We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be c...We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be calculated explicitly which is a squared function.展开更多
Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher ...Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher order Markov chain model and how to automatically select the proper order are given in this paper. The chi square test is first run on synthetic data sets to show that it can efficiently find the proper order of Markov chain. Using chi square test, distinct higher order context dependences inherent in ten sets of sequences of yeast S.cerevisiae from other literature have been found. So the Markov chain with higher order would be more suitable for modeling the non coding background sequences than an independent model.展开更多
It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. ...It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.展开更多
This study introduces a new classifier tailored to address the limitations inherent in conventional classifiers such as K-nearest neighbor(KNN),random forest(RF),decision tree(DT),and support vector machine(SVM)for ar...This study introduces a new classifier tailored to address the limitations inherent in conventional classifiers such as K-nearest neighbor(KNN),random forest(RF),decision tree(DT),and support vector machine(SVM)for arrhythmia detection.The proposed classifier leverages the Chi-square distance as a primary metric,providing a specialized and original approach for precise arrhythmia detection.To optimize feature selection and refine the classifier’s performance,particle swarm optimization(PSO)is integrated with the Chi-square distance as a fitness function.This synergistic integration enhances the classifier’s capabilities,resulting in a substantial improvement in accuracy for arrhythmia detection.Experimental results demonstrate the efficacy of the proposed method,achieving a noteworthy accuracy rate of 98% with PSO,higher than 89% achieved without any previous optimization.The classifier outperforms machine learning(ML)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm of arrhythmia classification.The promising results render it an effective method to support both academic and medical communities,offering an advanced and precise solution for arrhythmia detection in electrocardiogram(ECG)data.展开更多
In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For exampl...In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10th, 50th, and 90th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.展开更多
Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-v...Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-valued observations is asymmetric, and its functional form may not be known or easily characterized. In this case, comparisons of the groups in terms of their respective percentiles may be appropriate as these estimates are nonparametric and more robust to outliers and other irregularities. The median test is often used to compare distributions with similar but asymmetric shapes but may be uninformative when there are excess zeros or dissimilar shapes. For zero-inflated distributions, it is useful to compare the distributions with respect to their proportion of zeros, coupled with the comparison of percentile profiles for the observed non-zero values. A simple chi-square test for simultaneous testing of these two components is proposed, applicable to both continuous and discrete data. Results of simulation studies are reported to summarize empirical power under several scenarios. We give recommendations for the minimum sample size which is necessary to achieve suitable test performance in specific examples.展开更多
A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function an...A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.展开更多
To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concret...To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.展开更多
AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge st...AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.展开更多
Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model test...Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model tests is proposed.The fundamental principle and design of the sensor are demonstrated.The sensor comprises three earth pressure gages and one gyroscope,with the utilization of three-dimensional(3D)printing technology.The difficulties of installation location during model preparation and sensor rotation during testing can be effectively overcome using this sensor.Two different arrangements of the sensors are tested in verification tests.Additionally,the application of the sensor in an excavated-induced slope model is tested.The results demonstrate that the sensor exhibits commendable performance and achieves a desirable level of accuracy,with a principal stress angle error of±5°in the verification tests.The stress transformation of the slope model,generated by excavation,is demonstrated in the application test by monitoring the two miniature principal stress(MPS)sensors.The sensor has a significant potential for measuring primary stress in landslide model tests and other geotechnical model experiments.展开更多
A fault is a geological structure characterized by significant displacement of rock masses along a fault plane within the Earth's crust.The Yunnan Tabaiyi Tunnel intersects multiple fault zones,making tunnel const...A fault is a geological structure characterized by significant displacement of rock masses along a fault plane within the Earth's crust.The Yunnan Tabaiyi Tunnel intersects multiple fault zones,making tunnel construction in fault-prone areas particularly vulnerable to the effects of fault activity due to the complexities of the surrounding geological environment.To investigate the dynamic response characteristics of tunnel structures under varying surrounding rock conditions,a three-dimensional large-scale shaking table physical model test was conducted.This study also aimed to explore the damage mechanisms associated with the Tabaiyi Tunnel under seismic loading.The results demonstrate that poor quality surrounding rock enhances the seismic response of the tunnel.This effect is primarily attributed to the distribution characteristics of acceleration,dynamic strain,and dynamic soil pressure.A comparison between unidirectional and multi-directional(including vertical)seismic motions reveals that vertical seismic motion has a more significant impact on specific tunnel locations.Specifically,the maximum tensile stress is observed at the arch shoulder,with values ranging from 60 to 100 k Pa.Moreover,NPR(Non-Prestressed Reinforced)anchor cables exhibit a substantial constant resistance effect under low-amplitude seismic waves.However,when the input earthquake amplitude reaches 0.8g,local sliding occurs at the arch shoulder region of the NPR anchor cable.These findings underscore the importance of focusing on seismic mitigation measures in fault zones and reinforcing critical areas,such as the arch shoulders,in practical engineering applications.展开更多
Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the...Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the solidification time of conventional cement paste is long when shotcrete is used to treat cohesionless soil landslide.The idea of reinforcing slope with polyurethane solidified soil(i.e.,mixture of polyurethane and sand)was proposed.Model tests and finite element analysis were carried out to study the effectiveness of the proposed new method on the emergency treatment of cohesionless soil landslide.Surcharge loading on the crest of the slope was applied step by step until landslide was triggered so as to test and compare the stability and bearing capacity of slope models with different conditions.The simulated slope displacements were relatively close to the measured results,and the simulated slope deformation characteristics were in good agreement with the observed phenomena,which verifies the accuracy of the numerical method.Under the condition of surcharge loading on the crest of the slope,the unreinforced slope slid when the surcharge loading exceeded 30 k Pa,which presented a failure mode of local instability and collapse at the shallow layer of slope top.The reinforced slope remained stable even when the surcharge loading reached 48 k Pa.The displacement of the reinforced slope was reduced by more than 95%.Overall,this study verifies the effectiveness of polyurethane in the emergency treatment of cohesionless soil landslide and should have broad application prospects in the field of geological disasters concerning the safety of people's live.展开更多
Antimicrobial resistance(AMR)represents a substantial threat to global public health,complicating the treatment of common infections and leading to prolonged illness and escalated healthcare expenses.To effectively co...Antimicrobial resistance(AMR)represents a substantial threat to global public health,complicating the treatment of common infections and leading to prolonged illness and escalated healthcare expenses.To effectively combat AMR,timely and accurate detection is crucial for AMR surveillance and individual-based therapy.Phenotypic antibiotic resistance testing(AST)has long been considered the gold standard in clinical applications,serving as the foundation for clinical AMR diagnosis and optimized therapy.It has significantly contributed to ensuring patients′health and the development of novel antimicrobials.Despite advancements in automated culture-based AST technologies,inherent limitations impede the widespread use of phenotypic AST in AMR surveillance.Genotypic AST technologies offer a promising alternative option,exhibiting advantages of rapidity,high sensitivity,and specificity.With the continuous advancement and expanding applications of genotypic AST technologies,such as microfluidics,mass spectrometry,and high-resolution melting curve analysis,new vigor has been injected into the development and clinical implementation of genotypic AST technologies.In this narrative review,we discuss the principles,applications,and advancements of emerging genotypic AST methods in clinical settings.The comprehensive review aims to highlight the significant scientific potential of emerging genotypic AST technologies in clinical AMR diagnosis,providing insights to enhance existing methods and explore novel approaches.展开更多
In this paper Singular Decompositon Value (SVD) formula and modified Chi-square solution are provided, and the modified Chi-square is combined with FT-IR instrument to control biochemical reaction process. Using the m...In this paper Singular Decompositon Value (SVD) formula and modified Chi-square solution are provided, and the modified Chi-square is combined with FT-IR instrument to control biochemical reaction process. Using the modified Chi-square technique, the unknown concentration of reactants and products in test samples withdrawn from the process is determined. The technique avoids the need for the spectral data to conform to Beer’s Law and the best spectral range is determined automatically.展开更多
The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two c...The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted mean.Due to the wide applicability of these tools,we present a Java-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.展开更多
Diabetes mellitus is a metabolic disease that is ranked among the top 10 causes of death by the world health organization.During the last few years,an alarming increase is observed worldwide with a 70%rise in the dise...Diabetes mellitus is a metabolic disease that is ranked among the top 10 causes of death by the world health organization.During the last few years,an alarming increase is observed worldwide with a 70%rise in the disease since 2000 and an 80%rise in male deaths.If untreated,it results in complications of many vital organs of the human body which may lead to fatality.Early detection of diabetes is a task of significant importance to start timely treatment.This study introduces a methodology for the classification of diabetic and normal people using an ensemble machine learning model and feature fusion of Chi-square and principal component analysis.An ensemble model,logistic tree classifier(LTC),is proposed which incorporates logistic regression and extra tree classifier through a soft voting mechanism.Experiments are also performed using several well-known machine learning algorithms to analyze their performance including logistic regression,extra tree classifier,AdaBoost,Gaussian naive Bayes,decision tree,random forest,and k nearest neighbor.In addition,several experiments are carried out using principal component analysis(PCA)and Chi-square(Chi-2)fea-tures to analyze the influence of feature selection on the performance of machine learning classifiers.Results indicate that Chi-2 features show high performance than both PCA features and original features.However,the highest accuracy is obtained when the proposed ensemble model LTC is used with the proposed fea-ture fusion framework-work which achieves a 0.85 accuracy score which is the highest of the available approaches for diabetes prediction.In addition,the statis-tical T-test proves the statistical significance of the proposed approach over other approaches.展开更多
基金the National Natural Science Foundation of China (10571139)
文摘We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be calculated explicitly which is a squared function.
文摘Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher order Markov chain model and how to automatically select the proper order are given in this paper. The chi square test is first run on synthetic data sets to show that it can efficiently find the proper order of Markov chain. Using chi square test, distinct higher order context dependences inherent in ten sets of sequences of yeast S.cerevisiae from other literature have been found. So the Markov chain with higher order would be more suitable for modeling the non coding background sequences than an independent model.
文摘It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.
文摘This study introduces a new classifier tailored to address the limitations inherent in conventional classifiers such as K-nearest neighbor(KNN),random forest(RF),decision tree(DT),and support vector machine(SVM)for arrhythmia detection.The proposed classifier leverages the Chi-square distance as a primary metric,providing a specialized and original approach for precise arrhythmia detection.To optimize feature selection and refine the classifier’s performance,particle swarm optimization(PSO)is integrated with the Chi-square distance as a fitness function.This synergistic integration enhances the classifier’s capabilities,resulting in a substantial improvement in accuracy for arrhythmia detection.Experimental results demonstrate the efficacy of the proposed method,achieving a noteworthy accuracy rate of 98% with PSO,higher than 89% achieved without any previous optimization.The classifier outperforms machine learning(ML)and deep learning(DL)techniques,underscoring its reliability and superiority in the realm of arrhythmia classification.The promising results render it an effective method to support both academic and medical communities,offering an advanced and precise solution for arrhythmia detection in electrocardiogram(ECG)data.
文摘In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10th, 50th, and 90th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.
文摘Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-valued observations is asymmetric, and its functional form may not be known or easily characterized. In this case, comparisons of the groups in terms of their respective percentiles may be appropriate as these estimates are nonparametric and more robust to outliers and other irregularities. The median test is often used to compare distributions with similar but asymmetric shapes but may be uninformative when there are excess zeros or dissimilar shapes. For zero-inflated distributions, it is useful to compare the distributions with respect to their proportion of zeros, coupled with the comparison of percentile profiles for the observed non-zero values. A simple chi-square test for simultaneous testing of these two components is proposed, applicable to both continuous and discrete data. Results of simulation studies are reported to summarize empirical power under several scenarios. We give recommendations for the minimum sample size which is necessary to achieve suitable test performance in specific examples.
文摘A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.
文摘To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.
文摘AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine eye.METHODS:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring ACP.This was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge tip.Using a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured ACP.For the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge tip.The bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was calculated.RESULTS:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge tips.Similarly,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly equal.The bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge tip.CONCLUSION:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.
基金supported by the National Nature Science Foundation of China(Grant No.42207216)the Major Program of the National Natural Science Foundation of China(Grant No.42090055)the National Nature Science Foundation of China(Grant No.42377182).
文摘Understanding the stress distribution derived from monitoring the principal stress(PS)in slopes is of great importance.In this study,a miniature sensor for quantifying the two-dimensional(2D)PS in landslide model tests is proposed.The fundamental principle and design of the sensor are demonstrated.The sensor comprises three earth pressure gages and one gyroscope,with the utilization of three-dimensional(3D)printing technology.The difficulties of installation location during model preparation and sensor rotation during testing can be effectively overcome using this sensor.Two different arrangements of the sensors are tested in verification tests.Additionally,the application of the sensor in an excavated-induced slope model is tested.The results demonstrate that the sensor exhibits commendable performance and achieves a desirable level of accuracy,with a principal stress angle error of±5°in the verification tests.The stress transformation of the slope model,generated by excavation,is demonstrated in the application test by monitoring the two miniature principal stress(MPS)sensors.The sensor has a significant potential for measuring primary stress in landslide model tests and other geotechnical model experiments.
基金funded by the National Natural Science Foundation of China(Grant No.42377195)。
文摘A fault is a geological structure characterized by significant displacement of rock masses along a fault plane within the Earth's crust.The Yunnan Tabaiyi Tunnel intersects multiple fault zones,making tunnel construction in fault-prone areas particularly vulnerable to the effects of fault activity due to the complexities of the surrounding geological environment.To investigate the dynamic response characteristics of tunnel structures under varying surrounding rock conditions,a three-dimensional large-scale shaking table physical model test was conducted.This study also aimed to explore the damage mechanisms associated with the Tabaiyi Tunnel under seismic loading.The results demonstrate that poor quality surrounding rock enhances the seismic response of the tunnel.This effect is primarily attributed to the distribution characteristics of acceleration,dynamic strain,and dynamic soil pressure.A comparison between unidirectional and multi-directional(including vertical)seismic motions reveals that vertical seismic motion has a more significant impact on specific tunnel locations.Specifically,the maximum tensile stress is observed at the arch shoulder,with values ranging from 60 to 100 k Pa.Moreover,NPR(Non-Prestressed Reinforced)anchor cables exhibit a substantial constant resistance effect under low-amplitude seismic waves.However,when the input earthquake amplitude reaches 0.8g,local sliding occurs at the arch shoulder region of the NPR anchor cable.These findings underscore the importance of focusing on seismic mitigation measures in fault zones and reinforcing critical areas,such as the arch shoulders,in practical engineering applications.
基金the financial support from the Fujian Science Foundation for Outstanding Youth(2023J06039)the National Natural Science Foundation of China(Grant No.41977259,U2005205,41972268)the Independent Research Project of Technology Innovation Center for Monitoring and Restoration Engineering of Ecological Fragile Zone in Southeast China(KY-090000-04-2022-019)。
文摘Shotcrete is one of the common solutions for shallow sliding.It works by forming a protective layer with high strength and cementing the loose soil particles on the slope surface to prevent shallow sliding.However,the solidification time of conventional cement paste is long when shotcrete is used to treat cohesionless soil landslide.The idea of reinforcing slope with polyurethane solidified soil(i.e.,mixture of polyurethane and sand)was proposed.Model tests and finite element analysis were carried out to study the effectiveness of the proposed new method on the emergency treatment of cohesionless soil landslide.Surcharge loading on the crest of the slope was applied step by step until landslide was triggered so as to test and compare the stability and bearing capacity of slope models with different conditions.The simulated slope displacements were relatively close to the measured results,and the simulated slope deformation characteristics were in good agreement with the observed phenomena,which verifies the accuracy of the numerical method.Under the condition of surcharge loading on the crest of the slope,the unreinforced slope slid when the surcharge loading exceeded 30 k Pa,which presented a failure mode of local instability and collapse at the shallow layer of slope top.The reinforced slope remained stable even when the surcharge loading reached 48 k Pa.The displacement of the reinforced slope was reduced by more than 95%.Overall,this study verifies the effectiveness of polyurethane in the emergency treatment of cohesionless soil landslide and should have broad application prospects in the field of geological disasters concerning the safety of people's live.
基金supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-04)。
文摘Antimicrobial resistance(AMR)represents a substantial threat to global public health,complicating the treatment of common infections and leading to prolonged illness and escalated healthcare expenses.To effectively combat AMR,timely and accurate detection is crucial for AMR surveillance and individual-based therapy.Phenotypic antibiotic resistance testing(AST)has long been considered the gold standard in clinical applications,serving as the foundation for clinical AMR diagnosis and optimized therapy.It has significantly contributed to ensuring patients′health and the development of novel antimicrobials.Despite advancements in automated culture-based AST technologies,inherent limitations impede the widespread use of phenotypic AST in AMR surveillance.Genotypic AST technologies offer a promising alternative option,exhibiting advantages of rapidity,high sensitivity,and specificity.With the continuous advancement and expanding applications of genotypic AST technologies,such as microfluidics,mass spectrometry,and high-resolution melting curve analysis,new vigor has been injected into the development and clinical implementation of genotypic AST technologies.In this narrative review,we discuss the principles,applications,and advancements of emerging genotypic AST methods in clinical settings.The comprehensive review aims to highlight the significant scientific potential of emerging genotypic AST technologies in clinical AMR diagnosis,providing insights to enhance existing methods and explore novel approaches.
文摘In this paper Singular Decompositon Value (SVD) formula and modified Chi-square solution are provided, and the modified Chi-square is combined with FT-IR instrument to control biochemical reaction process. Using the modified Chi-square technique, the unknown concentration of reactants and products in test samples withdrawn from the process is determined. The technique avoids the need for the spectral data to conform to Beer’s Law and the best spectral range is determined automatically.
文摘The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted mean.Due to the wide applicability of these tools,we present a Java-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.
基金supported by the Florida Center for Advanced Analytics and Data Science funded by Ernesto.Net(under the Algorithms for Good Grant).
文摘Diabetes mellitus is a metabolic disease that is ranked among the top 10 causes of death by the world health organization.During the last few years,an alarming increase is observed worldwide with a 70%rise in the disease since 2000 and an 80%rise in male deaths.If untreated,it results in complications of many vital organs of the human body which may lead to fatality.Early detection of diabetes is a task of significant importance to start timely treatment.This study introduces a methodology for the classification of diabetic and normal people using an ensemble machine learning model and feature fusion of Chi-square and principal component analysis.An ensemble model,logistic tree classifier(LTC),is proposed which incorporates logistic regression and extra tree classifier through a soft voting mechanism.Experiments are also performed using several well-known machine learning algorithms to analyze their performance including logistic regression,extra tree classifier,AdaBoost,Gaussian naive Bayes,decision tree,random forest,and k nearest neighbor.In addition,several experiments are carried out using principal component analysis(PCA)and Chi-square(Chi-2)fea-tures to analyze the influence of feature selection on the performance of machine learning classifiers.Results indicate that Chi-2 features show high performance than both PCA features and original features.However,the highest accuracy is obtained when the proposed ensemble model LTC is used with the proposed fea-ture fusion framework-work which achieves a 0.85 accuracy score which is the highest of the available approaches for diabetes prediction.In addition,the statis-tical T-test proves the statistical significance of the proposed approach over other approaches.