Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

探讨Chinese way术式在关节镜下治疗巨大肩袖损伤的应用价值

目的探讨Chinese way术式在关节镜下治疗巨大肩袖损伤的应用价值,为临床治疗提供参考。方法选取2022年3月至2024年3月于扬州市江都中医院接受治疗的70例巨大肩袖损伤患者的临床资料,进行回顾性分析。根据治疗方式不同分为双排锚钉缝线桥组和Chinese way组,每组35例。双排锚钉缝线桥组患者采用关节镜下双排锚钉缝线桥固定术治疗,Chinese way组患者采用关节镜下Chinese way术式治疗。比较两组患者肩关节活动度、并发症发生情况、Fugl-Meyer评定量表(FMA-UE)评分。结果术后3个月,两组患者前屈、后伸、内旋、外旋的肩关节活动度均增加,且Chinese way组均大于双排锚钉缝线桥组(均P<0.05)。Chinese way组患者并发症总发生率低于双排锚钉缝线桥组(均P<0.05)。术后3个月,两组患者运动功能、感觉功能、平衡功能、关节活动度、疼痛的各项FMA-UE评分均升高,且Chinese way组均高于双排锚钉缝线桥组(均P<0.05)。结论Chinese way术式在关节镜下治疗巨大肩袖损伤的效果较好,可有效提升患者肩关节活动度和上肢运动功能,且安全性较高,值得临床应用。

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal tract.However,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence rates.When these concerns develop,traditional Chinese medicine(TCM)may have advantages.TCM is based on the concept of completeness and aims to eliminate pathogens and strengthen the body.It has the potential to prevent this condition while also boosting the rate of Helicobacter pylori eradication.This review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

Literature study on traditional Chinese medicine syndromes after renal transplantation

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,etc.still have not been effectively solved.This study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying patterns.AIM To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical research.METHODS The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically analyzed.RESULTS Following the established inclusion and exclusion criteria,13 studies were selected for analysis.Post-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM viscera.However,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the frequency.CONCLUSION Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent phase.It is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

A Contrastive Study of Honorific and Depreciatory Address Forms in Chinese,English and Japanese

Honorific and depreciatory address forms, as an indispensable part of speech communication, occur in all languages. But due to the cultural diversity, different languages require different laws and regularities in the choice of them. This paper is firstly to make a contrastive analysis of honorific and depreciatory address forms in Chinese, English and Japanese, then explore the different basic values in Chinese, American and Japanese culture and discuss their influences on honorific and depreciatory address forms in the hope of a better understanding of their pragmatic and cultural differences and an avoidance of miscommunication in intercultural interactions.

Regard History as a Mirror and Create a New World of Peace,Development and Cooperation—In Commemoration of the 60^(th) Anniversary of the Victory of the Chinese People's War of Resistance Against Japanese Aggression and the World's Anti-Fascist War

The year 2005 marks the 60th anniversary of the victory of the Chinese People’s War of Resistance Against Japanese Aggression and the world’s anti-fascist war. China and many other countries have held all kinds of activities to commemorate this event that has most deeply impacted human history. The Second World War, the crudest war

Implications of Japanese Culture for Cultural Construction of Chinese Agricultural Enterprises

The cultural construction in agricultural enterprises in China is not so optimistic especially compared with developed countries. In2015,as the Party Central Committee in China put forward strategy of building a moderately prosperous society in all aspects,it is necessary for Chinese agricultural enterprise to gain implications for cultural construction by studying Japanese culture. Japanese culture features " group spirit,interpersonal relation,absorbing advanced culture and rational spirit" as its quintessence and with " lifetime employment,annual merits,decision making on application,cooperative management ". Chinese agricultural enterprises should find ways for cultural construction which is beneficial for enhancing staff awareness and management from quintessence and outward manifestation of Japanese culture. By doing so,it will promote the cultural construction of Chinese agricultural enterprises and lift the core-competitiveness.

Chinese Dishes Popular In Japanese Restaurants

Several styles of Chinese cuisine were introduced in to Japan after the Meiji Restoration and Chinese dishes have become a must in high-class hotels and restaurants in modem Japan. The earliest Chinese restaurant in Japan, called "Yonghe," was opened in Tokyo in 1879 (the 12th year of

Buddhist Nuns in Early Medieval Japanese Sources （In Comparison With Tibetan Yoginis and Chinese Nuns）

A history of the formation of the first Buddhist Sangha in Japan in VI c. A.D. could serve as an example of the unique history of interaction between Buddhism and Japanese autochthonous religion Shinto. The first Buddhist Sangha in Japan, at the same time was also a female Buddhist community of nuns in this country. It could be assumed that the choice of the women, designed to embody the Dharma in Japan, was not accidental and was driven by the perception of the Buddha image at the time of its introduction in Japan in VI century, especially to compare with the hagiographies of Tibetan yoginis （Machig LabdrSn, Yeshe Tsogyal） and Chinese nuns （＂Bikuni Zhuan＂） of V-VII cc. With a number of similarities （persecutions of the anti-Buddhists, desire to receive a full knowledge of Dharma）, the information of the first Japanese nuns still differ considerably from the hagiographies of yoginis and Chinese Buddhist nuns. The activity of first Japanese nuns, consisted in the worship of the statue of the Buddha, rather remind the shamanistic responsibilities of the Shinto priestesses, who were the intermediates between people and gods. This is reflected in the early Japanese description of Buddhist monks and nuns in Nihon ShOki, Gangoji Garan Engi and Nihon ryOiM as the Shamanistic priests and guardians of the Buddha-imase with a special magical status, rather than the preachers of Dharma, in comparison with the Tibetan and Chinese sources.

The Changes and Characteristics of the Exchange of Chinese and Japanese Food Culture—From the Perspective of the Acceptance of Japanese Food Culture

This paper investigates the characteristics and evolution process of Sino-Japanese diet culture exchange in each historical period,analyzes the possible impact of globalization on Sino-Japanese diet culture exchange,and discusses the development direction of innovative mode of Sino-Japanese diet culture exchange under the background of globalization.

Comparative Study on Physical Fitness Test Models of Chinese, Japanese and American Students

The physical health of adolescents is related to the future of the nation and the competitiveness of the country.Through a comparative analysis of the backgrounds,organizations,testing programs and evolution processes of physical health tests in China,Japan and the United States,the three countries are explored.The development trends and problems of student physical fitness tests,find the differences,learn about the research results and experiences of physical fitness tests in Japan and the United States,draw on Japanese and American management models and successful cases,and propose some methods to optimize and improve China's physical fitness test models.It is recommended to make full use of the existing resources to promote the improvement of students'physical fitness.

A Contrastive Analysis of Chinese and Japanese Homographs and a Study on the Causes of Differences

Since ancient times,China and Japan have had a close relationship in cultural exchanges,and there are words borrowed and influenced by each other in terms of words.Therefore,there are a large number of words in the languages of China and Japan that are identical or similar in appearance,but differ in meaning or usage.As Learners of Japanese,it is necessary for us to make a comparative study of homomorphic words.This paper tries to analyze and discuss the characteristics and causes of homomorphic words based on the classification of homomorphic words from the perspective of lexicology.

An Exploratory Data Analysis of Mazu Culture Research Based on Diaolong-Full-Text Database of Ancient Chinese and Japanese Books

Mazu is the most famous goddess of canal transport in China,and one of the three folk beliefs in China.Japan is our neighbor across the sea.As early as 1000 years ago,Japan was influenced by the Mazu ceremonial culture.Through big data analysis,this study conducted database counting,screening,and analysis on the Mazu culture in Diaolong,the full-text database of Chinese and Japanese ancient books.Besides,it explored the hot topics of concern and emotional attitudes,and then analyzed the important role of Mazu culture in the cultural exchange and mutual learning between China and Japan in the new era,with a view to completing the contemporary task of“people-to-people bond”and achieving common development.

CAFIU Hosts a Webinar Themed"New Practices on Exchanges and Mutual Learning between Chinese and Japanese Civilisation on the 50th Anniversary of the Normalisation of China-Japan Diplomatic Ties"

On October 28,2022,the Chinese Association for International Understanding(CAFIU)played host to an online seminar themed"New Practices on the Exchanges and Mutual Learning between Chinese and Japanese Civilisation on the 50th Anniversary of the Normalisation of China-Japan Diplomatic Ties".Ai Ping,Vice-President of CAFIU attended the webinar.

Chinese Wushu and Japanese Judo

Wushu routine techniques were greatly developed during the Song Dynasty (960-1279), mainly to meet the demand for civilian entertainment as well as in military training. More attention began to be paid to bodywork, physical strength, and rhythm and movement design. Each routine consisted of a starting position and a finishing position.