Objective: To investigate the effect of the integrated nursing model in the prevention of chemotherapy-induced peripheral injury. Methods: A total of 60 tumor patients receiving oxaliplatin for 1 - 6 cycles of chemoth...Objective: To investigate the effect of the integrated nursing model in the prevention of chemotherapy-induced peripheral injury. Methods: A total of 60 tumor patients receiving oxaliplatin for 1 - 6 cycles of chemotherapy from January to September 2023 were selected. 30 patients were selected from January to March and divided into the control group, and 30 patients were selected from July to 9 as the experimental group. The control group received conventional chemotherapy nursing, while the experimental group received integrated nursing. Anxiety, peripheral nerve toxicity stage and quality of life score were compared between the two groups before and after intervention. Results: After intervention, the scores of the self-rating Anxiety Scale (SAS) and the total scores of the oxaliplatin Levi specific sensory neurotoxicity scale in the experimental group were significantly lower than those in the control group, and the differences were statistically significant (P< 0.05);The Quality of Life Scale (FACT-G) score of cancer patients was higher than that of control group, and the difference was statistically significant (P< 0.05). Conclusion: The integrated nursing model can effectively reduce the anxiety of patients, reduce the incidence of peripheral nerve injury and improve the quality of life of patients.展开更多
Objective: The aim of the study was to observe the clinical effects of Shenqi Fuzheng injection decreasing sideeffects of chemotherapy for patients with ovarian epithelial cancer. Methods: The 36 cases of ovarian epit...Objective: The aim of the study was to observe the clinical effects of Shenqi Fuzheng injection decreasing sideeffects of chemotherapy for patients with ovarian epithelial cancer. Methods: The 36 cases of ovarian epithelial cancer in The Third Affiliated Hospital of SUN Yat-sen University(Guangzhou, China) from June 2010 to June 2013, were randomly divided into the study group and the control group. The study group contained 18 cases using Shenqi Fuzheng injection combined with TP(Taxol + Carboplatin/cisplatin) chemotherapy, and the control group contained 18 cases only using TP chemotherapy without Shenqi Fuzheng injection. During and after chemotherapy, the side-effects and therapy effects were observed. Results: The grade II of nausea and vomit were less in the study group than that in the control group, which was significantly different(P < 0.05). But there were no significantly differences in grade I of nausea and vomit between the two groups(P > 0.05). There was less degree of decrease of lymphocyte in the study group than that in the control group, which was significantly different(P < 0.05). But between two groups, there were no significant differences in the drop of white blood cells and red blood cells, the incidence of allergic reaction, liver and renal functions, nerve lesion and phalacrosis(P > 0.05). There was no significant difference in chemotherapy effect between the two groups(P > 0.05). Conclusion: Shenqi Fuzheng injection can in some degree relieve the side effects of TP chemotherapy for the patients with ovarian epithelial cancer, including relieving nausea and vomiting, protecting lymphocytes, and has no conflict effect on chemotherapy efficacy.展开更多
BACKGROUND Breast cancer(BC)is the second leading cause of tumor-related mortality after lung cancer.Chemotherapy resistance remains a major challenge to progress in BC treatment,warranting further exploration of feas...BACKGROUND Breast cancer(BC)is the second leading cause of tumor-related mortality after lung cancer.Chemotherapy resistance remains a major challenge to progress in BC treatment,warranting further exploration of feasible and effective alternative therapies.AIM To analyzed the quality of life(QoL)and survival of patients with BC treated with integrated traditional Chinese and Western medicine(TCM-WM).METHODS This study included 226 patients with BC admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine between February 2018 and February 2023,including 100 who received conventional Western medicine treatment(control group)and 126 who received TCM-WM treatment(research group).The total effective rate,side effects(alopecia,nausea and vomiting,hepatorenal toxicity,and myelosuppression),QoL assessed using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30),1-year overall survival(OS),recurrence and metastasis rates,and serum inflammatory factors[interleukin(IL)-6,IL-10,and tumor necrosis factor alpha]were comparatively analyzed.RESULTS The research group showed statistically better overall efficacy,EORTC QoL-C30 scores,and 1-year OS than the control group,with markedly lower side effects and 1-year recurrence and metastasis rates.Moreover,the posttreatment levels of serum inflammatory in the research group were significantly lower than the baseline and those in the control group.CONCLUSION Overall,TCM-WM demonstrated significantly improved therapeutic efficacy while ensuring drug safety in BC,which not only improved patients’QoL and prolonged survival,but also significantly inhibited the inflammatory response.展开更多
In comparison with the normal people group, values of blood CD<sub>2</sub><sup>+</sup> and CD<sub>4</sub><sup>+</sup> in pa-tients with mallgnant tumors treated with rad...In comparison with the normal people group, values of blood CD<sub>2</sub><sup>+</sup> and CD<sub>4</sub><sup>+</sup> in pa-tients with mallgnant tumors treated with radiotherapy and chemotherapy were significantly lower andthe ratio of CD<sub>助</sub><sup>+</sup> and CD<sub>8</sub><sup>+</sup> decreased obviously （all P【0.001）; CD<sub>8</sub><sup>+</sup> had no apparent change （P】0.05）. Following acupunctural treatment, values of CD<sub>2</sub><sup>+</sup>,CD<sub>4</sub><sup>+</sup> and the ratio of CD<sub>4</sub><sup>+</sup> to CD<sub>8</sub><sup>+</sup> increasedobviously （all P【0.001）; while those of the medicinal control group had no significant change aftertreatment（P】0. 05）. Values of IgG, IgA and IgM in patients’ serum presented an abnormal de-creasing or increasing tendency, and C<sub>3</sub> in minority of patients were raised. Results indicated thatthere was a biphasic regulatory effect of acupuncture on the disturbance of humoral immunity andcould correct the deviation of C<sub>3</sub> level; and its effect was better than or similar to that of the medicinecontrol group. It demonstrates that acupuncture can enhance and regulate. the immune function of pa-tients treated with radiotherapy展开更多
目的系统评价中西医结合治疗化疗后周围神经病变的疗效及安全性,为临床用药提供循证依据。方法在Pubmed、Web of science、Cochrane Library、Embase、知网、万方、维普、中国生物医学文献数据库八个数据库中检索相关文献,检索时限为建...目的系统评价中西医结合治疗化疗后周围神经病变的疗效及安全性,为临床用药提供循证依据。方法在Pubmed、Web of science、Cochrane Library、Embase、知网、万方、维普、中国生物医学文献数据库八个数据库中检索相关文献,检索时限为建库至2023年11月。筛选文献、提取数据,采用Cochrane系统风险评估工具进行质量评价。采用Revman 5.3和stata 12.0进行meta分析,敏感性分析和发表偏倚检验。结果共纳入23篇RCT研究,共计1758例患者。Meta分析结果显示:中西医结合治疗组患者的总有效率[RR=1.40,95%CI(1.24,1.58)],正中感觉神经的传导速度(正中神经SNCV)[MD=6.42,95%CI(5.67,7.17)],正中运动神经的传导速度(正中神经MNCV)[MD=4.39,95%CI(3.40,5.39)],腓总感觉神经的传导速度(腓总神经SNCV)[MD=5.16,95%CI(2.87,7.45)],腓总运动神经的传导速度(腓总神经MNCV)[MD=5.19,95%CI(4.13,6.26)],周围神经毒性分级[OR=2.69,95%CI(2.05,3.49)],血清神经生长因子水平(NGF)[SMD=1.65,95%CI(1.07,2.22)],生活质量KPS评分[MD=9.69,95%CI(4.78,14.60)]均显著优于单纯西医治疗组。结论中西医结合治疗能一定程度改善化疗患者周围神经病变的情况,并具有较少的不良反应,但由于受纳入研究质量限制,以上结论需更高质量的随机对照试验进行验证。展开更多
目的:通过网状Meta分析评价中医外治疗法缓解化疗诱导外周神经病变(CIPN)症状的疗效。方法:检索PubMed、the Cochrane Library、EMbase、Web of Science、中国知网、万方数据库、维普数据库等中英文数据库中有关中医外治疗法缓解CIPN症...目的:通过网状Meta分析评价中医外治疗法缓解化疗诱导外周神经病变(CIPN)症状的疗效。方法:检索PubMed、the Cochrane Library、EMbase、Web of Science、中国知网、万方数据库、维普数据库等中英文数据库中有关中医外治疗法缓解CIPN症状的随机对照试验,检索时限为各数据库建库到2023年8月15日。由2名研究者独立筛选文献、提取数据及文献质量评价。应用Stata 17.0软件进行网状Meta分析。结果:共纳入32项随机对照试验,共计2492例CIPN病人,涉及穴位贴敷、中药熏洗+甲钴胺联合治疗、穴位针灸+甲钴胺联合治疗等多种中西医结合疗法。网状Meta分析结果显示:总有效率疗效较好的为中药熏洗+甲钴胺治疗和穴位针灸大类+甲钴胺治疗;生活质量指数较优的为中药熏洗、穴位针灸大类+甲钴胺治疗。结论:现有证据显示,6种中西医结合治疗有效率高于常规护理和两种单纯西医治疗,且中药熏洗+甲钴胺治疗、穴位针灸大类+甲钴胺治疗两类中西医结合治疗疗效较好。展开更多
文摘Objective: To investigate the effect of the integrated nursing model in the prevention of chemotherapy-induced peripheral injury. Methods: A total of 60 tumor patients receiving oxaliplatin for 1 - 6 cycles of chemotherapy from January to September 2023 were selected. 30 patients were selected from January to March and divided into the control group, and 30 patients were selected from July to 9 as the experimental group. The control group received conventional chemotherapy nursing, while the experimental group received integrated nursing. Anxiety, peripheral nerve toxicity stage and quality of life score were compared between the two groups before and after intervention. Results: After intervention, the scores of the self-rating Anxiety Scale (SAS) and the total scores of the oxaliplatin Levi specific sensory neurotoxicity scale in the experimental group were significantly lower than those in the control group, and the differences were statistically significant (P< 0.05);The Quality of Life Scale (FACT-G) score of cancer patients was higher than that of control group, and the difference was statistically significant (P< 0.05). Conclusion: The integrated nursing model can effectively reduce the anxiety of patients, reduce the incidence of peripheral nerve injury and improve the quality of life of patients.
基金Supported by a grant of Chinese Medicine Scientific Research of Guangdong Province(No.2010113)
文摘Objective: The aim of the study was to observe the clinical effects of Shenqi Fuzheng injection decreasing sideeffects of chemotherapy for patients with ovarian epithelial cancer. Methods: The 36 cases of ovarian epithelial cancer in The Third Affiliated Hospital of SUN Yat-sen University(Guangzhou, China) from June 2010 to June 2013, were randomly divided into the study group and the control group. The study group contained 18 cases using Shenqi Fuzheng injection combined with TP(Taxol + Carboplatin/cisplatin) chemotherapy, and the control group contained 18 cases only using TP chemotherapy without Shenqi Fuzheng injection. During and after chemotherapy, the side-effects and therapy effects were observed. Results: The grade II of nausea and vomit were less in the study group than that in the control group, which was significantly different(P < 0.05). But there were no significantly differences in grade I of nausea and vomit between the two groups(P > 0.05). There was less degree of decrease of lymphocyte in the study group than that in the control group, which was significantly different(P < 0.05). But between two groups, there were no significant differences in the drop of white blood cells and red blood cells, the incidence of allergic reaction, liver and renal functions, nerve lesion and phalacrosis(P > 0.05). There was no significant difference in chemotherapy effect between the two groups(P > 0.05). Conclusion: Shenqi Fuzheng injection can in some degree relieve the side effects of TP chemotherapy for the patients with ovarian epithelial cancer, including relieving nausea and vomiting, protecting lymphocytes, and has no conflict effect on chemotherapy efficacy.
文摘BACKGROUND Breast cancer(BC)is the second leading cause of tumor-related mortality after lung cancer.Chemotherapy resistance remains a major challenge to progress in BC treatment,warranting further exploration of feasible and effective alternative therapies.AIM To analyzed the quality of life(QoL)and survival of patients with BC treated with integrated traditional Chinese and Western medicine(TCM-WM).METHODS This study included 226 patients with BC admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine between February 2018 and February 2023,including 100 who received conventional Western medicine treatment(control group)and 126 who received TCM-WM treatment(research group).The total effective rate,side effects(alopecia,nausea and vomiting,hepatorenal toxicity,and myelosuppression),QoL assessed using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30),1-year overall survival(OS),recurrence and metastasis rates,and serum inflammatory factors[interleukin(IL)-6,IL-10,and tumor necrosis factor alpha]were comparatively analyzed.RESULTS The research group showed statistically better overall efficacy,EORTC QoL-C30 scores,and 1-year OS than the control group,with markedly lower side effects and 1-year recurrence and metastasis rates.Moreover,the posttreatment levels of serum inflammatory in the research group were significantly lower than the baseline and those in the control group.CONCLUSION Overall,TCM-WM demonstrated significantly improved therapeutic efficacy while ensuring drug safety in BC,which not only improved patients’QoL and prolonged survival,but also significantly inhibited the inflammatory response.
文摘In comparison with the normal people group, values of blood CD<sub>2</sub><sup>+</sup> and CD<sub>4</sub><sup>+</sup> in pa-tients with mallgnant tumors treated with radiotherapy and chemotherapy were significantly lower andthe ratio of CD<sub>助</sub><sup>+</sup> and CD<sub>8</sub><sup>+</sup> decreased obviously （all P【0.001）; CD<sub>8</sub><sup>+</sup> had no apparent change （P】0.05）. Following acupunctural treatment, values of CD<sub>2</sub><sup>+</sup>,CD<sub>4</sub><sup>+</sup> and the ratio of CD<sub>4</sub><sup>+</sup> to CD<sub>8</sub><sup>+</sup> increasedobviously （all P【0.001）; while those of the medicinal control group had no significant change aftertreatment（P】0. 05）. Values of IgG, IgA and IgM in patients’ serum presented an abnormal de-creasing or increasing tendency, and C<sub>3</sub> in minority of patients were raised. Results indicated thatthere was a biphasic regulatory effect of acupuncture on the disturbance of humoral immunity andcould correct the deviation of C<sub>3</sub> level; and its effect was better than or similar to that of the medicinecontrol group. It demonstrates that acupuncture can enhance and regulate. the immune function of pa-tients treated with radiotherapy
