Gardner syndrome (also known as familial colorectal polyposis) is a rare autosomal dominant condition. It is characterized by osteomas, familial polyposis of the colon, cutaneous epidermoid cysts, soft tissue tumors, ...Gardner syndrome (also known as familial colorectal polyposis) is a rare autosomal dominant condition. It is characterized by osteomas, familial polyposis of the colon, cutaneous epidermoid cysts, soft tissue tumors, as well as certain dental anomalies. We report the case of a 29 years old male patient with Gardner’s syndrome who presented with no intestinal polyps but instead had an osteoma on the left side of the mandible and multiple impacted teeth. The case showed the possibility to manage the multiple impacted teeth without jeopardizing the health of the teeth in terms of mobility or significant root resorption taking into consideration the increased bone density in such patients.展开更多
Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize....Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diff icult. This distinct pathological entity is reviewed with a specif ic focus on aetiology and management.展开更多
Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis,osteomas and a multitude of soft tissue tumors. The syndrome may present at any age from 2 mo to 70 years with...Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis,osteomas and a multitude of soft tissue tumors. The syndrome may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic.We present a case of a 11-year-old female patient with Gardner's syndrome who presented with a lumbar area desmoid tumor and treated with resection of the desmoid,restorative proctocolectomy and ileal pouch anal anastomosis,A review of the current literature has been performed.展开更多
We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because ex...We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because extirpation of an osteoma of the left temporo-occipital region was made 10 years ago. Restorative procto-colectomy and ileal pouch anal anastomosis was made but histology delineated adenocarcinoma of the rectum (Dukes C stage). We conclude that cranial osteomas often precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome and such patients should be evaluated with genetic testing followed by colonoscopy if results are positive to prevent the development of colorectal carcinoma. If the diagnosis is positive all family members should be evaluated for familial adenomatous polyposis.展开更多
Gardner's syndrome(GS) is a rare syndrome with autosomal dominant inheritance, which is characterized by multiple intestinal polyps, dental anomalies, desmoid tumors, and soft tissue tumors. All gastrointestinal s...Gardner's syndrome(GS) is a rare syndrome with autosomal dominant inheritance, which is characterized by multiple intestinal polyps, dental anomalies, desmoid tumors, and soft tissue tumors. All gastrointestinal symptoms seen in GS are associated with the underlying familial adenomatosis polyposis and abdominal desmoid tumors, with the most common symptoms being anemia, lower gastrointestinal bleeding, abdominal pain, diarrhea, obstruction, and mucous defecation. To our best knowledge, no case of GS that has presented with gastrointestinal perforation and bleeding has ever been reported in the English language medical literature. A 37-year-old male who had been diagnosed with GS five years earlier was referred to our clinic for lower gastrointestinal bleeding. Despite the absence of a bleeding focus on conventional angiography, the patient was operated on with laparotomy, due to the persistence of both signs and symptoms of mild peritonitis. On the laparotomy, the patient was noted to have areas of perforation in the duodenum, splenic flexura, and midrectum. The third and fourth part of the duodenum, the proximal 15 cm segment of the jejunum, a 10 cm segment of the terminal ileum, the whole colon, and the upper and middle rectum were resected, and duodenojejunal side-to-side anastomosis and terminal ileostomy were performed. The histopathological analysis of the large mass measuring 30 cm × 20 cm was reported as a desmoid tumor. The pathological examination of the tumor foci detected in the colonic specimen revealed poorly differentiated adenosquamous carcinoma.展开更多
Familial adenomatous polyposis(FAP)or Gardner’s syndrome is often accompanied by adenomas of the stomach and duodenum.We experienced a case of adenomas of the common bile duct in a 40-year-old woman with FAP presenti...Familial adenomatous polyposis(FAP)or Gardner’s syndrome is often accompanied by adenomas of the stomach and duodenum.We experienced a case of adenomas of the common bile duct in a 40-year-old woman with FAP presenting with acute cholangitis.Only 8 cases of adenomas or adenocarcinoma ofthe common bile duct have been reported in the literature in patients with FAP or Gardner’s syndrome.Those patients presented with acute cholangitis or pancreatitis.Local excision or Whipple procedure may be the reasonable surgical option.展开更多
Conventional petrophysical investigations are based on P-wave seismic velocity analysis to predict density information, while ignoring the important S-wave velocity. This study is based on S-wave velocity analysis of ...Conventional petrophysical investigations are based on P-wave seismic velocity analysis to predict density information, while ignoring the important S-wave velocity. This study is based on S-wave velocity analysis of density estimation of Meyal Oil Field(Potwar Plateau, Pakistan), which reveals a very high correlation(R=0.87) between predicted and actual density. Since the availability of S-wave velocity(Vs) data increases, it’s highly appreciable to take into account the contribution of Vs in improvement of density estimates. This investigation only focuses on driving new constants(a = 1.92 and b = 0.186) for Gardner’s relationship to estimate density of pure carbonates(Vsh< 10%) in the study area, where the traditional model gave poorer density predictions. The proposed empirical expression with locally extracted unknowns from well log data proved its ability in terms of density prediction(showing very close agreement with measured densities) and best fitting the datasets at low as well as high density values when compared with Gardner’s equation. Based on our analysis, the exploratory study neither intends to replace the well established density estimation models nor to extend information over what information can possibly be extractable from Vp. However, our research does stimulate the growing use of Vs and importance of local unknown constants especially in carbonates reservoir interval to avoid misuse of most widely used Gardner relation in all geological settings.展开更多
A new dynamic equation of aerosol in air is derived, using a model-in-model, by equilibrium of buoyancy, gravity and pressure, together with conservation laws of mass, momentum and energy via Reynolds transport theore...A new dynamic equation of aerosol in air is derived, using a model-in-model, by equilibrium of buoyancy, gravity and pressure, together with conservation laws of mass, momentum and energy via Reynolds transport theorem and supplemented by corresponding scientific laws for related properties of air and aerosols. This new dynamic equation of aerosol in air is a set of non-linear partial differential equations involved six unknown functions of mass densities, pressure, air and aerosol speeds and temperature. It has features: 1, it belongs to certain type;2, it emphases the effect of buoyancy in equilibrium and potential energy, and the Archimedes principle of buoyancy is firstly extended to lateral directions based on logical deduction, the phenomenon of stirring a glass of oil-water mixture and the recorded of Hurricane Isabel (2003) from space station. The later shows the evidence of existence of lateral buoyancy;3, the mass densities of air and aerosol of a point in our model are varied in different directions due to traction and are treated as vectors, and they have been used in the calculation of lateral buoyancy.展开更多
The paper presents an analysis of computer programming languages based on the semiotics of Charles S. Peirce. The author describes how such languages could evolve in order to achieve some of the expressive characteris...The paper presents an analysis of computer programming languages based on the semiotics of Charles S. Peirce. The author describes how such languages could evolve in order to achieve some of the expressive characteristics of natural languages. This description evinces otherwise unnoticed differences between natural languages and programming languages, showing that Peircean semiotics is an efficient analysis tool. This suggests further research on the technical features needed to implement an easier way to program computers.展开更多
The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mamm...The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mammary carcinoma;however only the histological examination can confirm the diagnosis. It is characterized by a strictly local evolution with an infiltration and recidivism tendancy without giving metastasis. The treatment is basically surgical. We report here-with an observed case of 13-year-old girl, presenting with a huge tumor located in the left breast with ulceration of the nipple-areolar plate. The diagnosis is confirmed by the histological study. The treatment consisted of a mastectomy. Suites are simple. In view of the clinical evidence of the literature, we call back the difficulties of management of this tumor.展开更多
Desmoid tumor of the breast is an extremely rare entity. Histologically, it corresponds to a benign fibroblastic proliferation of a local evolution, with a high recurrence potential. We report the first case of elderl...Desmoid tumor of the breast is an extremely rare entity. Histologically, it corresponds to a benign fibroblastic proliferation of a local evolution, with a high recurrence potential. We report the first case of elderly woman presented with desmoid-tumor of the breast as a manifestation of Gardner’s syndrome. A brief literature review was provided. We report the case of a 72-year-old woman who presented with five months history of painful and an exophytic mass of her left breast. She is known to have familial polyposis and had a total colectomy with Gardner’s syndrome. She had a history of osteomas of the maxilla. On clinical examination, there was an exophytic painless mass, on the upper medial quadrant of the breast. She had also lipoma in the left leg and pigmented skin lesions in legs. Her mammograms showed a suspicious stellar image. A computed tomography scan showed an ovoid lesion. Excision of the lesion was performed. Histopathology confirms a desmoid-tumor of the breast. Evolution was marked by lesion recurrence. In conclusion, desmoid tumor of the breast is rare, non-metastatic but locally aggressive. Clinical expression is often nonspecific. Treatment remains controversial;surgical excision is the treatment of choice.展开更多
In the field of philosophy of technology,the concept of mediation is central to understanding how technology shapes human experience and behavior.Our aim in this paper is to contribute to the understanding of technolo...In the field of philosophy of technology,the concept of mediation is central to understanding how technology shapes human experience and behavior.Our aim in this paper is to contribute to the understanding of technological mediation,in particular how and why it is possible.Technological mediation occurs within a mediation space between the technological realm and the user realm.In the technological realm,technology regularizes events and actions,while in the user realm,the user interprets the significative potential of the technology.This interpretation process is identical with use and involves the formation of user habits,which are constrained by technological,cognitive,and sociocultural factors.To provide a theoretical framework for our analysis,we propose the Semiotic Model of Technological Mediation(SMTM),which draws on Charles Peirceʼs semiotics.To illustrate our argument,we focus on assistive technology and provide a recurring example of the Medimi®Smart,a digital,comprehensive system for medication handling.展开更多
The critical analysis examines the concept of value in C.S.Peirce’s philosophical writings,distinguishing between value as(1)worth,(2)meaning,(3)significance,(4)semiotic value,(5)in the mathematical sense,(6)money va...The critical analysis examines the concept of value in C.S.Peirce’s philosophical writings,distinguishing between value as(1)worth,(2)meaning,(3)significance,(4)semiotic value,(5)in the mathematical sense,(6)money value,and(7)value by other names.The focus is on value in the sense of Peirce’s three normative sciences aesthetics,ethics,and logic.The values associated with them are detailed in their phenomenological contexts and with respect to a supreme value,the summum bonum.Peirce’s objections against utilitarian conceptions of value in the philosophy of his century and his conception of scientific research as a value in itself are the author’s final topic.展开更多
文摘Gardner syndrome (also known as familial colorectal polyposis) is a rare autosomal dominant condition. It is characterized by osteomas, familial polyposis of the colon, cutaneous epidermoid cysts, soft tissue tumors, as well as certain dental anomalies. We report the case of a 29 years old male patient with Gardner’s syndrome who presented with no intestinal polyps but instead had an osteoma on the left side of the mandible and multiple impacted teeth. The case showed the possibility to manage the multiple impacted teeth without jeopardizing the health of the teeth in terms of mobility or significant root resorption taking into consideration the increased bone density in such patients.
文摘Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diff icult. This distinct pathological entity is reviewed with a specif ic focus on aetiology and management.
文摘Gardner's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis,osteomas and a multitude of soft tissue tumors. The syndrome may present at any age from 2 mo to 70 years with a variety of symptoms, either colonic or extracolonic.We present a case of a 11-year-old female patient with Gardner's syndrome who presented with a lumbar area desmoid tumor and treated with resection of the desmoid,restorative proctocolectomy and ileal pouch anal anastomosis,A review of the current literature has been performed.
文摘We present a case of a 25-year-old female with diagnosed familial adenomatous polyposis and elevated carcinoembryonic antigen with negative family history. The suspicion of Gardner's syndrome was raised because extirpation of an osteoma of the left temporo-occipital region was made 10 years ago. Restorative procto-colectomy and ileal pouch anal anastomosis was made but histology delineated adenocarcinoma of the rectum (Dukes C stage). We conclude that cranial osteomas often precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome and such patients should be evaluated with genetic testing followed by colonoscopy if results are positive to prevent the development of colorectal carcinoma. If the diagnosis is positive all family members should be evaluated for familial adenomatous polyposis.
文摘Gardner's syndrome(GS) is a rare syndrome with autosomal dominant inheritance, which is characterized by multiple intestinal polyps, dental anomalies, desmoid tumors, and soft tissue tumors. All gastrointestinal symptoms seen in GS are associated with the underlying familial adenomatosis polyposis and abdominal desmoid tumors, with the most common symptoms being anemia, lower gastrointestinal bleeding, abdominal pain, diarrhea, obstruction, and mucous defecation. To our best knowledge, no case of GS that has presented with gastrointestinal perforation and bleeding has ever been reported in the English language medical literature. A 37-year-old male who had been diagnosed with GS five years earlier was referred to our clinic for lower gastrointestinal bleeding. Despite the absence of a bleeding focus on conventional angiography, the patient was operated on with laparotomy, due to the persistence of both signs and symptoms of mild peritonitis. On the laparotomy, the patient was noted to have areas of perforation in the duodenum, splenic flexura, and midrectum. The third and fourth part of the duodenum, the proximal 15 cm segment of the jejunum, a 10 cm segment of the terminal ileum, the whole colon, and the upper and middle rectum were resected, and duodenojejunal side-to-side anastomosis and terminal ileostomy were performed. The histopathological analysis of the large mass measuring 30 cm × 20 cm was reported as a desmoid tumor. The pathological examination of the tumor foci detected in the colonic specimen revealed poorly differentiated adenosquamous carcinoma.
文摘Familial adenomatous polyposis(FAP)or Gardner’s syndrome is often accompanied by adenomas of the stomach and duodenum.We experienced a case of adenomas of the common bile duct in a 40-year-old woman with FAP presenting with acute cholangitis.Only 8 cases of adenomas or adenocarcinoma ofthe common bile duct have been reported in the literature in patients with FAP or Gardner’s syndrome.Those patients presented with acute cholangitis or pancreatitis.Local excision or Whipple procedure may be the reasonable surgical option.
文摘Conventional petrophysical investigations are based on P-wave seismic velocity analysis to predict density information, while ignoring the important S-wave velocity. This study is based on S-wave velocity analysis of density estimation of Meyal Oil Field(Potwar Plateau, Pakistan), which reveals a very high correlation(R=0.87) between predicted and actual density. Since the availability of S-wave velocity(Vs) data increases, it’s highly appreciable to take into account the contribution of Vs in improvement of density estimates. This investigation only focuses on driving new constants(a = 1.92 and b = 0.186) for Gardner’s relationship to estimate density of pure carbonates(Vsh< 10%) in the study area, where the traditional model gave poorer density predictions. The proposed empirical expression with locally extracted unknowns from well log data proved its ability in terms of density prediction(showing very close agreement with measured densities) and best fitting the datasets at low as well as high density values when compared with Gardner’s equation. Based on our analysis, the exploratory study neither intends to replace the well established density estimation models nor to extend information over what information can possibly be extractable from Vp. However, our research does stimulate the growing use of Vs and importance of local unknown constants especially in carbonates reservoir interval to avoid misuse of most widely used Gardner relation in all geological settings.
文摘A new dynamic equation of aerosol in air is derived, using a model-in-model, by equilibrium of buoyancy, gravity and pressure, together with conservation laws of mass, momentum and energy via Reynolds transport theorem and supplemented by corresponding scientific laws for related properties of air and aerosols. This new dynamic equation of aerosol in air is a set of non-linear partial differential equations involved six unknown functions of mass densities, pressure, air and aerosol speeds and temperature. It has features: 1, it belongs to certain type;2, it emphases the effect of buoyancy in equilibrium and potential energy, and the Archimedes principle of buoyancy is firstly extended to lateral directions based on logical deduction, the phenomenon of stirring a glass of oil-water mixture and the recorded of Hurricane Isabel (2003) from space station. The later shows the evidence of existence of lateral buoyancy;3, the mass densities of air and aerosol of a point in our model are varied in different directions due to traction and are treated as vectors, and they have been used in the calculation of lateral buoyancy.
文摘The paper presents an analysis of computer programming languages based on the semiotics of Charles S. Peirce. The author describes how such languages could evolve in order to achieve some of the expressive characteristics of natural languages. This description evinces otherwise unnoticed differences between natural languages and programming languages, showing that Peircean semiotics is an efficient analysis tool. This suggests further research on the technical features needed to implement an easier way to program computers.
文摘The mammary fibromatosis is a rare clinical entity. The etiopathogeny remains unclear. The clinical and radiological characteristics of this injury are often worrying within the main differential diagnosis of the mammary carcinoma;however only the histological examination can confirm the diagnosis. It is characterized by a strictly local evolution with an infiltration and recidivism tendancy without giving metastasis. The treatment is basically surgical. We report here-with an observed case of 13-year-old girl, presenting with a huge tumor located in the left breast with ulceration of the nipple-areolar plate. The diagnosis is confirmed by the histological study. The treatment consisted of a mastectomy. Suites are simple. In view of the clinical evidence of the literature, we call back the difficulties of management of this tumor.
文摘Desmoid tumor of the breast is an extremely rare entity. Histologically, it corresponds to a benign fibroblastic proliferation of a local evolution, with a high recurrence potential. We report the first case of elderly woman presented with desmoid-tumor of the breast as a manifestation of Gardner’s syndrome. A brief literature review was provided. We report the case of a 72-year-old woman who presented with five months history of painful and an exophytic mass of her left breast. She is known to have familial polyposis and had a total colectomy with Gardner’s syndrome. She had a history of osteomas of the maxilla. On clinical examination, there was an exophytic painless mass, on the upper medial quadrant of the breast. She had also lipoma in the left leg and pigmented skin lesions in legs. Her mammograms showed a suspicious stellar image. A computed tomography scan showed an ovoid lesion. Excision of the lesion was performed. Histopathology confirms a desmoid-tumor of the breast. Evolution was marked by lesion recurrence. In conclusion, desmoid tumor of the breast is rare, non-metastatic but locally aggressive. Clinical expression is often nonspecific. Treatment remains controversial;surgical excision is the treatment of choice.
文摘In the field of philosophy of technology,the concept of mediation is central to understanding how technology shapes human experience and behavior.Our aim in this paper is to contribute to the understanding of technological mediation,in particular how and why it is possible.Technological mediation occurs within a mediation space between the technological realm and the user realm.In the technological realm,technology regularizes events and actions,while in the user realm,the user interprets the significative potential of the technology.This interpretation process is identical with use and involves the formation of user habits,which are constrained by technological,cognitive,and sociocultural factors.To provide a theoretical framework for our analysis,we propose the Semiotic Model of Technological Mediation(SMTM),which draws on Charles Peirceʼs semiotics.To illustrate our argument,we focus on assistive technology and provide a recurring example of the Medimi®Smart,a digital,comprehensive system for medication handling.
文摘The critical analysis examines the concept of value in C.S.Peirce’s philosophical writings,distinguishing between value as(1)worth,(2)meaning,(3)significance,(4)semiotic value,(5)in the mathematical sense,(6)money value,and(7)value by other names.The focus is on value in the sense of Peirce’s three normative sciences aesthetics,ethics,and logic.The values associated with them are detailed in their phenomenological contexts and with respect to a supreme value,the summum bonum.Peirce’s objections against utilitarian conceptions of value in the philosophy of his century and his conception of scientific research as a value in itself are the author’s final topic.
