Sixteen cases of chordoms were studied with various polycolonal and monoilonal antibodies and ABC technic.such as antibodies S-100 protein, neurou specific enodas(NSE ), lysozyme, α1- AT, Myoglobin, desmin, keratin ...Sixteen cases of chordoms were studied with various polycolonal and monoilonal antibodies and ABC technic.such as antibodies S-100 protein, neurou specific enodas(NSE ), lysozyme, α1- AT, Myoglobin, desmin, keratin and cytokeratin. Two embryonic notochords and three chondrosarcomas were studied as control. Most of chordomas revealed positive results with NSE ( 12/16 ). Des ( 12 / 16 ) . α1-AT ( 11/ 16 ), MG( 11/16 ) . S-100( 10 /16)and CK ( 8 / 16 ), while K and Lys were negative in all( 16 )cases. It denotes that chordoma has the potentiality for both mesodermal and ectodermal differentiation. Lys was positive in all 3 chondrosarcomas while the CK was negative. So that Lys can be considered as an useful antibody to distinguish chordoma from chondrosarcoma, and CK is somewhat useful for this differential diagnosis too.展开更多
文摘Sixteen cases of chordoms were studied with various polycolonal and monoilonal antibodies and ABC technic.such as antibodies S-100 protein, neurou specific enodas(NSE ), lysozyme, α1- AT, Myoglobin, desmin, keratin and cytokeratin. Two embryonic notochords and three chondrosarcomas were studied as control. Most of chordomas revealed positive results with NSE ( 12/16 ). Des ( 12 / 16 ) . α1-AT ( 11/ 16 ), MG( 11/16 ) . S-100( 10 /16)and CK ( 8 / 16 ), while K and Lys were negative in all( 16 )cases. It denotes that chordoma has the potentiality for both mesodermal and ectodermal differentiation. Lys was positive in all 3 chondrosarcomas while the CK was negative. So that Lys can be considered as an useful antibody to distinguish chordoma from chondrosarcoma, and CK is somewhat useful for this differential diagnosis too.
