AIM To verify through animal experiment the validity of chemical cholecytectomy. METHOD Experimental animals used were healthy juvenile pigs. A 3*!cm incision was made at the right costal margin for passing the...AIM To verify through animal experiment the validity of chemical cholecytectomy. METHOD Experimental animals used were healthy juvenile pigs. A 3*!cm incision was made at the right costal margin for passing the cold light source and some laparoscopic instruments into the abdominal cavity. The cystic duct was clamped with a siver clip and the gallbladder perfused with anhydrous alcohol (the sclerosing agent used). Gross observations and microscopic studies of the gallbladder, cystic duct, duodenum and adjoining liver specimens were made at the end of 2, 4, 6, 8 and 10 weeks. RESULTS Coagulative necrosis and inflam matory reaction of the gallbladder and cystic duct appeared early, followed by extensive fibrosis and scar formation by the 8th week, and at the end of 10 weeks complete fibrosis of the whole gallbladder occurred. CONCLUSION Chemical cholecystectomy is a safe, reliable, simple and practical minor surgical technique.展开更多
文摘AIM To verify through animal experiment the validity of chemical cholecytectomy. METHOD Experimental animals used were healthy juvenile pigs. A 3*!cm incision was made at the right costal margin for passing the cold light source and some laparoscopic instruments into the abdominal cavity. The cystic duct was clamped with a siver clip and the gallbladder perfused with anhydrous alcohol (the sclerosing agent used). Gross observations and microscopic studies of the gallbladder, cystic duct, duodenum and adjoining liver specimens were made at the end of 2, 4, 6, 8 and 10 weeks. RESULTS Coagulative necrosis and inflam matory reaction of the gallbladder and cystic duct appeared early, followed by extensive fibrosis and scar formation by the 8th week, and at the end of 10 weeks complete fibrosis of the whole gallbladder occurred. CONCLUSION Chemical cholecystectomy is a safe, reliable, simple and practical minor surgical technique.
