Association of preschool children behavior and emotional problems with the parenting behavior of both parents

BACKGROUND Parental behaviors are key in shaping children’s psychological and behavioral development,crucial for early identification and prevention of mental health issues,reducing psychological trauma in childhood.AIM To investigate the relationship between parenting behaviors and behavioral and emotional issues in preschool children.METHODS From October 2017 to May 2018,7 kindergartens in Ma’anshan City were selected to conduct a parent self-filled questionnaire-Health Development Survey of Preschool Children.Children’s Strength and Difficulties Questionnaire(Parent Version)was applied to measures the children’s behavioral and emotional performance.Parenting behavior was evaluated using the Parental Behavior Inventory.Binomial logistic regression model was used to analyze the association between the detection rate of preschool children’s behavior and emotional problems and their parenting behaviors.RESULTS High level of parental support/participation was negatively correlated with conduct problems,abnormal hyperactivity,abnormal total difficulty scores and abnormal prosocial behavior problems.High level of maternal support/participation was negatively correlated with abnormal emotional symptoms and abnormal peer interaction in children.High level of parental hostility/coercion was positively correlated with abnormal emotional symptoms,abnormal conduct problems,abnormal hyperactivity,abnormal peer interaction,and abnormal total difficulty scores in children(all P<0.05).Moreover,paternal parenting behaviors had similarly effects on behavior and emotional problems of preschool children compared with maternal parenting behaviors(all P>0.05),after calculating ratio of odds ratio values.CONCLUSION Our study found that parenting behaviors are associated with behavioral and emotional issues in preschool children.Overall,the more supportive or involved the parents are,the fewer behavioral and emotional problems the children experience;conversely,the more hostile or controlling the parents are,the more behavioral and emotional problems the children face.Moreover,the impact of fathers’parenting behaviors on preschool children’s behavior and emotions is no less significant than that of mothers’parenting behaviors.

Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of preschool children with congenital ectopia lentis(CEL).METHODS:A prospective self-controlled study was conducted in Zhongshan Ophthalmic Center.Children aged from 5 to 7y whom were diagnosed with CEL and underwent phacoemulsification with scleral-fixated posterior chamber intraocular lens implantation and their parents were enrolled in this study.All of them completed the child and proxy(parental)PedsQL™4.0 before and after the surgery.Their preoperative scores were compared to their postoperative ones.Subgroup analyses were performed based on gender and preoperative bilateral presenting visual acuity of the children.RESULTS:Thirty-two children with CEL successfully underwent surgery without any complications,among whom 8 had monocular surgery and 24 had binocular surgery.Preoperative and postoperative questionnaires were completed by 32 child-parent pairs.Surgical intervention could significantly improve the vision of affected children(P<0.001).The medians of physical,psychosocial and total health scores self-reported by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)preoperatively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)postoperatively.The preoperative scores of the affected children were significantly lower in all scales than age-matched healthy children(P<0.001).All the postoperative scores were significantly higher than the preoperative scores in affected children and their parents(P<0.001).In the physical functioning evaluation,the preoperative score reported by parents of girls was higher than parents of boys(P=0.041),and the postoperative score of girls was higher than that of boys(P=0.036).CONCLUSION:CEL is associated with significantly worse quality of life in preschool children.Surgical intervention can significantly improve the HRQoL in affected children from both personal and family perspective.

Research on the intelligent internet nursing model based on the child respiratory and asthma control test scale for asthma management of preschool children

BACKGROUND Childhood asthma is a common respiratory ailment that significantly affects preschool children.Effective asthma management in this population is particularly challenging due to limited communication skills in children and the necessity for consistent involvement of a caregiver.With the rise of digital healthcare and the need for innovative interventions,Internet-based models can potentially offer relatively more efficient and patient-tailored care,especially in children.AIM To explore the impact of an intelligent Internet care model based on the child respiratory and asthma control test(TRACK)on asthma management in preschool children.METHODS The study group comprised preschoolers,aged 5 years or younger,that visited the hospital's pediatric outpatient and emergency departments between January 2021 and January 2022.Total of 200 children were evenly and randomly divided into the observation and control groups.The control group received standard treatment in accordance with the 2016 Guidelines for Pediatric Bronchial Asthma and the Global Initiative on Asthma.In addition to above treatment,the observation group was introduced to an intelligent internet nursing model,emphasizing the TRACK scale.Key measures monitored over a six-month period included the frequency of asthma attack,emergency visits,pulmonary function parameters(FEV1,FEV1/FVC,and PEF),monthly TRACK scores,and the SF-12 quality of life assessment.Post-intervention asthma control rates were assessed at six-month follow-up.RESULTS The observation group had fewer asthma attacks and emergency room visits than the control group(P<0.05).After six months of treatment,the children in both groups had higher FEV1,FEV1/FVC,and PEF(P<0.05).Statistically significant differences were observed between the two groups(P<0.05).For six months,children in the observation group had a higher monthly TRACK score than those in the control group(P<0.05).The PCS and MCSSF-12 quality of life scores were relatively higher than those before the nursing period(P<0.05).Furthermore,the groups showed statistically significant differences(P<0.05).The asthma control rate was higher in the observation group than in the control group(P<0.05).CONCLUSION TRACK based Intelligent Internet nursing model may reduce asthma attacks and emergency visits in asthmatic children,improve lung function,quality of life,and the TRACK score and asthma control rate.The effect of nursing was significant,allowing for development of an asthma management model.

The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children

Post-exposure prophylaxis(PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children(aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.

Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age

AIM: To explore the distribution pattern of macular choroidal thickness(ChT) and its association with age as well as refractive status in Chinese preschoolers.METHODS: School-based, cross-sectional study. A total of 550 healthy preschool children aged 3 to 6 years old from 6 kindergartens were enrolled. Comprehensive ocular examinations, including measurement of visual acuity, axial length, intraocular pressure and slit-lamp examination before cycloplegia, as well as refraction measurement and sweptsource optical coherence tomography(SS-OCT) examination after cycloplegia, were performed. The macular ChT in each sector of the ETDRS grid was measured by the builtin software of SS-OCT.RESULTS: The mean central ChT of the participants was 312±59 μm. The mean axial length and spherical equivalent refraction were 22.36±0.72 mm and 1.51±0.83 D, respectively. Axial length increased with age(P<0.001), while the spherical equivalent refraction was similar among different age groups. Similarly, no significant difference was observed in ChT in all sectors among different age groups(all P>0.05). The central ChT of 3-4, 5 and 6 years old children was 314±59 μm, 312±60 μm and 312±59 μm, respectively(P=0.920). No difference was observed in ChT in most of the sectors between genders. No statistical significant difference was observed among different refractive groups(all P>0.05), though the ChT of each sector seemed to be smaller in myopic children. Axial length and weight were the independent factors of central Ch T. Children with longer axial length(β=-21.184, P<0.001) and smaller weight(β=1.502, P=0.041) tended to have thinner choroid.CONCLUSION: In preschool children, the ChT remains relatively stable with age, while a negative association between ChT and axial length existed. This will be helpful to elucidate the characteristics of ChT during the early refractive development.

Hair Mercury Levels and Their Relationship with Seafood Consumption among Preschool Children in Shanghai

Mercury is a global pollutant. Children are vulnerable to environmental toxicants. Seafood consumption is a major source of methylmercury exposure. In order to ascertain children's mercury exposure levels and study their relationship with seafood consumption, we conducted a cross-sectional study among preschool children in Shanghai. According to our data, the geometric mean of the mercury levels in children's hair was 191.9(95% CI: 181.8, 202.4) μg/kg. These results indicate that high income may be a predictor of elevated mercury levels in children's hair. Intake of marine fish, especially tuna and pomfret, was documented in our study and found to increase the risk of high mercury levels. Frequency of fish consumption was positively related with hair mercury levels. Our study is the first to provide baseline data for hair mercury concentration among preschool children in Shanghai.

Effect of interesting games on relief of preoperative anxiety in preschool children

Purpose:To evaluate the effect of interesting games on reducing preoperative anxiety and improving compliance with anaesthesia in children.Methods:Ninety preschool-aged children undergoing elective surgery were randomly assigned to two groups.The children in the control group were admitted to a general preoperative room with one parent for 15e20 min,and were then taken into the anaesthesia room.During anaesthetic induction,the nurse attracted the children’s attention using an interesting game with encouragement and attention diversion.The children’s anxiety was assessed using the Modified Yale Preoperative Anxiety Scale(mYPAS)when they entered the operating room,while they were waiting to undergo s0urgery,and during anaesthetic induction.Moreover,the children’s compliance with anaesthetic induction was assessed using the Induction Compliance Checklist(ICC).Results:No statistically significant differences in the mYPAS scores were observed between the two groups upon entering the operating room(p>0.05).The mYPAS scores were significantly lower in the experimental group than in the control group while waiting for surgery and during anaesthetic induction(p<0.05),while there were no significant differences in the mYPAS scores upon entering the operating room.The children’s compliance with anaesthetic induction was significantly higher in the experimental group than in the control group(p<0.05).Conclusion:Engagement in an interesting game can reduce preschool-aged children’s preoperative anxiety and improve their compliance with anaesthetic induction.

How parents' education and working status affect the nutrition and immunization status of preschool children in India

Objective:The aim of the paper is to see how educational and working status of the parents affect the nutritional and immunization status of preschool children in India.Methods:We have used data of more than 24 000 preschool children spread over different states in India.The data were collected by National Family Health Survey(NFHS-2) in 1998-99.For assessing the nutritional status,only the Z-scores of weight-forheight (WHZ) have been computed and for immunization status,it has been seen whether BCG,DPT3,Polio3 and measles have been administered.Children who fall below -2SD(-3SD) from median are considered to be moderately(severely) malnourished.Results:According to the NFHS-2 data,70%of children are vaccinated by BCG,50%receive the full course of DPT,54%get all the three dozes of polio and only 42%are protected from measles by vaccination in India.The percentages of moderately and severely wasted children in India are 12.1 and 2.8,respectively.There is a marked regional variation of these percentages.Bivariate and multivariate analysis clearly points to the need of educational status of mothers rather than fathers for proper nutritional and immunization status of preschool children.Parents’occupation and working status also have some effect,but not so pronounced as parents’education.Conclusion:The Indian preschool children need particular attention for high risk of wasting and low immunization.The prevalence of malnutrition can be arrested more by improving the mother’s education level rather than their fathers and by raising the standard of living of their house-holds.

Behavioral Intervention Reduces Unhealthy Eating Behaviors in Preschool Children via a Behavior Card Approach

Many eating behaviors form in childhood,and some unhealthy behaviors may persist into adulthood and have potential impacts on people's health.This study evaluated the effectiveness of behavioral intervention in reducing consumption of Western fast food,sweetened beverages,fried food in preschool children,and changing parents' rewarding behaviors that encourage the consumption of the unhealthy foods.The research was a cluster randomized trial of seven kindergartens,involving 1138 children aged 3–6 years and their parents in Beijing,China.Parents and children allocated to the intervention group received two lectures and printed resources,including behavior cards,educational sheets.Children's behavior cards,applied with behavior-changing techniques,were used to intervene,and monitor behavior changes over time.Children in the control group just followed their usual health education curriculum in kindergartens.Intervention effects on food consumption behaviors were assessed by examining pre-and post-questionnaires.Of the 1138 children screened at baseline,880(77.3%) were measured at the end of the intervention period.The intervention lasted from March to June in 2010.The results showed that consumption of Western fast food,sweetened beverages,and fried food was decreased among the intervention group(P<0.001).Proportions of parents using Western fast food as rewards for their children were decreased(P=0.002).From March to June 2010,the frequency of each target behavior in children tended to decrease over the intervention period(P<0.001).Most parents favored regularly-delivered behavior cards or materials for behavioral intervention.In conclusion,the behavioral intervention encourages the healthier eating behaviors of children and reduces the parents' practice of using unhealthy foods as reward.

Preventable head and facial injuries by providing free bicycle helmets and education to preschool children in a head start program

The objectives of the study were to determine helmet use rates, incidence rates (IRs) of head and facial injuries for population attributable fraction (PAF) estimation, and to elucidate the magnitude of and changes in PAFs as the result of helmet use changes among preschool children. A study consisting of cross-sectional (survey) and longitudinal (follow-up) component was designed by including a randomly selected group of participants (n = 322) from 10 Head Start sites provided with free bicycle helmets along with a subgroup of prior helmet owners (n = 68) from the other random group (n = 285). All participants received bicycle helmet education. Helmet use surveys were conducted in May (1st Survey) and November 2008 (2nd Survey). The helmet owners were followed up to determine IRs, and incidence rate ratios (IRRs) for head and facial injuries. PAFs were computed using IRs as well as helmet use rates and IRRs. Helmet use rates increased significantly from the 1st to the 2nd Survey. The mean follow-up person-time was 5 months. The IRs for head, face (all portions), and face (upper/mid portions) injuries were higher in non-helmeted than helmeted riders. By using IRs, PAFs for the 3 injuries among the riders in both groups of helmet owners were 77%, 22%, and 32% respectively. The PAFs for each of the above injuries decreased by about 10% as helmet use rates increased. The magnitude of and changes in preventable head and facial injuries following free bicycle helmet distribution and education among helmeted riders was elucidated in this Head Start preschool children population.

Central body fat distribution indices in Thai preschool children

Background: Central obesity is associated with adverse health outcomes. This study aimed to determine the characteristics of central body fat distribution in Thai preschool children and to examine factors that could influence on body fat distribution of children. Methods: The total 811, 5 - 6 years old children were randomly sampled from 9 primary schools in Saraburi province. Body weight and height were measured in each child. Waist circumference (WC) was measured at the umbilicus level and hip circum-ference (HC) at the level yielding maximum circumference over buttock. Subcutaneous skinfold was measured on biceps, triceps, subscapular, suprailiac and abdominal regions. Total body fat (TBF) was measured with bioelectrical impedance analyzer. Results: Mean values of WC, waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) of boys were not different from those of girls. Even though trunk skinfolds of both genders were similar, girls tended to have slightly greater biceps, triceps and subscapular skinfolds than boys. Strongly positive correlation was found between WC, WHtR, trunk skinfold and child’s BMI (p = 0.01) as well as between WC, WHtR, trunk skinfold and child’s TBF (p = 0.01). Multiple regression analysis demonstrated, in both genders, that BMI, age and TBF were strongly associated with WC (Adjusted R2 0.92 - 0.93) and WHtR (Adjusted R2 0.90 - 0.92) and that BMI and TBF were strongly associated with trunk skinfold (Adjusted R2 0.88 - 0.89). The association between WHR and TBF for boys and between WHR and BMI for girls were found to be weak in this study. Conclusion: No gender difference in body fat distribution indices was found in Thai preschool children. Change in central body fat distribution of children could be strongly influenced by their changes in age, BMI and TBF.

Resilience Training of Preschool Children Based on Traditional Folk Games

Traditional folk games inherit the history,culture and identity of a country and nation,and they have even more important meanings for China,which has a long history and many ethnic groups.However,with the rapid globalization of modem technology and economy,many Chinese traditional folk games are facing the crisis of disappearing.This article discusses how to develop and utilize the new functions of traditional folk games.That is to use them to train the resilience of preschool children,thus to initiate a new understanding of traditional folk games by teachers and parents.The article firstly discusses the importance of cultivating preschool children's resilience,then analyzes the role of games in cultivating preschool children's resilience,studies the traditional folk game classification method for preschool children's resilience,and gives the development orientation traditional folk game teaching strategies and steps for the cultivation of resilience.This research not only inherits Chinese traditional culture in preschool education,but also trains preschool children's resilience and strengthens their minds.It has important practical significance and reference value for the current training and education of preschool children in China and East Asia.

Habitual physical activity levels and sedentary time of children in different childcare arrangements from a nationally representative sample of Canadian preschoolers

Background:Children spend substantial time in childcare,and the reasons parents choose a particular childcare type may differ by family.However,little is known about how childcare type influences habitual(full day)activity levels among children.Therefore,exploring patterns between childcare type and habitual physical activity(PA)(i.e.,light,moderate-to-vigorous PA(MVPA),and total PA)and sedentary time(ST)in young Canadian children is needed.Methods:A nationally representative sample of preschoolers from Cycles 3 and 4 of the Canadian Health Measures Survey was used in this cross-sectional study.Childcare type(e.g.,center-based childcare,home-based childcare,home with parent,kindergarten)was reported by parents.Preschoolers wore an Actical accelerometer for 7 days.Device and population-spcific cut-points were applied to delineate PA intensities and ST.Population means and sample totals were calculated to examine average daily and hourly rates of activity.Results:Preschoolers’rates of MVPA and total PA from the 4 childcare arrangements ranged from 65.99 min/day to 74.62 min/day(5.48-6.18 min/h)and 274.20 min/day to 281.66 min/day (22.69-23.21 min/h),respectively,while ST ranged from 443.13 min/day to 460.57 min/day(36.80-37.31 min/h).No significant differences were observed in daily or hourly rates of activity.Conclusion:This study provides a snapshot of the levels of PA and ST among preschoolers in various childcare settings at a national level,with no differences observed in habitual activity levels based on childcare enrollment.Additional research is needed to clarify the relationship between young children’s PA and childcare type,with consideration given to the quality of the childcare settings.

Effects of Yogurt Supplementation on the Growth of Preschool Children in Beijing Suburbs

Objective To investigate the effect of yogurt supplementation on the growth of preschool children in Beijing suburbs. Methods Four hundred and two preschool children (217 males, 185 females), aged 3-5 years, whose height for age and/or weight for age were less than the reference level, were selected as subjects from 7 kindergartens in Beijing Fangshan District. The subjects were divided randomly into control group (CG, 201) and yogurt supplemented group (YG, 201). Each subject in YG was given one serving of yogurt (125 g) for 5 days a week from March to December in 2001, while nothing additional was provided to CG. All subjects kept their usual diet during the study. Anthropometry (body height and weight and upper-arm circumference) and the bone mineral density (BMD) of forearm were measured every 3 months. Disease status and dietary intake were also recorded and assessed. Results The intake of calcium, zinc, and vitamin B2 in YG was significantly higher than that in CG. The incidence and duration of upper-respiratory infection and diarrhea of children in YG were significantly less than those in CG. The height gain of children in YG was significantly higher than that in CG after yogurt was supplemented for 3, 6, and 9 months (P<0.05) (1.90±0.49 cm vs 1.77±0.54 cm, 3.83±0.57cm vs 3.64±0.66 cm and 5.43±0.69 cm vs 5.24±0.76 cm, respectively). The weight gain of children in YG was significantly higher than that in CG after yogurt was supplemented for 3, 6, and 9 months (P<0.05) (0.70±0.43 kg vs 0.49±0.35 kg, 0.98±0.62 kg vs 0.80±0.60 kg and 1.42±0.76 kg vs 1.20±0.67 kg, respectively). The BMD of children in YG was significantly higher than that in CG after yogurt was supplemented for 9 months (P<0.05) (0.415±0.058 g/cm2 vs 0.400±0.065 g/cm2). Conclusion Yogurt is beneficial to the improvement of calcium, zinc, and vitamin B2 intake, the decreasing of the incidence and duration of upper-respiratory infection and diarrhea, and the promotion of the health and the growth and development of preschool children.

Effect of Micronutrient Supplementation on the Growth of Preschool Children in China

Objective To study the relationship between micronutrient supplementation and children growth. Methods A double-blind, placebo-controlled trial was conducted in 156 growth retarded preschool children. They were randomly assigned to five groups: supplemental control (S-control, n=28), zinc supplementation(+Zn, 3.5mg Zn/day, n=34), zinc and calcium supplementation (+ZnCa, 3.5mg Zn+250mg Ca/day, n=37), zinc and calcium and vitamin A supplementation (+ZnCaVA, 3.5mgZn +250mgCa+200gVA/day, n=28), Calcium and vitamin A supplementation (+CaVA, 250mgCa + 200gVA/day, n=29). Another 34 children with normal height were selected as normal control (N-control). Supplementation continued for twelve months. Results The height gain in +Zn group (7.84cm per year) and +ZnCa group (7.70 cm per year) was significantly higher than that in S-control group (6.74 cm per year, P<0.05); The weight gain in +ZnCaVA group (2.55kg per year) and +CaVA group (2.57 kg per year) was also significantly higher than that in S-control group (2.19kg per year, P<0.05); The average days of illness in each supplementation group were lower than that in S-control (13 days per year compared with 23 days per year). No significant difference was observed on bone age. Conclusion Zinc and Zinc+Calcium supplementation can improve the height gain, and vitamin A can improve weight gain in growth retarded preschool children, but do not affect the maturity of bone. Micronutrient supplementation can lower the morbidity of these children.

Childlife干预在儿童隐匿阴茎围术期护理中的应用

分析儿童隐匿阴茎围术期护理中采取Child life干预的效果。方法 选取2022年1月-2023年2月纳入的隐匿性阴茎儿童60例作为观察对象,经随机抽签法分组,对照组、观察组各有30例。两组分别采取常规护理、Child life干预,观察围术期患儿的心理状态,并评估患儿术后疼痛评分及护理满意度、护理依从性。结果 护理前,组间SAS及SDS评分相比,p>0.05;护理后,观察组SAS及SDS评分比对照组低,p<0.05;观察组Wong-Baker分值低于对照组,p<0.05;观察组依从性及护理满意度高于对照组,p<0.05。结论 在隐匿性阴茎儿童围术期护理中采取Child life护理模式可提升患儿的依从性、护理满意度,并改善患儿心理状态,减轻其疼痛感。

Relationship between Authoritative Parenting Style and Preschool Children’s Emotion Regulation:A Moderated Mediation Model

An authoritative parenting style has been shown to promote children’s emotion regulation in European-American family studies.However,little is known about how sleep problems and the child’s sibling status in Chinese families affect this relationship.Based on family system theory,this study attempts to better understand the relationship between authoritative parenting style and emotion regulation.Mothers of preschool children in Chinese kindergartens completed questionnaires about their children’s sleep habits,their authoritative parenting styles,and children’s emotion regulation.A total of 531 children participated in this study.Results showed that authoritative parenting was positively associated with emotional regulation.Sleep problems mediated the effects of authoritative parenting style on emotion regulation.The child’s sibling status moderated the mediating effects of sleep problems in authoritative parenting and emotion regulation relationships.Specifically,the relationship between the authoritative parenting style and sleep problems was significant for only children,while birth order had no significant influence on the authoritative parenting style and sleep problems in two-child families.These findings suggest that a lowauthoritative parenting style predicts low emotion regulation through sleep problems,and this depends on the child’s sibling status,indicating that children without siblings may impair emotion regulation due to increased sleep problems.

Exploration of Child-friendly Urban Park Design Strategies Based on Child Behavioral Psychology

By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities.

不同Child-Pugh分级肝硬化患者血清TSP-1、球蛋白/胆碱酯酶的表达水平差异及其疾病预后危险因素分析

目的分析不同Child-Pugh分级肝硬化患者血清凝血酶敏感蛋白-1(TSP-1)、球蛋白/胆碱酯酶的表达水平差异及其疾病预后危险因素。方法回顾性选取2020年2月至2023年2月新疆医科大学第一附属医院收治的70例肝硬化患者作为主要研究对象,根据Child-Pugh分级将其分为Child-Pugh A级组(n=20),Child-Pugh B级组(n=34),Child-Pugh C级组(n=16),另选取同期在本院进行体检的50名健康人群作为对照组。采用酶联免疫吸附试验法检测4组及肝硬化不同预后患者的血清TSP-1、球蛋白、胆碱酯酶、球蛋白/胆碱酯酶表达水平;采用双变量Spearman相关性检验血清TSP-1、球蛋白、胆碱酯酶、球蛋白/胆碱酯酶与肝硬化患者Child-Pugh分级和预后的相关性;建立多因素Logistic模型分析影响肝硬化患者预后的独立危险因素,并绘制受试者工作特征(ROC)曲线分析血清TSP-1、球蛋白/胆碱酯酶对肝硬化预后的预测价值。结果与对照组比较,Child-Pugh A级组、Child-Pugh B级组、Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低;与Child-Pugh A级组患者比较,Child-Pugh B级组、Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低;与Child-Pugh B级组比较,Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低,差异均有统计学意义(P<0.05)。与预后良好组比较,预后不良组血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低,差异均有统计学意义(P<0.05)。肝硬化患者血清TSP-1、球蛋白/胆碱酯酶与Child-Pugh分级和预后均呈正相关(P<0.05)。多因素Logistic分析结果显示,Child-Pugh分级、TSP-1、球蛋白/胆碱酯酶均是影响肝硬化患者预后的独立危险因素(P<0.05)。血清TSP-1、球蛋白/胆碱酯酶与TSP-1+球蛋白/胆碱酯酶预测肝硬化患者预后的曲线下面积值分别为0.814、0.824、0.885。结论血清TSP-1、球蛋白/胆碱酯酶异常表达与肝硬化Child-Pugh分级及其预后均存在一定关联,可作为肝硬化患者的Child-Pugh分级及预后的辅助预测指标。