Objective:To assess the relationship between the severity of atopic dermatitis(AD)in children of varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]levels.Methods:The study population comprised 899 ...Objective:To assess the relationship between the severity of atopic dermatitis(AD)in children of varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]levels.Methods:The study population comprised 899 patients with AD and 854 age-and sex-matched controls.The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups,and Spearman correlation analysis was used to test correlation.Results:The 25(OH)D level in the AD group was M(Q_(25),Q_(75)),24.0(19.7,28.4)ng/mL,which was significantly lower than the control group(26.4[23.6,29.9]ng/mL;Z=-3.34,P=0.001).25(OH)D levels in children with AD were negatively correlated with body mass index(r=-0.30,P<0.001),Severity scoring of Atopic Dermatitis(SCORAD;r=-0.14,P<0.001),total immunoglobulin E(r=-0.13,P<0.001),and eosinophil(r=-0.08,P=0.017).There were statistically significant differences in 25(OH)D(H=18.46,P<0.001),total immunoglobulin E(H=9.13,P=0.010),eosinophil(H=67.17,P<0.001),and SCORAD(H=10.49,P=0.005)among groups with different body mass index classification.The 25(OH)D levels were 22.3(17.5,27.1)ng/mL in the overweight AD group and 22.3(17.6,25.7)ng/mL in the obese AD group,which were significantly lower than those in the normal-weight AD group(24.7[20.4,25.5]ng/mL;P=0.003,P=0.004).25(OH)D levels were negatively correlated with SCORAD in obese AD patients(r=-0.25,P=0.010).Conclusion:Vitamin D insufficient or deficient is obvious in children AD patients.The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group.Vitamin D level is negatively correlated with SCORAD in obese children with AD.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)has been the cause of a global health crisis since the end of 2019.All countries are following the guidelines and recommendations released by the World Health Organizat...BACKGROUND The coronavirus disease 2019(COVID-19)has been the cause of a global health crisis since the end of 2019.All countries are following the guidelines and recommendations released by the World Health Organization to decrease the spread of the disease.Children account for only 3%-5%of COVID-19 cases.Few data are available regarding the clinical course,disease severity,and mode of treatment in children with malignancy and COVID-19.AIM To evaluate the treatment plan and outcome of children with malignancy who contracted COVID-19.METHODS A retrospective study of the medical files of patients with malignancy who contracted COVID-19 between July 2020 and June 2021 was performed.The following data were reviewed for all patients:primary disease,laboratory data,admission ward,clinical status upon admission,disease course,treatment plan,and outcome.Eligible patients were those with malignancy who tested positive for COVID-19 by reverse transcription polymerase chain reaction.RESULTS A total of 40 patients who had malignancy contracted COVID-19 from July 1,2020 to June 1,2021.Their primary diseases were as follows:34 patients(85%)had hematological malignancies(30 had acute lymphoblastic leukemia,2 had acute myeloblastic leukemia,and 2 had Hodgkin lymphoma),whereas 6 patients(15%)had solid tumors(2 had neuroblastoma,2 had rhabdomyosarcoma,and 2 had central nervous system tumors).Twelve patients(30%)did not need hospitalization and underwent home isolation only,whereas twenty-eight patients(70%)required hospitalization(26 patients were admitted in the COVID-19 ward and 2 were admitted in the pediatric intensive care unit).CONCLUSION COVID-19 with malignancy in the pediatric age group has a benign course and does not increase the risk of having severe infection compared to other children.展开更多
Background Despite the streaks of severity,severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection is,in general,less frequent and severe in children than in adults.We searched for causal evidence of this...Background Despite the streaks of severity,severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection is,in general,less frequent and severe in children than in adults.We searched for causal evidence of this mystery.Data sources An extensive search strategy was designed to identify papers on coronavirus disease 2019(COVID-19).We searched Ovid MEDLINE,PubMed,EMBASE databases,and Cochrane library and carried out a review on the causes of this dilemma.Results Our searches produced 81 relevant articles.The review showed that children accounted for a lower percentage of reported cases,and they also experienced less severe illness courses.Some potential explanations,including the tendency to engage the upper airway,the different expression in both receptors of angiotensin-converting enzyme and renin-angiotensin system,a less vigorous immune response,the lower levels of interleukin(IL)-6,IL-10,myeloperoxidase,and P-selectin and a higher intracellular adhesion molecule-1,a potential protective role of lymphocytes,and also lung infiltrations might have protective roles in the immune system-respiratory tract interactions.Finally,what have shed light on this under representa-tion comes from two studies that revealed high-titer immunoglobulin-G antibodies against respiratory syncytial virus and mycoplasma pneumonia,may carry out cross-protection against SARS-CoV-2 infection,just like what suggested about the vaccines.Conclusions These results require an in-depth look.Properties of the immune system including a less vigorous adaptive system beside a preliminary potent innate response and a trained immunity alongside a healthier respiratory system,and their interactions,might protect children against SARS-CoV-2 infection.However,further studies are needed to explore other possible causes of this enigma.展开更多
目的探讨新型冠状病毒感染后儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)患儿的临床特征及诊治策略。方法对徐州医科大学附属徐州儿童医院心血管内科2023年1—2月收治的4例MIS-C患儿的病例资料进行回...目的探讨新型冠状病毒感染后儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)患儿的临床特征及诊治策略。方法对徐州医科大学附属徐州儿童医院心血管内科2023年1—2月收治的4例MIS-C患儿的病例资料进行回顾性分析。结果4例患儿均伴有多脏器功能受累及炎症指标升高,入院后接受川崎病标准治疗方案效果不理想,其中2例予2次静脉注射免疫球蛋白冲击治疗,4例均加用糖皮质激素抗炎治疗,积极治疗后患儿预后良好。结论MIS-C常出现在新型冠状病毒感染后4~6周或更长时间,及时在川崎病标准治疗方案基础上加强抗炎治疗可取得良好治疗效果。展开更多
基金supported by the Key Project of Social Development in Jiangsu Province(No.BE2020632)National Natural Science Foundation of China(Nos.82073446 and 82103735)+1 种基金CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059)Nanjing Incubation Program for National Clinical Research Center(No.2019060001)
文摘Objective:To assess the relationship between the severity of atopic dermatitis(AD)in children of varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]levels.Methods:The study population comprised 899 patients with AD and 854 age-and sex-matched controls.The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups,and Spearman correlation analysis was used to test correlation.Results:The 25(OH)D level in the AD group was M(Q_(25),Q_(75)),24.0(19.7,28.4)ng/mL,which was significantly lower than the control group(26.4[23.6,29.9]ng/mL;Z=-3.34,P=0.001).25(OH)D levels in children with AD were negatively correlated with body mass index(r=-0.30,P<0.001),Severity scoring of Atopic Dermatitis(SCORAD;r=-0.14,P<0.001),total immunoglobulin E(r=-0.13,P<0.001),and eosinophil(r=-0.08,P=0.017).There were statistically significant differences in 25(OH)D(H=18.46,P<0.001),total immunoglobulin E(H=9.13,P=0.010),eosinophil(H=67.17,P<0.001),and SCORAD(H=10.49,P=0.005)among groups with different body mass index classification.The 25(OH)D levels were 22.3(17.5,27.1)ng/mL in the overweight AD group and 22.3(17.6,25.7)ng/mL in the obese AD group,which were significantly lower than those in the normal-weight AD group(24.7[20.4,25.5]ng/mL;P=0.003,P=0.004).25(OH)D levels were negatively correlated with SCORAD in obese AD patients(r=-0.25,P=0.010).Conclusion:Vitamin D insufficient or deficient is obvious in children AD patients.The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group.Vitamin D level is negatively correlated with SCORAD in obese children with AD.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)has been the cause of a global health crisis since the end of 2019.All countries are following the guidelines and recommendations released by the World Health Organization to decrease the spread of the disease.Children account for only 3%-5%of COVID-19 cases.Few data are available regarding the clinical course,disease severity,and mode of treatment in children with malignancy and COVID-19.AIM To evaluate the treatment plan and outcome of children with malignancy who contracted COVID-19.METHODS A retrospective study of the medical files of patients with malignancy who contracted COVID-19 between July 2020 and June 2021 was performed.The following data were reviewed for all patients:primary disease,laboratory data,admission ward,clinical status upon admission,disease course,treatment plan,and outcome.Eligible patients were those with malignancy who tested positive for COVID-19 by reverse transcription polymerase chain reaction.RESULTS A total of 40 patients who had malignancy contracted COVID-19 from July 1,2020 to June 1,2021.Their primary diseases were as follows:34 patients(85%)had hematological malignancies(30 had acute lymphoblastic leukemia,2 had acute myeloblastic leukemia,and 2 had Hodgkin lymphoma),whereas 6 patients(15%)had solid tumors(2 had neuroblastoma,2 had rhabdomyosarcoma,and 2 had central nervous system tumors).Twelve patients(30%)did not need hospitalization and underwent home isolation only,whereas twenty-eight patients(70%)required hospitalization(26 patients were admitted in the COVID-19 ward and 2 were admitted in the pediatric intensive care unit).CONCLUSION COVID-19 with malignancy in the pediatric age group has a benign course and does not increase the risk of having severe infection compared to other children.
文摘Background Despite the streaks of severity,severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection is,in general,less frequent and severe in children than in adults.We searched for causal evidence of this mystery.Data sources An extensive search strategy was designed to identify papers on coronavirus disease 2019(COVID-19).We searched Ovid MEDLINE,PubMed,EMBASE databases,and Cochrane library and carried out a review on the causes of this dilemma.Results Our searches produced 81 relevant articles.The review showed that children accounted for a lower percentage of reported cases,and they also experienced less severe illness courses.Some potential explanations,including the tendency to engage the upper airway,the different expression in both receptors of angiotensin-converting enzyme and renin-angiotensin system,a less vigorous immune response,the lower levels of interleukin(IL)-6,IL-10,myeloperoxidase,and P-selectin and a higher intracellular adhesion molecule-1,a potential protective role of lymphocytes,and also lung infiltrations might have protective roles in the immune system-respiratory tract interactions.Finally,what have shed light on this under representa-tion comes from two studies that revealed high-titer immunoglobulin-G antibodies against respiratory syncytial virus and mycoplasma pneumonia,may carry out cross-protection against SARS-CoV-2 infection,just like what suggested about the vaccines.Conclusions These results require an in-depth look.Properties of the immune system including a less vigorous adaptive system beside a preliminary potent innate response and a trained immunity alongside a healthier respiratory system,and their interactions,might protect children against SARS-CoV-2 infection.However,further studies are needed to explore other possible causes of this enigma.
文摘目的探讨新型冠状病毒感染后儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)患儿的临床特征及诊治策略。方法对徐州医科大学附属徐州儿童医院心血管内科2023年1—2月收治的4例MIS-C患儿的病例资料进行回顾性分析。结果4例患儿均伴有多脏器功能受累及炎症指标升高,入院后接受川崎病标准治疗方案效果不理想,其中2例予2次静脉注射免疫球蛋白冲击治疗,4例均加用糖皮质激素抗炎治疗,积极治疗后患儿预后良好。结论MIS-C常出现在新型冠状病毒感染后4~6周或更长时间,及时在川崎病标准治疗方案基础上加强抗炎治疗可取得良好治疗效果。
