Chiral Discrimination in N-(O, O-dialkyl)phosphoamino Acid Monolayers at the Air-water Interface

In this paper, chiral discrimination in N-(O,O-dialkyl)phosphoamino acid monolayers at the air/water interface was studied and it was revealed that the D:L=1:1 racemic monolayer of N-(O, O-dihexadecyl)phosphoalanine is packed more densely in solid phase while shows a higher LE to LC transition pressure than the enantiomeric ones.

Enantiodifferentiation of chiral diols and diphenols via recognition-enabled chromatographic^(19)F NMR

A novel and efficient method for distinguishing between chiral diols and diphenols has been established through the use of^(19)F NMR spectroscopy.Central to this system's efficacy is a chiral amine,strategically modified with a CF_(3)group.This amine reacts in-situ with 2-formylphenylboronic acid to create a chiral^(19)F-labeled probe.This probe demonstrates discriminatory capabilities by interacting with hydroxy-containing analytes to form boronic esters.These esters produce distinct^(19)F NMR signals that vary according to their stereoconfiguration,facilitating accurate chiral differentiation.The method's resolution capacity was demonstrated by successfully identifying 12 distinct chiral analytes(six pairs of enantiomers)in complex mixtures,highlighting its extensive potential in diverse chiral analysis applications.

Cyclodextrin derivatives functionalized highly sensitive chiral sensor based on organic field-effect transistor

Novel highly sensitive chiral organic field-effect transistors(COFET)were developed by directly assembling imidazolium3,5-dimethylphenylcabamoylated-β-cyclodextrin(lm^+-Ph-β-CD)and 3,5-dimethylphenylcarbamoylated-β-CD(Ph-β-CD)respectively onto the semiconductor layer as sensing units.The Im+-Ph-β-CD/COFET afforded better enantioselectivity and a lowest detection concentration of10^-18 L/mol as well as the potentiality in quantitative analysis of commercial medicines.

Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers

Two pairs of amino-acid functionalized poly（3,4-ethylenedioxythiophene）（PEDOT） derivatives, namely, poly（N-（tert-butoxycarbonyl）-L-methionyl（3,4-ethylenedioxythiophene-2＇-yl）methylamide）（L-PEDOT-Boc-Met） and poly（N-（tertbutoxycarbonyl）-D-methionyl（3,4-ethylenedioxythiophene-2＇-yl）methylamide）（D-PEDOT-Boc-Met）; poly（L-methionyl（3,4-ethylenedioxythiophene-2＇-yl）methylamide）（L-PEDOT-Met） and poly（D-methionyl（3,4-ethylenedioxythiophene-2＇-yl）methylamide）（D-PEDOT-Met） were synthesized via chemical oxidative polymerization of corresponding monomers. The structural characterization, spectroscopic properties and thermal stability of these monomers and polymers were systematically explored by FTIR spectra, Raman spectra, XRD spectra, UV-Vis spectra and thermogravimetric analysis. As chiral electrode materials, these polymers were employed to successfully recognize 3,4-dihydroxyphenylalanine（DOPA） enantiomers by cyclic voltammetry（CV） in sulphuric acid solution. The measurement results reveal that the tendency was hetero-chiral interaction between L-PEDOT-Met/PVA/GCE and D-DOPA, D-PEDOT-Met/PVA/GCE and L-DOPA, respectively. Also, the mechanism of chiral discrimination was discussed. All the results implied that the combination of electrochemical molecular recognition technology and chiral PEDOT materials can be a promising approach for chiral recognition and may open new opportunities for facile, biocompatible, sensitive and robust chiral assays in biochemical applications.