Modern technology-based exploration of mechanism of traditional Chinese medicine in prevention and treatment of gastric cancer

This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.

Exploration of Teaching Reform of TCM Dispensing Technology in Higher Vocational Colleges Based on Traditional Chinese Medicine Skills Competition

This paper aims to thoroughly explore the teaching reform of Traditional Chinese Medicine(TCM)dispensing technology in higher vocational colleges,with a focus on the Traditional Chinese Medicine Skills Competition.By analyzing the current teaching status and main challenges of TCM dispensing technology,and aligning with the requirements of the skills competition,a series of detailed and practical teaching reform measures are proposed.These measures are designed to comprehensively improve the teaching quality of TCM dispensing technology in higher vocational colleges,enhance students’practical skills and professional qualities,and ultimately meet the demand for high-quality,skilled talents in the field of TCM.

Progress of Traditional Chinese Medicine Nursing Technology in Rectus Abdominis Diastasis

Rectus abdominis diastasis is a common condition in postpartum women,causing back pain,and in severe cases,it can result in abdominal wall hernias and downward migration of abdominal organs.At present,there is no clearly established optimal non-surgical treatment for rectus abdominis diastasis,but traditional Chinese medicine(TCM)nursing techniques have proven to be an effective intervention for postpartum rectus abdominis separation.This paper comprehensively analyzes the TCM nursing technology as an intervention for postpartum rectus abdominis separation,discusses the shortcomings and prospects of TCM nursing technology,and provides references for further exploring and optimizing the intervention program for postpartum rectus abdominis separation.

Insights into Fermentation Technology for Traditional Chinese Medicine:Progress and Applications

Traditional Chinese medicine(TCM)has an exemplary role in the treatment and prevention of diseases.However,the advancement of TCM has been constrained by several factors,including its intricate structure,low active ingredient concentration,prolonged growth cycle,and the dfficulty in artificial cultivation.In recent years,research on the fermentation technology of TCM has increased.This paper provides an overview of the advantages of TCM fermentation technology,including efficiency enhancement and toxicity reduction,the development of new drugs,and the secondary utilization of dregs.Additionally,it discusses the progress of research on the application of fermented TCM in animal husbandry and disease treatment.The aim is to provide theoretical guidance for TCM fermentation technology research and the development of fermented TCM.

Application and Practice of Traditional Chinese Medicine Characteristic Technology Inheritance in Research and Development of Traditional Chinese Medicine Preparations in Medical Institutions

Medical institution preparations play an important role in the development of hospitals,being one of the main forms of traditional Chinese medicine clinical characteristic medication,as well as an important carrier for the inheritance and innovation of traditional Chinese medicine.In recent years,the research and development of traditional Chinese medicine preparations has become a hot spot in the research and development of preparations by medical institutions.Traditional Chinese medicine preparations prepared by traditional processes and their entrusted preparation matters have changed from the current licensing management to filing management.The registration model of traditional Chinese medicine preparations has undergone significant changes,emphasizing more on real data and evaluation results from the objective world,respecting traditional medication experience,and emphasizing the inheritance and innovative development of traditional technological experience.In the process of following teachers in the inheritance project of traditional Chinese medicine,we combined the inheritance of traditional Chinese medicine characteristic technology with the research and development practice of traditional Chinese medicine preparations in medical institutions,and focused on the analysis and discussion of technical problems such as prescription screening,dosage form selection,process route design and clinical observation of traditional Chinese medicine preparations,hoping to provide reference for scholars in the same field of traditional Chinese medicine.

Computational investigation on the molecular structure and chemical reactivity of a traditional Chinese medicine extract MK-1 molecule

MK-1 molecule(C_(16)H_(16)O_(2)),the simplest structure of vitamin K(VK)compound family,is an extract from traditional Chinese medicine Cymbopogon distans(Nees ex Steud.)Wats(Chinese name YunXiangCao),which has attracted a great deal of attention in recent years due to its antiasthmatic,antitussives and expectorant effects.To investigate the molecular structure and chemical reactivity of MK-1 molecule,computational investigations on six conformational minima structures were carried out at the MP2/6-311++G(2d,2p)level of theory.Several local reactivity descriptors including condensed Fukui function,average local ionization energy,and molecular electrostatic potential on each individual atom were determined to predict the intrinsic reactivity of MK-1 molecule.

Research on Technology Development of Traditional Chinese Medicine Extraction Based on Patent Information

Objective To understand the development status of traditional Chinese medicine extraction technology,so as to provide a reference for enterprises and scientific research institutions to determine the direction of technological innovation.Besides,the government can formulate scientific and technological innovation strategies.Methods Based on patent information,statistical methods were applied to analyze the development of traditional Chinese medicine extraction technology.Then,the core technology was identified by constructing a patent citation network.Finally,the main path analysis method was applied to discover the technological evolution path.Results and Conclusion The extraction technology of traditional Chinese medicine is still in the growth stage.At present,its R&D is based on enterprises,supplemented by scientific research institutions.The core technologies are ultrasonic extraction and enzymatic extraction.The main path represented by enzymatic extraction technology reveals the evolution process of traditional Chinese medicine extraction technology.Based on this,relevant suggestions are put forward.Firstly,technological innovation cooperation should be strengthened to explore new models of achievement transformation and cooperation.Secondly,key enterprises of technology clusters should be cultivated to accelerate breakthroughs in core technologies.Thirdly,combined technologies can achieve high-efficiency enzyme-assisted extraction and open up new ways of extracting traditional Chinese medicine.Fourthly,traditional techniques should be improved to develop innovative modern techniques.

Bibliometrics and visual analysis for clinical research on intervention of traditional Chinese medicine nursing technology on rheumatoid arthritis

Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.

Computer Handling of Chemical and Biological Data of Traditional Chinese Medicines

A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. Designed as a relational system capable of analyzing, comparing, and correlating data, the system can retrieve information in assimilated tabular formats. The database can provide information supports to researchers in the fields of medicinal chemistry, biochemistry, pharmacology, botany and other disciplines of natural products research.

A Systematic Review on Chemical Constituents of Suanzaoren Decoction, a Traditional Chinese Medicine Prescription

Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system diseases such as insomnia and anxiety for thousands of years. This paper aims to systematically understand varieties and quantities of compounds and clarify chemical components of SZRD, subsequently to further provide the reference for phytochemistry and pharmacology researches of SZRD. Our results showed that SZRD contained 145 components, including flavonoids, triterpenoids, steroids, coumarins, phthalides, and volatile oils, etc., while five-single herbs contain 1104 components. Only in terms of compound number, there were 80 common components in SZRD and its five herbs, which accounted for 6.8% of total compounds in all 5 herbs and 55.2% of compounds in SZRD. The components of SZRD were not simply the sum of one in every single herb. It is necessary to perform parallel studies among SZRD and its herbs. This review discussed the problems that existed in the chemical research of SZRD and pointed out the direction for its further research.

Machine learning models for stroke detection by observing the eye-movement features under five-color visual stimuli in traditional Chinese medicine

Objective:To develop a novel diagnostic modality to identify and diagnose stroke in daily life scenarios for improving the therapeutic effects and prognoses of patients.Methods:In this study,16 stroke patients and 24 age-matched healthy participants as controls were recruited for comparative analysis.Leveraging a portable eye-tracking device and integrating traditional Chinese medicine theory with modern color psychology principles,we recorded the eye movement signals and calculated eye movement features.Meanwhile,the stroke recognition models based on eye movement features were further trained by using random forest(RF),k-nearest neighbors(KNN),decision tree(DT),gradient boosting classifier(GBC),XGBoost,and CatBoost.Results:The stroke group and the healthy group showed significant differences in some eye movement features(P<.05).The models trained based on eye movement characteristics had good performances in recognizing stroke individuals,with accuracies ranging from 77.40%to 88.45%.Under the red stimulus,the eye movement model trained by RF became the best machine learning model with a recall of 84.65%,a precision of 86.48%,a F1 score of 85.47%.Among the six algorithms,RF and CatBoost performed better in classification.Conclusion:This study pioneers the application of traditional Chinese medicine's five-color stimuli to visual observation tasks.On the basis of the combined design,the eye-movement models can accurately identify stroke,and the developed high-performance models may be used in daily life scenarios.

Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia

As an important branch of medicine, Traditional Chinese Medicine(TCM) has been applied for the treatment of diseases for thousands of years in China and other countries in East Asia. The Chinese Pharmacopoeia(ChP) is a drug code formulated by the Chinese government, and it includes a special volume for the monographs of TCM, which plays an important role in ensuring the quality of drugs. The use of quality control technology has always been a complex and important factor in TCM. Owing to the chemical diversity of TCM, chromatography technology has been proven to be a comprehensive strategy for the assessment of the overall quality of TCM and has become the main analytical method in the ChP.This article provides an overview of the classical and modern chromatographic technologies applied in the ChP, and summarizes the advantages and disadvantages of each technique in the TCM monographs.In 2020, the new edition of the Ch P(the 2020 edition) has been implemented at the end of 2020. This paper also contains a brief introduction about the application of chromatographic technologies in the new edition of the ChP.

Health technology assessment in traditional Chinese medicine in China: current status, opportunities, and challenges

Objectives:The widespread usage of traditional Chinese medicine(TCM)and the government's emphasis on TCM in China have created a positive macro-environment and great opportunities to develop and strengthen health technology assessment(HTA)in TCM.Over the past ten years,a series of policies have been issued by the government to promote the application of HTA and the development of TCM in China.This study reviews the concepts and characteristics of TCM,summarizes the current status of HTA in TCM,and analyzes the opportunities and challenges faced by HTA development in TCM with respect to deepening of healthcare reforms.Methods:Literature review and website searches were used to acquire information regarding the basic theories of TCM and the current status,opportunities,and challenges for HTA in TCM.Results:The number of articles on HTA in TCM rose substantially,especially those published in China National Knowledge Infrastructure(CNKI).With the optimistic policy environment and huge market demand for TCM,the development of HTA in TCM is expected to flourish in China.However,HTA in TCM also faces numerous challenges such as the absence of a clinical efficacy evaluation system for TCM and insufficient basic research evidence and qualified personnel.Conclusions:TCM has unique characteristic that distinguishes it from Western medicine.Currently,it is important to take all measures to address the existing main challenges and thereby take advantage of the present opportunities to develop and improve HTA in TCM.

Hospital-based health technology assessment:The next frontier for traditional Chinese medicine hospitals

Hospital-based health technology assessment(HB-HTA)is highly valuable in the application of hospital medical technology,cost control,improvement of medical quality,and protection of medical safety,and its use is increasing daily globally.However,in China,HB-HTA is still in its infancy,and it is yet to be adopted in traditional Chinese medicine(TCM).Therefore,this article introduces the application and development of HB-HTA,as well as discusses the current situation of TCM and related future development strategies to provide ideas and references for the development of HB-HTA in TCM.We conclude and recommend that all major stakeholders,including the state,health departments,and hospital leaders,support and promote the exploration and development of HB-HTA in TCM hospitals and integrative medicine hospitals.We also suggest the utilization of existing talents and introduction of other necessary talents to promote better and faster organizational development,as well as suggest the formation of a national and internationally recognized HB-HTA guidance manual and toolkit for TCM hospitals based on both the national HTA guidelines and the evaluation of TCM hospitals pilot projects.Moreover,we recommend that HB-HTA pilot study should be executed with Chinese patent medicine as the starting point to form the implementation process and framework in the TCM arena.

Effects of Traditional Chinese Medicine Leaching Solutions on Rice Yield

[Objective] The aim was to explore the effects of different leaching solu- tions on yield increasing of rice. [Method] Three rice parents were chosen from dif- ferent areas to treat with leaching solutions and rice leaves were sprayed with leaching solutions in seedling stage and tillering stage, respectively. The test data were recorded. Horizontal and vertical researches were carried out on agronomic traits of rice in different varieties in test or control groups. [Result] The horizontal test showed that hybrid rice parents, submerged with traditional Chinese medicines increased significantly in rice yield and vertical research indicated that rice in control group decreased sharply in yield and in test group improved in both yield and quality, which was also true for following generations. [Conclusion] The test provides references for hybrid rice maintaining rice traits.

Analysis of the application of Chinese medicine nursing technology in obstetrics

Objective:To analyze the application value of traditional Chinese medicine(TCM)nursing technology in obstetrics.Methods:204 patients with obstetrics were enrolled in the study and entered into the Chinese medicine group and thereference group according to the random number(n=102).The reference group received routine care,and the Chinesemedicine group received Chinese medicine nursing.The anxiety and depression scores of the two groups of patientsand the patient's nursing satisfaction status were compared.Results:There was no difference in the scores betweenthe pre-treatment groups.The value of the reduction in anxiety and depression scores in the TCM group wassignificantly higher than that in the reference group.The numerical comparison was statistically significant(P<0.05).The comprehensive nursing satisfaction rate of patients in the Chinese medicine group was 99.02%,and the comprehensivenursing satisfaction rate of the reference group was 80.39%.The numerical comparison was statistically significant(P<0.05).Conclusion:The application of TCM nursing technology in obstetrics helps to improve the negativeemotions of patients and improve the overall satisfaction rate of patients.The value of nursing intervention is higher

Specification of manual lactation traditional Chinese medicine technology

Acute mastitis is one of the common diseases of postpartum lactating women,also known as lactational mastitis,which can occur during breastfeeding,especially in the postpartum 3–4 weeks.Acute mastitis can lead to the cessation of breastfeeding.Improving breastfeeding behavior and extending breastfeeding duration have become a global strategy to promote maternal and child health.Manual lactation traditional Chinese medicine technology is one of the important measures to improve the rate of breastfeeding,which can solve the problems of breast swelling,pain,and reduction of milk production.This article introduces the definition,indications,standard operating procedures,precautions,and treatment of adverse events of manual lactation in traditional Chinese medicine technology,so as to provide more comprehensive guidance for clinical workers to carry out manual lactation operations.

Operating procedures of moxibustion technology

Moxibustion therapy is a treatment and health-care method that originated from China.It is a kind of therapy for preventing and treating diseases by stimulating meridians and acupoints using heat to regulate the viscera and enhance immunity.This article introduces the definition and mechanism of moxibustion technology,clinical operation technics,and precautions of moxibustion in practice,and demonstrates plenty of iconic cases of application of moxibustion in the treatment of insomnia,dysmenorrhea,urinary retention,knee arthritis,chronic eczema,etc.,so as to provide a reference for the wide application of moxibustion technology.

Application Status and Future Prospects of Traditional Chinese Medicine Nursing Technology

In recent years,the nursing technology of traditional Chinese medicine(TCM)has developed rapidly in the country.TCM nursing technology mainly refers to the application of TCM therapy in clinical nursing practice,such as acupoint massage,cupping,ear point pressure beans,scraping,wet compress of traditional Chinese medicine,etc.Its application can not only effectively reduce the pain of patients,but also can promote the treatment effect,help patients recover early,but also help to further improve the quality of service of nursing staff.In clinical nursing practice,however,the application of TCM nursing technology still has some problems,such as the theory of traditional Chinese medicine nursing quality to promote,“Internet+TCM nursing”is still in the exploratory stage,etc.This article mainly discusses the application status and existing problems of Chinese medicine nursing technique,coping strategies and its future prospects for related analysis and research,hope to be able to improve the quality of TCM nursing technology application in China to provide some reference and reference.

基于UPLC-Q-TOF-MS的参芪扶正注射液主要成分鉴定及其治疗三阴性乳腺癌的网络药理学研究

目的 应用超高效液相色谱串联四极杆飞行时间质谱联用(UPLC-Q-TOF-MS)技术和网络药理学方法,鉴定参芪扶正注射液的主要成分,探究其治疗三阴性乳腺癌(TNBC)的作用机制,为其药效物质基础研究提供依据。方法 (1)参芪扶正注射液主要成分鉴定:采用UPLC-Q-TOF-MS技术,结合天然产物高分辨质谱数据库及相关文献,明确参芪扶正注射液的主要成分。(2)网络药理学研究:基于中药系统药理学数据库与分析平台(TCMSP)、中草药化合物蛋白质靶标数据库(HIT)、有机小分子生物活性数据库(PubChem)、化合物靶点预测平台(Swiss Target Prediction)、本草组鉴数据库(HERB)获取参芪扶正注射液主要成分的潜在靶点,利用人类基因综合数据库(GeneCards)、在线人类孟德尔遗传数据库(OMIM)、治疗靶点数据库(TTD)获得TNBC疾病潜在靶点,二者相结合得到参芪扶正注射液治疗TNBC的潜在靶点;运用蛋白互作关系数据库(STRING)平台、Cytoscape 3.9.1软件构建蛋白互作网络图并进行网络拓扑分析,获得参芪扶正注射液治疗TNBC的关键靶点;运用R语言进行京都基因与基因组百科全书(KEGG)通路富集分析。(3)动物实验验证:制备异种移植瘤乳腺癌小鼠模型,分为模型组与参芪扶正注射液低、中、高剂量(20、40、60 mL/kg)组,干预4周后取肿瘤组织,运用Western blot方法检测肿瘤组织中磷酸化磷脂肌醇3激酶(p-PI3K)、磷脂肌醇3激酶(PI3K)、P-糖蛋白(P-gp)、乳腺癌耐药蛋白(ABCG2)表达情况,并对预测潜在靶点进行实验验证。结果 (1)参芪扶正注射液的主要成分为党参炔苷、鸟苷、毛蕊异黄酮苷、壬二酸、黄芪甲苷、美迪紫檀苷等。(2)网络药理学研究结果显示,参芪扶正注射液的主要成分主要作用于肿瘤蛋白p53(TP53)、白介素-2(IL-2)、白介素-6(IL-6)、白介素-10(IL-10)、己糖激酶2(HK2)、缺氧诱导因子1亚基α(HIF1A)、半胱氨酸天冬氨酸蛋白酶9(CASP9)、ABCG2、ATP结合盒转运体B1(ABCB1)、原癌基因(MYC)等关键靶点,调控磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、缺氧诱导因子-1(HIF-1)、T细胞受体等信号通路。(3)动物实验验证结果显示,参芪扶正注射液降低了实验动物肿瘤组织中p-PI3K水平,抑制了P-gp和ABCG2的表达。结论 参芪扶正注射液中的主要成分为党参炔苷、鸟苷、毛蕊异黄酮苷、壬二酸、黄芪甲苷、美迪紫檀苷等,其抗TNBC的作用机制与其通过调控PI3K信号通路和调节耐药相关蛋白表达有关。