P-glycoprotein(P-gp)is an important transmembrane ATP-binding cassette(ABC)drug efflux transporter expressed in various human tissues such as the intestines,liver,kidneys,and bloodbrain barrier.It limits the intracell...P-glycoprotein(P-gp)is an important transmembrane ATP-binding cassette(ABC)drug efflux transporter expressed in various human tissues such as the intestines,liver,kidneys,and bloodbrain barrier.It limits the intracellular concentration of xenobiotics by pumping them out of the cells,affecting drug pharmacokinetics and therapeutic effects.With its broad substrate specificity,it has the potential to remove a wide range of drugs from Chinese materia medica(CMM),including conventional medicines and active compounds.Increasing evidence has confirmed the superior therapeutic effectiveness of CMM in treating a wide range of diseases worldwide,as well as in conjunction with western drugs.As a result,herbal medicine-drug compounds have prompted widespread concern,with the majority of these interactions involving transporters such as P-gp.This review systematically summarizes the inhibition or induction of P-gp expression/function by active CMM compounds and the underlying regulatory mechanisms.It will aid in improving understanding of the synergistic or inhibiting effects associated with transporter P-gp as well as rational safety concerns for using CMM,particularly in combination with drugs.展开更多
ISO 18662-1：2017, Traditional Chinese medicine - Vocabulary - Part 1： Chinese Materia Medica （CMM） was officially released recently. The standard is the first terminology standard published by ISO/TC 249, Traditi...ISO 18662-1：2017, Traditional Chinese medicine - Vocabulary - Part 1： Chinese Materia Medica （CMM） was officially released recently. The standard is the first terminology standard published by ISO/TC 249, Traditional Chinese medicine, which provides an important basis to standardize and uniform the terminology of traditional Chinese medicine in the international community.展开更多
This article outlines the composition and species characteristics of Chinese materia medica(CMM)resources identified in the fourth national survey of CMM resources.The survey was conducted based on field investigation...This article outlines the composition and species characteristics of Chinese materia medica(CMM)resources identified in the fourth national survey of CMM resources.The survey was conducted based on field investigations and office collation,adhering to the“four principles”emphasizing the existence of survey records,voucher specimens,actual photographs,and evidence of medicinal use,to summarize the species ofCMMresources and ensure the scientific integrity and accuracy of the results.According to the findings,China has 18,817 CMM resources,including 15,321 medicinal plants,826 medicinal fungi,2517 medicinal animals,and 153 medicinal minerals.Additionally,in the fourth national survey of CMM resources,3151 species of unique medicinal plants,464 species of rare and endangered medicinal plants,and 196 new species in China underwent specialized investigations.These latest statistics are expected to provide themost up-to-date foundational data for the protection,management,development,and utilization of these CMMresources over an extended period,offering scientific guidance for the development of the traditional Chinese medicine industry.展开更多
Research Objective and Overview It is necessary to find effective Chinese materia medica （CMM） for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tende...Research Objective and Overview It is necessary to find effective Chinese materia medica （CMM） for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.展开更多
Current pharmaceutical research has realized that the conventional principles in drug discovery might have some oversights. These included that many drugs were previously believed to bind exclusively to a single targe...Current pharmaceutical research has realized that the conventional principles in drug discovery might have some oversights. These included that many drugs were previously believed to bind exclusively to a single target, actually interact with multiple targets, and only in such way it could take effect （Dar et al, 2012）.展开更多
基金the Macao Science and Technology Development Fund(No.0067/2019/A2 and No.0075/2019/AMJ)from the Macao Special Administrative Region。
文摘P-glycoprotein(P-gp)is an important transmembrane ATP-binding cassette(ABC)drug efflux transporter expressed in various human tissues such as the intestines,liver,kidneys,and bloodbrain barrier.It limits the intracellular concentration of xenobiotics by pumping them out of the cells,affecting drug pharmacokinetics and therapeutic effects.With its broad substrate specificity,it has the potential to remove a wide range of drugs from Chinese materia medica(CMM),including conventional medicines and active compounds.Increasing evidence has confirmed the superior therapeutic effectiveness of CMM in treating a wide range of diseases worldwide,as well as in conjunction with western drugs.As a result,herbal medicine-drug compounds have prompted widespread concern,with the majority of these interactions involving transporters such as P-gp.This review systematically summarizes the inhibition or induction of P-gp expression/function by active CMM compounds and the underlying regulatory mechanisms.It will aid in improving understanding of the synergistic or inhibiting effects associated with transporter P-gp as well as rational safety concerns for using CMM,particularly in combination with drugs.
文摘ISO 18662-1：2017, Traditional Chinese medicine - Vocabulary - Part 1： Chinese Materia Medica （CMM） was officially released recently. The standard is the first terminology standard published by ISO/TC 249, Traditional Chinese medicine, which provides an important basis to standardize and uniform the terminology of traditional Chinese medicine in the international community.
基金supported by the Specific Funding Project of the Fourth National Survey on Chinese Materia Medica Resources(GZY-KJS-2019-001)the Science&Technology Fundamental Resources Investigation Program(2022FY101003).
文摘This article outlines the composition and species characteristics of Chinese materia medica(CMM)resources identified in the fourth national survey of CMM resources.The survey was conducted based on field investigations and office collation,adhering to the“four principles”emphasizing the existence of survey records,voucher specimens,actual photographs,and evidence of medicinal use,to summarize the species ofCMMresources and ensure the scientific integrity and accuracy of the results.According to the findings,China has 18,817 CMM resources,including 15,321 medicinal plants,826 medicinal fungi,2517 medicinal animals,and 153 medicinal minerals.Additionally,in the fourth national survey of CMM resources,3151 species of unique medicinal plants,464 species of rare and endangered medicinal plants,and 196 new species in China underwent specialized investigations.These latest statistics are expected to provide themost up-to-date foundational data for the protection,management,development,and utilization of these CMMresources over an extended period,offering scientific guidance for the development of the traditional Chinese medicine industry.
基金Supported by Australia-China Links Program sponsored by IDP Education Australia (NoⅡ-8)the National Natural Science Foundation of China (No 30070933)+1 种基金the Natural Science Foundation of Zhejiang Province as the key project (No DZ007)State Administration of TCM of China (No 972025)
文摘Research Objective and Overview It is necessary to find effective Chinese materia medica （CMM） for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents of tendemonstrate poor efficacy and serious side effects.
文摘Current pharmaceutical research has realized that the conventional principles in drug discovery might have some oversights. These included that many drugs were previously believed to bind exclusively to a single target, actually interact with multiple targets, and only in such way it could take effect （Dar et al, 2012）.
