Research Progress of External Treatment of Acute Gouty Arthritis with Traditional Chinese Medicine

External application of traditional Chinese medicine has a long history and definite curative effect on gout.By searching the latest literature on the treatment of acute gouty arthritis by external treatment of traditional Chinese medicine,the research progress of external treatment of acute gouty arthritis in recent years was summarized.According to the existing research results,the external treatment of Chinese medicine in the treatment of acute gout has better efficacy and higher safety,and has a broad application prospect.

Clinical study on the treatment of acute pancreatitis with external application of Yi-Dan Therapy based on the method of“stagnation requiring dispersion”:study protocol for a randomized controlled trial

Background:Acute pancreatitis is an unpredictable and potentially lethal disease,causing tremendous pain in patients.The initial treatment of acute pancreatitis in modern medicine is supportive,but it is generally ineffective in relieving abdominal pain and distension.Traditional Chinese medicine has been shown to be more effective in regulating the body’s homeostasis and reducing the clinical symptoms of pancreatitis.Yi-Dan ointment,derived from Dahuang-Mudan Decoction,is an effective external ointment for treating acute pancreatitis.The aim of this trial is to investigate the clinical efficacy of Yi-Dan ointment,providing a valuable complement to existing treatment options for pancreatitis.Methods:This is a randomized controlled clinical trial with two parallel groups.Patients in the control group were given basic treatment and nursing for 7 days;in the treatment group,Yi-Dan ointment was applied externally in addition to basic treatment and nursing.The main indicator is the overall efficacy,serum amylase,acute physiology and chronic health evaluationⅡscore,symptom score,inflammatory markers,and classification of computed tomography.Conclusion:The trial results will provide high-quality evidence for Yi-Dan ointment,and provide a complement to existing treatment options for pancreatitis.

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, mul-tiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM) monomers have markedly good effect for treating SAP. Many TCM monomers can inhibit pancreatin, resist inflammation, im-prove microcirculation and immunoloregulation, etc. to block the pathological progress of SAP in multiple ways, reduce com-plications and lower mortality with rapid effects. It is significant for enhancing SAP treatment to deeply understand the current situation in TCM monomers for treating SAP and take precious references therein. This article summarizes the treating effects and mechanisms of TCM monomers for SAP in recent years.

Comprehensive Comparison and Analysis of the Prevention and Treatment of Coronavirus Disease 2019 and Severe Acute Respiratory Syndrome with Traditional Chinese Medicine

Since December 2019 the Coronavirus Disease 2019(COVID-19)has erupted in many places around the world,which is strong infectious and highly epidemic.After the outbreak of COVID-19 in China,traditional Chinese medicine(TCM)has been in the front line of the fight against the epidemic.It has shown characteristics and advantages in the prevention and treatment of COVID-19.TCM also played an important role in the winter of 2002 and in the spring of 2003 during the outbreak of severe acute respiratory syndrome(SARS).This article compares the strategies,programs,measures,resource investments,and effects of TCM for the prevention and treatment of COVID-19 with those for SARS.At present,the involvement of TCM has been earlier,faster,and more comprehensive in the fight against the epidemic and has shown good clinical efficacy and treatment prospects.

Summary and correlation analysis of TCM syndromes in 159 elderly patients with acute myeloid leukemia

Objective:To investigate the characteristics of TCM syndromes in elderly patients with acute myeloid leukemia(AML)at the onset,and to analyze the main syndrome types and their correlation with age,percentage of bone marrow blasts,and genetic prognostic stratification.Methods:A retrospective analysis was performed on 159 AML patients aged over 60 years who were diagnosed and treated in our hospital,and the clinical data were collected and analyzed statistically.Results:In 159 elderly AML patients,the main clinical symptoms were fatigue,poor appetite,conscious fever,and various hemorrhages.The main syndromes were Ying(42.01%),Wei(31.25%),Essential(14.81%)and Blood(11.69%);the syndromes are divided into Qi and Yin deficiency(32.70%),Qi and blood deficiency(30.19%),true Yin deficiency(28.03%)and Qi heat and blood(8.81%).The age difference between the two groups was statistically significant(P<0.001),and the multiple comparison results showed that the age of the Qi-blood deficiency group was younger than the true-Yin deficiency group and the Qi-Yin deficiency group;the percentage of bone marrow blasts was statistically significant in the three groups at the initial diagnosis(P<0.05),multiple comparison results showed that the percentage of bone marrow blasts in the true Yin deficiency group was higher than that in the Qi-blood deficiency group and the Qi-Yin deficiency group;the genetic prognostic stratification of the three groups was statistically significant(P<0.05),multiple comparisons.The results showed that the genetic prognosis of the true Yin deficiency group was poorer than that of the Qi and blood deficiency group and the Qi and Yin deficiency group.Conclusion:The most common clinical symptoms of elderly AML patients are fatigue,the disease is located in the bone marrow,and the disease is Ying,Wei,essence,and blood.With the increase in the patient's age,the TCM syndrome types tend to be more insufficiency of true Yin and deficiency of both Qi and Yin,and the prognosis of patients with insufficiency of true Yin is poor.It provides a directional scientific basis for the treatment of senile AML with integrated traditional Chinese and Western medicine.

Effects of Rebixiao Granules (热痹消颗粒剂) on Blood Uric Acid in Patients with Repeatedly Attacking Acute Gouty Arthritis

Objective: To observe the clinical effect of Rebixiao granule (热痹消颗粒剂, RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism. Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group ( n =60) and control group ( n =30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models. Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference ( P >0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference ( P <0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different ( P <0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice. Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs.

急性外踝韧带损伤中药外治方案专家共识

急性外踝韧带损伤是一种常见的关节运动损伤类型,随着近年来运动人群的增加,患病人数也呈现上升趋势。急性韧带损伤如果早期处理不当,可能出现慢性疼痛、关节不稳等症状,严重者需考虑手术治疗。中医药有着悠久的历史,对于韧带损伤的诊治积累了丰富经验,临床实践中,中医药与现代医学的诊疗方式相互结合。针对急性韧带损伤早、中、晚3个时期不同阶段组织损伤及修复特点,专家组总结相关研究证据,形成中药三期论治方案,并首次提出“凉血止血、活血化瘀、和营生新”三期中药外治方案。为提高医务工作者对急性韧带损伤的诊疗水平,实现急性外踝韧带损伤诊疗的标准化、规范化,基于临床研究证据、临床经验,采用德尔菲法结合专家讨论,最终形成专家共识。

中西医治疗急性痛风性关节炎的进展

急性痛风性关节炎(AGA)是一种临床常见疾病。近年来,随着人们生活水平的提高,急性AGA的发病率不断上升,严重影响人们的工作、学习和生活。痛风归属于中医学“痹证”“历节”的范畴,中医药治疗急性AGA具有效果显著、不良作用小、价格低廉等诸多优点,能够根据患者的具体症状、体征等辨证论治、标本兼治,减少复发概率。文章从中医内治法、中医外治法,以及西医治疗、外科治疗等方面进行综述,以期为急性AGA的治疗提供思路。

四妙散治疗急性痛风性关节炎的药理、临床及实验研究进展

痛风性关节炎是多系统受累的全身性疾病,具有高发病率、高复发率、年轻化趋势的特点,严重者可造成关节畸形、骨质破坏,探讨痛风性关节炎的治疗对人类健康具有重要意义。四妙散是临床上治疗痛风性关节炎的经典方剂,具有很好的临床效果;四妙散治疗急性痛风性关节炎(AGA)具有多靶点、多通路协同作用,安全性高等特点,在缓解炎症、改善临床症状、改善实验室指标以及降低不良反应发生率和复发率等方面具有良好的效果,临床上值得推荐使用,尤其是有西药使用禁忌证时。

急性痛风性关节炎的中医辨证论治

急性痛风性关节炎(acute gouty arthritis,AGA)是一类以嘌呤代谢障碍、血尿酸水平升高、尿酸盐类结晶物沉淀于关节周围组织所导致的晶体性关节炎。尿酸水平升高和炎症反应被认为是导致痛风性关节炎发展的主要因素。此病侵蚀关节,降低生活质量,对患者生命造成严重危害。目前临床常用治疗方案以口服抗痛风药及非甾体类药物为主,必要时候手术治疗,然非甾体类药物具有不良胃肠道反应,抗痛风药物肝肾损伤相对较大,部分患者不愿接受。然而,在临床实践中发现,中医在治疗该病方面历史悠久,效美价廉,且不良反应少,患者普遍易接受。为丰富临床治疗思路,使广大患者受益,本文就中医药治疗急性痛风性关节炎的病因病机及辨证论治方面做一综述,以供临床借鉴。

李京涛三期辨治慢加急性肝衰竭经验探析

该文对李京涛教授中西医治疗慢加急性肝衰竭经验进行探析和分享。慢加急性肝衰竭是临床难治性肝病之一,多属中医“急黄”范畴,其病机主要为正虚邪盛,虚证多以气、血、阴、阳虚为主;邪实多以湿、热、瘀、毒为主;李京涛教授辨治本病,注重分三期辨治,内治以解毒祛邪、健脾祛湿、益气温阳为法组方遣药,辅以外治灌肠和药膳饮食等,疗效显著。

中西医结合治疗高脂血症性急性胰腺炎的研究进展

高脂血症性急性胰腺炎(hyperlipidemia in acute pancreatitis,HTG-AP)是由血清甘油三酯升高引起的急性胰腺炎,临床以保守治疗为主,除西医常规治疗以外,传统中医药治疗具有显著疗效,大柴胡汤、大承气汤等化裁被临床广泛应用,且联合中药外治法治疗,效果更佳。目前,中外学者从不同靶点探究HTG-AP的治疗。文章从靶向治疗、炎症机制及肠道菌群等方面介绍HTG-AP中西医治疗的研究进展。

儿童急性喉炎中医证素及发生喉梗阻危险因素相关性分析

目的:探讨儿童急性喉炎的中医证素及儿童急性喉炎发生喉梗阻危险因素的相关性分析。方法:收集2011年8月—2023年4月在广州中医药大学第一附属医院儿科住院治疗的255例急性喉炎患儿的病历资料(基本资料、四诊信息、白细胞数值、喉梗阻情况等),采取证素辨证法确定中医证素,将结果导入SPSS Modeler18.0软件,采用Apriori算法进行关联规则分析,证素之间的关系以复杂网络图表示,采取系统聚类分析法分析不同证素组合情况,并将相关因素进行二元Logistic回归分析。结果:共纳入255例患儿,其中以婴幼儿居多。255例患儿共提取证素14个,包括病位证素4个和病性证素10个。病位证素为肺、表、心神、小肠,病性证素中热、外风、痰为高频证素,证素组合以肺+表+热+外风占比最高。证素组成以肺、表、热为中心,形成了肺-热、表-肺、表-热、外风-肺、外风-表、外风-热、肺-痰、热-痰8组强链接。取类间距为24,可取得2个聚类单元,其中病位证素肺、表与病性证素热、血热、外风、痰、饮、寒为一类,病位证素心神、小肠与病性证素毒、闭、动风、湿为一类。证素饮对急性喉炎患儿发生喉梗阻的影响有统计学意义(P<0.05)。证素表、外风、闭、血热及白细胞增高对急性喉炎患儿发生喉梗阻的影响无统计学意义(P>0.05)。结论:儿童急性喉炎发病是因风热、风寒之邪侵犯肺脏或痰热壅盛,阻遏肺气,肺失宣降,声门开阖不利所致。证素饮是急性喉炎患儿发生喉梗阻的危险因素。

从“肺玄府-气液-络脉”理论分期辨治脓毒症急性肺损伤探析

笔者认为脓毒症急性肺损伤的病机演变与“肺玄府-气液-络脉”理论关系密切,宜分期辨治,早期宜清肺调玄、活血化饮、通利肺络,以阻断病情进展;炎性渗出期当泻肺调玄、活血利水、行气通络;肺水肿期需宣肺通玄、祛瘀逐饮、益气通络;肺实变期应益肺开玄、祛瘀化痰、补虚通络。提倡早期干预,中西医结合综合治疗,尽早阻断病情恶性循环,降低死亡率,为中医药防治脓毒症急性肺损伤提供新的思路。

中医外治法治疗急性痛风性关节炎的基础与临床研究进展

急性痛风性关节炎(AGA)属于晶体性关节炎,以关节红、肿、热、痛和功能障碍为主要临床表现。中药外治法、针刺、针刀、刺络拔罐、刮痧等中医外治法可显著改善AGA症状,降低炎症因子表达水平,减轻胃肠道及肝肾功能损伤,且操作简单、方式多样、不良反应少,在临床中广泛应用。目前关于中医外治法治疗AGA的基础与临床研究较多,关于其作用机制方面的研究则较少。未来,深入研究中医外治法治疗AGA的作用机制,可以为疾病的治疗提供新思路。

中医药治疗脓毒症急性肝损伤的研究进展

脓毒症仍是当今社会严重威胁人类健康的危重疾病。肝脏是脓毒症早期出现的损伤器官之一,目前现代医学对脓毒症急性肝损伤尚无特异性治疗药物。中医药治疗具有求权衡的防治原则、多样化的给药途径、天然化的用药取向、个性化的辨证论治及治疗方法等特点,有独特的治疗作用,可通过多靶点治疗脓毒症急性肝损伤。本文针对近年来关于中医药治疗脓毒症急性肝损伤的相关研究进行综述,为中西医协同治疗脓毒症急性肝损伤提供理论依据。

基于生物信息学分析急性肾损伤关键基因及靶向中药筛选

目的为深入了解急性肾损伤(acute kidney injury,AKI)发生的分子机制和探索AKI的中药防治策略,本研究利用生物信息学方法分析了AKI的关键基因,并预测了具有防治作用的中药。方法从基因表达综合数据库(gene expression omnibus database,GEO)下载AKI基因芯片数据集GSE30718并利用GEO2R在线工具分析,同时从比较毒理基因组学数据库(comparative toxicogenomics database,CTD)下载AKI的作用靶点,取二者交集即为AKI的差异表达基因(differential expression genes,DEGs);对DEGs进行富集分析和蛋白质相互作用分析,并运用Cytoscape软件计算关键基因;然后利用医学信息检索平台(Coremine Medical)检索关键基因对应的中药,统计出现频次最高的中药,再利用BATMAN-TCM数据库进一步分析其治疗AKI的分子机制。结果该研究共获得了206个DEGs,生物学功能富集分析提示这些DEGs主要与细胞外基质、免疫炎症反应和转录调控有关;FN1、ALB、COL1A1 JUN、TGFB1、FOS、PXDN、COL1A2、EGF、TIMP1是AKI的关键基因,由此获得可能用于治疗AKI的中药有丹参、人参、当归、三七等;其中以丹参出现频次最高,其治疗AKI的主要信号通路为磷脂酰肌醇3激酶/蛋白激酶B信号通路。结论本研究利用生物信息学工具和方法初步筛选了参与AKI的10个关键基因以及相关防治中药,并具体分析了丹参治疗AKI的分子机制,为AKI的临床治疗提供了新思路,也为后续科研提供了理论依据。

中医药治疗急性白血病化疗后骨髓抑制的研究进展

急性白血病(AL)是常见的血液系统恶性疾病,患者通常需要进行化疗,但化疗会导致骨髓抑制,进而使患者免疫功能下降、感染风险增加,并可能导致出血等严重并发症。近年来,AL化疗后骨髓抑制一直是临床关注的重点,未来还需要深入探讨骨髓抑制的机制,寻找更加有效的治疗方法,以提高AL患者的生存质量和预后。中医药对AL化疗后骨髓抑制的治疗主要从整体观念和辨证论治的角度出发,强调调理气血、平衡阴阳,具有一定的疗效和优势。

李军教授四期辨证治疗急性心肌梗死的经验总结

急性心肌梗死(Acute myocardial infarction,AMI)发病率和病死率日趋升高,严重危害我国人民的身体健康。中医药对于改善AMI患者的症状、提高生活质量、改善预后颇具特色。李军教授认为,AMI病因包括外邪侵袭、情志过极、年老体虚、饮食不节,总体为本虚标实之证,本虚以心之气虚、阴阳亏虚为主,标实为痰、瘀、热、滞、饮停留。提出“四期辨证治疗”理论,分别总结急性期、亚急性期、陈旧期及终末期患者病机特点、症状、治法及方药。

芙蓉膏外敷治疗早期急性乳腺炎临床观察

目的观察并分析外用芙蓉膏治疗早期急性乳腺炎患者的有效性及安全性。方法将早期急性乳腺炎患者88例随机分为对照组与观察组各44例。观察组采用外敷芙蓉膏治疗,对照组采用外敷如意金黄膏治疗,两组均治疗3 d。对比分析两组乳房肿块范围、乳房红肿范围、视觉模拟量表(VAS)评分、泌乳通畅度变化,评价两组的临床疗效。结果观察组总有效率为95.34%,对照组有效率为90.24%,两组差异无统计学意义(P>0.05)。两组患者治疗后乳房肿块范围和红肿范围较治疗前均缩小,VAS评分降低、泌乳通畅度改善(P<0.05);治疗组在乳房肿块范围、乳房疼痛评分和泌乳通畅度较对照组改善明显(P<0.05)。结论芙蓉膏外敷能够有效缓解早期急性乳腺炎患者乳房肿块和皮肤红肿、减轻乳房疼痛、改善泌乳通畅度,具有较好的临床疗效。