Objective To explore the possible preventive mechanism of Hunan expert group recommended Chinese medicine prescription of No.2(Pre-No.2)against coronavirus disease 2019(COVID-19)by network pharmacology method.Methods ...Objective To explore the possible preventive mechanism of Hunan expert group recommended Chinese medicine prescription of No.2(Pre-No.2)against coronavirus disease 2019(COVID-19)by network pharmacology method.Methods The target proteins of effective components and active compounds in Pre-No.2 were screened by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).A component-target-disease interaction network of Pre-No.2 was constructed by Cytoscape 3.7.2,gene ontology(GO)analysis,and Kyoto encyclopedia of genes and genomes(KEGG)analysis of target protein pathway by DAVID.Results A total of 163 compounds and 278 target protein targets in Pre-No.2 were collected from the TCMSP database.Kaempferol,wogonin,7-methoxy-2-methyl isoflavone,formononetin,isorhamnetin,and licochalcone A were the most frequent targets in the regulatory network.GO enrichment analysis showed that Pre-No.2 regulated response to virus,viral processes,humoral immune responses,defense responses to virus and viral entry into host cells.KEGG enrichment analysis showed that the formula regulated the NF-κB signaling pathway,B cell receptor signaling pathway,viral carcinogenesis,T cell signaling pathway and FcγR-mediated phagocytosis signaling pathway.Conclusions Pre-No.2 may play a preventive role against COVID-19 through regulation of the Toll-like signaling,T cell signaling,B cell signaling and other signaling pathways.It may regulate the immune system to protect against anti-influenza virus.展开更多
Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordin...Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordings from ＂Hong Fan-Book of Documents （Shang Shu Hong Fan）＂, and is also in general agreement with teachings from ＂Longevity-Yellow Emperor＇s Canon of Internal Medicine （Huang Di Nei Jing ~ Tian Nian）＂ where it is said ＇a man is to die at age of a hundred years＇ meaning ＇passing away after living a hundred years＇. Recently there is a report of people dying at the age of 150 years in England, I am afraid this is misinformed.展开更多
Chronic venous insufficiency is characterized by high incidence,difficult treatment and high recurrence rate.Traditional Chinese Medicine Preventive Treatment Theory is one of the important core contents in the theory...Chronic venous insufficiency is characterized by high incidence,difficult treatment and high recurrence rate.Traditional Chinese Medicine Preventive Treatment Theory is one of the important core contents in the theory of TCM.By using the theory of Traditional Chinese Medicine Preventive Treatment,using the theory of“prevention before illness,prevention the disease continues to change and prevention repeated when the disease has been cured”,can reduce the incidence rate effectively,improve the effect of clinical treatment,it is also to enrich and develop the theory of Traditional Chinese Medicine Preventive Treatment.展开更多
Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Head...Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU展开更多
The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become t...The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become the Department of Virology (1956-1963). This Institute has a total of around 350 staff and 11 departments, namely, the Departments of Hepatitis Viruses, Epidemic Hemorrhagic Fever Viruses, Arboviruses, Influenza Viruses, Viral Immunology, Viral Genetics, Viral Diagnosis, Viral Oncology, Viral Morphology, Viral Biological Product Development, and the National Laboratory of Molecular Virology and Genetic Engineering. It acts as the展开更多
The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staf...The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staff and 8 departments, namely, Department of Epidemiology; Department of Parasite Biology; Department of Vector Biology and Control; Department of Diagnosis and Immunology; Department of Biochemistry; Department of Pharmaceutical Chemistry; Department of展开更多
The Chinese Academy of Preventive Medicine (CAPM), previously known as the China National Center for Preventive Medicine before 1986, was established on December 23, 1983. It consists of eight institutes (Institute of...The Chinese Academy of Preventive Medicine (CAPM), previously known as the China National Center for Preventive Medicine before 1986, was established on December 23, 1983. It consists of eight institutes (Institute of Parasitic Diseases, Institute of Virology, Institute of Epidemiology and Microbiology, Institute of Occupational Medicine, Institute of Environmental Health and Engineering, Institute of Nutrition and Food Hygiene, Institute of Environmental Health Monitoring, Institute of Food Safety Control and Inspection) and a Vocational School of Public Health. CAPM together with its Subordinate institutes has more than 2000 staff members in total, 70% of which are scientists of different levels. Among them, 25%展开更多
The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become t...The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become the Department of Virology (1956-1963). This Institute has a total of around 350 staffand 11 departments, namely,展开更多
The Institute of Epidemiology and Microbiology was established in 1953.It hasaround 400 staff and 18 departments,namely,the Departments of Hemorrhagic Fever,Genetic Engineering,Brucellosis,Leptospirosis,Immunology,Bio...The Institute of Epidemiology and Microbiology was established in 1953.It hasaround 400 staff and 18 departments,namely,the Departments of Hemorrhagic Fever,Genetic Engineering,Brucellosis,Leptospirosis,Immunology,Biochemistry,Plague,AIDS Surveillance,EPI Evaluation,Diarrhoea,Rickettsiosis,Microbiology,Meningitis,Vector Biology and Control,Disinfection,Epidemiology,Social展开更多
The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staf...The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staff and 8 departments, namely, Department of Epidemiology; Department of Parasite Biology; Department of Vector Biology and Control; Department of Diagnosis and Immunology; Department of Biochemistry; Department of Pharmaceutical Chemistry; Department of Pharmacology; Department of Scientific Information; and a Central Laboratory of Instrumentation. This Institute has been designated as a WHO Collaborating Center for Malaria, Schistosomiasis, and Filariasis.展开更多
The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954...The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954,was establishedin1986.This Institute has around 220 staff in total and 11 departments,namely,theDepartment of Environmental Epidemiology;Department of EnvironmentalChemistry;Department of Environmental Toxicology;Department of EnvironmentalMicrobiology;Department of Soil Hygiene;Department of Water Treatment;展开更多
Since December 2019 the Coronavirus Disease 2019(COVID-19)has erupted in many places around the world,which is strong infectious and highly epidemic.After the outbreak of COVID-19 in China,traditional Chinese medicine...Since December 2019 the Coronavirus Disease 2019(COVID-19)has erupted in many places around the world,which is strong infectious and highly epidemic.After the outbreak of COVID-19 in China,traditional Chinese medicine(TCM)has been in the front line of the fight against the epidemic.It has shown characteristics and advantages in the prevention and treatment of COVID-19.TCM also played an important role in the winter of 2002 and in the spring of 2003 during the outbreak of severe acute respiratory syndrome(SARS).This article compares the strategies,programs,measures,resource investments,and effects of TCM for the prevention and treatment of COVID-19 with those for SARS.At present,the involvement of TCM has been earlier,faster,and more comprehensive in the fight against the epidemic and has shown good clinical efficacy and treatment prospects.展开更多
Objective Oxaliplatin-induced peripheral neurotoxicity（OIPN） is the main limitation for its continuation in cancer patients.Traditional Chinese medicines（TCMs） have been used to prevent OIPN in China and have been...Objective Oxaliplatin-induced peripheral neurotoxicity（OIPN） is the main limitation for its continuation in cancer patients.Traditional Chinese medicines（TCMs） have been used to prevent OIPN in China and have been demonstrated to be effective.However,due to the lack of direct comparison among TCMs,it remains unclear that which TCM is the best for OIPN prevention.Consequently,the present study aimed to compare the relative efficacies of TCMs to find out the best TCM by applying a network meta-analysis.Methods Studies were identified by searching PubMed,EMbase,Cochrane Libraries,CNKI,WanFang,and WeiPu database from January 1990 to May2016.Randomized controlled trials（RCTs） that evaluated the efficacy of TCMs in preventing OIPN in cancer patients were included.Statistical analysis was performed with ADDIS 1.1 6.6.Results Twenty-five RCTs（1572 patients） involving five TCMs were included.The results of network meta-analyses showed that compared with oxaliplatin-based chemotherapy alone,the combination with Huangqi Injection（HQI）,Shenmai Injection（SMI）,Shenfu Injection（SFI）,Buyang Huanwu Decoction（BHD）,and Huangqi Guizhi Wuwu Decoction（HGWD） could decrease the overall OIPN incidence and the severe OIPN incidence in cancer patients.In addition,probability ranking results showed the order of efficacy in preventing overall OIPN incidence was HQI 〉 HGWD 〉 SFI =SMI 〉 BHD,while the order of efficacy in preventing severe OIPN incidence was HQI 〉HGWD 〉 BHD 〉 SFI = SMI.Conclusion All five TCMs are effective neuroprotective agents against OIPN.Among these TCMs,HQI and HGWD were superior to others in clinical efficacy.Moreover,Astragalus membranaceus might be a more promising herb for the OIPN prevention.However,more direct head-to-head RCTs with high quality and large sample size are still needed to further confirm the conclusion.展开更多
基金funding support from the Scientific Research Fund of Hunan Administration of TCM(No.KYGG06,No.KYGG07)。
文摘Objective To explore the possible preventive mechanism of Hunan expert group recommended Chinese medicine prescription of No.2(Pre-No.2)against coronavirus disease 2019(COVID-19)by network pharmacology method.Methods The target proteins of effective components and active compounds in Pre-No.2 were screened by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).A component-target-disease interaction network of Pre-No.2 was constructed by Cytoscape 3.7.2,gene ontology(GO)analysis,and Kyoto encyclopedia of genes and genomes(KEGG)analysis of target protein pathway by DAVID.Results A total of 163 compounds and 278 target protein targets in Pre-No.2 were collected from the TCMSP database.Kaempferol,wogonin,7-methoxy-2-methyl isoflavone,formononetin,isorhamnetin,and licochalcone A were the most frequent targets in the regulatory network.GO enrichment analysis showed that Pre-No.2 regulated response to virus,viral processes,humoral immune responses,defense responses to virus and viral entry into host cells.KEGG enrichment analysis showed that the formula regulated the NF-κB signaling pathway,B cell receptor signaling pathway,viral carcinogenesis,T cell signaling pathway and FcγR-mediated phagocytosis signaling pathway.Conclusions Pre-No.2 may play a preventive role against COVID-19 through regulation of the Toll-like signaling,T cell signaling,B cell signaling and other signaling pathways.It may regulate the immune system to protect against anti-influenza virus.
文摘Life Expectancy Study International geriatric life science community, including medical and scientific communities, currently considers human life expectancy to be about 120 years. This is in congruence with recordings from ＂Hong Fan-Book of Documents （Shang Shu Hong Fan）＂, and is also in general agreement with teachings from ＂Longevity-Yellow Emperor＇s Canon of Internal Medicine （Huang Di Nei Jing ~ Tian Nian）＂ where it is said ＇a man is to die at age of a hundred years＇ meaning ＇passing away after living a hundred years＇. Recently there is a report of people dying at the age of 150 years in England, I am afraid this is misinformed.
基金Beijing innovation cultivation research funding project for biomedicine and life science(No.Z151100003915132)The youth project of national natural science foundation(No.81804095)。
文摘Chronic venous insufficiency is characterized by high incidence,difficult treatment and high recurrence rate.Traditional Chinese Medicine Preventive Treatment Theory is one of the important core contents in the theory of TCM.By using the theory of Traditional Chinese Medicine Preventive Treatment,using the theory of“prevention before illness,prevention the disease continues to change and prevention repeated when the disease has been cured”,can reduce the incidence rate effectively,improve the effect of clinical treatment,it is also to enrich and develop the theory of Traditional Chinese Medicine Preventive Treatment.
文摘Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU
文摘The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become the Department of Virology (1956-1963). This Institute has a total of around 350 staff and 11 departments, namely, the Departments of Hepatitis Viruses, Epidemic Hemorrhagic Fever Viruses, Arboviruses, Influenza Viruses, Viral Immunology, Viral Genetics, Viral Diagnosis, Viral Oncology, Viral Morphology, Viral Biological Product Development, and the National Laboratory of Molecular Virology and Genetic Engineering. It acts as the
文摘The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staff and 8 departments, namely, Department of Epidemiology; Department of Parasite Biology; Department of Vector Biology and Control; Department of Diagnosis and Immunology; Department of Biochemistry; Department of Pharmaceutical Chemistry; Department of
文摘The Chinese Academy of Preventive Medicine (CAPM), previously known as the China National Center for Preventive Medicine before 1986, was established on December 23, 1983. It consists of eight institutes (Institute of Parasitic Diseases, Institute of Virology, Institute of Epidemiology and Microbiology, Institute of Occupational Medicine, Institute of Environmental Health and Engineering, Institute of Nutrition and Food Hygiene, Institute of Environmental Health Monitoring, Institute of Food Safety Control and Inspection) and a Vocational School of Public Health. CAPM together with its Subordinate institutes has more than 2000 staff members in total, 70% of which are scientists of different levels. Among them, 25%
文摘The Institute of Virology was established in 1964. Its precursor was the Laboratory of Virology, Department of Microbiology, Chinese Academy of Medical Sciences (1949-1955), which was subsequently expanded to become the Department of Virology (1956-1963). This Institute has a total of around 350 staffand 11 departments, namely,
文摘The Institute of Epidemiology and Microbiology was established in 1953.It hasaround 400 staff and 18 departments,namely,the Departments of Hemorrhagic Fever,Genetic Engineering,Brucellosis,Leptospirosis,Immunology,Biochemistry,Plague,AIDS Surveillance,EPI Evaluation,Diarrhoea,Rickettsiosis,Microbiology,Meningitis,Vector Biology and Control,Disinfection,Epidemiology,Social
文摘The Institute of Parasitic Diseases was set up in 1950 in Nanjing and moved to the current location of Shanghai in 1957. Its precursor was the Huadong Branch of the National Institute of Health. It has around 350 staff and 8 departments, namely, Department of Epidemiology; Department of Parasite Biology; Department of Vector Biology and Control; Department of Diagnosis and Immunology; Department of Biochemistry; Department of Pharmaceutical Chemistry; Department of Pharmacology; Department of Scientific Information; and a Central Laboratory of Instrumentation. This Institute has been designated as a WHO Collaborating Center for Malaria, Schistosomiasis, and Filariasis.
文摘The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954,was establishedin1986.This Institute has around 220 staff in total and 11 departments,namely,theDepartment of Environmental Epidemiology;Department of EnvironmentalChemistry;Department of Environmental Toxicology;Department of EnvironmentalMicrobiology;Department of Soil Hygiene;Department of Water Treatment;
基金funded by the National Program for Ten-thousand Talents(W02020052)。
文摘Since December 2019 the Coronavirus Disease 2019(COVID-19)has erupted in many places around the world,which is strong infectious and highly epidemic.After the outbreak of COVID-19 in China,traditional Chinese medicine(TCM)has been in the front line of the fight against the epidemic.It has shown characteristics and advantages in the prevention and treatment of COVID-19.TCM also played an important role in the winter of 2002 and in the spring of 2003 during the outbreak of severe acute respiratory syndrome(SARS).This article compares the strategies,programs,measures,resource investments,and effects of TCM for the prevention and treatment of COVID-19 with those for SARS.At present,the involvement of TCM has been earlier,faster,and more comprehensive in the fight against the epidemic and has shown good clinical efficacy and treatment prospects.
基金Science and Technology Project of Public Health Bureau(No.2014KY09)
文摘Objective Oxaliplatin-induced peripheral neurotoxicity（OIPN） is the main limitation for its continuation in cancer patients.Traditional Chinese medicines（TCMs） have been used to prevent OIPN in China and have been demonstrated to be effective.However,due to the lack of direct comparison among TCMs,it remains unclear that which TCM is the best for OIPN prevention.Consequently,the present study aimed to compare the relative efficacies of TCMs to find out the best TCM by applying a network meta-analysis.Methods Studies were identified by searching PubMed,EMbase,Cochrane Libraries,CNKI,WanFang,and WeiPu database from January 1990 to May2016.Randomized controlled trials（RCTs） that evaluated the efficacy of TCMs in preventing OIPN in cancer patients were included.Statistical analysis was performed with ADDIS 1.1 6.6.Results Twenty-five RCTs（1572 patients） involving five TCMs were included.The results of network meta-analyses showed that compared with oxaliplatin-based chemotherapy alone,the combination with Huangqi Injection（HQI）,Shenmai Injection（SMI）,Shenfu Injection（SFI）,Buyang Huanwu Decoction（BHD）,and Huangqi Guizhi Wuwu Decoction（HGWD） could decrease the overall OIPN incidence and the severe OIPN incidence in cancer patients.In addition,probability ranking results showed the order of efficacy in preventing overall OIPN incidence was HQI 〉 HGWD 〉 SFI =SMI 〉 BHD,while the order of efficacy in preventing severe OIPN incidence was HQI 〉HGWD 〉 BHD 〉 SFI = SMI.Conclusion All five TCMs are effective neuroprotective agents against OIPN.Among these TCMs,HQI and HGWD were superior to others in clinical efficacy.Moreover,Astragalus membranaceus might be a more promising herb for the OIPN prevention.However,more direct head-to-head RCTs with high quality and large sample size are still needed to further confirm the conclusion.
