With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and fut...With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.展开更多
Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high c...Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.展开更多
背景:静电纺丝多孔纳米纤维是一种具有优良性能和可设计性的材料,将传统中药与其联合构建新型中药控释系统是实现中药的控制释放和提高生物利用度的有效途径,具有广阔应用前景。目的:综述静电纺丝中药控释系统的构建方法及其在医学领域...背景:静电纺丝多孔纳米纤维是一种具有优良性能和可设计性的材料,将传统中药与其联合构建新型中药控释系统是实现中药的控制释放和提高生物利用度的有效途径,具有广阔应用前景。目的:综述静电纺丝中药控释系统的构建方法及其在医学领域相关研究进展。方法:以“静电纺丝,中药,药物载体,释药系统,组织工程,敷料”为中文检索词,以“electrospinning,traditional Chinese medicine,drug carrier,drug delivery system,tissue engineering,dressing”为英文检索词,检索中国知网、PubMed和Web of Science数据库的关于静电纺丝中药控释系统的研究应用文献,检索时间范围为2013-2023年,最终纳入62篇文献进行综述分析。结果与结论:①构建电纺多孔纤维中药控释系统的关键要素为基质材料、中药成分和载药方式。②电纺多孔纤维中药控释系统的构建可依据应用场景和治疗目的进行,首先选定中药成分种类,然后依据药物特性选择与其适配的聚合物基体及溶液,最后依据释药需求设计纤维结构并采用适宜的载药方式。③目前在电纺纤维中药控释系统中所应用的药剂以易制备纺丝溶液的植物中药提取物为主,缺少动物中药和矿物中药的系统研究。④共混载药是研究应用最多的载药方式,且通过对溶液理化性质的优化和负载物质多样性的选择不断扩展其释药特性和适应场景;同轴、多轴及顺序纺丝等载药方式可以制备具有多层成分性质不同的复合纤维,具有广阔发展前景。⑤电纺纤维中药控释系统早期应用集中于医用敷料方面,利用中药活性成分的抗菌止血功能,近年来发现中药某些成分能促进细胞黏附增殖分化,开启了组织工程领域的探索研究。⑥目前对电纺多孔纤维中药控释系统的研究主要集中在对负载材料、工艺、理化性能、生物性能的表征和优化上,而对机制的研究较少,其在临床中的应用尚未普及,在体内的不良反应尚不明了,对其降解行为与释药行为的相互影响也缺乏研究。⑦未来研究中需要考虑:通过改善中药与纺丝溶剂的理化性能和加大中药活性成分的提纯以扩大非植物中药的应用范围,对中药成分的治疗效果和作用机制进行全面研究,并阐明控释系统的降解行为与释药行为的相互影响规律,在更准确的机制下实现中药与电纺纳米纤维更完美的联合和应用。展开更多
Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the cha...Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides,proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids.In this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both singleand multi-component from Danshen.展开更多
Objective： To study the effect of the transdermal preparation of traditional Chinese medicine in treating cancer pain. Methods： From October 2016 to January 2018, 126 patients with cancer pain were enrolled and divi...Objective： To study the effect of the transdermal preparation of traditional Chinese medicine in treating cancer pain. Methods： From October 2016 to January 2018, 126 patients with cancer pain were enrolled and divided into 4 groups, 39 patients in group A （directed TCM permeation）, 26 patients in group B （oxycodone sustained-release tablets）, 32 patients in group C （Chinese medicine directed drug penetration ＋ oxycodone sustained-release tablets）, and 29 patients group D （Chinese medicine directed drug penetration ＋ oxycodone sustained-release tablets ＋ nimesulide sustained release tablets）, according to KPS scores. Results： Transdermal preparations of traditional Chinese medicine can significantly alleviate cancer pain. For the treatment of moderate to severe cancer pain, the Chinese medicine transdermal preparation can reduce the dosage of oxycodone sustained-release tablets. At the same time, the patient＇s KPS and NRS scores were significantly reduced. Moreover, the transdermal preparation of traditional Chinese medicine has a better therapeutic effect on visceral pain. Conclusion： The traditional Chinese medicine tra_nsdermal preparation combined with western medicine for the treatment of cancer pain may be a new method for the treatment of cancer pain.展开更多
文摘With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.
基金This work is supported by National Key Research and Development Program of China(No.2022YFC3501905)Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302)+2 种基金National Natural Science Foundation of China(NSFC,No.82104076)Science and Technology Commission of Shanghai Municipal(STCSM,No.22S21902400,China)Medicine-Engineering joint foundation of Shanghai Jiao Tong University(No.YG2022QN025 and YG2022QN050,China).
文摘Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.
文摘背景:静电纺丝多孔纳米纤维是一种具有优良性能和可设计性的材料,将传统中药与其联合构建新型中药控释系统是实现中药的控制释放和提高生物利用度的有效途径,具有广阔应用前景。目的:综述静电纺丝中药控释系统的构建方法及其在医学领域相关研究进展。方法:以“静电纺丝,中药,药物载体,释药系统,组织工程,敷料”为中文检索词,以“electrospinning,traditional Chinese medicine,drug carrier,drug delivery system,tissue engineering,dressing”为英文检索词,检索中国知网、PubMed和Web of Science数据库的关于静电纺丝中药控释系统的研究应用文献,检索时间范围为2013-2023年,最终纳入62篇文献进行综述分析。结果与结论:①构建电纺多孔纤维中药控释系统的关键要素为基质材料、中药成分和载药方式。②电纺多孔纤维中药控释系统的构建可依据应用场景和治疗目的进行,首先选定中药成分种类,然后依据药物特性选择与其适配的聚合物基体及溶液,最后依据释药需求设计纤维结构并采用适宜的载药方式。③目前在电纺纤维中药控释系统中所应用的药剂以易制备纺丝溶液的植物中药提取物为主,缺少动物中药和矿物中药的系统研究。④共混载药是研究应用最多的载药方式,且通过对溶液理化性质的优化和负载物质多样性的选择不断扩展其释药特性和适应场景;同轴、多轴及顺序纺丝等载药方式可以制备具有多层成分性质不同的复合纤维,具有广阔发展前景。⑤电纺纤维中药控释系统早期应用集中于医用敷料方面,利用中药活性成分的抗菌止血功能,近年来发现中药某些成分能促进细胞黏附增殖分化,开启了组织工程领域的探索研究。⑥目前对电纺多孔纤维中药控释系统的研究主要集中在对负载材料、工艺、理化性能、生物性能的表征和优化上,而对机制的研究较少,其在临床中的应用尚未普及,在体内的不良反应尚不明了,对其降解行为与释药行为的相互影响也缺乏研究。⑦未来研究中需要考虑:通过改善中药与纺丝溶剂的理化性能和加大中药活性成分的提纯以扩大非植物中药的应用范围,对中药成分的治疗效果和作用机制进行全面研究,并阐明控释系统的降解行为与释药行为的相互影响规律,在更准确的机制下实现中药与电纺纳米纤维更完美的联合和应用。
基金financial support from National Natural Science Foundation of China (Nos. 81903557, 82074024)Natural Science Foundation of Jiangsu Province (No. BK20190802)+1 种基金Natural Science Foundation Youth Project of Nanjing University of Chinese Medicine (No. NZY81903557)Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.19KJB350003)。
文摘Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides,proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids.In this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both singleand multi-component from Danshen.
文摘Objective： To study the effect of the transdermal preparation of traditional Chinese medicine in treating cancer pain. Methods： From October 2016 to January 2018, 126 patients with cancer pain were enrolled and divided into 4 groups, 39 patients in group A （directed TCM permeation）, 26 patients in group B （oxycodone sustained-release tablets）, 32 patients in group C （Chinese medicine directed drug penetration ＋ oxycodone sustained-release tablets）, and 29 patients group D （Chinese medicine directed drug penetration ＋ oxycodone sustained-release tablets ＋ nimesulide sustained release tablets）, according to KPS scores. Results： Transdermal preparations of traditional Chinese medicine can significantly alleviate cancer pain. For the treatment of moderate to severe cancer pain, the Chinese medicine transdermal preparation can reduce the dosage of oxycodone sustained-release tablets. At the same time, the patient＇s KPS and NRS scores were significantly reduced. Moreover, the transdermal preparation of traditional Chinese medicine has a better therapeutic effect on visceral pain. Conclusion： The traditional Chinese medicine tra_nsdermal preparation combined with western medicine for the treatment of cancer pain may be a new method for the treatment of cancer pain.
