Treatment for Persistent Chlamydial Infection in the Urogenital Tract-a Review Study

Objective： To investigate treatment efficacy for persistent chlamydial infection in the urogenital tract. Methods： 207 patients with persistent chlamydial urogenital infection were treated with tetracycline,azithromycin, ofloxacin or a combination of these.Result： 47.92%-68.60% of patients with persistent chlamydial urogenital infection were cured depending on the drug used. Ofloxacin had better results than tetracycline and azithromycin.Conclusion： Many patients were resistant to treatment with tetracycline and azithromycin. Ofloxacin proved effective.

Patients with Cervical Ureaplasma Urealyticum and Chlamydia Trachomatis Infection Undergoing IVF/ICSI-ET: The Need for New Paradigm

Genital tract infections with ureaplasma urealyticum（UU） and chlamydia trachomatis（CT） are the most frequent sexually-transmitted disease worldwide. UU and CT infections are considered to be the leading cause for infertility and adverse pregnancy outcomes. However, little is known about the specific effect of cervical UU and CT infections on the etiology of female infertility, as well as the pregnancy outcomes of the patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET）. In order to find the association between cervical UU and/or CT infection and pregnancy outcomes, we conducted a retrospective case-control study on the patients undergoing IVF/ICSI-ET with cervical UU and/or CT infection. A total of 2208 patients who received IVF/ICSI-ET were enrolled in this study. Data on the general conditions, pregnancy history and clinical pregnant outcomes were analyzed in terms of the cervical UU and CT detection. Our results revealed that cervical UU and CT infections were the risk factors for ectopic pregnancy and tubal factor-induced infertility. Moreover, the pregnancy rate, abortion rate, ectopic pregnancy rate and premature birth rate in patients with UU and/or CT infections showed no significant difference when compared with the control group. We recommend that cervical UU and CT detection should be an optional item for infertility patients and clinical UU detection should differentiate the subtypes of cervical UU. Positive cervical UU and CT infections should not be taken as strict contraindications for IVF/ICSI-ET.

Clinical Study of Continuous Infection in the Urogenital System of Chlamydiae trachomatis

Objective： To analyze the causes of persistent infection of Chlamydia trachomatis in the urogenital system. Method： We followed 223 patients with Chlamydia trachomatis infection who were treated regularly. Result： After treatment, 22.87% of cases still tested positive. After one year and change of treatment regime,4.48% of cases remained positive, most of whom were female. Conclusion： The course of Chlamydia trachomatis infection in the urogenital system is varied. This diversity has many causes including immunocompetence the characteristics of chalmydia trchomatis infection and genetic resistance.

Clinical Observation of Pregnancy with Chlamydia Trachomatis Infection.

From 1992 to 1993, 1 389 cases of pregnancy at 12-20 gestational weeks were investigated. At first antenatal visit the samples of cervical secretion were taken for chlamydia trachomatis antigen test and blood samples were tested for antidody simultaneously. Micro immunofluorescence method