Survival prognostic analysis of laparoscopic D2 radical resection for locally advanced gastric cancer: A multicenter cohort study

BACKGROUND With the development of minimally invasive surgical techniques,the use of laparoscopic D2 radical surgery for the treatment of locally advanced gastric cancer(GC)has gradually increased.However,the effect of this procedure on survival and prognosis remains controversial.This study evaluated the survival and prognosis of patients receiving laparoscopic D2 radical resection for the treatment of locally advanced GC to provide more reliable clinical evidence,guide clinical decision-making,optimize treatment strategies,and improve the survival rate and quality of life of patients.METHODS A retrospective cohort study was performed.Clinicopathological data from 652 patients with locally advanced GC in our hospitals from December 2013 to December 2023 were collected.There were 442 males and 210 females.The mean age was 57±12 years.All patients underwent a laparoscopic D2 radical operation for distal GC.The patients were followed up in the outpatient department and by telephone to determine their tumor recurrence,metastasis,and survival.The follow-up period ended in December 2023.Normally distributed data are expressed as the mean±SD,and normally distributed data are expressed as M(Q1,Q3)or M(range).Statistical data are expressed as absolute numbers or percentages;theχ^(2) test was used for comparisons between groups,and the Mann-Whitney U nonparametric test was used for comparisons of rank data.The life table method was used to calculate the survival rate,the Kaplan-Meier method was used to construct survival curves,the log rank test was used for survival analysis,and the Cox risk regression model was used for univariate and multifactor analysis.RESULTS The median overall survival(OS)time for the 652 patients was 81 months,with a 10-year OS rate of 46.1%.Patients with TNM stages II and III had 10-year OS rates of 59.6%and 37.5%,respectively,which were significantly different(P<0.05).Univariate analysis indicated that factors such as age,maximum tumor diameter,tumor diffe-rentiation grade(low to undifferentiated),pathological TNM stage,pathological T stage,pathological N stage(N2,N3),and postoperative chemotherapy significantly influenced the 10-year OS rate for patients with locally advanced GC following laparoscopic D2 radical resection for distal stomach cancer[hazard ratio(HR):1.45,1.64,1.45,1.64,1.37,2.05,1.30,1.68,3.08,and 0.56 with confidence intervals(CIs)of 1.15-1.84,1.32-2.03,1.05-1.77,1.62-2.59,1.05-1.61,1.17-2.42,2.15-4.41,and 0.44-0.70,respectively;P<0.05].Multifactor analysis revealed that a tumor diameter greater than 4 cm,low tumor differentiation,and pathological TNM stage III were independent risk factors for the 10-year OS rate in these patients(HR:1.48,1.44,1.81 with a 95%CI:1.19-1.84).Additionally,postoperative chemotherapy emerged as an independent protective factor for the 10-year OS rate(HR:0.57,95%CI:0.45-0.73;P<0.05).CONCLUSION A maximum tumor diameter exceeding 4 cm,low tumor differentiation,and pathological TNM stage III were identified as independent risk factors for the 10-year OS rate in patients with locally advanced GC following laparoscopic D2 radical resection for distal GC.Conversely,postoperative chemotherapy was found to be an independent protective factor for the 10-year OS rate in these patients.

Expert panel’s guideline on cervicogenic headache:The Chinese Association for the Study of Pain recommendation

Cervicogenic headache(CEH)has been recognized as a unique category of headache that can be difficult to diagnose and treat.In China,CEH patients are managed by many different specialties,and the treatment plans remain controversial.Therefore,there is a great need for comprehensive evidence-based Chinese experts’recommendations for the management of CEH.The Chinese Association for the Study of Pain asked an expert panel to develop recommendations for a series of questions that are essential for daily clinical management of patients with CEH.A group of multidisciplinary Chinese Association for the Study of Pain experts identified the clinically relevant topics in CEH.A systematic review of the literature was performed,and evidence supporting the benefits and harms for the management of CEH was summarized.Twenty-four recommendations were finally developed through expert consensus voting for evidence quality and recommendation strength.We hope this guideline provides direction for clinicians and patients making treatment decisions for the management of CEH.

Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study

Environmental exposure to heavy metals has been linked to a wide range of human health hazards. We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study （Jinchang Cohort） to directly evaluate metal exposure levels. Fifteen metals, namely As, Ba, Be, Cd, Cs, Cr, Co, Cu, Pb, Mn, Ni, Se, TI, U, and Zn, were detected by inductively coupled plasma quadruple mass spectrometry. The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group, except Se and Zn, than other reported general or occupational populations. Further studies should address the effects of heavy metals on human health.

Editorial for the special issue of the Chinese Association for the Study of Pain

The Ministry of Health of China officially issued a document,adding the first level diagnosis and treatment discipline“Algology”in the list of diagnosis and treatment subjects of medical institutions on July 16,2007.As the most important pain academic organization in China,the Chinese Association for the Study of Pain has made outstanding contributions in promoting the development of pain discipline and in establishing pain standards and disease diagnosis and treatment guidelines.In this special issue,under the leadership of Yan-Qing Liu,Chairman of the 7th Committee of the Chinese Association for the Study of Pain,nine consensus and one guideline were included.

Study on the Key to Massage Therapy of Traditional Chinese Medicine

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A Commentary on the Chinese Coronary Secondary Prevention Study

Chinese coronary secondary prevention study （CCSPS） is a key project in the field of medicine of the Ninth Five-year Plan of China, and is also called the Study of Xuezhikang Capsule （血脂康胶囊, XZK）in regulating blood lipids for secondary prevention of coronary heart diseases .Since the results of the study was publicized in June 2004 at the news release and deliberation by experts took place in the Great Hall of the People in Beijing, wide attention and high opinions have been gotten, and at the same time,

Study of Traditional Chinese Medicine in Intervening Vascular Remodeling after Percutaneous Transluminal Coronary Angioplasty

Interventional therapy of coronary heart disease (CHD) includes percutaneous transluminal coronary angioplasty (PTCA), stent implantation etc. Owing to its revascularization without cardiac surgery, it has been the main effective method in treating CHD. But at the same time, there exists the problem of restenosis (RS). After PTCA, RS

Important Progress Made in the Study of Chinese Geological Carbon Sink Potential

From 2010 to 2012, geologists at the Institute of Karst Geology the Chinese Academy of Geological Sciences carried out the ＂Chinese Geological Carbon Sink Projects Research＂. They did investigation and research work according to three aspects of carbon sink： karst, soil, and mineral, and achieved important results.

Study on Active Principle and Modernization of Chinese Drugs

The people as a whole cannot live for one day without drug, and the requirement of drugs would never come to an end or stay on the same level. Pharmaceutical industry, being of great significance, has become a new and important one in economic growth in the 21st century. Therefore, the modernization of Chinese drugs has also become a hot spot in public opinion in recent years.

Some Hot Spots in the Study of Chinese Drugs in the 21st Century

Mankind has entered the 21st century of high speed development in science and e-conomics. Owing to the alteration of disease modes in the new century, the greatly elevated quality of human life and the arrival of aged society, the modes of medicine have obviously changed from the treatment mode

FullChinese at MIT:A Non-Disruptive Integration of Technology for Intermediate Students

We describe here ten years of development of a Chinese learning technology and five years of practical experience in integrating this technology in MIT classrooms for intermediate-high and advanced-low students.Key results are as follows:There is no need to disrupt the classroom experience(both for the teacher and the students);Technology provides a sharp increase in learning efficiency and motivation,as confirmed by students;and This overall improvement in learning is achieved by focusing on the efficiency of personal study time.The most salient type of feedback from students falls into two categories:“I wouldn’t have been able to take a class at that level without FullChinese,”and“The use of technology allowed me to prepare for class two to three times faster.”Results were achieved through a slow iterative process during which our learning technology evolved to solve observed needs in acquiring complex new material.

Historical Starting Point, Contemporary Vision and World Insight——New Thinking for the Study of Ancient Chinese Capitals

The topic can be summarized in three interconnected aspects; historical starting point, contemporary vision, and world insight. The historical starting point requires the study of ancient Chinese capitals to abide by rigid academic principles and must be based on historical facts. Contemporary vision refers to the obligation to contribute to contemporary society and civilization through ancient Chinese capital research. World insight expresses our need of an integral and systematic concept to correctly assess the historical status and role of ancient Chinese capitals in the larger context to unveil the unique cultural values and historical significance of ancient capitals across China. Chengdu is an ideal case for us to explore new research approaches from the above three aspects.

THE BRIEF INTRODUCTION OF CHANGCHUN JINGYUETAN OPEN REMOTE SENSING STUDY AND TEST SITE OF THE CHINESE ACADEMY OF SCIENCES

In 1979, the Changchun Jingyuetan Remote Sensing Study and Test Site (RSSTS)began its work, and it was formally established in 1985. The RSSTS is subordinated the Changchun Branch of Chinese Academy of Sciences and is supported by the Changchun Institute of Geography and Changchun Institute of Optics and Fine Machnics, Chinese Academy of Sciences. It is under the management of the Resource & Environment Bureau of Chinese Academy of Sciences and it is the study base of remote sensing basis and application tests in China. The RSSTS is situated in the Jingyuetan scenic spot of the suburbs of Changchun City, Jilin Province. It is located at 43°40′—43°50′N and 125°18′-125°18′E.

A Study on Advertisements in The Chinese Recorder and Missionary Journal

The Chinese Recorder and Missionary Journal is one of the most valued English literature in China’s history of Christianity and the key publications of missionaries from the second half of the 19th Century to the first half of the 20th Century.The advertisements in it have not been properly stressed by the academic world,most of which are even deleted in the bound volumes.This paper aims to give a preliminary study on the advertisements in Chinese Recorder and Missionary Journal,comparing and analyzing advertisers,slogans and text structures and appeal methods of advertisements of shipping,banking,schools and book introduction in Chinese Recorder and Missionary Journal,thus demonstrating its significance in China’s modern advertising industry and Sino-western commercial trade and cultural exchange.

A PRELIMINARY STUDY OF THE EFFECTS OF CHEMOTHERAPEUTICAGENTS IN COMBINATION WITH CHINESE HERBAL COMPOUNDS AS IMMUNOMODULATORS IN MOUSE S_(180)

The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be im-munomodulators and enhance the antitumor activity of some chemotherapeutic agents.

Choosing Mandarin Senegal’s public and private schools keep up with demand for study of the Chinese language

In Dakar, Happy Kids Kindergarten has set itself an ambitious challenge： to teach Senegalese toddlers to speak Chinese. This kindergarten, located in Ngor District, boasts of being the first trilingual school in Senegal. In addition to French （the country＇s official language） and English, the school also teaches Mandarin. With China being the world＇s most popu lous country and second largest economy, there is much to benefit from it this decision.

An In-Depth Study of Complex Power System Dynamic Behavior Characteristics for Chinese UHV Power Grid Security

In this paper,a series of major policy decisions used to improve the power grid reliability,reduce the risk and losses of major power outages,and realize the modernization of 21st century power grid are discussed. These decisions were adopted by American government and would also be helpful for the strategic development of Chinese power grid. It is proposed that China should take precaution,carry out security research on the overall dynamic behaviour characteristics of the UHV grid using the complexity theory,and finally provide safeguard for the Chinese UHV grid. It is also pointed out that,due to the lack of matured approaches to controll a cascading failure,the primary duty of a system operator is to work as a "watchdog" for the grid operation security,eliminate the cumulative effect and reduce the risk and losses of major cascading outages with the help of EMS and WAMS.

Exploring Study Options African students find new opportunities to study at Chinese universities

Scholarships [for Africans studying in China] are either fully funded, by the Chinese Government or are joint scholarships that are paid for by African governments and China, with each contributing 62 percent and 3,4,percent, respectively.

General Survey of Traditional Chinese Medicine and Western Medicine Researches on Tumor Metastasis

Metastasis and recurrence of tumors is the chief cause of death for such patients. Therefore, researches on the mechanism of its metastasis, prevention and treatment are the focal points in the field of traditional Chinese medicine （TCM） and Western medicine （WM） at present. WM practitioners＂ study on tumor metastasis involved its occurrence and development including every detail and process, and now it even has developed into the molecular biological field. py is used as the main means, but the efficacy is not n treatment surgical operation and radio- chemotheratoo optimistic. In recent years, TOM, as part of the comprehensive therapy, has been gradually gaining attention of oncologists. Aimed at solving the difficult problems in metastasis of tumor, many TOM practitioners on the basis of syndrome differentiation have raised theories about the cause of tumor metastasis. On the basis of these theories, some TOM recipes against tumor metastasis have been developed to serve as an effective supplement to surgical operation, radio- and chemotherapy. The present article summarizes research results in recent years about the cause of formation of tumor and its metastasis by TOM and WM, so as to offer some theoretical clues to the study of tumors metastasis.