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The value and association of CC chemokine receptor 7 expression in non-small cell lung cancer with lymph nodes metastasis
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作者 Tao Zeng Jianhu Wen Xing Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第11期650-654,共5页
Objective: The aim of this study was to analyze the expression of CC chemokine receptor 7 (CCR7) in pulmonary tumor tissue and metastasized lymph nodes of non-small cell lung cancer (NSCLC), explore the relations... Objective: The aim of this study was to analyze the expression of CC chemokine receptor 7 (CCR7) in pulmonary tumor tissue and metastasized lymph nodes of non-small cell lung cancer (NSCLC), explore the relationship between the expressions of CCR7 in pulmonary tumor tissue and metastasized lymph nodes, and discuss the significance. Methods: SABC immunohistochemical staining was used to investigate the expression of CCR7 by rabbit anti-human CCR7 monoclonal antibody, and the specimens were 17 cases of adenocarcinoma, 17 cases of squamous cell carcinoma, 12 cases of adenosquamous carcinoma, 4 cases of large cell carcinoma and 28 cases of metastasized lymph nodes of lung cancer. Negative control sections used 5 cases of inflammatory pseudotumor and 20 cases of normal lung tissue. Two independent pathologists observed all the specimens in the high power field (x 400) of microscope by double blind method. Results: (1) The expression of CCR7 in pulmonary tumor tissue was stronger than normal lung tissue (P 〈 0.005); (2) The expressions of CCR7 in pulmonary tumor tissues and metastasized lymph nodes had no significant differences (P = 0.177); (3) The expression of CCR7 had correlation with lymph nodes metastasis, and the expression in lymph nodes metastasis group was more than that of no lymph nodes metastasis group (P = 0.016); (4) Along with the increment of clinical stage, the CCR7 expression had a tendency to increase (P = 0.003). Conclusion: CCR7 has rich expression in carcinoma cell nests and lymph node metastasis. It demonstrates that CCR7 may be related to the development of lymph node metastasis in NSCLC. 展开更多
关键词 CC chemokine receptor 7 ccr7 non-small cell lung cancer (NSCLC) lymph nodes metastasis
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Dendritic cell migration in inflammation and immunity 被引量:25
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作者 Juan Liu Xiaomin Zhang +1 位作者 Yujie Cheng Xuetao Cao 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2021年第11期2461-2471,共11页
Dendritic cells(DCs)are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance.The trafficking of distinct DC ... Dendritic cells(DCs)are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance.The trafficking of distinct DC subsets across lymphoid and nonlymphoid tissues is essential for DC-dependent activation and regulation of inflammation and immunity.DC chemotaxis and migration are triggered by interactions between chemokines and their receptors and regulated by multiple intracellular mechanisms,such as protein modification,epigenetic reprogramming,metabolic remodeling,and cytoskeletal rearrangement,in a tissue-specific manner.Dysregulation of DC migration may lead to abnormal positioning or activation of DCs,resulting in an imbalance of immune responses and even immune pathologies,including autoimmune responses,infectious diseases,allergic diseases and tumors.New strategies targeting the migration of distinct DC subsets are being explored for the treatment of inflammatory and infectious diseases and the development of novel DC-based vaccines.In this review,we will discuss the migratory routes and immunological consequences of distinct DC subsets,the molecular basis and regulatory mechanisms of migratory signaling in DCs,and the association of DC migration with the pathogenesis of autoimmune and infectious diseases. 展开更多
关键词 dendritic cells cell migration chemokine receptor ccr7 INFLAMMATION autoimmune diseases
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