The efficacy and safety of anti-humidification traditional Chinese medicine in the treatment of viral pneumonia: A meta-analysis

Objective A meta-analysis was used to evaluate the efficacy and safety of traditional Chinese medicine(TCM)for dispelling dampness in the treatment of viral pneumonia.Methods The databases of CNKI,CBM,WanFang data,VIP,EMBASE,PubMed,and Cochrane library were searched,and the clinical trials of dispelling dampness TCM in the treatment of viral pneumonia were selected.The retrieval period is from the establishment of the database to December 2022.Stata 17.0 software was used to perform meta-analysis,and review manager 5.3 software was used to assess the risk of bias.Overall efficacy was evaluated by OR,and improvement in major clinical symptoms were evaluated by RR.Results A total of 20 randomized controlled trials were included,with a total of 2136 patients,including 1180 patients in the experimental group and 956 patients in the control group.Meta-analysis showed that TCM for dispelling dampness could significantly improve the efficacy of viral pneumonia patients[OR=2.652,95%CI=(2.187,3.217),Z=9.908,P<0.05];The child with abnormal lung X-rays returned to normal after treatment[RR=4.23,95%CI=(2.42,7.42),Z=5.04,P<0.05];In addition,patients had fewer adverse reactions to dispelling dampness TCM,and the safety of the trial was good.Conclusion This Meta-analysis further clarified the efficacy of TCM for dispelling dampness in the treatment of viral pneumonia by combining clinical data and has suggestive significance for the treatment of novel coronavirus pneumonia.

Analysis of knowledge graph based on CiteSpace research on the treatment of pediatric pneumonia with traditional Chinese medicine

Objective:Based on the CiteSpace tool,this study makes a visualization analysis on the treatment of infantile pneumonia with traditional Chinese medicine in the past 20 years,so as to explore the development status,research hotspots and frontier trends of the treatment of infantile pneumonia with traditional Chinese medicine,and provide a reference for the research on the treatment of infantile pneumonia and related diseases with traditional Chinese medicine.Methods:A total of 645 literatures related to the treatment of pediatric pneumonia with traditional Chinese medicine were retrieved from CNKI.The visual atlas was made by year,author,institution and key words,and the co-occurrence,clustering and emergence analysis were performed.Results:The related literatures span from January 2001 to February 2021,and the number of related literatures showed an obvious increasing trend,with an average annual publication of 38 papers.From 2002 to 2014,the increase was the most obvious,and began to show a gentle growth trend in 2015.Twelve main clusters were obtained by keyword cluster analysis.Emergent analysis results in a total of 19 emergent words,which are composed of 439 nodes and 1,452 lines in total.There are different research hotspots in different periods,and in the past five years,the clinical efficacy of traditional Chinese medicine in the treatment of infantile pneumonia and the related research of traditional Chinese medicine characteristic nursing has become a contemporary hot spot.Conclusion:At present,the research on the treatment of children's pneumonia with traditional Chinese medicine shows an increasing trend.There is still a lack of continuity among various studies.The cooperation between the authors and various institutions is low.Moreover,the research direction in this field mainly focuses on children's mycoplasma pneumonia.In addition,the clinical efficacy observation of the combination of traditional Chinese medicine and azithromycin in the treatment of children's pneumonia will become a hot topic in the future.In addition to the research focus in this field,the clinical efficacy of TCM(traditional Chinese medicine)in the treatment of infantile pneumonia and the characteristic nursing of traditional Chinese medicine may still become one of the hot spots in the future.

Analysis of diagnosis and treatment of traditional Chinese medicine for COVID-19 nucleic acid

Since the outbreak of coronavirus disease 2019(COVID-19),the author has been involved in the treatment of COVID-19 in the first line.It is found that some patients had a long viral nucleic acid negative time,and even the course of the disease lasted more than 40 days.After a thorough investigation of the root causes,it is found the four possible causes were:"Blood stasis syndrome"is difficult to remove;"Damp heat"sticky greasy;Stubborn basic diseases;weak constitution.All the patients treated with traditional Chinese medicine have turned negative,and now the typical cases were analyzed and summarized in order to provide reference for the traditional Chinese medicine treatment and scientific research of the patients with COVID-19 who were difficult to turn negative.

The Influence of Integrated Chinese and Western Medicine Treatment on the Quality of Life and Laboratory Indicators of Patients with Novel Coronavirus Pneumonia

Objective: To investigate the influence of integrated Chinese and Western medicine treatment on the quality of life and laboratory indicators of patients with novel coronavirus pneumonia (COVID-19). Methods: A prospective, self-controlled study was conducted to analyze the changes in corresponding laboratory indicators and quality of life in 75 confirmed COVID-19 patients treated with integrated Chinese and Western medicine in our hospital during the early stage, middle stage, recovery period, and two weeks after discharge. The effectiveness and safety of the treatment regimen were evaluated in conjunction with the time for 2019-nCoV nucleic acid conversion, disease progression, and adverse reactions. Results: The PLT levels in the initial stage were significantly lower than those in the recovery period in 75 patients. The CRP levels in the initial stage were significantly lower than those after discharge for 2 weeks. The TBIL, IBTL, and DHIL levels in the initial stage were significantly lower than those in the middle stage. The K+ levels in the initial stage were significantly lower than those in the recovery period and after discharge for 2 weeks. The LYMGH levels in the initial stage were significantly lower than those in the recovery period and after discharge for 2 weeks. The TP and ALB levels in the initial stage were higher than those in the middle stage and the recovery period. The LDH levels, scores of daily activity limitation, scores of respiratory distress symptoms, scores of psychological emotions, CT imaging scores, and positive rate of nucleic acid were significantly lower than those in the recovery period and after discharge for 2 weeks. The AG, CK, CK-MB, and α-HBDH levels in the initial stage were significantly higher than those in the recovery period. However, the AMY level in the initial stage was significantly lower than that in the recovery period and after discharge for 2 weeks (p Conclusion: Integrated Chinese and Western medicine treatment has a significant impact on laboratory indicators such as PLT, LYMGH, CRP, TBIL, IBTL, DHIL, TP, ALB, K+, AG, LDH, CK, CK-MB, α-HBDH, AMY, CT imaging, and 2019-nCoV nucleic acid in COVID-19 patients. It has good clinical efficacy and safety, and can improve the quality of life of patients.

Research Progress of Combination of Traditional Chinese and Western Medicine in Treatment of Infertility in Older Women

The main cause of infertility in elderly women is poor ovarian function,decreased quality and number of oocytes,which ultimately leads to poor fertility.Low ovarian function is the most difficult point in the research of reproductive medicine and reproductive health.At present,the treatment of integrated traditional Chinese and Western medicine has gradually achieved results.Western medicine mainly regulates endocrine and assisted reproductive treatment by supplementing estrogen and progesterone,while traditional Chinese medicine(TCM)mainly focuses on invigorating the kidney,adding and subtracting according to the syndrome.The treatment effect of TCM or western medicine alone is not significant.Many clinical observations show that integrated TCM and western medicine focuses on the specialties of western medicine,which not only makes up for the insufficiency of the slow action of TCM,but also improves its clinical efficacy when combined with western medicine.Based on domestic and foreign research,this article summarizes the treatment of infertility in elderly women with integrated TCM and western medicine.

Analysis of novel coronavirus pneumonia treatment with Chinese herbal compound

Objective: To analyze the prescription law of TCM compound in the treatment of new coronavirus pneumonia, and provides reference for the clinical treatment of new coronavirus pneumonia. Methods: Collected Collected 24 novel coronavirus pneumonia related diagnostic and therapeutic plans issued by the National Health Council and the Chinese medicine authority from January 26, 2020 to March 8th ,the filtered solution involved in the formula, establishing database of traditional Chinese medicine compound prescription for the treatment of new crown pneumonia, the frequency of using frequency analysis methods of analysis and clustering analysis and association rules analysis to sort out data mining analysis of traditional Chinese medicine compound. Results: In this study, a total of 159 TCM compounds were included in the treatment of new crown pneumonia from the country and 23 provinces, municipalities and autonomous regions, involving 189 TCM compounds. A total of 62 high-frequency traditional Chinese medicines (frequency ≥ 11) were obtained, mainly including licorice, almond, ephedra, gypsum, Poria cocos, Huoxiang, etc The drug types are mainly heat-clearing drugs, vacuous drugs, moisture-curing drugs, and surfactant drugs. The main effect of the medicine was warm, cold, lukewarm and flat, the main effect of the medicine was bitter and bitter, and the main effect of the medicine was the lung, stomach and spleen. Cluster analysis results according to the performance of traditional Chinese medicine treatment of new crown pneumonia high frequency drugs into 7 classes;Association rule analysis results in 29 common drug pairs. Conclusion: In the treatment of pneumonia caused by new coronavirus infection with traditional Chinese medicine, the following characteristics are presented: the number of times of supplementing qi and Yin is more than that of attacking evil and maintaining health;The method of dispersing and solving the attack of wet, beneficial, wet, permeable and wet medicine fully embodies a variety of ways to drive away evil;In terms of drugs, heat-clearing drugs, deficiency drugs, dampness drugs and surface drugs are the main ones, highlighting that the basic treatment method is to dissolve dampness and detoxify, and replenish qi and Yin. In summary, this study can provide reference for guiding clinical drug use and developing new drugs.

Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study

As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound challenge.This study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational study.All patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct treatment.Clinical characteristics during the treatment period and the clinical outcome of each patient were closely monitored and analysed.Our findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients.

Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia(NCP)

The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medicine has accumulated a solid theoretical foundation of plague in ancient and recent decades. Meanwhile, Traditional Chinese Medicine can provide the more effective and personalized treatment via adjusting the specific medicine for each patient based on the different syndromes. In addition, TCM often has different effect on the distinct stages of diseases, contributing to the prevention, treatment and rehabilitation. Nowadays, TCM has exhibited decent effect in the in the fight against NCP. Therefore, it is convinced that Traditional Chinese Medicine is an effective treatment for 2019 novel coronavirus pneumonia.

Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine

Since the outbreak of novel coronavirus pneumonia(coronavirus disease 2019,COVID-19),it has rapidly spread to 187 countries,causing serious harm to the health of people and a huge social burden.However,currently,drugs specifically approved for clinical use are not available,except for vaccines against COVID-19 that are being evaluated.Traditional Chinese medicine(TCM)is capable of performing syndrome differentiation and treatment according to the clinical manifestations of patients,and has a better ability of epidemic prevention and control.The authors comprehensively analyzed the etiology and pathogenesis of COVID-19 based on the theory of TCM,and discussed its syndrome differentiation,treatment and prevention measures so as to provide strategies and reference for the prevention and treatment with TCM.

一株大口黑鲈源ST-873型肺炎克雷伯菌(Klebsiella pneumoniae)的分离鉴定及生物学特性研究

从患腹水病大口黑鲈(Micropterus salmoides)的头肾、脾脏、肝脏组织中分离到一株优势菌,生长出圆形、边缘整齐的灰白色黏液状菌落;染色镜检可见短粗、卵圆形、有荚膜的革兰氏阴性杆菌。结合形态、生理生化特征、16S rRNA基因序列分析鉴定为肺炎克雷伯菌(Klebsiella pneumoniae),MLST分析进一步确定其为ST-873型,与ST-65型聚为一支;该菌株携带aere、alls、wca和ybt四种毒力基因,具有溶血活性;人工感染大口黑鲈,发现患病鱼呈现腹水等与自然发病类似的症状,且病鱼内脏的分离菌株与攻毒菌株相同;经统计,其LD50为3.4×10^(7) CFU/mL,具有中等生物被膜形成能力。耐药性分析结果显示,该菌株携带bla-shv、sul2、aadA和tetB四种耐药基因,对β-内酰胺类、氨基糖苷类、喹诺酮类、黏菌素类药物敏感,对四环素类、磺胺类、林可酰胺类、利福霉素类耐药;中药三七、款冬花对分离菌株有明显抑制作用。研究探明了大口黑鲈腹水病的主要病原,可为鱼源肺炎克雷伯菌的诊断和防治提供科学依据和数据参考。

Yinlai decoction alleviates lipopolysaccharide-induced pneumonia by changing the immune status of juvenile rats:A study based on network pharmacology

Objective:Pediatric pneumonia is a common respiratory disease and Yinlai Decoction (YLD) is a commonly used treatment in China.We explored the anti-inflammatory mechanism of action of this traditional Chinese medicine for pneumonia.Methods:We studied,by experimentation,the mechanism of action of YLD in treating pneumonia according to network pharmacology.By comparing YLD with dexamethasone (DXMS),we investigated the efficacy of YLD in treating pneumonia induced by lipopolysaccharide (LPS) in juvenile rats.Results:In an aqueous extract of YLD,22 chemical compounds were identified,among which 10 were related to inflammation,involving 78 target genes and 16 signaling pathways.Among them,45 core target proteins were related to biologic processes and functions,such as response to stimuli,biologic regulation,cell communication and protein binding.Animal experiments showed that YLD relieved pulmonary inflammation and demonstrated no significant damage to the liver,spleen or kidneys of rats.YLD could regulate expression of inflammatory cytokines in serum and inflammation-related proteins in lung tissues to some extent,but its effect is less significant than that of DXMS.Conclusions:YLD protected juvenile rats against LPS-induced pneumonia,and showed fewer side effects in comparison with DXMMS.YLD could be efficacious treatment for pediatric respiratory infections and even pneumonia.

Interpretation of Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)

On March 3,2020,the National Health Commission and the National Administration of Traditional Chinese Medicine of China jointly promulgated the Notice on Printing and Distributing the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7).The content has been revised and supplemented on the basis of the Version 6,including etiological characteristics and pathological changes in lung,heart,kidney,spleen,liver,gallbladder,esophagus,stomach and intestinal mucosal epithelium.In particular,the diagnosis and treatment methods of traditional Chinese medicine are supplemented.It provides an evidence-based diagnosis and treatment protocol for the treatment and recovery of suspected and confirmed cases of novel coronavirus pneumonia with traditional Chinese medicine and Western medicine.

The Experience of Treating Patients with Pneumonia Secondary to the Coronavirus Disease 2019 Using the Guizhi Method of Traditional Chinese Medicine

This paper is a discussion of Professor Tang Nong’s approach to the diagnosis and treatment of the coronavirus disease 2019(COVID-19)while providing a case report at the end.Professor Tang Nong considered that the main etiologies of the disease are"cold,wet,and poisonous."He suggested resolving the body’s dampness by balancing internal organ functions,detoxifying the lungs,and providing heat.However,the treatment of cold with herbs and cleansing heat must not be performed too early to prevent the spread of the disease.Using principles from the basic theory of Fuyang Pai from traditional Chinese medicine(TCM),this project used the Huashi Qingfei immune formula(modified Guizhi Erchen decoction),which has been shown to be effective,to treat patients diagnosed with COVID-19.At present,the participation of TCM in our hospital is over 96%with a cure rate of approximately 90%.

Clinical Observation of Senile Idiopathic Nephrotic Syndrome Treated with Integrated Traditional Chinese and Western Medicine

Objective: To observe the clinical effect of integrated traditional Chinese and western medicine (TCM-WM) in treating senile idiopathic nephrotic syndrome (SINS). Methods: Eighty-two patients of SINS were randomly divided into two groups. The 41 patients in the TCM-WM group were treated with prednisone, Cytoxan (CTX) and Chinese medicinal herbs according to Syndrome-type, and the 41 patients in the control group were treated with western medicine alone. The clinical remission rate and time, recurrence rate in patients as well as adverse reaction rate occurred were observed. Results: The complete remission rate and total effective rate of the TCM-WM group were 58.5% and 85.4%, which were significantly higher than those of the control group (39.0% and 63.4%, P<0.01). The adverse reaction rate in the TCM-WM group was 36.6%, which was significantly lower than that of the control group (80.5%, P<0.01). A follow-up of 35.1±9.7 months showed that there was no significant difference in the recurrence rate between the two groups (P>0.05), but the average remission period (30.6±3.8 months) of the TCM-WM group was significantly longer than that of the control group (12.7±3.7 months, P<0.01). Conclusion: TCM-WM treatment is obviously superior to that with western medicine alone in increasing clinical remission rate, relieving adverse reaction rate and extending remission period.

Fifty Patients of Infantile Protracted Chronic Pneumonia Treated withIntegrated Traditional Chinese and Western Medicine

Objective: To investigate the effects of integrated traditional Chinese and Western medicine in treating infantile protracted chronic pneumonia （IPCP）. Methods: One hundred patients of IPCP were divided equally into two groups, the TCM-WM group treated with Maqin Qizhu Decoction combining with antibiotics and the control group treated with antibiotics alone. Efficacy of the two groups was compared after 1 course（15）days） of treatment. Results: The total effective rate of the TCM-WM group was better than that of the control group. Moreover, the days needed in curing coughing, dyspnea, rales and X-ray shadow absorption of the former were fewer than those of the latter. Conclusion: The integrated TCM-WM therapy in treating IPCP could both inhibit the pathogens effectively and improve the humoral immunity and resistant ability of organism.

中医药基于“扶正宣肺”治则抗病毒性肺炎作用研究

病毒性肺炎是发生率较高的一种疾病,其中感染病毒是一个主要诱发因素。对于病毒性肺炎,西医主要采用对症治疗,以抗病毒药物为主,但是随着用药时间的延长,容易出现耐药性,并且不良反应多,可降低患者耐受性。而在瘟疫类疾病的预防和治疗中,“扶正祛邪”有着重要的历史地位,并且现代药理学研究表明,这一治法可以使机体免疫状态得到改善。论文以“扶正、宣肺”的原则为基本出发点,在对相关资料进行分析的基础上,阐述病毒性肺炎的中药治疗进展,明确其作用机制,以促进临床治疗水平的提高。

基于调控免疫炎症微血管损伤的补气活血法治疗肺炎“瘥后防复”思路的提出

肺炎恢复期后遗症严重影响患者身心健康,存在二次感染的风险,且与基础病相互影响导致恶性循环。做好肺炎恢复期康复工作,减少后遗症并预防反复发作是疾病防治的首选。研究显示肺炎长期后遗症和反复发作的机制可能与持续的机体免疫抑制和全身微炎症状态及微血管损伤有关。团队根据传统中医理论,结合长期临床与基础研究,提出“气虚血瘀”是肺炎恢复期的核心病机。因此,团队提出补气活血法治疗肺炎“瘥后防复”的机制与调控免疫炎症微血管损伤有关,调控T淋巴细胞紊乱提高免疫、抑制炎症因子改善机体微炎症状态和抗氧化保护内皮细胞调控微血管损伤,阐明其内在机制将为中医药治疗呼吸系统重大感染性疾病提供理论依据,传承精华、守正创新。

四物润燥止痒合剂方治疗血虚风燥型老年皮肤瘙痒症临床研究

目的观察四物润燥止痒合剂方治疗老年皮肤瘙痒症(SP)的临床疗效和安全性。方法将120例老年SP患者按随机数字表法分为2组,治疗组60例在一般治疗的基础上采用四物润燥止痒合剂方治疗,对照组60例在一般治疗的基础上采用润燥止痒胶囊治疗,疗程4周,每2周随访1次,治疗结束后随访2个月,评估2组临床疗效和不良反应发生及复发的情况。结果治疗组58例完成全程治疗和随访,对照组56例完成全程治疗和随访。治疗2周后,2组的瘙痒程度评分较治疗前明显降低,且治疗组评分低于对照组同期(P<0.05);治疗4周后,2组的瘙痒程度评分进一步降低,治疗组仍低于对照组,但2组评分比较差异无统计学意义(P>0.05)。治疗2周,治疗组有效率68.96%(40/58),对照组有效率50.00%(28/56),治疗组有效率高于对照组(P<0.05);治疗4周,治疗组有效率82.76%(48/58),对照组有效率78.57%(44/56),2组比较差异无统计学意义(P>0.05)。治疗组止痒起效短于对照组(P<0.05)。治疗组不良反应发生率5.17%(3/58),对照组不良反应发生率3.57%(2/56),2组比较差异无统计学意义(P>0.05)。2个月后随访,治疗组复发率低于对照组(P<0.05)。结论四物润燥止痒合剂方治疗血虚风燥型老年SP疗效显著,起效快,不良反应少,能显著减少复发,值得临床推广应用。

484例儿童大叶性肺炎临床资料回顾性分析

目的总结儿童大叶性肺炎的临床特点,分析中医药治疗本病的疗效,为临床诊治提供参考。方法对2021年3月至2024年2月在江苏省中医院儿科住院的484例大叶性肺炎患儿临床资料进行回顾性分析,总结大叶性肺炎的临床特点,通过分析退热时间、啰音消失时间、并发症的发生率、住院时间等探讨中医药治疗本病的优势。结果484例大叶性肺炎患儿男性236例、女性248例,发病年龄以2~10岁最为常见,多见于冬春季节。中医证型方面,痰热闭肺证和毒热闭肺证多见,共436例约占90.08%,风热闭肺证次之。中药组患儿治疗后退热时间、出院时咳嗽评分、啰音消失时间、住院天数、并发症的合并率明显低于对照组(P<0.05);化瘀中药组患儿在湿啰音消失时间、住院天数、出院时咳嗽评分、并发症的发生率方面明显低于基础中药组(P<0.05),有效率明显高于基础中药组和对照组(P<0.05)。结论在常规抗感染等治疗的基础上辨证加用中药治疗大叶性肺炎能促进啰音吸收、减少并发症发生、缩短病程;在常规中药的基础上加用活血化瘀之品疗效更佳。