Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a

Ischemic postconditioning renders brain tissue tolerant to brain ischemia,thereby alleviating ischemic brain injury.However,the exact mechanism of action is still unclear.In this study,a rat model of global brain ischemia was subjected to ischemic postconditioning treatment using the vessel occlusion method.After 2 hours of ischemia,the bilateral common carotid arteries were blocked immediately for 10 seconds and then perfused for 10 seconds.This procedure was repeated six times.Ischemic postconditioning was found to mitigate hippocampal CA1 neuronal damage in rats with brain ischemia,and up-regulate acid-sensing ion channel 2a expression at the m RNA and protein level.These findings suggest that ischemic postconditioning up-regulates acid-sensing ion channel 2a expression in the rat hippocampus after global brain ischemia,which promotes neuronal tolerance to ischemic brain injury.

Performance of M-QAM, M-DPSK and M-PSK with MRC diversity in a Nakagami-m fading channel

The nature of a wireless communication channel is very unpredictable. To design a good communication link, it is required to know the statistical model of the channel accurately. The average symbol error probability(ASER) was analyzed for different modulation schemes. A unified analytical framework was presented to obtain closed-form solutions for calculating the ASER of M-ary differential phase-shift keying(M-DPSK), coherent M-ary phase-shift keying(M-PSK), and quadrature amplitude modulation(QAM) over single or multiple Nakagami-m fading channels. Moreover, the ASER was estimated and evaluated by using the maximal ratio-combining(MRC) diversity technique. Simulation results show that an error rate of the fading channel typically depends on Nakagami parameters(m), space diversity(N), and symbol rate(M). A comparison between M-PSK, M-DPSK, and M-QAM modulation schemes was shown, and the results prove that M-ary QAM(M-QAM) demonstrates better performance compared to M-DPSK and M-PSK under all fading and non-fading conditions.

Experimental study on the energy dissipation characteristics of debris flow deceleration baffles

Debris flow can cause serious damages to roads, bridges, buildings and other infrastructures.Arranging several rows of deceleration baffles in the significant influence on the mobility and deposition characteristic of debris flow. The deposit amount first increased then decreased when the flow density rises,flow path can reduce the flow velocity and ensure better protection of life and property. In debris flow prevention projects, deceleration baffles can effectively reduce the erosion of the debris flow and prolong the running time of the drainage channel.This study investigated the degree to which a 6 m long flume and three rows of deceleration baffles reduce the debris flow velocity and affect the energy dissipation characteristics. The influential variables include channel slope, debris flow density, and spacing between baffle rows. The experimental results demonstrated that the typical flow pattern was a sudden increase in flow depth and vertical proliferation when debris flow flows through the baffles. Strong turbulence between debris flow and baffles can contribute to energy dissipation and decrease the kinematic velocity considerably. The results showed that the reduction ratio of velocity increased with the increase in debris flow density,channel slope and spacing between rows. Tests phenomena also indicated that debris flow density hasand the deposit amount of debris flow density of 1500kg/m^3 reached the maximum when the experimental flume slope is 12°.