Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM-WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism.Methods: Ninety-one repeated...Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM-WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism.Methods: Ninety-one repeatedly recurrent CPN patients were randomly divided into 2 groups, the control group (45 cases) treated with sufficient amount of sensitive antibiotics and other WM, the treated group (46 cases) treated with above-mentioned WM complemented with TCM syndrome differentiation (SD).Results: In the treated group completely cured was 14 cases (30.4%), markedly effective 14 cases (30.4%), the total effective rate was 91.3%; while that of the control group was 4 (8.9%), 5 (11.1%), and 48.9% respectively, (P < 0.05) and (P < 0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6±12.6 days and 24.3±11.5 days, obviously shorter than those of the control group (35.6±14.6 days and 53.6±16.4 days),P<0.01; the various symptoms of the treated group improved or disappeared in a short time, while in the control group a few patients improved in a longer period (P < 0.01); the various immune parameters improved in the treated group, while in the control group only IgA was elevated to some extent (P < 0.05), in comparing these data, the difference was significant (P < 0.01).Conclusion: The TCM-WM integrative treatment could obviously raise the clinical efficacy, accelerate the symptom improvement, and enhance the immune function.展开更多
目的:利用Meta分析方法对养阴活血类中药复方治疗放射性肺炎的作用进行系统评价。方法:检索PubMed、Embase、Medline、中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、维普中文科技期刊全文数据库(Vip Chinese Sci...目的:利用Meta分析方法对养阴活血类中药复方治疗放射性肺炎的作用进行系统评价。方法:检索PubMed、Embase、Medline、中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、维普中文科技期刊全文数据库(Vip Chinese Science and Technology Journal Database,VIP)及万方数据库(WanFang Data)等常用中、英文数据库,检索时间为从建库至2020年5月1日,筛选符合纳入标准的文献进行系统评价。结果:共纳入40项研究,涉及2528例患者。总有效率观察组优于对照组(P<0.01,RR=1.32,95%CI[1.27,1.38]);治疗后观察组影像学改善优于对照组(P<0.01,SMD=1.12,95%CI[1.01,1.25]),血浆白细胞介素6(interleukin-6,IL-6)变化较对照组明显(P<0.01,SMD=-0.96,95%CI[-1.18,-0.75]);血浆肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、血浆转化生长因子β(transforming growth factor-β,TGF-β)水平两组治疗后比较差异无统计学意义;治疗后观察组VC改善优于对照组(P<0.01,SMD=0.74,95%CI[0.50,0.99]);治疗后观察组第一秒用力肺活量/潮气量比值(first second forced vital capacity/tidal volume,FEV1/FVC)百分比缓解优于对照组(P<0.01,SMD=0.65,95%CI[0.41,0.90])。结论:养阴活血类中药复方在放射性肺炎患者总有效率、影像学、IL-6水平及肺功能(VC、FEV1/FVC百分比)方面有疗效优势。展开更多
文摘Objective: To explore the clinical efficacy of Chinese and western integrative medicine (TCM-WM) in treating repeatedly recurrent chronic pyelonephritis (CPN) and its therapeutic mechanism.Methods: Ninety-one repeatedly recurrent CPN patients were randomly divided into 2 groups, the control group (45 cases) treated with sufficient amount of sensitive antibiotics and other WM, the treated group (46 cases) treated with above-mentioned WM complemented with TCM syndrome differentiation (SD).Results: In the treated group completely cured was 14 cases (30.4%), markedly effective 14 cases (30.4%), the total effective rate was 91.3%; while that of the control group was 4 (8.9%), 5 (11.1%), and 48.9% respectively, (P < 0.05) and (P < 0.01); the mean days of urinary bacteria and urinary routine negative conversion were in the treated group 19.6±12.6 days and 24.3±11.5 days, obviously shorter than those of the control group (35.6±14.6 days and 53.6±16.4 days),P<0.01; the various symptoms of the treated group improved or disappeared in a short time, while in the control group a few patients improved in a longer period (P < 0.01); the various immune parameters improved in the treated group, while in the control group only IgA was elevated to some extent (P < 0.05), in comparing these data, the difference was significant (P < 0.01).Conclusion: The TCM-WM integrative treatment could obviously raise the clinical efficacy, accelerate the symptom improvement, and enhance the immune function.
文摘目的:利用Meta分析方法对养阴活血类中药复方治疗放射性肺炎的作用进行系统评价。方法:检索PubMed、Embase、Medline、中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、维普中文科技期刊全文数据库(Vip Chinese Science and Technology Journal Database,VIP)及万方数据库(WanFang Data)等常用中、英文数据库,检索时间为从建库至2020年5月1日,筛选符合纳入标准的文献进行系统评价。结果:共纳入40项研究,涉及2528例患者。总有效率观察组优于对照组(P<0.01,RR=1.32,95%CI[1.27,1.38]);治疗后观察组影像学改善优于对照组(P<0.01,SMD=1.12,95%CI[1.01,1.25]),血浆白细胞介素6(interleukin-6,IL-6)变化较对照组明显(P<0.01,SMD=-0.96,95%CI[-1.18,-0.75]);血浆肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、血浆转化生长因子β(transforming growth factor-β,TGF-β)水平两组治疗后比较差异无统计学意义;治疗后观察组VC改善优于对照组(P<0.01,SMD=0.74,95%CI[0.50,0.99]);治疗后观察组第一秒用力肺活量/潮气量比值(first second forced vital capacity/tidal volume,FEV1/FVC)百分比缓解优于对照组(P<0.01,SMD=0.65,95%CI[0.41,0.90])。结论:养阴活血类中药复方在放射性肺炎患者总有效率、影像学、IL-6水平及肺功能(VC、FEV1/FVC百分比)方面有疗效优势。
