To improve the deteriorated capacity gain and source recovery performance due to channel mismatch problem,this paper reports a research about blind separation method against channel mismatch in multiple-input multiple...To improve the deteriorated capacity gain and source recovery performance due to channel mismatch problem,this paper reports a research about blind separation method against channel mismatch in multiple-input multiple-output(MIMO) systems.The channel mismatch problem can be described as a channel with bounded fluctuant errors due to channel distortion or channel estimation errors.The problem of blind signal separation/extraction with channel mismatch is formulated as a cost function of blind source separation(BSS) subject to the second-order cone constraint,which can be called as second-order cone programing optimization problem.Then the resulting cost function is solved by approximate negentropy maximization using quasi-Newton iterative methods for blind separation/extraction source signals.Theoretical analysis demonstrates that the proposed algorithm has low computational complexity and improved performance advantages.Simulation results verify that the capacity gain and bit error rate(BER) performance of the proposed blind separation method is superior to those of the existing methods in MIMO systems with channel mismatch problem.展开更多
The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and test...The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and testing stages. The effect of input variables on GEP modeling was studied and 15 different GEP models with individual, binary, ternary, and quaternary input combinations were investigated. The sensitivity analysis results demonstrate that dimensionless parameter y/P, where y is the transverse coordinate, and P is the wetted perimeter, is the most influential parameter with regard to the shear stress distribution in circular channels. GEP model 10, with the parameter y/P and Reynolds number(Re) as inputs, outperformed the other GEP models, with a coefficient of determination of 0.7814 for the testing data set. An equation was derived from the best GEP model and its results were compared with an artificial neural network(ANN) model and an equation based on the Shannon entropy proposed by other researchers. The GEP model, with an average RMSE of 0.0301, exhibits superior performance over the Shannon entropy-based equation, with an average RMSE of 0.1049, and the ANN model, with an average RMSE of 0.2815 for all flow depths.展开更多
In this paper, a novel robust precoder with imperfect channel state information(CSI)is proposed for multi-input multi-output(MIMO)cognitive multiuser networks equipped with relays. In the proposed model, the secondary...In this paper, a novel robust precoder with imperfect channel state information(CSI)is proposed for multi-input multi-output(MIMO)cognitive multiuser networks equipped with relays. In the proposed model, the secondary users(SUs)are allowed to share the spectrum with the primary users(PUs)when the interference temperature(IT)is below a specific threshold. The transmitting strategy of relays is amplify-and-forward(AF), and the CSI error is characterized in terms of spherical uncertainty region. A minmax problem for the transmit power of the relays is considered when the mean square error(MSE)of SUs and the IT of PU meet their corresponding thresholds, and it is transformed into a semi-definite programming(SDP)problem to search for the solution. Numerical simulations demonstrate the effectiveness of the proposed precoder.展开更多
This paper proposes an optimization model for the airport ground movement problem(GMP)based on bilevel programming to address taxi conflicts on the airport ground and to improve the operating safety and efficiency.To ...This paper proposes an optimization model for the airport ground movement problem(GMP)based on bilevel programming to address taxi conflicts on the airport ground and to improve the operating safety and efficiency.To solve GMP,an iterative heuristic algorithm is designed.Instead of separately investigating each problem,this model simultaneously coordinates and optimizes the aircraft routing and scheduling.A simulation test is conducted on Nanjing Lukou International Airport(NKG)and the results show that the bilevel programming model can clearly outperform the widely used first-come-first-service(FCFS)scheduling scheme in terms of aircraft operational time under the precondition of none conflict.The research effort demonstrates that with the reduced operating cost and the improved overall efficiency,the proposed model can assist operations of the airports that are facing increasing traffic demand and working at almost maximum capacity.展开更多
An adaptive weighted stereo matching algorithm with multilevel and bidirectional dynamic programming based on ground control points (GCPs) is presented. To decrease time complexity without losing matching precision,...An adaptive weighted stereo matching algorithm with multilevel and bidirectional dynamic programming based on ground control points (GCPs) is presented. To decrease time complexity without losing matching precision, using a multilevel search scheme, the coarse matching is processed in typical disparity space image, while the fine matching is processed in disparity-offset space image. In the upper level, GCPs are obtained by enhanced volumetric iterative algorithm enforcing the mutual constraint and the threshold constraint. Under the supervision of the highly reliable GCPs, bidirectional dynamic programming framework is employed to solve the inconsistency in the optimization path. In the lower level, to reduce running time, disparity-offset space is proposed to efficiently achieve the dense disparity image. In addition, an adaptive dual support-weight strategy is presented to aggregate matching cost, which considers photometric and geometric information. Further, post-processing algorithm can ameliorate disparity results in areas with depth discontinuities and related by occlusions using dual threshold algorithm, where missing stereo information is substituted from surrounding regions. To demonstrate the effectiveness of the algorithm, we present the two groups of experimental results for four widely used standard stereo data sets, including discussion on performance and comparison with other methods, which show that the algorithm has not only a fast speed, but also significantly improves the efficiency of holistic optimization.展开更多
Graphical representation of groundwater major dissolved constituents greatly help researchers in understanding the hydro-chemical evolution, grouping and areal distribution. Durov diagram is one of the most widely use...Graphical representation of groundwater major dissolved constituents greatly help researchers in understanding the hydro-chemical evolution, grouping and areal distribution. Durov diagram is one of the most widely used technique but it requires a lot of tedious calculations. The DurovPlot program, which is used to plot the expanded Durov diagram as a graphical representation of groundwater major dissolved constituents is working on Disk Operating System (DOS) environment. Therefore, the need of a new program working under windows is a must. The program termed as DurovPwinis developed using Microsoft visual studio 2010. The DurovPwin program not only calculates the Durov coordinates and plot it, but also plots the total dissolved solids (TDS) on logarithmic scale and the measure of the activity of hydrogen ion (pH) of the given samples. The updated DurovPwin adds many features such as interface with Microsoft Office package (Word and Excel) to read the input chemical elements and automatically write result interpretation report. The user facility to group wells based on data features is added and the selection of the electric balance tolerance (10% as default) value is given. Another feature of the modified DurovPwinis has the ability to do useful X-Y plot for different hydro-chemical parameters to assist in data interpretation. The sodium adsorption ratio (SAR) is also calculated and written in the final report. Also, in the present study, the usability of the new version of DurovPwin program has been tested on the chemical data from 59 groundwater samples collected from A1-Jawf area, Saudi Arabia. The collected water samples were mainly from the Secondary-Tertiary-Quaternary (STQ) aquifer and some from Tawil and Jaufaquifers. The grouping of the major ions in the three aquifers have been displayed and presented using the DurovPwin program. The TDS values of Tawil aquifer ranges from 257.9 to 822.3 (2.4115 to 2.915) and for Jawf aquifer from 494.4 to 1,070 (2.6941 to 3.0294) and for STQ aquifer ranges from 399.5 to 9,861.8 (2.6015 to 3.994). The pH for the three aquifers ranges from 7 to 7.9, 7.6 to 7.8 and 7.2 to 8.3, respectively.展开更多
Based on the Chinese Meridian Project(CMP),the International Meridian Circle Program(IMCP)aims to coordinate the deployment of a comprehensive ground-based monitoring network along the 120°E-60°W Great Merid...Based on the Chinese Meridian Project(CMP),the International Meridian Circle Program(IMCP)aims to coordinate the deployment of a comprehensive ground-based monitoring network along the 120°E-60°W Great Meridian Circle to track the propagation and evolution of space weather events from the Sun to the Earth,as well as the imprints of other major natural and anthropic hazards on the ionosphere,the middle and upper atmosphere.Currently,we have completed the IMCP headquarters building in Beijing and established the China-Brazil Joint Laboratory for Space Weather in cooperation with Brazil.Meanwhile,the Chinese Meridian Project PhaseⅡand different components of the IMCP observation system are under construction.展开更多
Case studies are presented for two concrete lined channels shaken by strong ground motions during the 1994 Northridge earthquake, the high speed channel (HSC) and bypass channel (BC), on the Los Angeles Department...Case studies are presented for two concrete lined channels shaken by strong ground motions during the 1994 Northridge earthquake, the high speed channel (HSC) and bypass channel (BC), on the Los Angeles Department of Water and Power's Van Norman Complex. Performances of these two channels as they pass through different subsurface materials identify several important seismic aspects and the critical role of geotechnical earthquake engineering in assessing channel behaviors. Preliminary evaluations using detailed mapping of channel cracks, permanent ground movements, subsurface profiles, and nearby strong ground motion recordings from the 1994 earthquake show that the channel liners may have been damaged from both transient motions and permanent ground movements. Damage from permanent ground deformations is obvious by observation; therefore simplified analyses are presented only for transient movements. Site specific transient response analyses are performed to provide an initial assessment of the differing effects from transient and permanent ground movements on HSC and BC liner damage. These case studies are helpful for introducing the potential for lifeline damage from transient movements within zones of permanent ground movement, a concept not well understood in the earthquake engineering community展开更多
Transit gait programming is a key problem for a multi-legged robot to climb automatically from the ground up the wall, as well as between wall intersections. In this paper, a new idea is put forward by which the compl...Transit gait programming is a key problem for a multi-legged robot to climb automatically from the ground up the wall, as well as between wall intersections. In this paper, a new idea is put forward by which the complex transit gait is decomposed into a sequence of two relatively simpler parts - single-leg motion and body pitching motion. An algorithm based on the above concept shows its feasibility and effectiveness in the graphic kinematics simulation.展开更多
Rolling dynamic compaction (RDC),which employs non-circular module towed behind a tractor,is an innovative soil compaction method that has proven to be successful in many ground improvement applications.RDC involves r...Rolling dynamic compaction (RDC),which employs non-circular module towed behind a tractor,is an innovative soil compaction method that has proven to be successful in many ground improvement applications.RDC involves repeatedly delivering high-energy impact blows onto the ground surface,which improves soil density and thus soil strength and stiffness.However,there exists a lack of methods to predict the effectiveness of RDC in different ground conditions,which has become a major obstacle to its adoption.For this,in this context,a prediction model is developed based on linear genetic programming (LGP),which is one of the common approaches in application of artificial intelligence for nonlinear forecasting.The model is based on in situ density-related data in terms of dynamic cone penetrometer (DCP) results obtained from several projects that have employed the 4-sided,8-t impact roller (BH-1300).It is shown that the model is accurate and reliable over a range of soil types.Furthermore,a series of parametric studies confirms its robustness in generalizing data.In addition,the results of the comparative study indicate that the optimal LGP model has a better predictive performance than the existing artificial neural network (ANN) model developed earlier by the authors.展开更多
Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with...Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal systems.Nowadays,however,accumulating evidence shows that those TRP channels are also responsible for tumorigenesis and progression,inducing tumor invasion and metastasis.However,the overall underlying mechanisms and possible signaling transduction pathways that TRP channels in malignant tumors might still remain elusive.Therefore,in this review,we focus on the linkage between TRP channels and the significant characteristics of tumors such as multi-drug resistance(MDR),metastasis,apoptosis,proliferation,immune surveillance evasion,and the alterations of relevant tumor micro-environment.Moreover,we also have discussed the expression of relevant TRP channels in various forms of cancer and the relevant inhibitors’efficacy.The chemo-sensitivity of the anti-cancer drugs of various acting mechanisms and the potential clinical applications are also presented.Furthermore,it would be enlightening to provide possible novel therapeutic approaches to counteract malignant tumors regarding the intervention of calcium channels of this type.展开更多
Substations have a large number of signal transmission cables beneath the ground.Both the insulation safety and signal reliability of the cables are affected severely by the electromagnetic field.Under high-amplitude ...Substations have a large number of signal transmission cables beneath the ground.Both the insulation safety and signal reliability of the cables are affected severely by the electromagnetic field.Under high-amplitude impulsive currents,the dispersion of currents can cause soil discharge and thus cause unexpected distortions in an electromagnetic field.This paper focuses on the distortions of the electric field.In general,soil discharge channels occur in the vicinity of the independent rod.Closer development of the channel might enhance the electric field distribution and the potential surrounding the outer insulation of the cables(i.e.the surface potential on the cable).Therefore,this paper establishes a platform for observing the soil discharge channel and measuring the surface potential.Direction characteristic of the channel is extracted from the captured image of soil discharge channels and the surface potential is obtained by the measured coupling capacitive current on the shield experimentally.This paper also presents an improved model considering a dynamic growing discharge channel for the transient analysis of the grounding electrode.Study results show the surface potential increases as the discharge channel approaches the cable.To quantify this enhancement effect,the ratio of the highest to the lowest value of surface potential in different directions is taken as the multiple of the surface potential increase.The calculated multiples of the surface potential increase are in the range of 1 to 1.64 times under different conditions by the improved model.Therefore,taking the soil discharge channel into account is helpful to accurately analyze the impulsive interference of buried cables.展开更多
As 2006 unfolds, China plans to transform its economic development mode to usher in a new era of innovation. The National Conference on Science and Technology, held this month, provides a fresh impetus to that endeavo...As 2006 unfolds, China plans to transform its economic development mode to usher in a new era of innovation. The National Conference on Science and Technology, held this month, provides a fresh impetus to that endeavor. The strategy of "enhancing展开更多
This paper introduces an innovative approach to the synchronized demand-capacity balance with special focus on sector capacity uncertainty within a centrally controlled collaborative air traffic flow management(ATFM)f...This paper introduces an innovative approach to the synchronized demand-capacity balance with special focus on sector capacity uncertainty within a centrally controlled collaborative air traffic flow management(ATFM)framework.Further with previous study,the uncertainty in capacity is considered as a non-negligible issue regarding multiple reasons,like the impact of weather,the strike of air traffic controllers(ATCOs),the military use of airspace and the spatiotemporal distribution of nonscheduled flights,etc.These recessive factors affect the outcome of traffic flow optimization.In this research,the focus is placed on the impact of sector capacity uncertainty on demand and capacity balancing(DCB)optimization and ATFM,and multiple options,such as delay assignment and rerouting,are intended for regulating the traffic flow.A scenario optimization method for sector capacity in the presence of uncertainties is used to find the approximately optimal solution.The results show that the proposed approach can achieve better demand and capacity balancing and determine perfect integer solutions to ATFM problems,solving large-scale instances(24 h on seven capacity scenarios,with 6255 flights and 8949 trajectories)in 5-15 min.To the best of our knowledge,our experiment is the first to tackle large-scale instances of stochastic ATFM problems within the collaborative ATFM framework.展开更多
基金supported by Sichuan Youth Science and Technology Innovation Research Team Project(No.2015TD0022)the Talents Project of Sichuan University of Science and Engineering(No.2017RCL11 and No.2017RCL10)the first batch of science and technology plan key R&D project of Sichuan province(No.2017GZ0068)
文摘To improve the deteriorated capacity gain and source recovery performance due to channel mismatch problem,this paper reports a research about blind separation method against channel mismatch in multiple-input multiple-output(MIMO) systems.The channel mismatch problem can be described as a channel with bounded fluctuant errors due to channel distortion or channel estimation errors.The problem of blind signal separation/extraction with channel mismatch is formulated as a cost function of blind source separation(BSS) subject to the second-order cone constraint,which can be called as second-order cone programing optimization problem.Then the resulting cost function is solved by approximate negentropy maximization using quasi-Newton iterative methods for blind separation/extraction source signals.Theoretical analysis demonstrates that the proposed algorithm has low computational complexity and improved performance advantages.Simulation results verify that the capacity gain and bit error rate(BER) performance of the proposed blind separation method is superior to those of the existing methods in MIMO systems with channel mismatch problem.
文摘The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and testing stages. The effect of input variables on GEP modeling was studied and 15 different GEP models with individual, binary, ternary, and quaternary input combinations were investigated. The sensitivity analysis results demonstrate that dimensionless parameter y/P, where y is the transverse coordinate, and P is the wetted perimeter, is the most influential parameter with regard to the shear stress distribution in circular channels. GEP model 10, with the parameter y/P and Reynolds number(Re) as inputs, outperformed the other GEP models, with a coefficient of determination of 0.7814 for the testing data set. An equation was derived from the best GEP model and its results were compared with an artificial neural network(ANN) model and an equation based on the Shannon entropy proposed by other researchers. The GEP model, with an average RMSE of 0.0301, exhibits superior performance over the Shannon entropy-based equation, with an average RMSE of 0.1049, and the ANN model, with an average RMSE of 0.2815 for all flow depths.
基金Supported by the Beijing Key Laboratory of Work Safety Intelligent Monitoring(Beijing University of Posts and Telecommunications)
文摘In this paper, a novel robust precoder with imperfect channel state information(CSI)is proposed for multi-input multi-output(MIMO)cognitive multiuser networks equipped with relays. In the proposed model, the secondary users(SUs)are allowed to share the spectrum with the primary users(PUs)when the interference temperature(IT)is below a specific threshold. The transmitting strategy of relays is amplify-and-forward(AF), and the CSI error is characterized in terms of spherical uncertainty region. A minmax problem for the transmit power of the relays is considered when the mean square error(MSE)of SUs and the IT of PU meet their corresponding thresholds, and it is transformed into a semi-definite programming(SDP)problem to search for the solution. Numerical simulations demonstrate the effectiveness of the proposed precoder.
基金supported by the National Natural Science Foundations of China(Nos.U1933118,U2033205)。
文摘This paper proposes an optimization model for the airport ground movement problem(GMP)based on bilevel programming to address taxi conflicts on the airport ground and to improve the operating safety and efficiency.To solve GMP,an iterative heuristic algorithm is designed.Instead of separately investigating each problem,this model simultaneously coordinates and optimizes the aircraft routing and scheduling.A simulation test is conducted on Nanjing Lukou International Airport(NKG)and the results show that the bilevel programming model can clearly outperform the widely used first-come-first-service(FCFS)scheduling scheme in terms of aircraft operational time under the precondition of none conflict.The research effort demonstrates that with the reduced operating cost and the improved overall efficiency,the proposed model can assist operations of the airports that are facing increasing traffic demand and working at almost maximum capacity.
基金supported by the National Natural Science Foundation of China (No.60605023,60775048)Specialized Research Fund for the Doctoral Program of Higher Education (No.20060141006)
文摘An adaptive weighted stereo matching algorithm with multilevel and bidirectional dynamic programming based on ground control points (GCPs) is presented. To decrease time complexity without losing matching precision, using a multilevel search scheme, the coarse matching is processed in typical disparity space image, while the fine matching is processed in disparity-offset space image. In the upper level, GCPs are obtained by enhanced volumetric iterative algorithm enforcing the mutual constraint and the threshold constraint. Under the supervision of the highly reliable GCPs, bidirectional dynamic programming framework is employed to solve the inconsistency in the optimization path. In the lower level, to reduce running time, disparity-offset space is proposed to efficiently achieve the dense disparity image. In addition, an adaptive dual support-weight strategy is presented to aggregate matching cost, which considers photometric and geometric information. Further, post-processing algorithm can ameliorate disparity results in areas with depth discontinuities and related by occlusions using dual threshold algorithm, where missing stereo information is substituted from surrounding regions. To demonstrate the effectiveness of the algorithm, we present the two groups of experimental results for four widely used standard stereo data sets, including discussion on performance and comparison with other methods, which show that the algorithm has not only a fast speed, but also significantly improves the efficiency of holistic optimization.
文摘Graphical representation of groundwater major dissolved constituents greatly help researchers in understanding the hydro-chemical evolution, grouping and areal distribution. Durov diagram is one of the most widely used technique but it requires a lot of tedious calculations. The DurovPlot program, which is used to plot the expanded Durov diagram as a graphical representation of groundwater major dissolved constituents is working on Disk Operating System (DOS) environment. Therefore, the need of a new program working under windows is a must. The program termed as DurovPwinis developed using Microsoft visual studio 2010. The DurovPwin program not only calculates the Durov coordinates and plot it, but also plots the total dissolved solids (TDS) on logarithmic scale and the measure of the activity of hydrogen ion (pH) of the given samples. The updated DurovPwin adds many features such as interface with Microsoft Office package (Word and Excel) to read the input chemical elements and automatically write result interpretation report. The user facility to group wells based on data features is added and the selection of the electric balance tolerance (10% as default) value is given. Another feature of the modified DurovPwinis has the ability to do useful X-Y plot for different hydro-chemical parameters to assist in data interpretation. The sodium adsorption ratio (SAR) is also calculated and written in the final report. Also, in the present study, the usability of the new version of DurovPwin program has been tested on the chemical data from 59 groundwater samples collected from A1-Jawf area, Saudi Arabia. The collected water samples were mainly from the Secondary-Tertiary-Quaternary (STQ) aquifer and some from Tawil and Jaufaquifers. The grouping of the major ions in the three aquifers have been displayed and presented using the DurovPwin program. The TDS values of Tawil aquifer ranges from 257.9 to 822.3 (2.4115 to 2.915) and for Jawf aquifer from 494.4 to 1,070 (2.6941 to 3.0294) and for STQ aquifer ranges from 399.5 to 9,861.8 (2.6015 to 3.994). The pH for the three aquifers ranges from 7 to 7.9, 7.6 to 7.8 and 7.2 to 8.3, respectively.
基金Supported by the International Partnership Program of Chinese Academy of Sciences(183311KYSB20200003)。
文摘Based on the Chinese Meridian Project(CMP),the International Meridian Circle Program(IMCP)aims to coordinate the deployment of a comprehensive ground-based monitoring network along the 120°E-60°W Great Meridian Circle to track the propagation and evolution of space weather events from the Sun to the Earth,as well as the imprints of other major natural and anthropic hazards on the ionosphere,the middle and upper atmosphere.Currently,we have completed the IMCP headquarters building in Beijing and established the China-Brazil Joint Laboratory for Space Weather in cooperation with Brazil.Meanwhile,the Chinese Meridian Project PhaseⅡand different components of the IMCP observation system are under construction.
文摘Case studies are presented for two concrete lined channels shaken by strong ground motions during the 1994 Northridge earthquake, the high speed channel (HSC) and bypass channel (BC), on the Los Angeles Department of Water and Power's Van Norman Complex. Performances of these two channels as they pass through different subsurface materials identify several important seismic aspects and the critical role of geotechnical earthquake engineering in assessing channel behaviors. Preliminary evaluations using detailed mapping of channel cracks, permanent ground movements, subsurface profiles, and nearby strong ground motion recordings from the 1994 earthquake show that the channel liners may have been damaged from both transient motions and permanent ground movements. Damage from permanent ground deformations is obvious by observation; therefore simplified analyses are presented only for transient movements. Site specific transient response analyses are performed to provide an initial assessment of the differing effects from transient and permanent ground movements on HSC and BC liner damage. These case studies are helpful for introducing the potential for lifeline damage from transient movements within zones of permanent ground movement, a concept not well understood in the earthquake engineering community
文摘Transit gait programming is a key problem for a multi-legged robot to climb automatically from the ground up the wall, as well as between wall intersections. In this paper, a new idea is put forward by which the complex transit gait is decomposed into a sequence of two relatively simpler parts - single-leg motion and body pitching motion. An algorithm based on the above concept shows its feasibility and effectiveness in the graphic kinematics simulation.
基金supported under Australian Research Council’s Discovery Projects funding scheme(project No. DP120101761)
文摘Rolling dynamic compaction (RDC),which employs non-circular module towed behind a tractor,is an innovative soil compaction method that has proven to be successful in many ground improvement applications.RDC involves repeatedly delivering high-energy impact blows onto the ground surface,which improves soil density and thus soil strength and stiffness.However,there exists a lack of methods to predict the effectiveness of RDC in different ground conditions,which has become a major obstacle to its adoption.For this,in this context,a prediction model is developed based on linear genetic programming (LGP),which is one of the common approaches in application of artificial intelligence for nonlinear forecasting.The model is based on in situ density-related data in terms of dynamic cone penetrometer (DCP) results obtained from several projects that have employed the 4-sided,8-t impact roller (BH-1300).It is shown that the model is accurate and reliable over a range of soil types.Furthermore,a series of parametric studies confirms its robustness in generalizing data.In addition,the results of the comparative study indicate that the optimal LGP model has a better predictive performance than the existing artificial neural network (ANN) model developed earlier by the authors.
基金This work was supported by the National Natural Science Foundation of China(No.81930102 to Bo Yang)the National Natural Science Foundation of China(No.81773754 to Ling Ding).
文摘Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal systems.Nowadays,however,accumulating evidence shows that those TRP channels are also responsible for tumorigenesis and progression,inducing tumor invasion and metastasis.However,the overall underlying mechanisms and possible signaling transduction pathways that TRP channels in malignant tumors might still remain elusive.Therefore,in this review,we focus on the linkage between TRP channels and the significant characteristics of tumors such as multi-drug resistance(MDR),metastasis,apoptosis,proliferation,immune surveillance evasion,and the alterations of relevant tumor micro-environment.Moreover,we also have discussed the expression of relevant TRP channels in various forms of cancer and the relevant inhibitors’efficacy.The chemo-sensitivity of the anti-cancer drugs of various acting mechanisms and the potential clinical applications are also presented.Furthermore,it would be enlightening to provide possible novel therapeutic approaches to counteract malignant tumors regarding the intervention of calcium channels of this type.
基金supported by the National Natural Science Foundation of China(51777020)supported by the Science and Technology Project of State Grid Corporation of China(“Study on the Transient Characteristics of Grounding System and the Test and Evaluation Method of Current Dispersion Performance Under the Successive Impulse Current”,5500-202026088A-0-0-00)。
文摘Substations have a large number of signal transmission cables beneath the ground.Both the insulation safety and signal reliability of the cables are affected severely by the electromagnetic field.Under high-amplitude impulsive currents,the dispersion of currents can cause soil discharge and thus cause unexpected distortions in an electromagnetic field.This paper focuses on the distortions of the electric field.In general,soil discharge channels occur in the vicinity of the independent rod.Closer development of the channel might enhance the electric field distribution and the potential surrounding the outer insulation of the cables(i.e.the surface potential on the cable).Therefore,this paper establishes a platform for observing the soil discharge channel and measuring the surface potential.Direction characteristic of the channel is extracted from the captured image of soil discharge channels and the surface potential is obtained by the measured coupling capacitive current on the shield experimentally.This paper also presents an improved model considering a dynamic growing discharge channel for the transient analysis of the grounding electrode.Study results show the surface potential increases as the discharge channel approaches the cable.To quantify this enhancement effect,the ratio of the highest to the lowest value of surface potential in different directions is taken as the multiple of the surface potential increase.The calculated multiples of the surface potential increase are in the range of 1 to 1.64 times under different conditions by the improved model.Therefore,taking the soil discharge channel into account is helpful to accurately analyze the impulsive interference of buried cables.
文摘As 2006 unfolds, China plans to transform its economic development mode to usher in a new era of innovation. The National Conference on Science and Technology, held this month, provides a fresh impetus to that endeavor. The strategy of "enhancing
文摘This paper introduces an innovative approach to the synchronized demand-capacity balance with special focus on sector capacity uncertainty within a centrally controlled collaborative air traffic flow management(ATFM)framework.Further with previous study,the uncertainty in capacity is considered as a non-negligible issue regarding multiple reasons,like the impact of weather,the strike of air traffic controllers(ATCOs),the military use of airspace and the spatiotemporal distribution of nonscheduled flights,etc.These recessive factors affect the outcome of traffic flow optimization.In this research,the focus is placed on the impact of sector capacity uncertainty on demand and capacity balancing(DCB)optimization and ATFM,and multiple options,such as delay assignment and rerouting,are intended for regulating the traffic flow.A scenario optimization method for sector capacity in the presence of uncertainties is used to find the approximately optimal solution.The results show that the proposed approach can achieve better demand and capacity balancing and determine perfect integer solutions to ATFM problems,solving large-scale instances(24 h on seven capacity scenarios,with 6255 flights and 8949 trajectories)in 5-15 min.To the best of our knowledge,our experiment is the first to tackle large-scale instances of stochastic ATFM problems within the collaborative ATFM framework.