BACKGROUND Evaluation of suspected stable angina patients with probable coronary artery disease(CAD)in the community is challenging.In the United Kingdom,patients with suspected stable angina are referred by community...BACKGROUND Evaluation of suspected stable angina patients with probable coronary artery disease(CAD)in the community is challenging.In the United Kingdom,patients with suspected stable angina are referred by community physicians to be assessed by specialists within the hospital system in rapid access chest pain clinics(RACPC).The role of a highly sensitive troponin I(uscTnI)assay in the diagnosis of suspected CAD in a RACPC in a“real-life”setting in a non-academic hospital has not been explored.AIM To examine the diagnostic value of uscTnI(detection limit 0.12 ng/L,upper reference range 8.15 ng/L,and detected uscTnI in 96.8%of the reference population),in the evaluation of stable CAD in a non-selected patient group,with several co-morbidities,who presented to the RACPC.METHODS One hundred and seventy two RACPC patients were assigned to either functional or anatomical testing according to the hospital protocol.RESULTS The investigations offered to patients were exercise tolerance test 7.6%,24 h ECG 1.2%,Echocardiogram 14.5%,stress echocardiogram 8.1%,coronary computed tomography angiography(CCTA)12.8%,coronary angiogram 13.4%,17.4%were diagnosed with non-cardiac chest pain,3.5%treated as stable angina,8.2%reviewed by cardiologists,electronic medical records were not available in 10.4%.Receiver operating characteristic curves for CAD used uscTnI values measured in patients who underwent functional testing,angiogram or CCTA.Values>0.52 ng/L showed 100%sensitivity and at>11.6 ng/L showed 100%specificity.In the range>0.52-11.6 ng/L,uscTnI may not have the same diagnostic potential.In patients assigned to coronary angiogram higher concentrations of uscTnI was associated with severe CAD.Low levels of uscTnI and low pre-test probability of CAD(QRISK3)may decrease patient numbers assigned to CCTA.CONCLUSION The uscTnI diagnostic cut-off values in a RACPC will depend on patient population and their presenting co-morbidity.In the presence of clinical comorbidities and previous CAD the uscTnI needs to be used in conjunction with clinical assessment.展开更多
Giant coronary artery aneurysms and coronary artery fistulae are uncommon pathologies. We present the case of an elderly woman who was referred to cardiology for investigation of possible ischaemic heart disease prior...Giant coronary artery aneurysms and coronary artery fistulae are uncommon pathologies. We present the case of an elderly woman who was referred to cardiology for investigation of possible ischaemic heart disease prior to orthopaedic surgery. The patient had developed chest pain in the setting of a septic total knee replacement associated with changes on electrocardiography. Coronary angiography revealed multiple coronary arteriovenous fistulae associated with giant coronary artery aneurysm causing steal syndrome in the setting of haemodynamic stress.展开更多
BACKGROUND Coronary artery aneurysm combined with myocardial bridge is a very rare clinical situation.The prognosis of this clinical situation is not yet clear.CASE SUMMARY A coronary artery aneurysm and myocardial br...BACKGROUND Coronary artery aneurysm combined with myocardial bridge is a very rare clinical situation.The prognosis of this clinical situation is not yet clear.CASE SUMMARY A coronary artery aneurysm and myocardial bridge in the same segment of the coronary artery were found in a 54-year-old female patient who underwent coronary angiography and intravascular ultrasound examination.Through conservative treatment,the patient was discharged from the hospital smoothly,and she was in good condition during 5 mo of follow-up.CONCLUSION Coronary artery aneurysm combined with myocardial bridge seems to have a good prognosis,but due to the rarity of this clinical situation,further research and follow-up are needed.展开更多
Coronary artery disease (CAD) is the leading cause of death in both sexes worldwide, and becomes number one killer in women due to many factors including increase in traditional risk factors, delays in apparition of s...Coronary artery disease (CAD) is the leading cause of death in both sexes worldwide, and becomes number one killer in women due to many factors including increase in traditional risk factors, delays in apparition of symptoms, under estimation of diagnosis test and treatment. Our study aims to identify risk factors for coronary artery disease among women with chest pain underwent coronary angiography during years (2010-2013) in cardiology center. The study design is an observational among 688 women-aged 32 - 96 years;the mean age of our study population is 61 years. Risk factors are abstracted from patients’ files. Women with documented coronaries disease tend to be older, have higher, systolic blood pressure, serum level of triglyceride, and impaired clearance creatinine. 59.4% of them are menopause with higher prevalence of hypertension and diabetes (58.6% and 63.6%). Significant positive association is found in women with myocardial infarction, unstable angina, stable angina and presence of obstructive coronary artery disease respectively (89.6%, 82.3%, 59.1%) in opposite women presented with atypical chest pain have high prevalence of normal coronaries (95.7%). About 57.6% have more than three risk factors, and 55.3% are obese or overweight. In addition, 42.1% of them have impaired systolic function. We conclude that cardiovascular risk factors are highly prevalent among Palestinians women in Gaza and the combination of risk factors is common. Interventions to minimize CAD in our population are needed.展开更多
目的探讨双源CT前瞻性心电门控低剂量扫描技术(DSCT)对经皮冠状动脉介入术(PCI)后胸痛患者的诊断价值。方法选取本院2014年7月至2015年6月就诊的84例PCI术后胸痛患者进行心胸联合DSCT扫描,并有2位资深的放射科医师对患者的冠状动脉实施...目的探讨双源CT前瞻性心电门控低剂量扫描技术(DSCT)对经皮冠状动脉介入术(PCI)后胸痛患者的诊断价值。方法选取本院2014年7月至2015年6月就诊的84例PCI术后胸痛患者进行心胸联合DSCT扫描,并有2位资深的放射科医师对患者的冠状动脉实施靶重组,同时对图像质量进行评价,作出诊断。所有患者在DSCT扫描后的2周内均行冠状动脉造影术(CAG)。以CAG结果为"金标准",评估DSCT诊断PCI术后胸痛患者冠状动脉狭窄的特异性、敏感性、阴性预测值和阳性预测值。采用Kappa检验评估两种检查对冠状动脉狭窄评估的一致性。结果 DSCT诊断PCI术后胸痛患者冠状动脉狭窄的特异性、敏感性、阴性预测值和阳性预测值分别为85.5%、96.6%、94.6%、90.4%。DSCT与CAG诊断冠状动脉狭窄程度具有高度一致性(Kappa值=0.858)。DSCT的有效辐射剂量为4.67±0.87 m Sv。结论对PCI术后胸痛患者行DSCT冠状动脉成像能获取高质量的图像,评价冠状动脉狭窄程度准确,辐射剂量较低,值得临床推广。展开更多
文摘BACKGROUND Evaluation of suspected stable angina patients with probable coronary artery disease(CAD)in the community is challenging.In the United Kingdom,patients with suspected stable angina are referred by community physicians to be assessed by specialists within the hospital system in rapid access chest pain clinics(RACPC).The role of a highly sensitive troponin I(uscTnI)assay in the diagnosis of suspected CAD in a RACPC in a“real-life”setting in a non-academic hospital has not been explored.AIM To examine the diagnostic value of uscTnI(detection limit 0.12 ng/L,upper reference range 8.15 ng/L,and detected uscTnI in 96.8%of the reference population),in the evaluation of stable CAD in a non-selected patient group,with several co-morbidities,who presented to the RACPC.METHODS One hundred and seventy two RACPC patients were assigned to either functional or anatomical testing according to the hospital protocol.RESULTS The investigations offered to patients were exercise tolerance test 7.6%,24 h ECG 1.2%,Echocardiogram 14.5%,stress echocardiogram 8.1%,coronary computed tomography angiography(CCTA)12.8%,coronary angiogram 13.4%,17.4%were diagnosed with non-cardiac chest pain,3.5%treated as stable angina,8.2%reviewed by cardiologists,electronic medical records were not available in 10.4%.Receiver operating characteristic curves for CAD used uscTnI values measured in patients who underwent functional testing,angiogram or CCTA.Values>0.52 ng/L showed 100%sensitivity and at>11.6 ng/L showed 100%specificity.In the range>0.52-11.6 ng/L,uscTnI may not have the same diagnostic potential.In patients assigned to coronary angiogram higher concentrations of uscTnI was associated with severe CAD.Low levels of uscTnI and low pre-test probability of CAD(QRISK3)may decrease patient numbers assigned to CCTA.CONCLUSION The uscTnI diagnostic cut-off values in a RACPC will depend on patient population and their presenting co-morbidity.In the presence of clinical comorbidities and previous CAD the uscTnI needs to be used in conjunction with clinical assessment.
文摘Giant coronary artery aneurysms and coronary artery fistulae are uncommon pathologies. We present the case of an elderly woman who was referred to cardiology for investigation of possible ischaemic heart disease prior to orthopaedic surgery. The patient had developed chest pain in the setting of a septic total knee replacement associated with changes on electrocardiography. Coronary angiography revealed multiple coronary arteriovenous fistulae associated with giant coronary artery aneurysm causing steal syndrome in the setting of haemodynamic stress.
文摘BACKGROUND Coronary artery aneurysm combined with myocardial bridge is a very rare clinical situation.The prognosis of this clinical situation is not yet clear.CASE SUMMARY A coronary artery aneurysm and myocardial bridge in the same segment of the coronary artery were found in a 54-year-old female patient who underwent coronary angiography and intravascular ultrasound examination.Through conservative treatment,the patient was discharged from the hospital smoothly,and she was in good condition during 5 mo of follow-up.CONCLUSION Coronary artery aneurysm combined with myocardial bridge seems to have a good prognosis,but due to the rarity of this clinical situation,further research and follow-up are needed.
文摘Coronary artery disease (CAD) is the leading cause of death in both sexes worldwide, and becomes number one killer in women due to many factors including increase in traditional risk factors, delays in apparition of symptoms, under estimation of diagnosis test and treatment. Our study aims to identify risk factors for coronary artery disease among women with chest pain underwent coronary angiography during years (2010-2013) in cardiology center. The study design is an observational among 688 women-aged 32 - 96 years;the mean age of our study population is 61 years. Risk factors are abstracted from patients’ files. Women with documented coronaries disease tend to be older, have higher, systolic blood pressure, serum level of triglyceride, and impaired clearance creatinine. 59.4% of them are menopause with higher prevalence of hypertension and diabetes (58.6% and 63.6%). Significant positive association is found in women with myocardial infarction, unstable angina, stable angina and presence of obstructive coronary artery disease respectively (89.6%, 82.3%, 59.1%) in opposite women presented with atypical chest pain have high prevalence of normal coronaries (95.7%). About 57.6% have more than three risk factors, and 55.3% are obese or overweight. In addition, 42.1% of them have impaired systolic function. We conclude that cardiovascular risk factors are highly prevalent among Palestinians women in Gaza and the combination of risk factors is common. Interventions to minimize CAD in our population are needed.
文摘目的探讨双源CT前瞻性心电门控低剂量扫描技术(DSCT)对经皮冠状动脉介入术(PCI)后胸痛患者的诊断价值。方法选取本院2014年7月至2015年6月就诊的84例PCI术后胸痛患者进行心胸联合DSCT扫描,并有2位资深的放射科医师对患者的冠状动脉实施靶重组,同时对图像质量进行评价,作出诊断。所有患者在DSCT扫描后的2周内均行冠状动脉造影术(CAG)。以CAG结果为"金标准",评估DSCT诊断PCI术后胸痛患者冠状动脉狭窄的特异性、敏感性、阴性预测值和阳性预测值。采用Kappa检验评估两种检查对冠状动脉狭窄评估的一致性。结果 DSCT诊断PCI术后胸痛患者冠状动脉狭窄的特异性、敏感性、阴性预测值和阳性预测值分别为85.5%、96.6%、94.6%、90.4%。DSCT与CAG诊断冠状动脉狭窄程度具有高度一致性(Kappa值=0.858)。DSCT的有效辐射剂量为4.67±0.87 m Sv。结论对PCI术后胸痛患者行DSCT冠状动脉成像能获取高质量的图像,评价冠状动脉狭窄程度准确,辐射剂量较低,值得临床推广。
