Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibitio...Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibition of estrogen level展开更多
<span style="font-family:Verdana;">The subjects of this study were 80 patients who underwent mixed hemorrhoids surgery in our hospital from January to October 2020 (mixed hemorrhoids external and inter...<span style="font-family:Verdana;">The subjects of this study were 80 patients who underwent mixed hemorrhoids surgery in our hospital from January to October 2020 (mixed hemorrhoids external and internal ligation, internal hemorrhoids ligation or Xiaozhiling injection) and developed anal edge edema after surgery. According to the order of hospitalization, the patients were randomly divided into treatment group and control group, with 40 cases each.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">In the control group, blank hot pack was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema after operation;in the treatment group, hot pack of Traditional Chinese medicine was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema. The course of treatment was 7 days.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">The edema subsidence and postoperative pain scores were observed in both groups.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">Results: The scores of anal edema and pain in the treatment group were significantly lower than those in the control group (P < 0.05), and the significant efficiency and total effective rate in the treatment group were significantly better than those in the control group, with statistical difference (P < 0.05).</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">Conclusion: Chinese medicine hot election package is effective in treating postoperative anal edema of mixed hemorrhoids, and the method is simple and suitable for clinical promotion.</span>展开更多
In this study, objective differences between the Cold (Han) and Hot (Re) nature of traditional Chinese medicines, e.g. Strobal and Rhubarb, are determined by using a cold/hot plate differentiation technology. A novel,...In this study, objective differences between the Cold (Han) and Hot (Re) nature of traditional Chinese medicines, e.g. Strobal and Rhubarb, are determined by using a cold/hot plate differentiation technology. A novel, self-designed cold/hot plate differentiating instrument, with methodological study, was used to investigate the intervention of Strobal and Rhubarb on the temperature tropism of mice. Compared with the ICR and BALB/c mice, it was found that KM mice on the cold/hot plate were more sensitive to the change of temperature, within the tolerant temperature range of 15-40 ℃ . The temperature tropism behavior of mice is influenced by treatment with Rhubarb and Strobal, as is the activity of ATPase in liver tissue. These trends are consistent with the definition of the Cold/Hot nature of Chinese medicines based on traditional Chinese medicinal theory. This study showed that the differences of the Cold/Hot nature of traditional Chinese medicines. might be objectively represented by the temperature tropism of animal by means of cold/hot differentiating assay.展开更多
It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia...It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.展开更多
目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注...目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注射液,研究组在对照组基础上给予中药热敷。比较两组治疗后临床效果、治疗前后神经功能、认知功能、血清学指标、脑血流动力学。结果:研究组总有效率为95.45%,显著高于对照组的79.55%,差异有统计学意义(P<0.05)。治疗后,研究组蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易智能精神状态检查量表(mini-mental state examination,MMSE)评分均高于对照组,美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组S-100钙结合蛋白β(S-100 calcium binding protein β,S-100β)、视锥蛋白样蛋白-l(visinin like protein 1,VILIP-1)水平均低于对照组,胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组收缩期峰值流速(peak flow velocity of systole,Vp)、平均血流速度(mean velocity,Vm)均高于对照组,搏动指数(pulse index,PI)低于对照组,差异有统计学意义(P<0.05)。结论:谷红注射液联合中药热敷治疗卒中后认知障碍患者能促进神经功能恢复,改善认知功能,改善脑血流动力学,提高治疗效果。展开更多
文摘Breast cancer (BC) is the most common malignant tumor in women. Around 50% of BC receptor-positive patients are hormone-dependent cases, and it is necessary for them to use endocrine after operation. Through inhibition of estrogen level
文摘<span style="font-family:Verdana;">The subjects of this study were 80 patients who underwent mixed hemorrhoids surgery in our hospital from January to October 2020 (mixed hemorrhoids external and internal ligation, internal hemorrhoids ligation or Xiaozhiling injection) and developed anal edge edema after surgery. According to the order of hospitalization, the patients were randomly divided into treatment group and control group, with 40 cases each.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">In the control group, blank hot pack was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema after operation;in the treatment group, hot pack of Traditional Chinese medicine was applied on the basis of anorectal No. 1 lotion for prevention and treatment of anal edge edema. The course of treatment was 7 days.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">The edema subsidence and postoperative pain scores were observed in both groups.</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">Results: The scores of anal edema and pain in the treatment group were significantly lower than those in the control group (P < 0.05), and the significant efficiency and total effective rate in the treatment group were significantly better than those in the control group, with statistical difference (P < 0.05).</span><span style="font-size:10.0pt;font-family:;" "=""> </span><span style="font-size:10pt;font-family:Verdana;" "="">Conclusion: Chinese medicine hot election package is effective in treating postoperative anal edema of mixed hemorrhoids, and the method is simple and suitable for clinical promotion.</span>
基金National key basic research development program (973 Program)(Grant No.:2007CB512600)National Natural Science Foundation of China (Grant No.:81473369)+1 种基金Key research and development plan of Shandong province (Grant No.:2016CYJS08A01-1)Shandong Province TCM science and technology development plan project (2019-0037).
基金Supported by the National Basic Research and Development Program of China (Grant No. 2007CB512607)
文摘In this study, objective differences between the Cold (Han) and Hot (Re) nature of traditional Chinese medicines, e.g. Strobal and Rhubarb, are determined by using a cold/hot plate differentiation technology. A novel, self-designed cold/hot plate differentiating instrument, with methodological study, was used to investigate the intervention of Strobal and Rhubarb on the temperature tropism of mice. Compared with the ICR and BALB/c mice, it was found that KM mice on the cold/hot plate were more sensitive to the change of temperature, within the tolerant temperature range of 15-40 ℃ . The temperature tropism behavior of mice is influenced by treatment with Rhubarb and Strobal, as is the activity of ATPase in liver tissue. These trends are consistent with the definition of the Cold/Hot nature of Chinese medicines based on traditional Chinese medicinal theory. This study showed that the differences of the Cold/Hot nature of traditional Chinese medicines. might be objectively represented by the temperature tropism of animal by means of cold/hot differentiating assay.
基金supported by the Science and Technology Innovation Team of Shanxi Province(No.2013131015)Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi(OIT)
文摘It recently becomes an important and urgent mission for modern scientific research to identify and explain the theory of traditional Chinese medicine(TCM), which has been utilized in China for more than four millennia. Since few works have been contributed to understanding the TCM theory, the mechanism of actions of drugs with cold/hot properties remains unclear. In the present study, six kinds of typical herbs with cold or hot properties were orally administered into mice, and serum and liver samples were analyzed using an untargeted nuclear magnetic resonance(NMR) based metabolomics approach coupled with similarity analysis. This approach was performed to identify and quantify changes in metabolic pathways to elucidate drug actions on the treated mice. Our results showed that those drugs with same property exerted similar effects on the metabolic alterations in mouse serum and liver samples, while drugs with different property showed different effects. The effects of herbal medicines with cold/hot properties were exerted by regulating the pathways linked to glycometabolism, lipid metabolism, amino acids metabolism and other metabolic pathways. The results elucidated the differences and similarities of drugs with cold/hot properties, providing useful information on the explanation of medicinal properties of these TCMs.
文摘目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注射液,研究组在对照组基础上给予中药热敷。比较两组治疗后临床效果、治疗前后神经功能、认知功能、血清学指标、脑血流动力学。结果:研究组总有效率为95.45%,显著高于对照组的79.55%,差异有统计学意义(P<0.05)。治疗后,研究组蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易智能精神状态检查量表(mini-mental state examination,MMSE)评分均高于对照组,美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组S-100钙结合蛋白β(S-100 calcium binding protein β,S-100β)、视锥蛋白样蛋白-l(visinin like protein 1,VILIP-1)水平均低于对照组,胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组收缩期峰值流速(peak flow velocity of systole,Vp)、平均血流速度(mean velocity,Vm)均高于对照组,搏动指数(pulse index,PI)低于对照组,差异有统计学意义(P<0.05)。结论:谷红注射液联合中药热敷治疗卒中后认知障碍患者能促进神经功能恢复,改善认知功能,改善脑血流动力学,提高治疗效果。
