The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal p...The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.展开更多
An analytic hierarchy process(AHP)was employed to establish a landscape value evaluation model for 20 common species of perennial flowers in the flower border of Hefei City.With the overarching objective of determinin...An analytic hierarchy process(AHP)was employed to establish a landscape value evaluation model for 20 common species of perennial flowers in the flower border of Hefei City.With the overarching objective of determining the application value of the flower border,10 evaluation factors were identified and subsequently classified into 3 distinct grades.Grade I(L>2.5)was defined as perennial flower resources with the highest development and utilization value,including only one species of Salvia farinacea.Grade II(2.0≤L≤2.5)was defined as perennial flower varieties suitable for most areas,encompassing 9 species of plants,such asTaraxacummongolicum.Grade III(L<2.0)was defined as perennial flower varieties with low application value,encompassing 10 species of plants,such asRuellia brittoniana,but lacking the value of further popularization and application.Consequently,the proportion of their application in the flower border should be reduced.The evaluation results can serve as a theoretical foundation for the implementation of perennial flowers in urban flower borders.展开更多
“Strength”and“vitality”are the comments that people in the industry have used to describe China’s cross-border e-commerce in 2023,which has been proven by the latest statistics.According to the General Administra...“Strength”and“vitality”are the comments that people in the industry have used to describe China’s cross-border e-commerce in 2023,which has been proven by the latest statistics.According to the General Administration of Customs,in 2023,the total volume of imports and exports was RMB 2.38 trillion,up by 15.6%.The volume of exports was RMB 1.83 billion,up by 19.6%,and the volume of imports was RMB 548.3 billion,up by 3.9%.展开更多
With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and...With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and tuina undergraduates of Yunnan University of Traditional Chinese Medicine.The employment concept of acupuncture and tuina undergraduates in the minority border areas has changed greatly.After graduation,97.95%of students choose to work in fields related to medicine and acupuncture,prefer positions close to home,and are attracted to high-salary companies,among other factors.Therefore,enhancing the competitive advantages of medical students by guiding their career planning,providing employment selection advice,fostering innovation and entrepreneurship,improving basic skills,and offering graduate entrance examination guidance is crucial for broadening their employment opportunities.展开更多
Background:Babesiosis is an emerging health risk in several parts of the world.However,little is known about the prevalence of Babesia in malaria-endemic countries.The area along the China-Myanmar border in Yunnan is ...Background:Babesiosis is an emerging health risk in several parts of the world.However,little is known about the prevalence of Babesia in malaria-endemic countries.The area along the China-Myanmar border in Yunnan is a main endemic area of malaria in P.R.China,however,human infection with Babesia microti(B.microti)is not recognized in this region,and its profile of co-infection is not yet clear.Methods:To understand its profile of co-infections with B.microti,our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June 2013.Four parasite species,including B.microti,Plasmodium falciparum(P.falciparum),P.vivax,and P.malariae,were identified among 449 suspected febrile persons detected by nested polymerase chain reaction(PCR)assay based on small subunit ribosomal ribonucleic acid(RNA)genes of B.microti and Plasmodium spp.Results:Of all the collected samples from febrile patients,mono-infection with B.microti,P.vivax,P.falciparum,and P.malariae accounted for 1.8%(8/449),9.8%(44/449),2.9%(13/449),and 0.2%(1/449),respectively.The rate of mixed infections of B.microti with P.falciparum or P.vivax are both 0.2%(1/449),and mixed infections of P.falciparum and P.vivax accounted for 1.1%(5/449).Conclusions:This report supports the hypothesis that babesiosis caused by B.microti is emerging along the China-Myanmar border in the Yunnan province,P.R.China,but it was ignored because of low parasitemia or mixed infection with Plasmodium spp.More sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.展开更多
Background:Implementing effective interventions remain a lot of difficulties along all border regions.The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matte...Background:Implementing effective interventions remain a lot of difficulties along all border regions.The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matter of great concern.China has effectively controlled cross-border transmission of malaria and artemisinin resistance of P.falciparum along the China-Myanmar border.Methods:A combined quantitative and qualitative study was used to collect data,and then an integrated impact evaluation was conducted to malaria control along the China-Myanmar border during 2007-2013.Results:The parasite prevalence rate(PPR)in the five special regions of Myanmar was decreased from 13.6%in March 2008 to 1.5%in November 2013.Compared with the baseline(PPR in March 2008),the risk ratio was only 0.11[95%confidence interval(CI),0.09-0.14]in November 2013,which is equal to an 89%reduction in the malaria burden.Annual parasite incidence(API)across 19 Chinese border counties was reduced from 19.6 per 10000 person-years in 2006 to 0.9 per 10000 person-years in 2013.Compared with the baseline(API in 2006),the API rate ratio was only 0.05(95%CI,0.04-0.05)in 2013,which equates to a reduction of the malaria burden by 95.0%.Meanwhile,the health service system was strengthened and health inequity of marginalized populations reduced along the international border.Conclusion:The effective collaboration between China,Myanmar and the international non-governmental organization promptly carried out the core interventions through simplified processes.The integrated approaches dramatically decreased malaria burden of Chinese-Myanmar border.展开更多
Background:Plasmodium vivax remains the predominant species at the China–Myanmar border,imposing a major challenge to the recent gains in regional malaria elimination.To closely supervise the emerging of drug resista...Background:Plasmodium vivax remains the predominant species at the China–Myanmar border,imposing a major challenge to the recent gains in regional malaria elimination.To closely supervise the emerging of drug resistance in this area,we surveyed the variations in genes potentially correlated with drug resistance in P.vivax parasite and the possible drug selection with time.Methods:A total of 235 P.vivax samples were collected from patients sufering uncomplicated malaria at Yingjiang,Tengchong,and Longling counties,and Nabang port in China,Yunnan province,and Laiza sub-township in Myanmar,from 2008 to 2017.Five potential drug resistance genes were amplifed utilizing nested-PCR and analyzed,including pvdhfr,pvdhps,pvmdr1,pvcrt-o,and pvk12.The Pearson’s Chi-squared test or Fisher’s exact test were applied to determine the statistical frequency diferences of mutations between categorical data.Results:The pvdhfr F57I/L,S58R,T61M and S117T/N presented in 40.6%,56.7%,40.1%,and 56.0% of the sequenced P.vivax isolates,and these mutations signifcantly decreased with years.The haplotype formed by these quadruple mutations predominated in Yingjiang,Tengchong,Longling and Nabang.While a mutation H99S/R(56.6%)dominated in Laiza and increased with time.In pvdhps,the A383G prevailed in 69.2% of the samples,which remained the most prevalent haplotype.However,a signifcant decrease of its occurrence was also noticed over the time.The S382A/C and A553G existed in 8.4% and 30.8% of the isolates,respectively.In pvmdr1,the mutation Y976F occurred at a low frequency in 5/232(2.2%),while T958M was fxed and F1076L was approaching fxed(72.4%).The K10 insertion was detected at an occurrence of 33.2% in pvcrt-o,whereas there was no signifcant diference among the sites or over the time.No mutation was identifed in pvk12.Conclusions:Mutations related with resistance to antifolate drugs are prevalent in this area,while their frequencies decrease signifcantly with time,suggestive of increased susceptibility of P.vivax parasite to antifolate drugs.Resistance to chloroquine(CQ)is possibly emerging.However,since the molecular mechanisms underneath CQ resistance is yet to be better understood,close supervision of clinical drug efciency and continuous function investigation is urgently needed to alarm drug resistance.展开更多
Background:China has made progress in malaria control and aims to eliminate malaria nationwide,but implementing effective interventions along the border regions remain a huge task.The Plasmodium falciparum cases impor...Background:China has made progress in malaria control and aims to eliminate malaria nationwide,but implementing effective interventions along the border regions remain a huge task.The Plasmodium falciparum cases imported from Southeast Asia has frequently reported especially in the China-Myanmar border(CMB)area.Though,information is scant on P.falciparum genetic variability in this area.Methods:This study reported P.falciparum isolates genome sequence of six clinical isolates in the CMB area.Furthermore,we estimated the nucleotide diversity,Watterson’s estimator and Tajima’s D value for the whole genome mutation rate in slide window.Results:Our data were aligned onto 96.05-98.61%of the reference 3D7 genome in high fold coverages.Principal component analysis result showed that P.falciparum clustered generally according to their geographic origin.A total of 91 genes were identified as positive selection with Ka/Ks ratio significantly higher than 1,and most of them were multigene families encoding variant surface antigens(VSAs)such as var,rif and stevor.The enrichment of the positive selection on VSA genes implied that the environment complexity subjected CMB’s P.falciparum to more pressure for survival.Conclusions:Our research suggests that greater genetic diversity in CMB area and the positive selection signals in VSA genes,which allow P.falciparum to fit the host immune system well and aggravate the difficulty of treatment.Meanwhile,results obtained from this study will provide the fundamental basis for P.falciparum population genomic research in CMB area.展开更多
Background: Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination.The aim of this study is to investigate ...Background: Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination.The aim of this study is to investigate the epidemiology of malaria along the border,will identify challenges in the progress from control to elimination.Methods:: National reported malaria cases from China and Myanmar,along with the data of 18 Chinese border counties and 23 townships in Myanmar were obtained from a web-based diseases information reporting system in China and the national malaria control program of Myanmar,respectively.Epidemiological data was analyzed,including the number of reported cases,annual parasite index and proportion of vivax infection.Spatial mapping of the annual parasite index(API)at county or township level in 2014 and 2018 was performed by ArcGIS.The relationship of malaria endemicity on both sides of the border was evaluated by regression analysis.Results: The number of reported malaria cases and API declined in the border counties or townships.In 2014,392 malaria cases were reported from 18 Chinese border counties,including 8.4%indigenous cases and 91.6%imported cases,while the highest API(0.11)was occurred in Yingjiang County.There have been no indigenous cases reported since 2017,but 164 imported cases were reported in 2018 and 97.6%were imported from Myanmar.The average API in 2014 in 23 Myanmar townships was significantly greater than that of 18 Chinese counties(P<0.01).However,the API decreased significantly in Myanmar side from 2014 to 2018(P<0.01).The number of townships with an API between 0 and 1 increased to 15 in 2018,compared to only five in 2014,while still four townships had API>10.Plasmodium vivax was the predominant species along the border.The number of reported malaria cases and the proportion of vivax infection in the 18 Chinese counties were strongly correlated with those of the 23 Myanmar townships(P<0.05).Conclusions: Malaria elimination is approaching along the China-Myanmar border.However,in order to achieve the malaria elimination in this region and prevent the re-establishment of malaria in China after elimination,continued political,financial and scientific commitment is required.展开更多
The border effect(BE)is widely observed in crop field experiments,and it has been extensively studied in many crops.However,only limited attention has been paid to the BE of ratoon rice.We conducted field experiments ...The border effect(BE)is widely observed in crop field experiments,and it has been extensively studied in many crops.However,only limited attention has been paid to the BE of ratoon rice.We conducted field experiments on ratoon rice in Qichun County,Hubei Province,Central China in 2018 and 2019 to compare the BE in the main and ratoon crops,and to quantify the contribution of BE in the main crop to that in the ratoon crop.The BE of two hybrid varieties was measured for the outermost,second outermost,and third outermost rows in each plot of both crops.To determine the contribution of BE between the two crops,portions of hills in the outermost and second outermost rows were uprooted during the harvest of the main crop so that the second and third outermost rows then became the outermost rows in the ratoon crop.Overall,the BE on grain yield was greater in the main crop than in the ratoon crop.In the main crop,the BE on grain yield was 98.3%in the outermost row,which was explained by the BE on panicles m^(–2),spikelets/panicle,spikelets m^(–2),and total dry weight.In the ratoon crop,the BE on grain yield was reduced to 60.9 and 27.6%with and without the contribution of the BE in the main crop,respectively.Consequently,55.1%of the BE on grain yield in the ratoon crop was contributed from the main crop.High stubble dry weight and non-structural carbohydrate(NSC)accumulation at the harvest of the main crop were responsible for the contribution of BE in the main crop to that in the ratoon crop.Our results suggest that increases in stubble dry weight and NSC accumulation at the harvest of the main crop could be important strategies for developing high-yielding cropping practices in the rice ratooning system.展开更多
The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-borde...The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-border e-commerce roundtable meeting held on March 30th this year,indicating that cross-border e-commerce made a contribution of 37.32%to China’s total import and export trade value in goods(RMB 42.07 trillion)in 2022.展开更多
As major country competition is becoming ever more intense,data has become a key strategic resource,making rules of cross-border data flow going beyond the business scope in a traditional sense and becomin...As major country competition is becoming ever more intense,data has become a key strategic resource,making rules of cross-border data flow going beyond the business scope in a traditional sense and becoming a strategic issue concerning national development and security.Relevant parties compete against each other in three major areas of the collection of cross-border law enforcement data,cross-border flow of corporate data.展开更多
To strengthen border patrol measures, unmanned aerial vehicles(UAVs) are gradually used in many countries to detect illegal entries on borders. However, how to efficiently deploy limited UAVs to patrol on borders of l...To strengthen border patrol measures, unmanned aerial vehicles(UAVs) are gradually used in many countries to detect illegal entries on borders. However, how to efficiently deploy limited UAVs to patrol on borders of large areas remains challenging. In this paper, we first model the problem of deploying UAVs for border patrol as a Stackelberg game. Two players are considered in this game: The border patrol agency is the leader,who optimizes the patrol path of UAVs to detect the illegal immigrant. The illegal immigrant is the follower, who selects a certain area of the border to pass through at a certain time after observing the leader’s strategy. Second, a compact linear programming problem is proposed to tackle the exponential growth of the number of leader’s strategies. Third, a method is proposed to reduce the size of the strategy space of the follower. Then, we provide some theoretic results to present the effect of parameters of the model on leader’s utilities. Experimental results demonstrate the positive effect of limited starting and ending areas of UAV’s patrolling conditions and multiple patrolling altitudes on the leader ’s utility, and show that the proposed solution outperforms two conventional patrol strategies and has strong robustness.展开更多
The rapid development of the digital economy and profound changes in currency functions have driven the emergence of a large number of digital currencies.In order to improve the competitiveness and efficiency of payme...The rapid development of the digital economy and profound changes in currency functions have driven the emergence of a large number of digital currencies.In order to improve the competitiveness and efficiency of payment systems,governments all over the world have accelerated the research and development of central bank digital currency(CBDC).After years of preparation and research and development,Digital renminbi has also entered the pilot application stage.Given the many shortcomings of the current cross-border payment system,CBDC cross-border payment has become an important development direction.At present,some central banks are collaborating on CBDC cross-border payment research and initiating experimental plans to explore CBDC cross-border payment arrangements.With the expansion of the acceptance range of Digital renminbi and the improvement of the international use level of CNY,oil and gas enterprises will have broad prospects in the cross-border payment field in the future.This paper suggests that oil and gas enterprises,in accordance with the principle of"from easy to difficult,step by step",give priority to the introduction of Digital renminbi from regions and fields where RMB or local currency settlement has been achieved,and combine Digital renminbi with imported oil and gas to explore the use of Digital renminbi in cross-border payment.展开更多
After closing for 1,012 days due to the COVID-19 pandemic,the Jiegao border gate in Ruili City,south China’s Yunnan Province,reopened on January 8,2023.On January 14,traffic between Ruili and Muse in Myanmar resumed ...After closing for 1,012 days due to the COVID-19 pandemic,the Jiegao border gate in Ruili City,south China’s Yunnan Province,reopened on January 8,2023.On January 14,traffic between Ruili and Muse in Myanmar resumed at the Ruili-Kyalgaung border crossing and the Sino-Myanmar Friendship Street crossing.Still,the Border Gate crossing remains closed.展开更多
Based on a questionnaire survey and on-site research on the overview of the border tea industry,the importance of the development of border tea for ethnic unity work is analyzed,and improvement suggestions and impleme...Based on a questionnaire survey and on-site research on the overview of the border tea industry,the importance of the development of border tea for ethnic unity work is analyzed,and improvement suggestions and implementation strategies are proposed.展开更多
基金funded by the Natural Science Foundation of China (Grant No. 42271030)Fujian Provincial Funds for Distinguished Young Scientists (Grant No. 2022J06018)Applied Basic Research Programs of Yunnan province (Grant No. 202001BB050073)。
文摘The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.
基金Sponsored by Landscape Value Evaluation of Perennial Flower Border Application for Open Field Cultivation in Hefei City(S202212216134)Natural Science Key Research Program for Colleges and Universities in Anhui Province(2023AH051816)Anhui General Teaching Research Project(2022jyxm665).
文摘An analytic hierarchy process(AHP)was employed to establish a landscape value evaluation model for 20 common species of perennial flowers in the flower border of Hefei City.With the overarching objective of determining the application value of the flower border,10 evaluation factors were identified and subsequently classified into 3 distinct grades.Grade I(L>2.5)was defined as perennial flower resources with the highest development and utilization value,including only one species of Salvia farinacea.Grade II(2.0≤L≤2.5)was defined as perennial flower varieties suitable for most areas,encompassing 9 species of plants,such asTaraxacummongolicum.Grade III(L<2.0)was defined as perennial flower varieties with low application value,encompassing 10 species of plants,such asRuellia brittoniana,but lacking the value of further popularization and application.Consequently,the proportion of their application in the flower border should be reduced.The evaluation results can serve as a theoretical foundation for the implementation of perennial flowers in urban flower borders.
文摘“Strength”and“vitality”are the comments that people in the industry have used to describe China’s cross-border e-commerce in 2023,which has been proven by the latest statistics.According to the General Administration of Customs,in 2023,the total volume of imports and exports was RMB 2.38 trillion,up by 15.6%.The volume of exports was RMB 1.83 billion,up by 19.6%,and the volume of imports was RMB 548.3 billion,up by 3.9%.
文摘With the popularization of higher education in China,the employment situation of college students is more complex and severe.This paper adopts the questionnaire method to explore the employment view of acupuncture and tuina undergraduates of Yunnan University of Traditional Chinese Medicine.The employment concept of acupuncture and tuina undergraduates in the minority border areas has changed greatly.After graduation,97.95%of students choose to work in fields related to medicine and acupuncture,prefer positions close to home,and are attracted to high-salary companies,among other factors.Therefore,enhancing the competitive advantages of medical students by guiding their career planning,providing employment selection advice,fostering innovation and entrepreneurship,improving basic skills,and offering graduate entrance examination guidance is crucial for broadening their employment opportunities.
基金The research has been partially supported by the Special Fund for Health Research in the Public Interest China(No.201202019)Strengthen Action Plan for Shanghai Public Health System Construction 2011–2013(GW-11)by the National S&T Major Program(No.2012ZX10004-220).
文摘Background:Babesiosis is an emerging health risk in several parts of the world.However,little is known about the prevalence of Babesia in malaria-endemic countries.The area along the China-Myanmar border in Yunnan is a main endemic area of malaria in P.R.China,however,human infection with Babesia microti(B.microti)is not recognized in this region,and its profile of co-infection is not yet clear.Methods:To understand its profile of co-infections with B.microti,our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June 2013.Four parasite species,including B.microti,Plasmodium falciparum(P.falciparum),P.vivax,and P.malariae,were identified among 449 suspected febrile persons detected by nested polymerase chain reaction(PCR)assay based on small subunit ribosomal ribonucleic acid(RNA)genes of B.microti and Plasmodium spp.Results:Of all the collected samples from febrile patients,mono-infection with B.microti,P.vivax,P.falciparum,and P.malariae accounted for 1.8%(8/449),9.8%(44/449),2.9%(13/449),and 0.2%(1/449),respectively.The rate of mixed infections of B.microti with P.falciparum or P.vivax are both 0.2%(1/449),and mixed infections of P.falciparum and P.vivax accounted for 1.1%(5/449).Conclusions:This report supports the hypothesis that babesiosis caused by B.microti is emerging along the China-Myanmar border in the Yunnan province,P.R.China,but it was ignored because of low parasitemia or mixed infection with Plasmodium spp.More sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.
基金supported by the sixth(CHN-607-G09-M)and the tenth(CHN-011-G15-M)grants of the Global Fund to fight AIDS,Tuberculosis and Malaria(GFATM)to Chinasupported by the tenth(CHN-011-G15-M)grants of the GFATM to Chinasupported by the National Natural Science Foundation of China(NSFC/81560543).
文摘Background:Implementing effective interventions remain a lot of difficulties along all border regions.The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matter of great concern.China has effectively controlled cross-border transmission of malaria and artemisinin resistance of P.falciparum along the China-Myanmar border.Methods:A combined quantitative and qualitative study was used to collect data,and then an integrated impact evaluation was conducted to malaria control along the China-Myanmar border during 2007-2013.Results:The parasite prevalence rate(PPR)in the five special regions of Myanmar was decreased from 13.6%in March 2008 to 1.5%in November 2013.Compared with the baseline(PPR in March 2008),the risk ratio was only 0.11[95%confidence interval(CI),0.09-0.14]in November 2013,which is equal to an 89%reduction in the malaria burden.Annual parasite incidence(API)across 19 Chinese border counties was reduced from 19.6 per 10000 person-years in 2006 to 0.9 per 10000 person-years in 2013.Compared with the baseline(API in 2006),the API rate ratio was only 0.05(95%CI,0.04-0.05)in 2013,which equates to a reduction of the malaria burden by 95.0%.Meanwhile,the health service system was strengthened and health inequity of marginalized populations reduced along the international border.Conclusion:The effective collaboration between China,Myanmar and the international non-governmental organization promptly carried out the core interventions through simplified processes.The integrated approaches dramatically decreased malaria burden of Chinese-Myanmar border.
文摘Background:Plasmodium vivax remains the predominant species at the China–Myanmar border,imposing a major challenge to the recent gains in regional malaria elimination.To closely supervise the emerging of drug resistance in this area,we surveyed the variations in genes potentially correlated with drug resistance in P.vivax parasite and the possible drug selection with time.Methods:A total of 235 P.vivax samples were collected from patients sufering uncomplicated malaria at Yingjiang,Tengchong,and Longling counties,and Nabang port in China,Yunnan province,and Laiza sub-township in Myanmar,from 2008 to 2017.Five potential drug resistance genes were amplifed utilizing nested-PCR and analyzed,including pvdhfr,pvdhps,pvmdr1,pvcrt-o,and pvk12.The Pearson’s Chi-squared test or Fisher’s exact test were applied to determine the statistical frequency diferences of mutations between categorical data.Results:The pvdhfr F57I/L,S58R,T61M and S117T/N presented in 40.6%,56.7%,40.1%,and 56.0% of the sequenced P.vivax isolates,and these mutations signifcantly decreased with years.The haplotype formed by these quadruple mutations predominated in Yingjiang,Tengchong,Longling and Nabang.While a mutation H99S/R(56.6%)dominated in Laiza and increased with time.In pvdhps,the A383G prevailed in 69.2% of the samples,which remained the most prevalent haplotype.However,a signifcant decrease of its occurrence was also noticed over the time.The S382A/C and A553G existed in 8.4% and 30.8% of the isolates,respectively.In pvmdr1,the mutation Y976F occurred at a low frequency in 5/232(2.2%),while T958M was fxed and F1076L was approaching fxed(72.4%).The K10 insertion was detected at an occurrence of 33.2% in pvcrt-o,whereas there was no signifcant diference among the sites or over the time.No mutation was identifed in pvk12.Conclusions:Mutations related with resistance to antifolate drugs are prevalent in this area,while their frequencies decrease signifcantly with time,suggestive of increased susceptibility of P.vivax parasite to antifolate drugs.Resistance to chloroquine(CQ)is possibly emerging.However,since the molecular mechanisms underneath CQ resistance is yet to be better understood,close supervision of clinical drug efciency and continuous function investigation is urgently needed to alarm drug resistance.
基金This work was supported by the National Research and Development Plan of China(Grant No.2016YFC1202000 and 2016YFC1200500)the National Natural Science Foundation of China(Grant No.81702032 and 81101266)+2 种基金the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY17H190005)the Open Project of Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education(Grant No.GMU-2017-HJZ-002)the National Sharing Service Platform for Parasite Resources(Grant No.TDRC-22).
文摘Background:China has made progress in malaria control and aims to eliminate malaria nationwide,but implementing effective interventions along the border regions remain a huge task.The Plasmodium falciparum cases imported from Southeast Asia has frequently reported especially in the China-Myanmar border(CMB)area.Though,information is scant on P.falciparum genetic variability in this area.Methods:This study reported P.falciparum isolates genome sequence of six clinical isolates in the CMB area.Furthermore,we estimated the nucleotide diversity,Watterson’s estimator and Tajima’s D value for the whole genome mutation rate in slide window.Results:Our data were aligned onto 96.05-98.61%of the reference 3D7 genome in high fold coverages.Principal component analysis result showed that P.falciparum clustered generally according to their geographic origin.A total of 91 genes were identified as positive selection with Ka/Ks ratio significantly higher than 1,and most of them were multigene families encoding variant surface antigens(VSAs)such as var,rif and stevor.The enrichment of the positive selection on VSA genes implied that the environment complexity subjected CMB’s P.falciparum to more pressure for survival.Conclusions:Our research suggests that greater genetic diversity in CMB area and the positive selection signals in VSA genes,which allow P.falciparum to fit the host immune system well and aggravate the difficulty of treatment.Meanwhile,results obtained from this study will provide the fundamental basis for P.falciparum population genomic research in CMB area.
基金This work was supported by the Natural Science Foundation of Shanghai(No.18ZR1443400)the National Important Scientific&Technological Project 2018ZX10101002-002)the Forge Ahead Together for Elimination Towards Malaria free China–Myanmar border and National Malaria Elimination Program of China.
文摘Background: Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination.The aim of this study is to investigate the epidemiology of malaria along the border,will identify challenges in the progress from control to elimination.Methods:: National reported malaria cases from China and Myanmar,along with the data of 18 Chinese border counties and 23 townships in Myanmar were obtained from a web-based diseases information reporting system in China and the national malaria control program of Myanmar,respectively.Epidemiological data was analyzed,including the number of reported cases,annual parasite index and proportion of vivax infection.Spatial mapping of the annual parasite index(API)at county or township level in 2014 and 2018 was performed by ArcGIS.The relationship of malaria endemicity on both sides of the border was evaluated by regression analysis.Results: The number of reported malaria cases and API declined in the border counties or townships.In 2014,392 malaria cases were reported from 18 Chinese border counties,including 8.4%indigenous cases and 91.6%imported cases,while the highest API(0.11)was occurred in Yingjiang County.There have been no indigenous cases reported since 2017,but 164 imported cases were reported in 2018 and 97.6%were imported from Myanmar.The average API in 2014 in 23 Myanmar townships was significantly greater than that of 18 Chinese counties(P<0.01).However,the API decreased significantly in Myanmar side from 2014 to 2018(P<0.01).The number of townships with an API between 0 and 1 increased to 15 in 2018,compared to only five in 2014,while still four townships had API>10.Plasmodium vivax was the predominant species along the border.The number of reported malaria cases and the proportion of vivax infection in the 18 Chinese counties were strongly correlated with those of the 23 Myanmar townships(P<0.05).Conclusions: Malaria elimination is approaching along the China-Myanmar border.However,in order to achieve the malaria elimination in this region and prevent the re-establishment of malaria in China after elimination,continued political,financial and scientific commitment is required.
基金supported by the Major International(Regional)Joint Research Project of National Natural Science Foundation of China(32061143038)the earmarked fund for China Agriculture Research System(CARS-01-20)+1 种基金the National High Technology Research and Development Program of China(the 863 Project,2014AA10A605)the Fundamental Research Funds for the Central Universities,China(2662020ZKPY015).
文摘The border effect(BE)is widely observed in crop field experiments,and it has been extensively studied in many crops.However,only limited attention has been paid to the BE of ratoon rice.We conducted field experiments on ratoon rice in Qichun County,Hubei Province,Central China in 2018 and 2019 to compare the BE in the main and ratoon crops,and to quantify the contribution of BE in the main crop to that in the ratoon crop.The BE of two hybrid varieties was measured for the outermost,second outermost,and third outermost rows in each plot of both crops.To determine the contribution of BE between the two crops,portions of hills in the outermost and second outermost rows were uprooted during the harvest of the main crop so that the second and third outermost rows then became the outermost rows in the ratoon crop.Overall,the BE on grain yield was greater in the main crop than in the ratoon crop.In the main crop,the BE on grain yield was 98.3%in the outermost row,which was explained by the BE on panicles m^(–2),spikelets/panicle,spikelets m^(–2),and total dry weight.In the ratoon crop,the BE on grain yield was reduced to 60.9 and 27.6%with and without the contribution of the BE in the main crop,respectively.Consequently,55.1%of the BE on grain yield in the ratoon crop was contributed from the main crop.High stubble dry weight and non-structural carbohydrate(NSC)accumulation at the harvest of the main crop were responsible for the contribution of BE in the main crop to that in the ratoon crop.Our results suggest that increases in stubble dry weight and NSC accumulation at the harvest of the main crop could be important strategies for developing high-yielding cropping practices in the rice ratooning system.
文摘The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-border e-commerce roundtable meeting held on March 30th this year,indicating that cross-border e-commerce made a contribution of 37.32%to China’s total import and export trade value in goods(RMB 42.07 trillion)in 2022.
文摘As major country competition is becoming ever more intense,data has become a key strategic resource,making rules of cross-border data flow going beyond the business scope in a traditional sense and becoming a strategic issue concerning national development and security.Relevant parties compete against each other in three major areas of the collection of cross-border law enforcement data,cross-border flow of corporate data.
基金supported by the National Natural Science Foundation of China (71971075,71871079)the National Key Research and Development Program of China (2019YFE0110300)+1 种基金the Anhui Provincial Natural Science Foundation (1808085MG213)the Fundamental R esearch Funds for the Central Universities (PA2019GDPK0082)。
文摘To strengthen border patrol measures, unmanned aerial vehicles(UAVs) are gradually used in many countries to detect illegal entries on borders. However, how to efficiently deploy limited UAVs to patrol on borders of large areas remains challenging. In this paper, we first model the problem of deploying UAVs for border patrol as a Stackelberg game. Two players are considered in this game: The border patrol agency is the leader,who optimizes the patrol path of UAVs to detect the illegal immigrant. The illegal immigrant is the follower, who selects a certain area of the border to pass through at a certain time after observing the leader’s strategy. Second, a compact linear programming problem is proposed to tackle the exponential growth of the number of leader’s strategies. Third, a method is proposed to reduce the size of the strategy space of the follower. Then, we provide some theoretic results to present the effect of parameters of the model on leader’s utilities. Experimental results demonstrate the positive effect of limited starting and ending areas of UAV’s patrolling conditions and multiple patrolling altitudes on the leader ’s utility, and show that the proposed solution outperforms two conventional patrol strategies and has strong robustness.
文摘The rapid development of the digital economy and profound changes in currency functions have driven the emergence of a large number of digital currencies.In order to improve the competitiveness and efficiency of payment systems,governments all over the world have accelerated the research and development of central bank digital currency(CBDC).After years of preparation and research and development,Digital renminbi has also entered the pilot application stage.Given the many shortcomings of the current cross-border payment system,CBDC cross-border payment has become an important development direction.At present,some central banks are collaborating on CBDC cross-border payment research and initiating experimental plans to explore CBDC cross-border payment arrangements.With the expansion of the acceptance range of Digital renminbi and the improvement of the international use level of CNY,oil and gas enterprises will have broad prospects in the cross-border payment field in the future.This paper suggests that oil and gas enterprises,in accordance with the principle of"from easy to difficult,step by step",give priority to the introduction of Digital renminbi from regions and fields where RMB or local currency settlement has been achieved,and combine Digital renminbi with imported oil and gas to explore the use of Digital renminbi in cross-border payment.
文摘After closing for 1,012 days due to the COVID-19 pandemic,the Jiegao border gate in Ruili City,south China’s Yunnan Province,reopened on January 8,2023.On January 14,traffic between Ruili and Muse in Myanmar resumed at the Ruili-Kyalgaung border crossing and the Sino-Myanmar Friendship Street crossing.Still,the Border Gate crossing remains closed.
基金Supported by 2023 Open Research Project of Xianning Research Institute,Hubei University of Science and Technology(XNYJY2023002)2021 Open Project of South Hubei Cultural Research Center,Hubei Provincial Key Research Base for Humanities and Social Sciences(2022XZE03).
文摘Based on a questionnaire survey and on-site research on the overview of the border tea industry,the importance of the development of border tea for ethnic unity work is analyzed,and improvement suggestions and implementation strategies are proposed.