Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure

BACKGROUND Current treatments for chronic heart failure(CHF)are therapeutically ineffective.The optimization of treatments for this disease needs to be explored and analyzed.AIM To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function(CPF)and prognosis.METHODS In total,160 patients with CHF admitted between June 2022 and June 2023 were selected,including 75 receiving perindopril(control group)and 85 receiving Luhong Formula(research group).We conducted comparative analyses on the curative effects of traditional Chinese medicine(TCM)syndromes and cardiac function,CPF[oxygen consumption at the anaerobic threshold(VO2 AT)and at peak exercise(peak VO2)],echocardiographic indexes[left atrial volume index(LAVI),left ventricular muscle mass index(LVMI),left ventricular ejection fraction(LVEF)],and prognosis[major adverse cardiovascular events(MACEs)at 6 months follow-up].RESULTS The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group.In addition,post-treatment VO2 AT,peak VO2,LVMI and LVEF in the research group were significantly higher,whereas LAVI was significantly lower,than those of the control group.Furthermore,fewer patients in the research group developed MACEs at the 6-month follow-up.CONCLUSION Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF,specifically in enhancing CPF and prognosis.

Effect of Cardiac Rehabilitation on Physical Capacity of Heart Failure Patients in Senegal

Background: Heart failure is a chronic and severe condition that often results from various heart diseases. Cardiac rehabilitation (CR) is currently a crucial component in managing this condition. The aim was to assess the effects of cardiac rehabilitation on physical capacity of heart failure patients. Methods: This was a cross-sectional study conducted from February 1, 2021, to June 30, 2023. We included all patients with heart failure who underwent cardiac rehabilitation. Data analysis was performed using SPSS software version 24.0, with a significance level set at p Results: The study included 87 heart failure patients, with a male-to-female ratio of 1.8. Mean age was 57.10 years (±11.75). Coronary artery disease was the primary cause of heart failure, accounting for 75.9% of cases. Atrial fibrillation was present in 4.7% of cases. Following cardiac rehabilitation, Left Ventricular Ejection Fraction increased from 40.15% to 49.48% (p = 0.001). Resting heart rate decreased significantly from 81.4 bpm to 68.3 bpm (p = 0.000), and the number of METS increased from 4.3 to 6.57 (+56.8%;p = 0.000). The mean distance covered in the 6-minute walk test significantly increased from 337.8 meters to 522.7 meters (p = 0.000), reflecting a gain of 183.5 meters. Moreover, the increase in the number of METS was more pronounced in females (p = 0.001), non-obese individuals (p = 0.000), non-diabetics (p = 0.001), non-sedentary individuals (p = 0.000), and non-smokers (p = 0.000). The study reported a low readmissions rate of 2.2% and a mortality rate of 1.1%. Conclusion: Our study demonstrates that cardiac rehabilitation is beneficial for black African heart failure patients, resulting in significant improvements in symptoms, physical and capacity.

Research progress of traditional Chinese medicine rehabilitation of chronic heart failure

In recent years,the rehabilitation of heart disease in China has developed rapidly.Five types of cardiac rehabilitation prescriptions and numerous consensus on cardiac disease rehabilitation have been put forward,which further promote and standardize the development of cardiac rehabilitation in our country.Traditional Chinese medicine has a long history and is safe and effective in rehabilitation treatment.Combining with the research of modern cardiac rehabilitation medicine will be the inevitable choice for the development of cardiac rehabilitation medicine in China in the future.This article summarizes the progress of the application of modern Chinese medicine in the rehabilitation treatment of chronic heart failure,in order to provide reference for the clinical research and application of traditional Chinese medicine in the rehabilitation of chronic heart failure and to give full play to the advantages of modern traditional Chinese medicine rehabilitation treatment.

Application effect of exercise rehabilitation therapy in elderly patients with chronic heart failure

Objective:To investigate the effects of rehabilitation exercise therapy on 6-minute walking distance (6 minute walk distance, 6MWD), brain natriuretic titanium (Brain natriuretic peptide, BNP) and (Minnesota heart failure quality of life scale, MLHFQ score in elderly patients with chronic heart failure (CHF).Methods: Choose xi'an medical college affiliated hospital heart treated with 96 cases of elderly patients with chronic heart failure (from January 2016 to January 2018), according to random number table method, divide the patients as control group and observation group 48 cases/group, control group to implement regular heart failure treatment, the observation group in the control group, the implementation of rehabilitation exercise therapy on the basis of comparing the clinical curative effect of two groups of indicators, heart colour to exceed, 6 MWDS, BNP levels, plate movement, MLHFQ score. Results: (1) compared with the control group, the total effective rate of the observation group was higher than that of the control group (P<0.05). (2). After treatment, the left ventricular end-diastolic diameter (Left ventricular end diastolic diameter, LVEDD) and the left ventricular end-systolic diameter (Left ventricular end systolic diameter, LVESD), BNP) in the observation group were higher than those in the control group. All the MLHFQ scores were lower than those in the control group (P<0.05). The left ventricular ejection fraction (Left ventricular ejection fraction, LVEF), stroke output (Stroke volume, SV) and treadmill metabolic equivalent (Metabolic equivalent, METs) were higher than those in the control group (P<0.05). The treadmill exercise time was longer than that in the control group (P<0.05), and its 6MWD was higher than that in the control group (P<0.05).Conclusion: Rehabilitation exercise therapy in elderly patients with chronic heart failure can effectively improve the cardiac function, enhance their exercise endurance and energy metabolism level, and improve the clinical efficacy and quality of life.

The application of integrated medical and nursing rehabilitation in the management of patients with chronic heart failure and diabetes

Background At present,patients with chronic heart failure complicated with diabetes are often treated with drugs in clinical practice.Most patients cannot adhere to regular and quantitative medication for a long time,and their poor compliance has adverse effects on their rehabilitation.The aim of this study was to explore the application effects of integrated medical and nursing rehabilitation in the management of patients with chronic heart failure and diabetes.Methods A total of 75 patients with chronic heart failure and diabetes,admitted to our center from May 2020 to May 2023,were randomly divided into Group A(n=38)and Group B(n=37)using a random number table.Group A received integrated rehabilitation management,while Group B received conventional rehabilitation management.The left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),fasting blood glucose(FBG),2-hour postprandial blood glucose(2h PG),glycated hemoglobin(Hb Alc),and self-care ability were compared between the two groups before and after intervention.Results After intervention,the LVEDD and LVESD in both groups were lower than before,while LVEF was higher than before(P<0.05).The LVEDD and LVESD in Group A were lower than in Group B after intervention,while LVEF was higher than in Group B(P<0.05).After intervention,the levels of FBG,2h PG,Hb Alc,and the scores of the European Heart Failure Self-care Behavior Scale(EHFSc B-9)in both groups decreased,with Group A being lower than Group B(P<0.05).Conclusions Integrated medical and nursing rehabilitation can effectively improve the cardiac function and blood glucose levels of patients with chronic heart failure and diabetes,control the patients’condition,and enhance their quality of life and self-care ability.[S Chin J Cardiol 2024;25(1):44-49]

Health Promotion in Cardiac Rehabilitation Patients through the Use of a High-Intensity Interval Training Protocol

According to the American Heart Association’s (AHA) recent statistical update, over 2150 Americans die each day from cardiovascular disease (CVD), which equals approximately 1 death every 40 seconds;many of which were under the age of 65 years old [1]. In 2009, 386,324 people, 1 in 6 Americans, died as a result of coronary artery disease (CAD) alone [1]. They also estimate 150,000 people have “silent” heart attacks each year [1]. Even though the number of cardiovascular disease deaths has declined in the last 10 years, they still accounted for 32.3% of American deaths [1]. As a result, the AHA updated their 2020 goals to improve the nation’s cardiovascular health by 20% [1]. One of these methods is through the use of cardiac rehabilitation. Cardiac rehabilitation (CR) is a health promotion strategy to help return cardiac patients to their previous level of functioning, increase health, decrease comorbidities and promote education and lifestyle change. For select patients, another alternative exercise plan may exist to gain even better results. High intensity interval training (HIIT) has shown positive training results for athletes and many studies show that it may also be an effective exercise modality for many cardiac patients instead of the traditional circuit training method. This article will review current literature on the effects of HIIT on CR patients as well as a sample HIIT protocol for instituting this treatment with appropriate patients.

Quo vadis cardiac rehabilitation;the role of comprehensive cardiac rehabilitation in modern cardiology

In accordance with the guidelines established by prominent European and global cardiology associations,comprehensive cardiac rehabilitation(CR)stands as an officially endorsed and highly recommended therapeutic approach(class I recommendations;level of evidence A)for a diverse spectrum of cardiac patients.Nevertheless,it is a cause for concern to observe that fewer than 50%of eligible patients are being effectively referred for CR,whether in an outpatient or in-patient setting.Concurrently,studies reveal that a substantial proportion of individuals with atherosclerotic cardiovascular disease maintain unhealthy lifestyles and exhibit suboptimal management of modifiable cardiovascular risk factors,including hypertension,lipid levels,and diabetes.Beyond the conven-tional patient profile encompassing those recovering from acute coronary syndrome with or without percutaneous coronary intervention,as well as patients who have undergone coronary or valvular surgery,contemporary CR now emphasizes specialized subgroups of patients.These include frail elderly patients,the female population with its unique considerations,individuals burdened by multiple cardiovascular comorbidities,those who have developed psychological consequences due to a cardiac illness and particularly those grappling with chronic heart failure.This editorial seeks to offer a state-of-the-art assessment of the significance and role of comprehensive CR within modern cardiology.

The Administration and Effect of Sodium Nitroprusside in the Treatment of Chronic Congestive Heart Failure

To prove the effectiveness and safety of sodium nitroprusside (SNP) in the treatment of chronic congestive heart failure, 58 patients with heart failure and normal renal and hepatic function were selected and divided into 3 groups and treated differently. Group A was treated with routine vasodilators; Group B was treaeted intermittently with SNP (12. 5 -75mg/24hrs); Group C was treated continuously with SNP (continuous infusion of 100 - 300mg/24hrs) Positively inotropie agents and diuretic agents were used in each group. The results showed that the highly effective rates of the three groups were 46. 9% (15/32), 90. 5% (19/21) and 100% (12/12) respectively. The effective rates were 81.3% (26/32), 100% (21/21), 100% (12/12) respectively. The highly effective rates of group B and C were much higher than that of group A ( P < 0. 005, P < 0. 005) . The reduction of blood pressure of group B and C was greater than that of group A ( P < 0. 025) . Among the patients we studied, no body had severe side effects. We concluded that the use of SNP in the treatment of chronic congestive heart failure is safe, with better effect than routine treatment, and continous infusion of SNP is the best choice.

Effects of exercise training on diastolic and systolic dysfunction in patients with chronic heart failure

BACKGROUND Chronic heart failure(CHF)is a complex syndrome characterized by a progressive reduction of the left ventricular(LV)contractility,low exercise tolerance,and increased mortality and morbidity.Diastolic dysfunction(DD)of the LV,is a keystone in the pathophysiology of CHF and plays a major role in the progression of most cardiac diseases.Also,it is well estimated that exercise training induces several beneficial effects on patients with CHF.AIM To evaluate the impact of a cardiac rehabilitation program on the DD and LV ejection fraction(EF)in patients with CHF.METHODS Thirty-two stable patients with CHF(age:56±10 years,EF:32%±8%,88%men)participated in an exercise rehabilitation program.They were randomly assigned to aerobic exercise(AER)or combined aerobic and strength training(COM),based on age and peak oxygen uptake,as stratified randomization criteria.Before and after the program,they underwent a symptom-limited maximal cardiopulmonary exercise testing(CPET)and serial echocardiography evaluation to evaluate peak oxygen uptake(VO2peak),peak workload(Wpeak),DD grade,right ventricular systolic pressure(RVSP),and EF.RESULTS The whole cohort improved VO2peak,and Wpeak,as well as DD grade(P<0.05).Overall,9 patients(28.1%)improved DD grade,while 23(71.9%)remained at the same DD grade;this was a significant difference,considering DD grade at baseline(P<0.05).In addition,the whole cohort improved RVSP and EF(P<0.05).Not any between-group differences were observed in the variables assessed(P>0.05).CONCLUSION Exercise rehabilitation improves indices of diastolic and systolic dysfunction.Exercise protocol was not observed to affect outcomes.These results need to be further investigated in larger samples.

Tremendous Improvement of the Functional Capacity in Patient with Chronic Heart Failure after 12-Weeks of Exercise Training Program

Cardiac rehabilitation is recommended for patients with chronic heart failure (CHF) with preserved, or reduced left ventricular ejection fraction (LVEF). A cardiac rehabilitation program generally includes physical exercise, diet counseling, educational classes on lifestyle changes, and disease management as well as psychosocial support for patients and their families. Exercise training is a core component of the comprehensive cardiac rehabilitation program and is strongly recommended in combination with pharmacological treatment to patients with CHF, due to cardiorespiratory, metabolic, and autonomic cardiac response. Exercise-based cardiac rehabilitation affects positively functional capacity, exercise tolerance, and quality of life in CHF patients. The physical inactivity rate in Arabian Peninsula countries is extremely high, and exercise training of habitually physically inactive individuals should result in marked improvements of physical capacity. We present a case that demonstrates such a significant improvement in the physical capacity of a patient with CHF and a review of literature.

Effect of dyspnea and clinical variables on the quality of life and functional capacity in patients with chronic obstructive pulmonary disease and congestive heart failure

Background Chronic obstructive pulmonary disease （COPD） and congestive heart failure （CHF） are two chronic diseases that affect negatively the functional condition and quality of life of patients. We assessed the effect of symptoms and clinical variables on the functional capacity and quality of life in COPD and CHF patients. Methods The study included 42 COPD and 39 CHF patients. In both patient groups, dyspnea was assessed using Borg scale; functional capacity by shuttle-walk and cardiopulmonary exercise test and quality of life by short form-36 （SF36）. Results No statistically significant difference was found in neither of the two disease groups regarding the dyspnea score, shuttle-walk test and the majority of subgroup scores of SF36 （P〉0.05）. A statistically significant difference was observed in peak VO2 in favor of COPD group （P〈0.05）. No significant relationship was established between dyspnea score and forced expiratory volume in one second （FEV1） in COPD patients, and left ventricular ejection fraction （LVEF） in CHF patients （P〉0.05）. A significant negative correlation was observed between dyspnea score and functional capacity tests in both disease groups （P〈0.05）. On the other hand, no relationship was found between LVEF and FEV1 and quality of life and functional capacity （P〉0.05）. Conclusions It was revealed that symptoms have an impact on functional capacity and quality of life in both disease groups, however, objective indicators of disease severity do not show a similar relationship. Therefore, in addition to the objective data related to the disease, we recommend that symptoms should also be taken into consideration to assess cardiopulmonary rehabilitation program and during following-up.

Effects of Polysaccharides Extracted from Zhu Zi Shen(Rhizoma Panacis Majoris) on Oxidative Stress and Hemodynamics in Rats with Adriamycin-induced Chronic Heart Failure

Objective:To probe into the intervening action of polysaccharides of Zhu Zi Shen(Rhizoma Panacis Majoris)(PZZS) on oxidative stress and hemodynamics in rats with adriamycin-induced chronic congestive heart failure(CHF).Methods:After SD rats were successfully modeled with adriamycin,they were randomly divided into a normal control group,a model group,a PZZS group,and a captopril group,and were administrated respectively.At the end of experiment,the hemodynamic function,whole heart weight index,and the blood CK,SOD,MDA,NO,NOS were detected;and the myocardial morphological examinations were carried out.Results:Compared with the normal control group,the arterial systolic pressure(SBP),diastolic pressure(DBP),mean arterial pressure(MAP),heart rate(HR),left ventricular systolic peak(LVSP),and left ventricular pressure change rate(dp/dtmax) significantly decreased,and left ventricular end diastolic pressure(LVEDP),whole heart weight index,the blood CK,MDA,NO,NOS significantly increased in the model group.PZZS significantly improved the hemodynamic function,lowered the MDA and NO levels,and decreased the CK and NOS activities in the CHF rats.Conclusion:PZZS can improve the hemodynamic function,and alleviate the oxidative stress reaction in the CHF rat.

Prevalence of Chronic Kidney Disease in Patients with Cardiovascular Disease

Background: Chronic kidney disease (CKD) is a worldwide public health alarming problem. Although both heart and kidneys are separated by a quite distance within the body and they perform varied functions, there is a close physiological relationship between them. The diseases in the kidneys can trigger a disease in the heart and vice versa. High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progress. Chronic abnormalities in cardiac function (e.g., chronic congestive heart failure) causing, chronic kidney disease and anemia appear to act together in a vicious circle in which each condition causes or exacerbates the other progressive chronic kidney disease. Objective: To assess the prevalence of chronic kidney disease in patients with cardiovascular disease at Shebin El-Kom Teaching Hospital and Menoufia University Hospital Cardiology Outpatient Clinic, Menoufia Governorate, Egypt. Methods: This is a cross-sectional study that was conducted in Shebin El-Kom Teaching Hospital Cardiology Outpatient Clinic, Menoufia University Cardiology Outpatient Clinic from April 2019 to July 2019. This study included 200 patients with cardiovascular disease or hypertension for more than 6 months. All patients were subjected to detailed history taking, clinical examination, laboratory investigation, echo and abdominal ultrasound. Results: This study included 200 patients with cardiovascular disease or hypertension for more than 6 months, which showed that: 63 (31.5%) were diagnosed as chronic kidney disease, 24 (38%) known to be CKD, 39 (62%) not known diagnosed in our study. Uncontrolled hypertension, congestive heart failure, diuretics and ACEI or ARBS with diuretics together are significant risk factors for renal impairment;uncontrolled hypertension and diuretics are the most predictors for renal impairment. Conclusion: Uncontrolled hypertension is the most preventable cause of renal impairment;RAAS not cause renal impairment but lead to decreased GFR in CKD patients. We should be careful with ACEI or ARBS with diuretics or diuretics only and control congestive heart disease to avoid kidney injury and chronic cardiorenal.

基于恐惧-回避模型的康复护理方案在老年慢性心力衰竭患者中的应用

目的减轻老年慢性心力衰竭患者康复运动恐惧心理,促进其运动康复。方法便利抽取70例心内科住院老年慢性心力衰竭患者,按入院时间分为两组各35例;两组均行常规治疗护理,同时对照组行常规康复护理,干预组构建和实施基于恐惧-回避模型的康复运动方案,持续干预至出院后1个月评价效果。结果干预后干预组心功能指标显著优于对照组(均P<0.05),心脏病运动恐惧得分、明尼苏达州心力衰竭生活质量得分显著低于对照组(均P<0.05);运动方案实施过程中未发生运动相关不良事件。结论对老年慢性心力衰竭患者实施基于恐惧-回避模型的康复运动方案能减轻患者运动恐惧心理,改善心功能,提高生活质量。

循序渐进的运动康复护理对慢性心衰患者运动耐力、生活质量及不良心脏事件的影响

目的探究循序渐进的运动康复护理对慢性心衰患者运动耐力、生活质量及不良心脏事件的影响。方法选取2022年6月-2023年6月我院收治的106例慢性心衰患者进行研究。以随机数字表法均分为2组。对照组(53例):基础护理。观察组(53例):循序渐进的运动康复护理。比较6 MWD、生活质量、不良心脏事件、满意度。结果干预前,两组6 MWD相比差异不显著(t=0.267,P=0.790),干预3个月后,两组6 MWD均显著提升(t=11.710,P=0.000,t=8.469,P=0.000),且观察组(403.18±62.11)m高于对照组(375.51±68.43)分,差异显著(t=2.180,P=0.032)。干预前,两组生活质量评分相比差异不显著(t=1.690,P=0.094),干预3个月后,两组生活质量评分均显著提升(t=14.053,P=0.000,t=8.409,P=0.000),且观察组(47.11±3.16)分高于对照组(42.34±3.28)分,差异显著(t=7.625,P=0.000)。与对照组16.98%的心衰加重、心源性再入院、急性心肌梗死、心律失常等不良心脏事件总发生率相比,观察组(3.77%)显著降低,差异显著(χ^(2)=4.970,P=0.026)。观察组满意度(90.57%)优于对照组(75.47%),差异显著(χ^(2)=4.283,P=0.039)。结论循序渐进的运动康复护理在提升慢性心衰患者运动耐力方面有积极意义。该护理能够提高患者生活质量及满意度,降低不良心脏事件的发生率。

八段锦联合广播体操对慢性心力衰竭患者相关指标及预后的影响

目的分析八段锦联合广播体操对慢性心力衰竭患者相关指标及预后的影响。方法选取2022年10月至2023年10月鄂尔多斯市中心医院收治的100例慢性心力衰竭患者作为研究对象,依据随机数字表法将研究对象分为对照组及试验组,两组各50例;两组均给予常规药物治疗,在此基础上,对照组给予常规运动康复治疗,试验组给予八段锦联合广播体操运动康复治疗,两组均干预6个月,对比两组干预前后超声心动图、心肺运动试验相关指标、N末端B型利钠肽原(NT-proBNP)水平及不良心血管事件(MACE)发生率。结果运动康复治疗前,对照组与试验组的各项指标比较组间差异无统计学差异(P>0.05)。治疗6个月后,试验组患者左心室射血分数(LVEF)和左室短轴缩短率(LVFS)明显高于治疗前(P<0.05),NT-proBNP和左心室舒张末期内径(LVEDD)明显低于治疗前(P<0.05);对照组患者LVEF和LVFS明显高于治疗前(P<0.05),NT-proBNP明显低于治疗前(P<0.05),LVEDD较治疗前无明显变化(P>0.05);试验组患者的LVEDD和NT-proBNP明显低于对照组[(54.33±6.58)mm比(58.60±5.23)mm、(1037.37±352.94)pg/ml比(1503.86±610.97)pg/ml,P<0.05],LVEF和LVFS明显高于对照组[(51.89±4.98)%比(47.98±5.86)%,P<0.05]。试验组患者MET、Peak VO_(2)/kg、Peak O2pulse明显高于治疗前(P<0.05);对照组患者的MET、Peak O2pulse明显高于治疗前(P<0.05),Peak VO_(2)/kg较治疗前无明显变化(P>0.05);试验组的MET、Peak VO_(2)/kg、Peak O2pulse明显高于对照组[(5.52±0.99)比(4.59±0.70)、(16.37±1.71)ml·kg^(-1)·min^(-1)比(15.36±1.44)ml·kg^(-1)·min^(-1)、(9.87±1.68)ml/beat比(9.15±1.60)ml/beat,P<0.05]。试验组的MACE发生率和对照组相比无统计学意义(P>0.05)。结论八段锦联合广播体操可能较常规康复治疗更能够改善CHF患者的心肺功能、运动耐量及预后。

探讨沙库巴曲缬沙坦联合曲美他嗪治疗慢性充血性心力衰竭的临床疗效及安全性

目的探讨沙库巴曲缬沙坦、曲美他嗪联用治疗慢性充血性心力衰竭的疗效及安全性。方法以76例慢性充血性心力衰竭患者为研究对象,按抽签法分为甲组及乙组,每组38例。甲组给予依那普利+曲美他嗪治疗,乙组给予沙库巴曲缬沙坦+曲美他嗪治疗。比较两组患者的治疗效果,心功能指标[左心室射血分数(LVEF)、N末端脑钠肽前体(NT-proBNP)水平及6 min步行试验距离(6MWD)、左心室舒张末期内径(LVEDD)],不良反应发生率及住院时间。结果乙组治疗总有效率97.37%高于甲组的81.58%,差异具有统计学意义(χ^(2)=5.0294,P=0.0249<0.05)。两组治疗前的LVEF、NT-proBNP、6MWD、LVEDD比较,差异无统计学意义(P>0.05);乙组治疗后的LVEF(51.27±5.65)%高于甲组的(47.84±5.25)%、NT-proBNP(867.87±66.56)pg/ml低于甲组的(911.26±76.98)pg/ml、6MWD(366.73±55.68)m长于甲组的(314.54±65.65)m、LVEDD(53.12±5.23)mm小于甲组的(56.76±5.78)mm,差异具有统计学意义(P<0.05)。乙组不良反应发生率低于甲组,但差异无统计学意义(P>0.05)。乙组住院时间(8.34±2.17)d短于甲组的(12.90±2.89)d,差异具有统计学意义(P<0.05)。结论沙库巴曲缬沙坦联用曲美他嗪治疗慢性充血性心力衰竭疗效确切,同时对心脏功能有明显的改善,是一种具有较好临床应用价值的治疗方案。

心脏康复运动疗法结合沙库巴曲缬沙坦钠治疗慢性心衰的效果分析

目的:探讨心脏康复运动疗法结合沙库巴曲缬沙坦钠治疗慢性心衰(CHF)的效果。方法:选取120例CHF患者为研究对象,按照治疗方式不同将患者分为对照组与观察组,每组各60例。对照组接受沙库巴曲缬沙坦钠治疗;观察组在此基础上接受心脏康复运动治疗。治疗3个月后,比较两组患者心肺功能指标、无创血流动力学参数及运动耐力水平。结果:治疗后,两组患者左心室射血分数(LVEF)、左心室收缩期末容量(LVESV)及左心室舒张期末容量(LVEDV)均升高,且观察组高于对照组(P<0.05);两组患者左心室收缩期末内径(LVESD)、左心室舒张期末内径(LVEDD)均低于治疗前(P<0.05),但组间差异无统计学意义(P>0.05)。治疗后,观察组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC及最大通气量(MVV)均高于治疗前及对照组;两组患者心排血量、心排血指数、每搏输出量、每搏指数、6 min步行距离(6MWD)、运动峰耗氧量(PVO_(2))及氧脉搏(VO_(2)/HR)均高于治疗前,且观察组高于对照组(P<0.05)。结论:心脏康复运动治疗结合沙库巴曲缬沙坦钠治疗有利于改善CHF患者心肺功能及血流动力参数,提升运动耐力。

体外反搏联合心脏康复治疗慢性心力衰竭的疗效及其对线粒体标志物的影响

目的研究体外反搏联合心脏康复治疗慢性心力衰竭的疗效及其对线粒体标志物的影响。方法2022年1月至2023年1月期间在首都医科大学附属北京康复医院就诊的86例慢性心力衰竭患者按照随机数字表分为观察组和对照组,观察组接受常规抗心衰药物治疗及体外反搏联合心脏康复治疗,对照组接受常规抗心衰药物治疗。治疗前和治疗后36 d,检测心肌做功Tei指数、左心室射血分数(LVEF)、6分钟步行距离(6MWD)、明尼苏达心力衰竭生活质量调查表(MLHFQ)评分、日常生活活动能力(ADL)评分及血清线粒体转录因子A(TFAM)、线粒体偶联因子6(CF6)水平;随访治疗后6个月的预后不良发生率和再入院率。结果治疗后,观察组的Tei指数、LVEF、6MWD、ADL评分、血清TFAM水平高于对照组,差异有统计学意义(t=35.257、4.604、13.003、4.804、8.336,P<0.05),观察组的MLHFQ评分及血清CF6水平低于对照组,差异有统计学意义(t=12.233、7.967,P<0.05);随访6个月,观察组的预后不良发生率和再入院率均低于对照组,差异有统计意义(χ^(2)=6.515、5.460,P<0.05)。结论体外反搏联合心脏康复治疗慢性心力衰竭提高心功能和生活质量,改善线粒体功能、调节线粒体标志物是与之相关的可能分子机制。

基于中医体质辨识学说的个体化康复方案在老年慢性心衰患者中的应用

目的探讨基于中医体质辨识学说的个体化康复方案在老年慢性心衰(CHF)患者中的应用效果。方法选择2020年5月至2022年5月我院收治的老年CHF患者60例,随机分为参照组和观察组各30例。除常规西医基础治疗外,参照组接受西医常规运动联合中药汤剂辨证施治,观察组接受基于中医体质辨识学说的个体化康复方案联合中药汤剂辨证施治。比较两组患者的心功能及生活质量。结果治疗2周后,观察组的NYHA心功能分级情况优于参照组(P<0.05)。治疗2周后,两组的SF-36评分均高于治疗前,且观察组SF-36评分高于参照组(P<0.05)。结论基于中医体质辨识学说的个体化康复方案在老年CHF患者治疗中应用效果显著,能够明显改善患者的心功能,提升其生活质量,值得临床推广应用。