Background: Given that on the one side considerable similarities between hypochondriasis and obsessive- compulsive disorder (OCD) by means of sharing a number of features, including intrusive thoughts and repeated che...Background: Given that on the one side considerable similarities between hypochondriasis and obsessive- compulsive disorder (OCD) by means of sharing a number of features, including intrusive thoughts and repeated checking (Barsky, 1992), on the other side similar structural neuroimaging data that found hypochondriac patients to have significantly smaller mean left and right OFC, and greater left thalamus volumes compared to those of healthy controls. Aims: We considered to investigate the hippocampal neurochemicals, found changed in OCD patients, in hypochondriac patients. Methods: Fifteen patients with hypochondriasis, recruited from our out- or in-patient clinics, were compared with 15 healthy control comparisons in regard to proton magnetic resonance spectroscopy (1H-MRS) imaging of hippocampus. Results: The patients with hypochondriasis had lower right and left NAA/CHO, and NAA/CRE, and near-significant lower right CHO/CRE hippocampal ratios than healthy matched comparison subjects. Conclusion: The data of the present investigation in patients with hypochondriasis provide preliminary evidence of lower right and left NAA/CHO, and NAA/CRE, near-significant lower right CHO/CRE hippocampal ratios, revealing neurochemical alterations in hippocampus and a further support the notion that hypochondriasis shares a variety of neurobiological similarities with OCD.展开更多
[目的]探讨胶质瘤氢质子磁共振波谱(1-H magnetic resonance spectroscopy,1H-MRS)所示代谢物值与Ki-67抗原的相关性及其应用价值。[方法]回顾性分析83例术前行1H-MRS检查、术后病理学结果为脑胶质瘤的患者资料,对比分析胶质瘤实质部位...[目的]探讨胶质瘤氢质子磁共振波谱(1-H magnetic resonance spectroscopy,1H-MRS)所示代谢物值与Ki-67抗原的相关性及其应用价值。[方法]回顾性分析83例术前行1H-MRS检查、术后病理学结果为脑胶质瘤的患者资料,对比分析胶质瘤实质部位主要代谢物N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)及其比值(Cho/Cr、Cho/NAA、NAA/Cr)与Ki-67表达的相关性。[结果 ]Cho/Cr、Cho/NAA比值与Ki-67表达呈正相关(r=0.257,P=0.019;r=0.329,P=0.002),NAA/Cr比值与Ki-67表达呈负相关(r=-0.206,P=0.049);Lip出现率与Ki-67表达呈正相关(r=0.304,P=0.005)。[结论]1H-MRS检查的各代谢物值与Ki-67表达关系密切,可有效反应脑胶质瘤的增殖活性,其中Cho/NAA比值的诊断价值最高。展开更多
文摘Background: Given that on the one side considerable similarities between hypochondriasis and obsessive- compulsive disorder (OCD) by means of sharing a number of features, including intrusive thoughts and repeated checking (Barsky, 1992), on the other side similar structural neuroimaging data that found hypochondriac patients to have significantly smaller mean left and right OFC, and greater left thalamus volumes compared to those of healthy controls. Aims: We considered to investigate the hippocampal neurochemicals, found changed in OCD patients, in hypochondriac patients. Methods: Fifteen patients with hypochondriasis, recruited from our out- or in-patient clinics, were compared with 15 healthy control comparisons in regard to proton magnetic resonance spectroscopy (1H-MRS) imaging of hippocampus. Results: The patients with hypochondriasis had lower right and left NAA/CHO, and NAA/CRE, and near-significant lower right CHO/CRE hippocampal ratios than healthy matched comparison subjects. Conclusion: The data of the present investigation in patients with hypochondriasis provide preliminary evidence of lower right and left NAA/CHO, and NAA/CRE, near-significant lower right CHO/CRE hippocampal ratios, revealing neurochemical alterations in hippocampus and a further support the notion that hypochondriasis shares a variety of neurobiological similarities with OCD.
文摘[目的]探讨胶质瘤氢质子磁共振波谱(1-H magnetic resonance spectroscopy,1H-MRS)所示代谢物值与Ki-67抗原的相关性及其应用价值。[方法]回顾性分析83例术前行1H-MRS检查、术后病理学结果为脑胶质瘤的患者资料,对比分析胶质瘤实质部位主要代谢物N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)及其比值(Cho/Cr、Cho/NAA、NAA/Cr)与Ki-67表达的相关性。[结果 ]Cho/Cr、Cho/NAA比值与Ki-67表达呈正相关(r=0.257,P=0.019;r=0.329,P=0.002),NAA/Cr比值与Ki-67表达呈负相关(r=-0.206,P=0.049);Lip出现率与Ki-67表达呈正相关(r=0.304,P=0.005)。[结论]1H-MRS检查的各代谢物值与Ki-67表达关系密切,可有效反应脑胶质瘤的增殖活性,其中Cho/NAA比值的诊断价值最高。
