showing statistical differences（all P〈0.05）. Inter-group comparison of global and subscales scores of PSQI showed statistical differences（all P〈0.05）. The total effective rate in the acupuncture group was 92.9%, higher than 67.9% in the medication group, and between-group comparison showed a statistical difference（P〈0.05）. Conclusion： Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] as the main treatment method can produce a better effect than oral intake of zopiclone tablet.
