Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Meth...Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.展开更多
Cholesteryl ester transfer protein （CETP）, an important regulatory factor in reverse cholesterol transport, has been investigated in relation to plasma HDL cholesterol, which is associated with restenosis after perc...Cholesteryl ester transfer protein （CETP）, an important regulatory factor in reverse cholesterol transport, has been investigated in relation to plasma HDL cholesterol, which is associated with restenosis after percutaneous transluminal coronary angioplasty （PTCA） and stent implantation. We examined the effect of plasma CETP activity and the Taq1B polymorphism on restenosis in Chinese HaM population. Methods and Results Our study included 228 patients with symptomatic coronary artery disease （CAD）. The genotype of the subjects for Taq1B polymorphism of CETP was analyzed by using polymerase chain reaction-restriction fragment length poly- morphism （PCR-RFLP）. In-stent restenosis （ISR） was observed in 93 patients （40.8 %）. Baseline clinical, angiographic,and procedural characteristics data were not significantly different in patients with and without restenosis,except previous history of myocardial infarction （MI）, left ventricular ejection fraction （LVEF）, statin medication, and stent type. Taq1B polymorphism and plasma activity of CETP were not associated with the incidence of ISR （P = 0.68, P = 0.30, respectively）. Linear regression analysis revealed that the risk of ISR was statistically significant correlation with stent type, LVEF, statin medication, and lesion length （P 〈 0.05）. Conclusions Useful markers for risk of ISR were stent type, LVEF, statin medication and lesion length but not the Taq1B polymorphism and plasma activity of CETP.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos. 30900526 and 81070250)the Fundamental Research Funds for the Central Universitiesthe China Postdoctoral Science Foundation(No. 20100471616)
文摘Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.
基金Natural Science Foundation of Guangdong Province,China(No.5001160)
文摘Cholesteryl ester transfer protein （CETP）, an important regulatory factor in reverse cholesterol transport, has been investigated in relation to plasma HDL cholesterol, which is associated with restenosis after percutaneous transluminal coronary angioplasty （PTCA） and stent implantation. We examined the effect of plasma CETP activity and the Taq1B polymorphism on restenosis in Chinese HaM population. Methods and Results Our study included 228 patients with symptomatic coronary artery disease （CAD）. The genotype of the subjects for Taq1B polymorphism of CETP was analyzed by using polymerase chain reaction-restriction fragment length poly- morphism （PCR-RFLP）. In-stent restenosis （ISR） was observed in 93 patients （40.8 %）. Baseline clinical, angiographic,and procedural characteristics data were not significantly different in patients with and without restenosis,except previous history of myocardial infarction （MI）, left ventricular ejection fraction （LVEF）, statin medication, and stent type. Taq1B polymorphism and plasma activity of CETP were not associated with the incidence of ISR （P = 0.68, P = 0.30, respectively）. Linear regression analysis revealed that the risk of ISR was statistically significant correlation with stent type, LVEF, statin medication, and lesion length （P 〈 0.05）. Conclusions Useful markers for risk of ISR were stent type, LVEF, statin medication and lesion length but not the Taq1B polymorphism and plasma activity of CETP.
