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Research review on the main chemical constituents and pharmacological effects of Chloranthus japonicus Sieb.
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作者 Shuhe Jia Rui Guo +1 位作者 Xiaoxiao Huang Shaojiang Song 《Asian Journal of Traditional Medicines》 CAS 2022年第6期275-284,共10页
Chloranthus japonicus Sieb.,belonging to the Chloranthaceae family,is a perennial herb widely distributed in East Asia,including China,Japan and Korea.Previous phytochemical studies have revealed the presence of a var... Chloranthus japonicus Sieb.,belonging to the Chloranthaceae family,is a perennial herb widely distributed in East Asia,including China,Japan and Korea.Previous phytochemical studies have revealed the presence of a variety of secondary metabolites,such as terpenoids,phenylpropanoids and phenolic derivatives.Among them,sesquiterpenes and dimers,as the main chemical constituents and research focus in this plant,have a variety of biological activities.This review mainly focuses on the research progress of pharmacological activity of sesquiterpenes in this plant,which will lay the foundation for the development and utilization of its medicinal value in the future. 展开更多
关键词 chloranthus japonicus Sieb. chemical constituents pharmacological effects
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Chlorajaponins A—Q,Lindenane-Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities
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作者 Wei-Jiao Feng Yue Gu +6 位作者 Pei-Zhi Huang Hong-Ying Yang Rui Zhang Yi-Lin He Ting-Hong Lv Ya Li Kun Gao 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第11期1247-1259,共13页
Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus Sieb.Compound 1 possesses an unprecedented 3/5/7/5/5/6/... Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus Sieb.Compound 1 possesses an unprecedented 3/5/7/5/5/6/5/3 fused octacyclic scaffold,featuring a 6(5→4)-abeo-lindenane monomer,while 2 exhibits a 3/5/6/6/5/6/5/3 fused octacyclic scaffold.Their structures were determined through a combination of spectroscopic analyses and X-ray crystallography.Compounds 1,2,and 18 demonstrated significant inhibitory effects on lipid accumulation and effectively reduced the levels of triglycerides and total cholesterol,as well as the levels of aspartate aminotransferase and alanine aminotransferase in a HepG2 cell model.In addition,compounds 1,2,and 18 significantly suppressed the protein expression of the fatty acid synthase(FASN)and the sterol regulatory element-binding protein 1(SREBP1).Moreover,the anti-inflammatory assay showed that compounds 19—22 and 25 inhibited the NO production induced by lipopolysaccharide in RAW 264.7 macrophages with IC50 values of 7.89±0.44,6.25±0.46,2.98±0.29,10.77±0.60,and 3.60±0.28μmol/L. 展开更多
关键词 chloranthus japonicus Lindenane-type sesquiterpenoid dimers Lipid-lowering activity Anti-inflammatory activity NMR spectroscopy Natural products X-ray diffraction
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