Objective To investigate the function of cytokine in the patients suffered from chronic Keshan disease. Methods Serum IL 6, INF α was tested among 55 patients of chronic Keshan disease and 30 health controls by t...Objective To investigate the function of cytokine in the patients suffered from chronic Keshan disease. Methods Serum IL 6, INF α was tested among 55 patients of chronic Keshan disease and 30 health controls by the methods of ELISA, read in the unit of pg·mL -1 . Results The cytokine was significantly higher in Keshan disease patients than that in health control group. Conclusion Serum levels of IL 6, TNF α is higher in chronic Keshan disease patients than in health control group .It was showed that cytokine plays an important role during the etiopathology and the development in Chronic Keshan disease.展开更多
为探讨山东慢型克山病与柯萨奇 B 组病毒的关系,用缺口平移法制备生物素标记 CoxB_3病毒的 cDNA 探针与慢型克山病14例尸检心肌组织及10例脑外伤,CO 中毒等意外死亡的正常成人心肌组织及10例非病区7~8个月引产胎儿的心肌组织切片进行...为探讨山东慢型克山病与柯萨奇 B 组病毒的关系,用缺口平移法制备生物素标记 CoxB_3病毒的 cDNA 探针与慢型克山病14例尸检心肌组织及10例脑外伤,CO 中毒等意外死亡的正常成人心肌组织及10例非病区7~8个月引产胎儿的心肌组织切片进行原位杂交,14例慢克中有9例检测到柯萨奇 B 组病毒的 RNA,阳性率达64%,而对照组均为阴性。提示柯萨奇 B 组病毒感染可能是山东慢型克山病发病因素之一。展开更多
基金ThisworkwassupportedbytheScientificCommitteFoundationofShaanxiProvince China (No .2 0 0 0K14 -G14 )
文摘Objective To investigate the function of cytokine in the patients suffered from chronic Keshan disease. Methods Serum IL 6, INF α was tested among 55 patients of chronic Keshan disease and 30 health controls by the methods of ELISA, read in the unit of pg·mL -1 . Results The cytokine was significantly higher in Keshan disease patients than that in health control group. Conclusion Serum levels of IL 6, TNF α is higher in chronic Keshan disease patients than in health control group .It was showed that cytokine plays an important role during the etiopathology and the development in Chronic Keshan disease.
文摘为探讨山东慢型克山病与柯萨奇 B 组病毒的关系,用缺口平移法制备生物素标记 CoxB_3病毒的 cDNA 探针与慢型克山病14例尸检心肌组织及10例脑外伤,CO 中毒等意外死亡的正常成人心肌组织及10例非病区7~8个月引产胎儿的心肌组织切片进行原位杂交,14例慢克中有9例检测到柯萨奇 B 组病毒的 RNA,阳性率达64%,而对照组均为阴性。提示柯萨奇 B 组病毒感染可能是山东慢型克山病发病因素之一。
文摘克山病是原因未明的地方性心肌病,慢型克山病有关病毒病因的研究未见有关报道,作者用生物素标记的柯萨奇 B_3病毒的 cDNA 探针与黑龙江病区慢型克山病尸检心肌组织及非正常死亡成人心肌组织和非病区7~8个月引产胎儿心肌组织进行了原位杂交,以检测柯萨奇 B 组病毒 RNA。结果13例慢型克山病中有9例呈现阳性杂交信号,阳性率达69.2%,两对照组均为阴性。表明黑龙江慢型克山病心肌组织中有柯萨奇 B 组病毒 RNA 的存在,提示黑龙江病区慢型克山病与柯萨奇 B 组病毒的感染呈现高度相关。