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ASARA,a prediction model based on Child-Pugh class in hepatocellular carcinoma patients undergoing transarterial chemoembolization 被引量:1
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作者 Ke-Feng Jia Hao Wang +5 位作者 Chang-Lu Yu Wei-Li Yin Xiao-Dong Zhang Fang Wang Cheng Sun Wen Shen 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2023年第5期490-497,共8页
Background:Due to the high heterogeneity among hepatocellular carcinoma(HCC)patients receiving transarterial chemoembolization(TACE),the prognosis of patients varies significantly.The decisionmaking on the initiation ... Background:Due to the high heterogeneity among hepatocellular carcinoma(HCC)patients receiving transarterial chemoembolization(TACE),the prognosis of patients varies significantly.The decisionmaking on the initiation and/or repetition of TACE under different liver functions is a matter of concern in clinical practice.Thus,we aimed to develop a prediction model for TACE candidates using risk stratification based on varied liver function.Methods:A total of 222 unresectable HCC patients who underwent TACE as their only treatment were included in this study.Cox proportional hazards regression was performed to select the independent risk factors and establish a predictive model for the overall survival(OS).The model was validated in patients with different Child-Pugh class and compared to previous TACE scoring systems.Results:The five independent risk factors,including alpha-fetoprotein(AFP)level,maximal tumor size,the increase of albumin-bilirubin(ALBI)grade score,tumor response,and the increase of aspartate aminotransferase(AST),were used to build a prognostic model(ASARA).In the training and validation cohorts,the OS of patients with ASARA score≤2 was significantly higher than that of patients with ASARA score>2(P<0.001,P=0.006,respectively).The ASARA model and its modified version“AS(ARA)”can effectively distinguish the OS(P<0.001,P=0.004)between patients with Child-Pugh class A and B,and the C-index was 0.687 and 0.706,respectively.For repeated TACE,the ASARA model was superior to Assessment for Retreatment with TACE(ART)and ALBI grade,maximal tumor size,AFP,and tumor response(ASAR)among Child-Pugh class A patients.For the first TACE,the performance of AS(ARA)was better than that of modified hepatoma arterial-embolization prognostic(mHAP),mHAP3,and ASA(R)models among Child-Pugh class B patients.Conclusions:The ASARA scoring system is valuable in the decision-making of TACE repetition for HCC patients,especially Child-Pugh class A patients.The modified AS(ARA)can be used to screen the ideal candidate for TACE initiation in Child-Pugh class B patients with poor liver function. 展开更多
关键词 Hepatocellular carcinoma Transarterial chemoembolization Scoring system Prognostic model child-pugh class Survival prediction
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Child-Pugh C级患者伏立康唑血药浓度监测结果分析 被引量:4
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作者 赵庆国 任秋霞 +1 位作者 杜春辉 王艳红 《中国药物应用与监测》 CAS 2019年第1期11-14,共4页
目的:根据伏立康唑血药浓度监测结果探讨严重肝损害患者(Child-Pugh C级)伏立康唑的用药情况及用药方案调整经验。方法:应用统计学方法回顾性分析肝功能不全患者应用伏立康唑治疗真菌感染过程中在体质量、年龄、给药方式、维持剂量及合... 目的:根据伏立康唑血药浓度监测结果探讨严重肝损害患者(Child-Pugh C级)伏立康唑的用药情况及用药方案调整经验。方法:应用统计学方法回顾性分析肝功能不全患者应用伏立康唑治疗真菌感染过程中在体质量、年龄、给药方式、维持剂量及合并用药等方面的统计学差异。结果:应用维持剂量为200 mg,q 12 h的患者伏立康唑血药浓度高于推荐浓度上限的占比50%,且药物蓄积严重;维持剂量100 mg,q 12 h的患者伏立康唑血药浓度在推荐浓度范围内的占比62.20%,具有更高的安全性。伏立康唑血药浓度与患者年龄、性别,给药方式无明显相关性,但患者体质量会影响伏立康唑血药浓度结果,随体质量增加伏立康唑血药浓度呈降低趋势。同时,应用质子泵抑制剂也会对患者伏立康唑血药浓度结果产生影响,应密切监测及时调整给药方案。结论:Child-Pugh C级患者按常规剂量应用伏立康唑很容易导致其在体内蓄积,应使用更低的维持剂量。同时伏立康唑给药剂量和血药浓度关系十分不稳定,应密切监测血药浓度及时调整给药方案,以确保临床用药的安全性和有效性。 展开更多
关键词 伏立康唑 血药浓度监测 child-pugh c
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Child-Pugh C级伴肝炎肝硬化的肝癌患者行肝癌切除术分析
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作者 姚卫洲 《中国医药导报》 CAS 2011年第18期187-188,共2页
目的:探讨Child-Pugh C级伴有肝炎肝硬化的肝癌患者行肝癌切除术增加可行性的方法,减少手术死亡率。方法:对我院2005年6月~2010年6月收治的33例行肝癌切除术的Child-Pugh C级伴有肝炎肝硬化的肝癌患者进行回顾性分析。结果:手术失血... 目的:探讨Child-Pugh C级伴有肝炎肝硬化的肝癌患者行肝癌切除术增加可行性的方法,减少手术死亡率。方法:对我院2005年6月~2010年6月收治的33例行肝癌切除术的Child-Pugh C级伴有肝炎肝硬化的肝癌患者进行回顾性分析。结果:手术失血量为300~3 500 ml,平均(1 407.3±122.0)ml;手术时间2.3~9.0 h,平均(5.3±1.2)h。33例肝癌患者死亡5例,余28例术后出现腹水、胆漏、感染、急性肾功能衰竭等各种并发症62例次,经对症治疗均痊愈出院。结论:Child-Pugh C级伴肝炎肝硬化的肝癌患者行肝癌切除术难度大、风险大,但只要选择合理术式,术中控制出血量,加强围术期治疗,手术是相对可行和安全的。 展开更多
关键词 child-pughc 肝癌切除术 肝炎肝硬化
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新城疫病毒ClassⅠ强毒株磷蛋白在细胞中的表达与定位
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作者 程靖华 孙英杰 陈鸿军 《中国畜牧兽医文摘》 2013年第9期166-166,共1页
根据Class Ⅰ新城疫病毒分离株9a5b编码序列设计特异性引物扩增P蛋白基因,原核表达后利用纯化的蛋白免疫BALB/c小鼠制备单克隆抗体,经二次亚克隆后筛选N4株针对P蛋白的单克隆抗体,利用所得单抗进行P蛋白在细胞内定位分析,NDV9a5b株... 根据Class Ⅰ新城疫病毒分离株9a5b编码序列设计特异性引物扩增P蛋白基因,原核表达后利用纯化的蛋白免疫BALB/c小鼠制备单克隆抗体,经二次亚克隆后筛选N4株针对P蛋白的单克隆抗体,利用所得单抗进行P蛋白在细胞内定位分析,NDV9a5b株按5M.0.I感染量接种DF1单层细胞. 展开更多
关键词 细胞内定位 class 新城疫病毒 磷蛋白 强毒株 BALB c小鼠 单克隆抗体 特异性引物
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基于C-STEAM理念下的《莆仙戏鼓课间操》实践探究
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作者 陈育燕 王若思 胡慧 《龙岩学院学报》 2024年第5期117-122,共6页
推动中华优秀传统文化进中小学课堂是落实党和国家立德树人根本任务的重要途径。C-STEAM教育旨在深刻挖掘文化内涵,创建项目式教学模式,在中小学校中弘扬与传承中华民族优秀的文化遗产,全面培养学生综合能力和必备技能。基于C-STEAM发... 推动中华优秀传统文化进中小学课堂是落实党和国家立德树人根本任务的重要途径。C-STEAM教育旨在深刻挖掘文化内涵,创建项目式教学模式,在中小学校中弘扬与传承中华民族优秀的文化遗产,全面培养学生综合能力和必备技能。基于C-STEAM发展过程及特征。以《莆仙戏鼓课间操》为例,探究面向文化传承的学科融合教育的育人价值与路径,构建系统合理的项目式教学模式,以期在中小学生中建立“更基础、更广泛、更深厚”的文化自信。 展开更多
关键词 文化传承 c-STEAM教育 莆仙戏 课间操
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参桃软肝方治疗Child-Pugh C级原发性肝癌的临床观察 被引量:5
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作者 李穗晖 周瑞生 +3 位作者 蔡玉荣 王雄文 贺凡 周岱翰 《广州中医药大学学报》 CAS 2018年第6期993-997,共5页
【目的】观察参桃软肝方治疗Child-Pugh C级(简称Child C级)原发性肝癌的有效性及安全性。【方法】将入组的60例Child C级原发性肝癌患者,按2∶1比例随机分为治疗组40例和对照组20例。对照组给予最佳支持治疗,治疗组给予最佳支持治疗+... 【目的】观察参桃软肝方治疗Child-Pugh C级(简称Child C级)原发性肝癌的有效性及安全性。【方法】将入组的60例Child C级原发性肝癌患者,按2∶1比例随机分为治疗组40例和对照组20例。对照组给予最佳支持治疗,治疗组给予最佳支持治疗+参桃软肝方口服治疗,21 d为1个周期,共观察2个周期。观察2组患者治疗前后中医肝癌相关症状评分、肝功能Child-Pugh评分、外周血肝纤维化指标[Ⅲ型原胶原(PC-Ⅲ)、层黏蛋白(LN)、透明质酸(HA)]的变化情况,评价2组患者的瘤体稳定性疗效和安全性。【结果】(1)治疗后,治疗组的肝癌相关症状积分、肝功能Child-Pugh评分和分级情况均较治疗前明显改善(P<0.05),而对照组改善均不明显(P>0.05),组间比较,治疗组在改善肝癌相关症状积分、肝功能Child-Pugh评分和分级情况方面均优于对照组(P<0.05)。(2)治疗后,治疗组外周血HA水平有所改善,但差异无统计学意义(P>0.05),LN水平有明显改善(P<0.05),而对照组各项肝纤维化指标均无明显改善(P>0.05),组间比较,治疗组在改善外周血HA和LN水平方面优于对照组(P<0.05)。(3)治疗后,治疗组的瘤体稳定率虽较对照组略高,但差异无统计学意义(P>0.05)。(4)治疗期间,治疗组有9例(22.5%)出现I~Ⅱ级不良反应,无Ⅲ~Ⅳ级毒性反应,对照组有5例(25.0%)出现I~Ⅱ级不良反应,无Ⅲ~Ⅳ级毒性反应,2组不良反应比较,差异无统计学意义(P>0.05)。【结论】参桃软肝方治疗Child C级原发性肝癌具有较好的瘤体稳定性疗效,能保护患者的肝功能,改善患者的肝癌相关症状,且不良反应轻微,可作为Child C级肝癌患者中医药治疗的选择之一。 展开更多
关键词 参桃软肝方 child-pugh c 原发性肝癌 有效性 安全性
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基于C-class和E-class的B-learning在高职英语教学中的应用研究 被引量:6
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作者 徐红 《职业时空》 2012年第4期76-77,80,共3页
B-learning是传统课堂教学C-class和网络平台学习E-class混合互补的教学模式,体现了《大学英语课程要求》提出的英语教学模式改革精神。结合山东外贸职业学院目前正在进行的高职英语B-learning改革尝试,讨论了高职英语B-learning模式下... B-learning是传统课堂教学C-class和网络平台学习E-class混合互补的教学模式,体现了《大学英语课程要求》提出的英语教学模式改革精神。结合山东外贸职业学院目前正在进行的高职英语B-learning改革尝试,讨论了高职英语B-learning模式下的教学设计及其效果。 展开更多
关键词 c-class E-class B-learning 英语应用能力
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Utilization of Class C Fly Ash As A Raw Material for Manufacturing of Refractory Materials 被引量:1
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作者 Lucie KERSNEROVA Karel LANG +1 位作者 Pavel KOVAR Frantisek SOUKAL 《China's Refractories》 CAS 2017年第4期24-30,共7页
There have been increasing efforts to utilize energy by-products (EBP) all over the world. In the Czech Re- public fly ash is usually used in ceramic technology, es- pecially in brick manufacturing and for ceramic t... There have been increasing efforts to utilize energy by-products (EBP) all over the world. In the Czech Re- public fly ash is usually used in ceramic technology, es- pecially in brick manufacturing and for ceramic tiles. The average production of EBP is about Ig million tons per year. The range of potential products, where EBP could be used, is very wide and energy by-products have become an important raw material source. In this paper the attention was focused on class C fly ash and its usage in field of refractory materials. Experimental works were carried out on mixtures with fly ash and clay. There were also tested batches for lightweight fireclay bricks. The maximal amount of CFA should be up to 50%. 展开更多
关键词 energy by-products class c fly ash re- fractory materials
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Comparative Analysis of Rigid PVC Foam Reinforced with Class C and Class F Fly Ash 被引量:1
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作者 Parisa Khoshnoud Subhashini Gunashekar +1 位作者 Murtatha M. Jamel Nidal Abu-Zahra 《Journal of Minerals and Materials Characterization and Engineering》 2014年第6期554-565,共12页
Fly ash particles are usually spherical and based on their chemical composition;they are categorized into two classes: C and F. This study compares the microstructural, mechanical and thermal properties of extruded ri... Fly ash particles are usually spherical and based on their chemical composition;they are categorized into two classes: C and F. This study compares the microstructural, mechanical and thermal properties of extruded rigid PVC foam composites reinforced with class C and class F fly ash. The mechanical properties: such as tensile and flexural strength of composites containing class C fly ash were superior to the composites containing class F fly ash particles. Composites containing 6 phr class C fly ash showed a 24% improvement in the tensile strength in comparison to a mere 0.5% increase in composites reinforced with class F fly ash. Similarly, the addition of 6 phr of class F fly ash to the PVC foam matrix resulted in a 5.74% decrease in the flexural strength, while incorporating the same amount of class C fly ash led to a 95% increase in flexural strength. The impact strength of the composites decreased as the amount of either type of fly ash increased in the composites indicating that fly ash particles improve the rigidity of the PVC foam composites. No significant changes were observed in the thermal properties of the composites containing either type of fly ash particles. However, the thermo-mechanical properties measured by DMA indicated a steep increase in the viscoelastic properties of composites reinforced with class C flyash. The microstructural properties studied by Scanning Electron Microscopy (SEM) confirmed that fly ash particles were mechanically interlocked in the PVC matrix with good interfacial interaction with the matrix. However, particle agglomeration and debonding was observed in composites reinforced with higher amounts of fly ash. 展开更多
关键词 RIGID PVc Foam class c FLY ASH class F FLY ASH THERMO-MEcHANIcAL Properties Morphology
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National Data of Class A, B, and C Communicable Diseases in September 2013 in China 被引量:2
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作者 Center for Public Health Surveillance and Information Service,China CDC 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第10期874-874,共1页
关键词 AHc National Data of class A and c communicable Diseases in September 2013 in china HPAI
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Utilization of Thermally Treated Flue Gas Desulfurization (FGD) Gypsum and Class-C Fly Ash (CFA) to Prepare CFA-Based Geopolymer 被引量:4
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作者 郭晓潞 施惠生 Warren A Dick 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第1期132-138,共7页
The feasibility of utilization of flue gas desulfurization (FGD) gypsum and Class-C fly ash (CFA) to prepare CFA-based geopolymer were studied. The results showed that geopolymer made from 90% CFA and 10% FGD gyps... The feasibility of utilization of flue gas desulfurization (FGD) gypsum and Class-C fly ash (CFA) to prepare CFA-based geopolymer were studied. The results showed that geopolymer made from 90% CFA and 10% FGD gypsum (FGDG) which was thermally treated at 800 ℃ for 1 h obtained the better compressive strength of 37.0 MPa. The micro characteristics and structures of the geopolymer samples of CFA and CFA-FGDG were tested by XRD, FT-IR, and SEM-EDXA after these samples cured at 75 ℃ for 8 h followed by 23 ℃ for 28 d. Both the geopolymer samples of CFA and CFA-FGDG have significant asymmetric stretching of A1-O/Si-O bonds and Si-O-Si / Si-O-A1 bending band. In geopolymer sample of CFA-FGDG, a small quantity of lathy products probably being the ettringite wrapped over the spherical fly ash particle, and the concentration of sulfur is much more than that in geopolymer sample of CFA. It is indicated that FGD gypsum may react during alkali-activated and geopolymeric process. 展开更多
关键词 flue gas desulphurization (FGD)gypsum class-c fly ash(cFA) GEOPOLYMER thermal treatment
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Comparative study on occurrence of class A and class Cβ-lactamase genes and their co-occurrence in Indian Enterobacteriaceae during years 2009 and 2010
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作者 Anuradha Singh Mohd Shahid +2 位作者 Farrukh Sobia Umesh Haris M Khan 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第10期764-768,共5页
Objective:To determine the occurrence of class A and class Cβ-Iactamase genes and their cooccurrence in Indian Enterobacteriaceae.Methods:52 third generation cephalosporin resistant isolates were phenotypically detec... Objective:To determine the occurrence of class A and class Cβ-Iactamase genes and their cooccurrence in Indian Enterobacteriaceae.Methods:52 third generation cephalosporin resistant isolates were phenotypically detected by combination disk method and screened by PCR to identify class A and class C typeβ-lactamase genes.Results:Of the 52 isolates,94.2%(49) were found harboring any of the bla<sub>?</sub>,bla<sub>CTX-M</sub>,bla<sub>SHV</sub> and bla<sub>TEM</sub> were present in 82.6%(43/52), 59.6%(31/52),and 42.3%(22/52) isolates,respectively.Of the 49 ESBL positive isolates 57.1% (28/49) showed co-occurrence of bla<sub>ampC</sub>with bla<sub>?</sub>.On the contrary,the collection from 2009 showed their co-occurrence in 81.4%isolates.Conclusions:The comparative study shows a downward trend for co-existence of bla<sub>?</sub> with bla<sub>ampC</sub> from 2009 to 2010.Further large scale studies are needed to address the co-occurrence of class A and class Cβ-lactamases in India and the resistance trend occurring over a period of time. 展开更多
关键词 class A ESBL class c ESBL cTX-M AMPc ENTEROBAcTERIAcEAE India
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血清APPL1、CTHRC1、胱抑素C水平联合检测诊断慢性HBV感染肝硬化患者Child-Pugh分级的价值 被引量:1
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作者 葛晓萍 张会芬 《中国民康医学》 2023年第21期100-103,共4页
目的:观察血清磷酸酪氨酸衔接蛋白1(APPL1)、胶原三股螺旋重复蛋白1(CTHRC1)、胱抑素C水平联合检测诊断慢性乙型肝炎病毒(HBV)感染肝硬化患者Child-Pugh分级的价值。方法:选取2021年1月至2023年1月该院收治的136例慢性HBV感染肝硬化患... 目的:观察血清磷酸酪氨酸衔接蛋白1(APPL1)、胶原三股螺旋重复蛋白1(CTHRC1)、胱抑素C水平联合检测诊断慢性乙型肝炎病毒(HBV)感染肝硬化患者Child-Pugh分级的价值。方法:选取2021年1月至2023年1月该院收治的136例慢性HBV感染肝硬化患者进行前瞻性研究,设为研究组。选取同期于该院体检的136名健康者为对照组。比较两组血清APPL1、CTHRC1、胱抑素C水平;比较不同Child-Pugh分级慢性HBV感染肝硬化患者入院时血清APPL1、CTHRC1、胱抑素C水平;采用Spearman相关性分析慢性HBV感染肝硬化患者入院时血清APPL1、CTHRC1、胱抑素C水平与Child-Pugh分级的相关性;采用受试者工作特征(ROC)曲线评估慢性HBV感染肝硬化患者入院时血清APPL1、CTHRC1、胱抑素C水平联合检测诊断Child-Pugh分级的价值。结果:入院时,研究组血清APPL1、CTHRC1、胱抑素C水平均高于对照组,差异有统计学意义(P<0.05);入院时,Child-Pugh分级为C级慢性HBV感染肝硬化患者血清APPL1、CTHRC1、胱抑素C水平均高于B级、A级者,且B级者高于A级者,差异均有统计学意义(P<0.05);Spearman相关性分析结果显示,慢性HBV感染肝硬化患者入院时血清APPL1、CTHRC1、胱抑素C水平与Child-Pugh分级均呈正相关(r>0,P<0.05);ROC曲线分析结果显示,慢性HBV感染肝硬化患者入院时血清APPL1、CTHRC1、胱抑素C水平联合检测诊断Child-Pugh分级为C级的AUC为0.931,具有较高诊断价值。结论:血清APPL1、CTHRC1、胱抑素C水平联合检测诊断慢性HBV感染肝硬化患者Child-Pugh分级的价值高于三者单项检测。 展开更多
关键词 乙型肝炎病毒 肝硬化 child-pugh分级 磷酸酪氨酸衔接蛋白1 胶原三股螺旋重复蛋白1 胱抑素c 相关性
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CC类趋化因子22、叉头框蛋白P1在急性髓系白血病外周血中的表达及对预后的预测价值
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作者 胡婕 刘瑞菡 +3 位作者 王高翔 熊婷 黄欣 程利民 《安徽医药》 CAS 2024年第2期371-375,共5页
目的探讨急性髓系白血病(AML)病人外周血中CC类趋化因子22(CCL22)、叉头框蛋白P1(FOXP1)表达水平及其预后预测价值。方法选择2018年5月至2019年5月在孝感市中心医院、华中科技大学医学院附属同济医院及咸宁市中心医院确诊的68例AML病人... 目的探讨急性髓系白血病(AML)病人外周血中CC类趋化因子22(CCL22)、叉头框蛋白P1(FOXP1)表达水平及其预后预测价值。方法选择2018年5月至2019年5月在孝感市中心医院、华中科技大学医学院附属同济医院及咸宁市中心医院确诊的68例AML病人设为观察组,另取同期健康体检者68例作为对照组,采用酶联免疫法测定外周血CCL22,FOXP1表达水平,分析其与临床特征的关系;采用Pearson法分析AML病人外周血中CCL22,FOXP1表达的相关性;采用Kaplan-Meier生存分析法分析CCL22,FOXP1表达与总体生存时间(OS)的关系;采用Cox比例风险回归模型分析病人预后死亡的影响因素。结果与对照组相比,观察组CCL22[(600.27±62.89)ng/L比(756.84±100.86)ng/L],FOXP1[(56.02±13.68)ng/L比(103.06±22.16)ng/L]表达均明显升高(t=10.86,14.90,均P<0.05);CCL22,FOXP1表达水平与AML病人年龄、性别、染色体预后、血红蛋白(HGB)、血小板计数(PLT)、FMS样酪氨酸激酶3-内部串联重复基因(FLT3-ITD)、核仁磷酸蛋白基因1(NPM1)突变无关(χ^(2)=0.06~2.95,均P>0.05),与脾肿大、白细胞计数(WBC)有关(χ^(2)=5.90~8.59,均P<0.05);Pearson法分析结果显示,AML病人外周血中CCL22与FOXP1表达呈正相关(r=0.27,P<0.05);Kaplan-Meier法分析结果显示,AML病人外周血CCL22,FOXP1高表达组3年生存率均低于低表达组(47.06%比70.59%,44.12%比73.53%)(χ^(2)=6.50,P<0.05);多因素logistic回归分析结果显示,CCL22,FOXP1是影响AML病人预后的独立危险因素(P<0.05)。结论CCL22,FOXP1在AML病人外周血中呈高表达,CCL22,FOXP1高表达组病人3年生存率均低于低表达组,二者有望成为AML病人预后评估的分子标志物。 展开更多
关键词 白血病 髓样 急性 cc类趋化因子22 叉头框蛋白P1 预后价值
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National Data of Class A,B,and C Communicable Diseases in October 2013 in China
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《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第11期944-944,共1页
关键词 National Data of class A B and c communicable Diseases in October 2013 in china
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The Comribution of the New Class C From Brazil to Deindustrialization and Increased Imports
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作者 Edmir Kuazaqui Talent Academy +1 位作者 Sao Paulo Brazil 《Journal of Modern Accounting and Auditing》 2012年第12期1879-1887,共9页
This research analyzes the growth impacts promoted by C class in the process of the freezing of the Brazilian industry and increased imports. This emerging market, called class C, which is incorporated in part by the ... This research analyzes the growth impacts promoted by C class in the process of the freezing of the Brazilian industry and increased imports. This emerging market, called class C, which is incorporated in part by the low-income segment, presents distinct characteristics and needs and for this precise reason eventually burdens the short-term production of Brazilian companies, which feel the need to opt for the importation of basic commodities, manufactured, and semi-manufactured goods, in order to maintain a market share and return on their investments. Although this fact is actually part of a trend of global economic transformation, here it is due to a number of irregular actions taken by the Brazilian government facing a short-term political need. Stemming from quantitative researches and qualitative data, this paper sought to learn more about the consumers' profile and draw up some recommendations for the organizations, in order to be better prepared to face this new demand. This paper also sought to know the actions already undertaken by a large cosmetics company, parts of whose products aim at class C. 展开更多
关键词 class c IMPORTS DEINDUSTRIALIZATION STRATEGIES
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National Data of Class A,B and C Communicable Diseases in August 2013 in China
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《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第9期785-785,共1页
关键词 National Data of class A B and c communicable Diseases in August 2013 in china
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天然构象GPRC5D磷脂纳米盘的组装研究
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作者 王婉雪 尹存龙 +1 位作者 赵宏鑫 王俊峰 《安徽大学学报(自然科学版)》 CAS 北大核心 2024年第5期102-108,共7页
将G蛋白偶联受体GPRC5D蛋白组装进磷脂纳米盘类膜体系内以维持蛋白天然构象的稳定性并对其进行生物活性的验证.首先通过蛋白表达和纯化得到了GPRC5D蛋白,然后以GPRC5D蛋白、膜支架蛋白(MSP)和磷脂按一定比例混合制备GPRC5D磷脂纳米盘.... 将G蛋白偶联受体GPRC5D蛋白组装进磷脂纳米盘类膜体系内以维持蛋白天然构象的稳定性并对其进行生物活性的验证.首先通过蛋白表达和纯化得到了GPRC5D蛋白,然后以GPRC5D蛋白、膜支架蛋白(MSP)和磷脂按一定比例混合制备GPRC5D磷脂纳米盘.组装后GPRC5D蛋白依旧展现出与阳性抗体结合的能力,充分表明磷脂纳米盘能够有效保留GPRC5D蛋白的生物活性.该研究为制备GPRC5D蛋白磷脂纳米盘提供了新的思路和方法,为探究其蛋白的结构与功能和药物研发奠定基础. 展开更多
关键词 磷脂纳米盘 GPRc5D G蛋白偶联受体 多发性骨髓瘤
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血清脂蛋白相关磷脂酶A2、胱抑素C水平变化与肝硬化患者Child-Pugh分级的关联性分析
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作者 宋红杰 付雪琴 唐建荣 《医学检验与临床》 2021年第11期17-19,38,共4页
目的:研究血清脂蛋白相关磷脂酶A2(Lp-PLA2)、胱抑素C(CysC)水平变化与肝硬化(LC)患者Child-Pugh分级的关联性。方法:选取我院120例乙型肝炎LC患者作为研究组,依据1∶1配对原则选取同期120例慢性乙型肝炎患者作为对照1组,120例健康体检... 目的:研究血清脂蛋白相关磷脂酶A2(Lp-PLA2)、胱抑素C(CysC)水平变化与肝硬化(LC)患者Child-Pugh分级的关联性。方法:选取我院120例乙型肝炎LC患者作为研究组,依据1∶1配对原则选取同期120例慢性乙型肝炎患者作为对照1组,120例健康体检者作为对照2组。检测并比较3组血清Lp-PLA2、CysC水平,并比较研究组不同Child-Pugh分级、不同预后患者血清Lp-PLA2、CysC水平,分析血清Lp-PLA2、CysC与Child-Pugh分级及预后的关联性。结果:研究组血清Lp-PLA2(338.64±72.79)μg/L、CysC水平(2.14±0.39)mg/L>对照1组(226.31±53.91μg/L、1.18±0.36mg/L)>对照2组(105.97±42.38μg/L、0.75±0.24mg/L)(P<0.05);研究组Child-Pugh分级A级患者血清Lp-PLA2、CysC水平(299.51±68.19μg/L、1.53±0.31Omg/L)<B级(335.24±71.58μg/L、2.18±0.38mg/L)<C级患者(381.25±78.36μg/L、2.71±0.42mg/L)(P<0.05);预后良好患者血清Lp-PLA2、CysC水平(302.51±70.56μg/L、1.70±0.37mg/L)低于预后不良患者(374.48±77.67μg/L、2.58±0.41Omg/L)(P<0.05);血清Lp-PLA2、CysOC均与乙型肝炎LC患者Child-Pugh分级呈正相关(P<0.05);血清Lp-PLA2、CysOC水平升高均与乙型肝炎LC患者预后存在显著关联性(P<0.05)。结论:乙型肝炎LC患者血清Lp-PLA2、CysOC水平明显升高,与患者Child-Pugh分级及预后存在显著关联性。 展开更多
关键词 肝硬化 脂蛋白相关磷脂酶A2 胱抑素c child-pugh分级
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Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma
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作者 Andrew Scott deLemos Jing Zhao +9 位作者 Milin Patel Banks Kooken Karan Mathur Hieu Minh Nguyen Areej Mazhar Maggie McCarter Heather Burney Carla Kettler Naga Chalasani Samer Gawrieh 《World Journal of Hepatology》 2024年第3期393-404,共12页
BACKGROUND Obesity is an independent risk factor for the development of hepatocellular carcinoma(HCC)and may influence its outcomes.However,after diagnosis of HCC,like other malignancies,the obesity paradox may exist ... BACKGROUND Obesity is an independent risk factor for the development of hepatocellular carcinoma(HCC)and may influence its outcomes.However,after diagnosis of HCC,like other malignancies,the obesity paradox may exist where higher body mass index(BMI)may in fact confer a survival benefit.This is frequently observed in patients with advanced HCC and cirrhosis,who often present late with advanced tumor features and cancer related weight loss.AIM To explore the relationship between BMI and survival in patients with cirrhosis and HCC.METHODS This is a retrospective cohort study of over 2500 patients diagnosed with HCC between 2009-2019 at two United States academic medical centers.Patient and tumor characteristics were extracted manually from medical records of each institutions'cancer registries.Patients were stratified according to BMI classes:<25 kg/m^(2)(lean),25-29.9 kg/m^(2)(overweight),and>30 kg/m^(2)(obese).Patient and tumor characteristics were compared according to BMI classification.We performed an overall survival analysis using Kaplan Meier by the three BMI classes and after adjusting for Milan criteria.A multivariable Cox regression model was then used to assess known risk factors for survival in patients with cirrhosis and HCC.RESULTS A total of 2548 patients with HCC were included in the analysis of which 11.2%(n=286)were classified as noncirrhotic.The three main BMI categories:Lean(n=754),overweight(n=861),and obese(n=933)represented 29.6%,33.8%,and 36.6%of the total population overall.Within each BMI class,the non-cirrhotic patients accounted for 15%(n=100),12%(n=94),and 11%(n=92),respectively.Underweight patients with a BMI<18.5 kg/m^(2)(n=52)were included in the lean cohort.Of the obese cohort,42%(n=396)had a BMI≥35 kg/m^(2).Out of 2262 patients with cirrhosis and HCC,654(29%)were lean,767(34%)were overweight,and 841(37%)were obese.The three BMI classes did not differ by age,MELD,or Child-Pugh class.Chronic hepatitis C was the dominant etiology in lean compared to the overweight and obese patients(71%,62%,49%,P<0.001).Lean patients had significantly larger tumors compared to the other two BMI classes(5.1 vs 4.2 vs 4.2 cm,P<0.001),were more likely outside Milan(56%vs 48%vs 47%,P<0.001),and less likely to undergo transplantation(9%vs 18%vs 18%,P<0.001).While both tumor size(P<0.0001)and elevated alpha fetoprotein(P<0.0001)were associated with worse survival by regression analysis,lean BMI was not(P=0.36).CONCLUSION Lean patients with cirrhosis and HCC present with larger tumors and are more often outside Milan criteria,reflecting cancer related cachexia from delayed diagnosis.Access to care for hepatitis C virus therapy and liver transplantation confer a survival benefit,but not overweight or obese BMI classifications. 展开更多
关键词 Hepatocellular carcinoma cIRRHOSIS OBESITY Body mass index class SARcOPENIA chronic hepatitis c
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