Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury

Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently restored.However,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical research.As a traditional Chinese medicinal formulation,Sanhua Decoction has gradually gained importance in the treatment of cerebrovascular diseases.Its main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate qi.In the treatment of neurological diseases,the therapeutic effects of the Sanhua Decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral edema.Among the studies conducted to date,many have found that the application of Sanhua Decoction in the treatment of neurological diseases has clear therapeutic effects.In addition,as a natural treatment,the Sanhua Decoction has received widespread attention,given that it is safer and more effective than traditional Western medicines.Consequently,research on the mechanisms of action and efficacy of the Sanhua Decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable significance.In this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the Sanhua Decoction.We hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice.

Integration of Traditional Chinese Medicine with Modern Science is the Way Forward

On behalf of the editorial team of World Journal of Traditional Chinese Medicine(WJTCM),we would like to convey our sincere gratitude to the great efforts of our editorial board members,referees,authors,readers and all the warmhearted supporters to contribute for the journal growth in the first year of its release in 2015.

Tendon-regulating and bone-setting manipulation plus endurance resistance exercises for female with chronic neck pain

Objective:To observe the clinical efficacy of tendon-regulating and bon e-setting manipulation combined with en dura nee resistance exercises in treating female with chronic neck pain,and explore the mechanism.Methods:A total of 57 female patients with chronic neck pain who met the inclusion criteria were randomly divided into a manipulation group(29 cases)and a medium-frequency electrotherapy group(28 cases).Patients in both groups received the same endura nee exercise therapy,while those in the man ipulation group received additi onalten don-regulating and bone-setting manipulation,and those in the medium-frequency electrotherapy group received additional medium-frequency electrotherapy.Both groups were treated for 5 weeks.Before and after treatment,the neck function of patients was evaluated by visual analog scale(VAS),Analgesy-Meter,Northwick Park questionnaire(NPQ),root mean square(RMS)and median frequency(MF)of surface electromyography of sternocleidomastoid muscle and posterior cervical extensor muscle,and the patients were followed up at a month after treatment.Results:All patients completed the treatment and were followed up.Compared with the same group before treatmerrt,the VAS scores of both groups decreased,the tenderness values increased,the RMS and MF values increased,and the NPQ scores decreased after treatment(all P<0.05).The improvement of manipulation group was more notable than that of medium-frequency electrotherapy group(all P<0.05).At one-month follow-up,the VAS and NPQ scores of the manipulation group were lower than those before and after treatment,and the VAS and NPQ scores of the mediumfreq ue ncy electrotherapy group were only lower than those before treatment;the two scores of the manipulation group were lower than those of the medium-frequency electrotherapy group(both P<0.05).Conclusion:Tendon-regulating and bone-setti ng man ipulati on combi ned with endurance resista nee exe rcises can relieve neck pain and cervical dysfunction in female patients with chronic neck pain.The efficacy of this method is more durable and better than that of medium-frequency electrotherapy combined with enduranee exercises.

Quantitative research technology of tuina manipulations

Tuina is a physical therapy for treatment and prevention of diseases. The predecessors had summed up the systematic tuina manipulations through experiences. In order to study the scientificity and usability of the technology, the researchers established a mathematical model of tuina man ipulati ons, and used video tech no logy to capture the trajectory of the manipulations. Using the mechanical sensor to sense the real manipulations, researchers developed a tuina manipulation in strument and obtained a lot of basic mecha nics data about the man ipulati on tech no logy. Through the summary of the research results of the predecessors, accurate, true and comprehe nsive mecha nical parameters of tech no logy of tuina manipulations were obtained to guide the research and development of instruments of tuina manipulations, and promote the development of the discipline of tuina scienee.