Two Chinese Medicine Experts Honoured at First Cheung On Tak International Award for Outstanding Contribution to Chinese Medicine

The School of Chinese Medicine of Hong Kong Baptist University organised the Award Presentation Ceremony cum Award Winners＇ Lectures of The First Cheung On Tak International Award for Outstanding Contribution to Chinese Medicine to honour the two award recipients on April 30. The winners of the inaugural award were Professor CHEN Ke-ji, Academician of the Chinese Academy of Sciences and Director of Cardiovascular Center, Xiyuan Hospital of China Academy of Chinese Medical Sciences; and Professor Tommy CHENG, Henry Bronson Professor of Pharmacology at Yale University and Chairman of the Consortium for the Globalization of Chinese Medicine.

Diagnosis and Management of Knee Osteoarthritis：Chinese Medicine Expert Consensus(2015)

Literature review shows that Chinese medicine and other related treatment are still the main stream treatment of knee osteoarthritis.Currently,there is short of handbook guiding Chinese medicine from evidence-based medical evidence,so it is a top priority to develop a clinical guideline from the expert consensus.After several rounds of discussion during the conference and examination by letter,which has collected opinions from nearly one hundred experts,consensus was reached.Nonpharmacologic interventions include health education,medical exercise,acupuncture,massage,acupotomology,and physiotherapy.Pharmacological interventions are as follows.Topical application includes fumigation,application,hot compressed,ironing and iontophoresis with Chinese herbs,etc.Chinese patent medicine for external use includes plaster,ointment,etc.Western medicine for external use mainly includes emulsion,ointment,plaster and embrocation containing nonsteroidal anti-inflammatory drugs（NSAIDs）.Intraarticular injection mainly includes sodium hyaluronic acid,chitosan（for injection） with prudent use of glucocorticoid.Chinese herbal medicine and Chinese patent medicine can be taken referring to syndrome differentiation which mainly includes syndromes of qi stagnation and blood stasis,cold dampness,deficiency of Gan（Liver） and Shen（Kidney）,deficiency of qi and blood.Western medicine mainly includes analgesic,NSAIDs,diseases modifying drugs.Surgery procedures mainly include joint irrigation,arthroscopic surgery,osteotomy,arthroplasty,etc.

Network Pharmacology Approach to Investigate the Preventive Mechanism of Hunan Expert Group Recommended Chinese Medicine Prevention No.2 Prescription Against COVID-19

Objective To explore the possible preventive mechanism of Hunan expert group recommended Chinese medicine prescription of No.2(Pre-No.2)against coronavirus disease 2019(COVID-19)by network pharmacology method.Methods The target proteins of effective components and active compounds in Pre-No.2 were screened by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).A component-target-disease interaction network of Pre-No.2 was constructed by Cytoscape 3.7.2,gene ontology(GO)analysis,and Kyoto encyclopedia of genes and genomes(KEGG)analysis of target protein pathway by DAVID.Results A total of 163 compounds and 278 target protein targets in Pre-No.2 were collected from the TCMSP database.Kaempferol,wogonin,7-methoxy-2-methyl isoflavone,formononetin,isorhamnetin,and licochalcone A were the most frequent targets in the regulatory network.GO enrichment analysis showed that Pre-No.2 regulated response to virus,viral processes,humoral immune responses,defense responses to virus and viral entry into host cells.KEGG enrichment analysis showed that the formula regulated the NF-κB signaling pathway,B cell receptor signaling pathway,viral carcinogenesis,T cell signaling pathway and FcγR-mediated phagocytosis signaling pathway.Conclusions Pre-No.2 may play a preventive role against COVID-19 through regulation of the Toll-like signaling,T cell signaling,B cell signaling and other signaling pathways.It may regulate the immune system to protect against anti-influenza virus.

Expert knowledge maps for knowledge management: a case study inTraditional Chinese Medicine research

OBJECTIVE:To design a model to capture information on the state and trends of knowledge creation,at both an individual and an organizational level,in order to enhance knowledge management.METHODS:We designed a graph-theoretic knowledge model,the expert knowledge map(EKM),based on literature-based annotation.A case study in the domain of Traditional Chinese Medicine research was used to illustrate the usefulness of the model.RESULTS:The EKM successfully captured various aspects of knowledge and enhanced knowledge management within the case-study organization through the provision of knowledge graphs,expert graphs,and expert-knowledge biography.CONCLUSION:Our model could help to reveal thehot topics,trends,and products of the research done by an organization.It can potentially be used to facilitate knowledge learning,sharing and decision-making among researchers,academicians,students,and administrators of organizations.

Study Design and Implementation for Population Pharmacokinetics of Chinese Medicine：An Expert Consensus

Although many population pharmacokinetics（PPK） researches have been conducted on chemical drugs,few have been in the field of Chinese medicine（CM）.Each ingredient in CMs possesses different pharmacokinetic characteristics,therefore,it is important to develop methods of PPK studies on them to identify the differences in CM drug safety and efficacy among the population subgroups and to conduct quantitative studies on the determinants of CM drug concentrations.To develop an expert consensus on study design and implementation for PPK of CM,in August 2013,6 experts in the field of PPK,CMs pharmacology,and statistics discussed problems on the PPK research protocol of CMs,and a consensus was reached.The medicines with toxicity and narrow therapeutic windows and with wide range of target population or with frequent adverse reactions were selected.The compositions with definite therapeutic effects were selected as indices,and specific time points and sample sizes were designed according to standard PPK design methods.Target components were tested through various chromatography methods.Total quantity statistical moment analysis was used to estimate PPK parameters of each component and PPK models reflecting the trend of CMs（which assists in reasonable adjustments on clinical dosage）.This consensus specifies the study design and implementation process of PPK.It provides guidance for the following：post-marketing clinical studies,in vivo investigations related to the metabolism in different populations,and development and clinical adjustment of dosages of CMs.