Research Progress in Traditional Chinese Medicine Treatment of Knee Osteoarthritis

Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee joint.Initially,knee joint pain is the main symptom,and in the later stages,deformities and mobility disorders may occur.Modern medicine lacks effective treatment methods for early and mid stage KOA,and has drawbacks such as significant side effects and high costs.A large number of stud‐ies have confirmed that traditional Chinese medicine has unique advantages in treating KOA,and has obvious advantages such as small trauma,low cost,and definite therapeu‐tic effect,which are gradually being accepted by a large number of KOA patients.The commonly used methods for preventing and treating KOA with traditional Chinese medicine in clinical practice include:oral administration of traditional Chinese medi‐cine,external application of traditional Chinese medicine,fumigation,acupuncture therapy,massage therapy for regulating tendons,and targeted penetration therapy of tra‐ditional Chinese medicine.According to relevant literature,traditional Chinese medicine can significantly alleviate knee joint symptoms and improve knee joint function in patients with knee osteoarthritis,which is of great significance for the prevention and treatment of knee osteoarthritis.This article provides a review of the research progress in the prevention and treatment of KOA using traditional Chinese medicine in recent years.

Research progress on the mechanism of traditional Chinese medicine in the treatment of autoimmune hepatitis

Autoimmune hepatitis is an inflammatory liver disease primarily mediated by T cell.It has not been fully elucidated about the pathogenesis,and it is presently thought to be related to genetic susceptibility,infection and environmental triggers,and abnormal autoimmune regulation.Recent studies have found that traditional Chinese medicine can improve the biochemical indicators and clinical symptoms of patients with autoimmune hepatitis.This article reviews the specific mechanism of traditional Chinese medicine on treating autoimmune hepatitis in order to propose new ideas for its clinical diagnosis and treatment.

Research Progress in the Treatment of Poststroke Depression with Traditional Chinese Medicine

In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of stroke patients.Traditional Chinese medicine has signifi‐cant therapeutic effects in treating this disease.This article provides a classification and review of traditional Chinese medicine treatment methods for post-stroke depression,and looks forward to the current problems.

Research Progress on Combined Chinese and Western Medicine Treatment of Mycoplasma pneumoniae Pneumonia in Children

With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research hotspot.As a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and improved.This article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in children.The article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in detail.The article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.

Research Progress of Traditional Chinese Medicine External Treatment for Cancer Pain

Cancer pain,as a common complication in patients with malignant tumors,is regarded as the fifth vital sign.The involvement of traditional Chinese medicine(TCM)in the treatment of malignant tumors has become a distinctive feature of oncology treatment in China.It is also an important component of cancer pain management.TCM analgesic treatments include various methods,such as internal medicine and external therapies.External analgesic therapies,in particular,are significant methods in TCM pain management and offer both local treatment and systemic regulation.These methods are simple,easy to perform,and non-invasive.They can enhance pain relief effects while reducing the difficulty of oral medication intake and avoiding adverse gastrointestinal reactions,providing new perspectives and approaches for cancer pain treatment with broad development prospects.This article provides a review of the external TCM therapies for cancer pain to share with peers in the field.

Understandings of Urban Sustainability in China:a Bibliometric Analysis Using Chinese Literatures

Cities hold a critical responsibility for achieving the Sustainable Development Goals(SDGs)due to their high population density,extensive resource consumption,and significant economic contributions.To examine the present state of understandings regarding urban sustainability(SDG 11:Sustainable Cities and Communities)within Chinese research communities,this study collected 15950 papers from 1994 to 2022 on the 12 indicators of SDG 11,from the China National Knowledge Infrastructure(CNKI),a hub of Chinese academic papers,that directly relate to policymaking.Significant research topics on SDG 11 were identified for each indicator using bibliometrics analysis approaches.The high-frequency keywords and clusters of keywords over the last three decades reveal that existing studies primarily concentrated on the physical aspects,such as transportation and environment,while there is a lack of consideration of societal aspects.This indicates a limited and biased understanding of the urban sustainability within the Chinese academic community.Hence,it is crucial to prioritize the societal aspects in order to develop a research agenda that further advances urban sustainability.

Research progress of integrated traditional Chinese and Western medicine in the treatment of advanced gastric cancer

Gastric cancer(GC)is a malignant tumor originating from the gastric epithelium,and its incidence and mortality rates rank third among all malignant tumors worldwide.It is also one of the most common cancers in China and is treated predominantly by Western medicine in clinical practice.However,with the advancements in medical technology and informatics,the values of traditional Chinese medicine(TCM)in preventing and treating GC and improving prognosis have increasingly been recognized.According to TCM,clinical manifestations of GC can be divided into Yege(dysphagia),regurgitation,stomach pain,and Zhengxia(abdominal mass).Due to the unbalanced distribution of health care resources in China,most GC patients already have progressive or advanced-stage disease at the first diagnosis.As a result,most GC patients have poor physical function,and surgery or chemotherapy alone will aggravate the impairment to the immune function and seriously affect the quality of life.In contrast,TCM therapies have shown promising efficacy in the management of these patients.Here we review the role of the integrated TCM and Western medicine in treating advanced GC.

Research misconduct in hospitals is spreading:A bibliometric analysis of retracted papers from Chinese university-affiliated hospitals

Purpose: The number of retracted papers from Chinese university-affiliated hospitals is increasing, which has raised much concern. The aim of this study is to analyze the retracted papers from university-affiliated hospitals in China’s mainland from 2000 to 2021. Design/methodology/approach: Data for 1,031 retracted papers were identified from the Web of Science Core collection database. The information of the hospitals involved was obtained from their official websites. We analyzed the chronological changes, journal distribution, discipline distribution and retraction reasons for the retracted papers. The grade and geographic locations of the hospitals involved were explored as well.Findings: We found a rapid increase in the number of retracted papers, while the retraction time interval is decreasing. The main reasons for retraction are plagiarism/self-plagiarism(n=255), invalid data/images/conclusions(n=212), fake peer review(n=175) and honesty error(n=163). The disciplines are mainly distributed in oncology(n=320), pharmacology & pharmacy(n=198) and research & experimental medicine(n=166). About 43.8% of the retracted papers were from hospitals affiliated with prestigious universities. Research limitations: This study fails to differentiate between retractions due to honest error and retractions due to research misconduct. We believe that there is a fundamental difference between honest error retractions and misconduct retractions. Another limitation is that authors of the retracted papers have not been analyzed in this study.Practical implications: This study provides a reference for addressing research misconduct in Chinese university-affiliated hospitals. It is our recommendation that universities and hospitals should educate all their staff about the basic norms of research integrity, punish authors of scientific misconduct retracted papers, and reform the unreasonable evaluation system.Originality/value: Based on the analysis of retracted papers, this study further analyzes the characteristics of institutions of retracted papers, which may deepen the research on retracted papers and provide a new perspective to understand the retraction phenomenon.

Research progress of related signal pathways in the prevention and treatment of heart failure with traditional Chinese medicine

Heart failure(HF)is a kind of continuous development syndrome of cardiac insufficiency caused by various heart diseases.Not only does the prevalence continue to rise,but the mortality rate and readmission rate remain high.Heart failure is also the end-stage of cardiovascular disease and the main cause of death of patients,which seriously affects the health and quality of life of people all over the world.Ventricular remodeling plays a key role in the occurrence and development of heart failure.Therefore,by improving ventricular remodeling,it is of important research value to explore the intervention of traditional Chinese medicine in the development of heart failure.Studies have shown that the mediation of multiple signaling pathways can lead to progressive aggravation of ventricular remodeling,and experimental studies often confirm the therapeutic effects of traditional Chinese medicine.Traditional Chinese medicine usually achieves the therapeutic effect of heart failure through multiple targets and multiple approaches.In recent years,there have been more and more researches on the role and mechanism of Chinese medicine intervention in heart failure.However,it is concluded that Chinese medicine intervention has less influence on heart failure signal pathways.This article summarizes the understanding of Chinese medicine on heart failure and the five signal pathways related to Chinese medicine intervention in heart failure.The 5 signaling pathways in the world,namely transforming growth factor-β1(TGF-β1)/signal transduction protein(Smads)signaling pathway,Toll-like receptor(TLR)/nuclear transcription factor-κB(NF-κB)inflammation signaling pathway,Renin-angiotensinaldosterone(RAAS)system,phosphoinositide 3-kinase(PI3K)-serine/threonine protein kinase(AKT)signaling pathway and mitogen-activated protein kinase(MAPK)dependent signaling pathway.

The Modernization of Traditional Chinese Opera and a Local Perspective of Local Operas:A Case Study of the Research on the Yisu Art Troupe by Li Youjun and Guo Hongjun

From both historical and artistic points of view,Qinqiang Opera can be considered a significant genre outside the realms of Peking Opera and Kunqu Opera.The research on Qinqiang Opera has long been a focal point in the research on local operas with particular emphasis from a local perspective of the Yisu Art Troupe,a key and hot topic in the studies of Qinqiang Opera.Taking the Yisu Art Troupe as a case study to scrutinize and address the intricacies within the process of modernization of traditional Chinese opera proved to be beneficial.Since the 20th century,studies on the Yisu Art Troupe have evolved from scattered and impressionistic self-narratives into systematic and theoretical academic research.In the new century,scholars,such as Xin Xuefeng,Li Youjun,and Guo Hongjun,have been especially diligent with studies in this field.As Xin Xuefeng is relatively unknown due to his emphasis on traditional opera music,Li Youjun and Guo Hongjun have gradually emerged as important contemporary scholars in the study of the Yisu Art Troupe.Guo and Li not only further theorize the study of the Yisu Art Troupe but also conduct in-depth and meticulous studies on the nature of the Yisu Art Troupe,the establishment of the director-centered mode in Qinqiang Opera,the social function,and the playwriting of the Yisu Art Troupe by examining and reflecting it within the broader context of the modernization of traditional Chinese opera in the 20th century.

Research progress of traditional Chinese medicine compound in the treatment of gout based on intestinal flora

Because of the continuous improvement of the quality of life,the population of gout patients is also increasing,which seriously affects the quality of life of patients.Traditional Chinese medicine compound has a long history and remarkable clinical effect in treating gout patients,and has been widely used.Intestinal flora and its metabolites are the focus of current research,which can promote intestinal mucosal barrier,improve immunity and improve metabolism.The regulation of intestinal flora can reduce serum uric acid and inhibit inflammation to fight gouty arthritis.Moreover,the mechanism of intestinal flora is related to the spleen in Chinese medicine theory.Therefore,this study discusses the research mechanism and clinical application of traditional Chinese medicine compound in treating gout by regulating intestinal flora,and provides theoretical basis for the clinical application of traditional Chinese medicine and the expansion of new dosage forms.

An Empirical Research on Integrating Chinese Traditional Culture into College English Teaching

198 non-English freshmen students from Shandong Yingcai College were selected as research subjects.The subjects were divided into the experimental group(EG) and the control group(CG).The students in EG were taught English integrated Chinese traditional culture for three semesters,while the ones in CG were taught as usual.The results indicate that the integration of Chinese culture broadens the students' horizons and improves the students' ability to express Chinese culture in English and intercultural communicative competence.

Progress of Chinese research in physical oceanography of the Southern Ocean

Oceanographic surveying has been one of the key missions of the Chinese National Antarctic Research Expedition since 1984. Using the field data obtained in these surveys and the results from remote sensing and numerical models, Chinese physical oceanographers have investigated the water masses, fronts and circulation patterns in the Southern Ocean. The results of nearly 30 years of research are summarized in this paper. Most oceanographic observations by Chinese researchers have been con- ducted in Prydz Bay and the adjacent seas. CTD （Conductivity Temperature and Depth） data, collected during the past 20 years, have been applied to study several features of the water masses in this region： The spatial variation of warm summer surface water, the northward extension of shelf water, the flow of ice shelf water from the cavity beneath the Amery Ice Shelf, the upweUing of the Circumpolar Deep Water, and the formation of the Antarctic Bottom Water. The circulation and its dynamic factors have been analyzed with dynamic heights calculated from CTD data as well as by numerical models. The structure and strength of the fronts in the southeast Indian Ocean and the Drake Passage were investigated with underway XBT/XCTD （Expendable Bathythermo- graph/Expendable CTD） and ADCP （Acoustic Doppler Current Profiler） data. Their interaunual variations have been determined and the factors of influence, especially the atmospheric forcing and mesoscale oceanic processes, were studied using remote sens- ing data. The dynamic mechanism of the Antarctic Circumpolar Current （ACC） was analyzed by theoretical models. The transport and pattern of the ACC have been well reproduced by coupled sea ice-ocean models. Additional details of ACC variability were identified based on satellite altimeter data. The response of the ACC to climate change was studied using reanalysis data. Prospects for future research are presented at the end of this paper.

Progress of Chinese zooplankton ecology research in Prydz Bay, Antarctica

Zooplankton are considered an important trophic link between primary producers and higher trophic level species in the Southern Ocean ecosystem. Since 1989, when the Chinese Antarctic Zhongshan Station was built, zooplankton have regularly been sampled and investigated in Prydz Bay through oceanographic surveys of each Chinese National Antarctic Research Expedition. This review summarizes the main results from zooplankton ecology studies conducted in Prydz Bay by Chinese researchers. Major topics covered in this review are： （1） a description of the biology and ecology of Antarctic krill （Euphausia superba）, the key zooplankton species of the Southern Ocean ecosystem; （2） zooplankton community structure, including the horizontal distribution in the epipelagic region and vertical distribution between 0-1500 m; （3） feeding ecology of dominant species such as Antarctic krill, salps and copepods; （4） a short introduction to the molecular research; and （5） prospects for future research.

Science Researches of Chinese Manned Space Flight

With the complete success of the 2nd stage of Chinese Manned Space Program(CMSP),several science researches have been performed on Tiangong-1 experimental spacelab, which was docked with three Shenzhou spaceships one after another. The China's real spacelab, Tiangong-2 will be launched in 2015, docked with a Shenzhou spaceship soon. After six months, it will be docked with the first Chinese cargo ship(Tianzhou-1). More space science researches, involving with space biology, fluid physics, fundamental physics, materials science, Earth science, astronomy and space environmental science, will be operated on Tiangong-2 spacelab, and crewed and cargo spaceships. Furthermore, the considerable large-scale space utilization of Shina's Space Station is planned. The research fields include yet not limited to space medicine and physiology, space life science and biotechnology, fluid physics and combustion in microgravity, space material science,and fundamental physics in microgravity, space astronomy, Earth science, space physics and space environment utilization, technology demonstration.

Optimization of evidence-based research in the prevention and treatment of coronary heart disease with traditional Chinese medicine:A comprehensive review

Coronary heart disease(CHD) has severely impacted the lives and health of patients for ages. Although the modern methods used for the prevention and treatment of CHD have been increasingly perfected,clinical problems remain that require solutions. In the prevention and treatment of CHD with traditional Chinese medicine(TCM), great therapeutic advantages have been demonstrated. However, the expression of its advantages relies on scientific evidence-based research and evaluation, which require further optimization and improvement. Therefore, this review aims to comprehensively emphasize our understanding of the current deficiencies in TCM evidence-based studies and the necessity of adopting scientific evidence-based optimization methods for use in research. In this process, evidence should be produced in a standard manner, and the advantages of TCM patterns should be accurately stated because these factors contribute to efficient transformation and proper verification of the obtained evidence.Additionally, focusing on patient-oriented medicine and doctor-patient relationships is also essential.These methods are of great significance to prove the clinical efficacy of TCM and promote its development.

Current research status and research hotspots in Chinese geriatric medicine: Data retrieved from the Chinese Journal of Geriatrics

Objective: To investigate the research hotspots and development trends of Chinese geriatric medicine by analyzing the high-frequency keywords, core authors, research institutions and their collaborations in papers published in the Chinese Journal of Geriatrics.Methods: Bibliometric methods and information visualization software(CiteSpace Ⅲ) were used to analyze the following 3 aspects: keywords, institutions and authors.Results: Overall, the number of papers published in the Chinese Journal of Geriatrics grew between 1994 and 2015. The top 3 institutions with the greatest numbers of published papers were Beijing Hospital,People's Liberation Army General Hospital and the Second Xiangya Hospital of Central South University.The authors with high productivity were Pulin Yu, Jianye Wang and Xiaoying Li. The terms "Diabetes","hypertension" and "myocardial infarction" were hotspot words that drew sustained attention in this field.Conclusions: Research on geriatric medicine is growing steadily in China. Hospitals and teaching hospitals are major contributors to publications. The collaboration of authors is more common within the same institutions or in the same regions. Clinical research is still the focus of current research. In the future, basic research should be strengthened, and collaborations between different institutions and regions should be promoted to achieve coordinated and integrated development in Chinese geriatric medicine.

Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer

Primary liver cancer(PLC) is one of the most common malignant tumors in China. PLC is characterized by insidious onset, rapid progress, poor quality of life, and short survival time. Notably, current treatment strategies remain unsatisfactory. Traditional Chinese medicines(TCM) have been used to treat a variety of diseases, including liver diseases, for more than 2000 years. In this study, we performed a review of the use frequency and clinical efficacy of TCM in treating PLC. Relevant literature from January 1, 2009, to January 1, 2021 was retrieved from network databases of China National Knowledge Infrastructure(CNKI), Chongqing VIP, Wanfang, PubMed, and SinoMed. The most frequently used TCM and their efficacy in PLC treatment were summarized. Based on the inclusion and exclusion criteria, 33 articles were selected. Overall, the efficacy of the combination of TCM and Western medicines in the treatment of PLC was higher than that in the control groups(i.e. treatment with Western medicines alone)(65.11% vs.44.31%, P <.05). Among the 33 selected articles, 11 were investigated for TCM preparation(marketed drugs) and 22 for TCM formulas. In total, 102 types of TCM(single herbs) were used to treat PLC. The top five most frequently used TCM were Poria(14.71%), Astragali radix(13.73%), Atractylodis Macrocephalae Rhizoma(12.75%), Bupleuri radix(12.75%), and Glycyrrhizae radix et Rhizoma(11.76%). Of the 102 types of TCM, tonics were the most frequently used categories, followed by heat-clearing medicines, blood-invigorating medicines, and stasis-resolving medicines. Of 207 papers, 174(84.06%) could not be subjected to statistical analysis due to research quality. Further high-quality research on herb sources, formula components and dosage, toxicology, and ethics of TCM is necessary. In conclusion, TCM play a promising role in the treatment and management of PLC, although further investigations are warranted.

Chinese Medicine in the United States:Historical Development and Growth

Chinese medicine is growing rapidly in the United States both as a field of research and in the daily treatment of illnesses.The popularity of Chinese medicine,particularly acupuncture,as a healing mechanism demonstrates American people’s positive experience with Chinese medicine and their embracing it as an alternative to the mainstream Western biomedicine.Chinese medicine is an important part of the Alternative and Complementary Medicine or Integrated Medicine in the United States health system.It is increasingly used and covered by health insurance.Although Chinese medicine has been in the United States since colonial times,it was discriminated against by local authorities.However,things began to change in the 1970s when individual states gradually passed laws to legalize the practice of acupuncture as a healing mechanism.American public interest in Chinese medicine,particularly acupuncture,was aroused by the media’s report of the“magic”power of acupuncture during President Nixon’s visit to China.Non-Asians studied acupuncture in the following decades,which contributed to the establishment of acupuncture as a profession in the American health system.The history of Chinese medicine in the United States illustrates that Chinese and Asian immigrants promoted Chinese medicine in the communities,while Chinese American medical scientists who were trained in biomedicine played an important role in shaping the biomedical method of acupuncture research.This article investigates the changes of Chinese medicine in the United States,with a focus on acupuncture.Situating the discussion in a larger context of social and cultural changes,this study examines the contributions of Chinese immigrants and the popularity of acupuncture in the United States.It analyzes the development of acupuncture practice and research,the professional training in Chinese medicine,and American people’s interest in using Chinese medicine as a reliable healing mechanism to many health problems,including chronic pain,cancer,and drug addictions.

Progresses in Integrated Traditional Chinese and Western Medical Research on Reproductive Immunology

Reproductive immunology is a crossed subject of reproductive biology and immunobiology. Great progresses have been achieved in the subject along with the deep development in life science. Modern reproductive immunology includes immunological regulation of fertility, materno-fetal immuno-regu-lation, and neuro-reproductive endocrino-immune network. With the integrated traditional Chinese and western medicine (ICWM) applied to reproductive immunology it has been greatly enriched in research contents and depth. The present review is to introduce the recent progresses in research of integrated medicine on reproductive immunology.