Analysis of Adverse Reactions in the Treatment of COVID-19 with Three Chinese Patent Medicines and Three Herbal Formulas

Objective To explore the rules and characteristics of the adverse drug reactions(ADRs)of three Chinese patent medicines and three herbal formulas for the treatment of COVID-19,and to provide a reference for clinical safe medication.Methods The cases and ADR reports of the three Chinese patent medicines and three herbal formulas in PubMed,Web of Science,Springer Link,CNKI,Wanfang and VIP database were retrieved from December 2019 to May 2021.Then we extracted and analyzed the effective information included in the literature.Results and Conclusion According to the pre-developed retrieval plan,a total of 136 documents were obtained,and a total of 6 documents met the inclusion criteria finally.553 patients used three Chinese patent medicines and three herbal formulas,and there were 133 cases of adverse reactions.The adverse reactions of patients taking the three Chinese patent medicines and three herbal formulas can all be explained under the theory of traditional Chinese medicine,and the adverse reactions can be eliminated by adding or subtracting the flavor of the medicine or stopping the medicine.

Analysis of high-frequency local coupling instability induced by multi- transmitting formula - P-SV wave simulation in a 2D waveguide

Local coupling instability will occur when the numerical scheme of absorbing boundary condition and that of the field wave equation allow energies to spontaneously enter into the computational domain. That is, the two schemes support common wave solutions with group velocity pointed into the computation domain. The key to eliminate local coupling instability is to avoid such wave solutions. For lumped-mass finite element simulation of P-SV wave motion in a 2D waveguide, an approach for stable implementation of high order multi-transmitting formula is provided. With a uniform rectangular mesh, it is proven and validated that high-freqaency local coupling instability can be eliminated by setting the ratio of the element size equal to or greater than x/2 times the ratio of the P wave velocity to the S wave velocity. These results can be valuable for dealing instability problems induced by other absorbing boundary conditions.

Plemelj Formula for Cauchy Type Integral on Certain Distinguished Boundary in Universal Clifford Analysis

Under the foundation of Cauchy integral formula on certain distinguished boundary for functions with values in universal Clifford algebra, we define the Cauchy type integral with values in a universal Clifford algebra, obtain its Cauchy principal value and Plemelj formula on certain distinguished boundary.

Reliability Verification and Practical Effectiveness Evaluation of the Nursing Administration Analysis Formulae Based on PSYCHOMS^(■)

In psychiatric hospitals, the ratios between patients versus physician and patients versus nurse are low as compared to those in general hospitals. Furthermore, usages of electronic medical records are also low so that nurse administrators are limited in their ability to compile, analyze, and generate patient care staffing information for their administrative use. Psychiatric nurse administrators anticipate the development of a nursing administration analysis system that could perform personnel data simulation, manage information on nursing staff, and manage ward/ practice operations. Responding to this situation, the authors developed a nursing administration analysis system utilizing formulae from the Psychiatric Outcome Management System, PSYCHOMS®to aid nurse administrators. Such formulae are awaiting patent approval. The purpose of this study was to examine the validity of the formulae and the Structured Query Language (SQL) statement, and its practical effectiveness of analyzing data. The study findings showed that two kinds of computation expressions—a classification and extraction were able to display required information desired by nurse administrators. Moreover, significant information critical to assigning staff was validated to ensure high quality of nursing care according to the function and characteristic of the hospital ward.

Association analysis datamining the compatibility regulations of Li Dong Yuan's formula of spleen and stomach

Analyzing systemically more than 550 Li Dong Y uan’s formula of spleen and stomach by using the association rule to mine the in formation relativity between formula, herbal medicine and syndrome.From this we can study better the compatibility regulations of the

ON LINE COMPUTATION OF EMPIRICAL FORMULA BY MEANS OF ELEMENTAL ANALYSIS AND ITS PROGRAM DESIGN

On line determination of empirical formula for organic compounds with an automatic elemental analyzer and its program design method were investigated. The computational results shews that the reliability of computational results depends on the accuracy of the analytical data and the organic compound itself.

Empirical formulae for electric double-layer repulsion between two arbitrarily inclined clay particles

To understand the mesoscopic mechanism of clayey soil in view of macroscopic behavior, it is essential to quantitatively calculate the electric double-layer repulsion between arbitrarily inclined clay particles.However, suitable calculation methods with high efficiency and accuracy are still rare at present in literature. Based on a great number of numerical calculations of the repulsion between two inclined platy clay particles, explicit empirical formulae for estimating electric double-layer repulsion between clay particles are put forward. Comparison between the empirical solutions and corresponding numerical results shows that the proposed formulae have a reasonable accuracy, and application of the presented formula is easy and efficient.

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula

AIM:To predict treatment success using only simple clinical data from peg-interferon plus ribavirin therapy for chronic hepatitis C. METHODS:We analyzed the clinical data of 176 patients with chronic hepatitis and hepatitis C virus genotype 1 who received 48 wk standard therapy, derived a predictive formula to assess a sustained virological response of the individual patient using a logistic regression model and confirmed the validity of this formula.The formula was constructed using data from the first 100 patients enrolled and validated using data from the remaining 76 patients. RESULTS:Sustained virological response was obtained in 83(47.2%)of the patients and we derived formulae to predict sustained virological response at pretreatment and weeks 4,12 and 24.The likelihood of sustained virological response could be predicted effectively bythe formulae at weeks 4,12 and 24(the area under the curve of the receiver operating characteristic:0.821, 0.802,and 0.891,respectively),but not at baseline (0.570).The formula at week 48 was also constructed and validation by test data achieved good prediction with 0.871 of the area under the curve of the receiver operating characteristic.Prediction by this formula was always superior to that by viral kinetics. CONCLUSION:These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.

Magic Formula轮胎模型动力学性能研究

进一步研究Magic Formula轮胎模型的动力学性能。在Adams软件中建立Magic Formula轮胎模型,并进行纯制动、纯转向和制动转向联合三种工况下的仿真。仿真得到纵向力与纵向滑移率、侧向力与侧偏角、侧向力与纵向力和回正力矩与滑移率等关系曲线,并进行分析。结果表明,Adams软件完成了Magic Formula轮胎模型多种工况下的仿真工作,Magic Formula轮胎模型可以较好地模拟轮胎动力学特性。

Women's experiences of formula feeding their infants:an interpretative phenomenological study

Objective: This study aimed to explore the experiences of women in the process of formula feeding their infants. The World Health Organization has emphasized the importance of breastfeeding for infant health. After decades of breastfeeding promotions,breastfeeding rates in Hong Kong have been rising consistently; however, the low continuation rate is alarming. This study explores women's experiences with formula feeding their infants, including factors affecting their decision to do so.Methods: A qualitative approach using an interpretative phenomenological analysis(IPA) was adopted as the study design. Data were collected from 2014 to 2015 through individual in-depth unstructured interviews with 16 women, conducted between 3 and 12 months after the birth of their infant. Data were analyzed using IPA.Results: Three main themes emerged as follows:(1) self-struggle, with the subthemes of feeling like a milk cow and feeling trapped;(2) family conflict, with the subtheme of sharing the spotlight; and(3) interpersonal tensions, with the subthemes of embarrassment,staring, and innocence. Many mothers suffered various stressors and frustrations during breastfeeding. These findings suggest a number of pertinent areas that need to be considered in preparing an infant feeding campaign.Conclusions: The findings of this study reinforce our knowledge of women's struggles with multiple sources of pressure, such as career demands, childcare demands, and family life after giving birth. All mothers should be given assistance in making informed decisions about the optimal approach to feeding their babies given their individual situation and be provided with support to pursue their chosen feeding method.

Network-pharmacological study of FuzhengHuayu formula againsts liver fibrosis

Aim Liver fibrosis is a consequence of chronic liver disease which can progress into liver cirrhosis evenhepatocarcinoma. FuzhengHuayu （FZHY） , a Chinese herbal formula, had been reported to have the effect of anti- fibrosis. This study aims to investigate the effective targets and the mechanisms of FZHY on liver fibrosis. Methods The liver tissue samples of normal group, model group and FZHY-treated group were examined by microarray and iTRAQ. Profiles of differentially expressed genes （DEGs） and differentially expressed proteins （DEPs） in CC14-in- duced liver fibrosis model in rat were analyzed. GO and Pathway were analyzed by DAVID, and protein-protein in- teraction （PPI） was analyzed by STRING and cytoscape. The targets of FZHY compounds were predicted by TCM- SP. Results The results showed that 255 genes （ fold change ≥ 1.5, P 〈 0.05） and 507 proteins （ fold change ≥ 1.2 ,P 〈 0.05 ） were differentially expressed between FZHY group and model group. The high-throughput data of transcriptomics and proteomics was analyzed synthetically. DAVID function annotation analysis showed that these DEGS and DEPs both enriched in 15 GO terms, among drug metabolic process, response to extracellular stimulus, response to vitamin, arachidonic acid metabolic process, response to wounding and oxidation reduction may involve in liver fibrosis. KEGG pathway analysis showed that these DEGS and DEPs both enriched in 9 pathways, among arachidonic acid metabolism, retinol metabolism, metabolism of xenobiotics by cytochrome P450 and drug metabo- lism may be related to liver fibrosis. PPI analysis found that 10 overlapped core genes and proteins, among, Ugt2a3, Cyp2bl and Cyp3al8 were of higher degree, which are all enriched in retinol metabolism. Interestedly, Cyp2bl and Cyp3al8 were also predicted with TCMSP as the targets of FZHY compounds. Conclusion The re- sults indicated that the effective mechanism of FZHY against liver fibrosis is involved in the regulation of multiple targets and multiple pathways, among, retinol metabolism pathway by targeting Ugt2a3, Cyp2bl and Cyp3al8 may play an important role in the treatment of liver fibrosis.

CAUCHY TYPE INTEGRALS AND A BOUNDARY VALUE PROBLEM IN A COMPLEX CLIFFORD ANALYSIS

Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution.

Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable uncertainty.Therefore,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and improvement.This study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation strategies.Through an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant accidents.Seventeen uncertainty parameters of the ISAA program were meticulously screened.Using Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch calculations.Statistical analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure vessel.Uncertainty calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,respectively.The ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

UFLC-DAD-ESI-IT-TOFMSn Analysis on Biotransformation of Tongmai Formula Incubated with Human Intestinal Bacteria

Objective To investigate the biotransformation of Tongmai formula（TMF） in incubated system of human intestinal flora（HIF）. Methods The technique of ultra fast liquid chromatography with diode array detector and coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry（UFLC-DAD-ESIIT-TOFMSn） was adopted to determine the products of TMF biotransformed by HIF. Results Totally 66 constituents were detected and identified according to the accurate mass measurements（〈 5 ppm） and effective MSn fragment ions. Meanwhile, the potential biotransformational pathways of compounds in TMF transformed by HIF were firstly proposed. Desugarization, hydroxylation, and methylation were the major reactions in the biotransformation mechanism of TMF by HIF. Conclusion This study will be helpful to clarify the material basis of pharmacological activities from TMF in vivo.

Is the Chinese Medicinal Formula Guipi Decoction(归脾汤) Effectiveas AnAdjunctive Treatment for Depression？AMeta-Analysis of Randomized Controlled Trials

Objectives： To evaluate the effectiveness and safety of Guipi Decoction（归脾汤, GPD） as an adjunctive in the treatment of depression. Methods： A review of all relevant studies retrieved from a search of the following databases were conducted without any language restriction： Excerpt Medica Database（EMBASE）, Pub Med, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure（CNKI）, VIP Information, Wanfang Data, and the Chinese Biomedical Literature Database. Papers published until February 2013 were taken into consideration. The analysis was performed using the Cochrane software Revman 5.1. Results： Nine randomized controlled trials involving 620 patients with depression were included in this review. The meta-analysis revealed that compared with antidepressant therapy alone, treatment with a combination of GPD and an antidepressant drug significantly improved the symptoms of depression [weighted mean difference（WMD）： –3.09; 95% confidence interval（CI）： –4.11 to –2.07] and increased the rates of effectiveness（OR： 4.75; 95% CI： 2.66–8.51） as well as recovery（OR： 1.73; 95% CI： 1.17–2.56）. The adverse effects of GPD were not found to be significant in these studies. Conclusions： The findings of this meta-analysis were in keeping with the notion that GPD formulations were effective in the treatment of depression without causing any severe adverse effects. However, currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression.

Derivation and Analysis of A New Reconstruction Formula from Cone－beam Projections

A new method to compute the first derivative of 3-DRadon transform is given for cone-beam data taken from any orbit.Smith and Grangeat even derived cone-beam inversion formulaswhich are the basic work in fully 3-D image reconstruction algorithm andare used extensively now. In thispaper we will give a new inversion formula and a simple necessaryand sufficient condition which guarantees the complete reconstructionalgorithm.

三种固废改性生土材料配方设计及力学性能研究

为改善生土材料的力学性能,本研究以铁尾矿、煤矸石、电石渣、油泥与水泥等材料作为掺和料对生土进行改性。基于单形格子法设计配方,对3种配方、180个改性生土试件进行抗压强度试验,研究不同因素对试件破坏形态、抗压强度和试验数据离散性的影响;利用频数分析法,研究了固废改性生土材料的最优配方;通过CT扫描,从细观层面分析受荷后材料内部的分形和孔隙。结果表明:改性生土试件抗压破坏形态基本相同,极限位移受掺料影响显著。以煤矸石与电石渣、铁尾矿与水泥、油泥与水泥作为掺和料均可大幅提高改性生土试件的力学性能,掺和料种类、掺量对改性生土试件强度及数据离散性影响显著。经过频数寻优,3种配方的理想强度掺和料配比分别为1)铁尾矿12.1%~19.5%(质量分数,下同)、水泥13.9%~19.1%、生土65.5%~69.9%;2)电石渣6.7%~14.1%、煤矸石8.9%~11.8%、生土76.7%~81.8%;3)油泥11.4%~14.4%、水泥17.4%~19.4%、生土67.1%~70.5%。材料内部的分形和孔隙特征稳定,表现出较小的波动性和良好的密实性。

基于回归分析法的矩形槽圆管吸能特性研究

为了研究矩形槽圆管吸能特性规律,提出了一种基于回归分析法的结构参数与吸能特性关系的拟合方法。针对轴向冲击下的圆管动态响应,首先,建立了6005A-T6材料的Cowper-Symonds本构模型,并验证了仿真模型的准确性;其次,设计了正交试验,建立了吸能特性与结构参数之间的计算模型;然后,利用多元线性与非线性回归分析方法对计算模型参数求解,并对比了两种拟合结果,得到了峰值力和吸能量的经验公式;接着,对比经验公式与有限元数值计算值表明,经验公式在研究范围内具有较高准确性,误差在8%以内;最后,引入吸能性能指标并使用遗传算法对圆管进行了结构优化,优化结果表明,在研究范围内当直径和槽端距最小、壁厚和槽宽最大、槽深最浅时,矩形槽圆管的吸能性能最优。

车桥耦合连续梁-拱组合桥冲击系数研究

为了得到连续梁-拱组合桥真实的冲击系数,以某三跨连续梁-钢管混凝土拱组合桥为依托,考虑车桥耦合振动效应,利用ANSYS建立大桥空间梁单元模型和车辆的三轴半车模型,分析桥面不平度、车速、车辆数对主梁不同部位及不同响应冲击系数的影响,并以车速和桥面不平度为自变量得到冲击系数二元回归公式,最后利用2座基频相近桥梁冲击系数的实测数据验证该公式。结果表明:桥面不平度对冲击系数影响最大,当桥面不平度达到B级以上,冲击系数超过规范值,最大可达规范值5.42倍;对于主梁,不同外部激励、不同响应和不同部位的冲击系数存在差异,部分冲击系数超出规范值;该文给出的冲击系数回归公式可用于类似结构主梁冲击系数估算。

渐开线圆柱齿轮接触分析计算与仿真研究

为方便实现渐开线圆柱齿轮接触分析,开发出渐开线圆柱齿轮啮合接触分析和齿廓修形算法程序.采用渐开线直齿轮参数方程精准建模,获得齿廓接触点的曲率半径,在考虑实际载荷的情况下,改进了赫兹接触公式来求解齿轮啮合接触应力.为减缓齿轮啮合冲击,在算法程序中提供了5种齿廓修形方式及其修形后的接触应力分析方法.与行业公认的齿轮设计仿真软件MASTA计算结果进行对比.结果表明,该算法程序接触应力求解精度较高,相对MASTA平均误差约为5.04%,齿廓修形后的接触应力分布一致,验证了该算法程序的合理性.