期刊文献+
共找到1,285篇文章
< 1 2 65 >
每页显示 20 50 100
Efficacy and safety of stellate ganglion block in chronic ulcerative colitis 被引量:7
1
作者 Eugene Lipov Ken Candido 《World Journal of Gastroenterology》 SCIE CAS 2017年第17期3193-3194,共2页
Sympathetic system modulation by stellate ganglion blockade may modulate immune dysfunction and significantly improve symptoms of chronic ulcerative colitis.
关键词 Stellate ganglion block ulcerative colitis Immune function chronic ulcerative colitis
下载PDF
Clinical Observation of Integrated Traditional Chinese and Western Medicine in the Treatment of Chronic Ulcerative Rectitis 被引量:1
2
作者 Yujiao Xue Yi Li +1 位作者 Hui Zhang Changan Zhou 《Journal of Clinical and Nursing Research》 2021年第6期118-121,共4页
Objective:To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis(UR).Methods:70 c... Objective:To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis(UR).Methods:70 cases of chronic ulcerative rectitis were selected in all hospitals of our hospital for comparison.Observation and control were set up.The number of people was the same,but there were differences in methods.The control group retained enema,and the observation group was treated with traditional Chinese medicine.Rectal mucosa scores after different treatments were compared to evaluate the effect of intervention.Results:It was found that the observation group scored lower(P<0.05),and the effect was better.Conclusion:For the treatment of patients with chronic ulcerative rectitis,the combination of traditional Chinese and Western medicine will help to promote the prognosis of the disease,improve the problem of ulcer,promote the improvement of gastrointestinal function and bring a more positive impact. 展开更多
关键词 Combination of traditional Chinese and Western medicine chronic ulcerative rectitis TREATMENT Analysis
下载PDF
Efficacy and safety of stellate ganglion block in chronic ulcerative colitis 被引量:13
3
作者 Hong-Ying Zhao Guo-Tao Yang +2 位作者 Ning-Ning Sun Yu Kong Yun-Feng Liu 《World Journal of Gastroenterology》 SCIE CAS 2017年第3期533-539,共7页
AIM To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis.METHODS A total of 120 randomly selected patients with chronic ulcerative colitis tre... AIM To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis.METHODS A total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group(n = 30), patients received oral sulfasalazine treatment; experimental group(n = 90), patients received stellate ganglion block treatment. Clinical symptoms and disease activity in these two groups were compared before and after treatment using endoscopy. Blood was collected from patients on day 0, 10, 20 and 30 after treatment. Enzyme-linked immunosorbent assay was performed to determine interleukin-8(IL-8) level. The changes in IL-8 level post-treatment in the two groups were compared using repeated measures analysis of variance.RESULTS After treatment, clinical symptoms and disease activity were shown to be alleviated by endoscopy in both the control and experimental groups. However, patients in the control group did not have obvious abdominal pain relief. In addition, the degree of pain relief in the experimental group was statistically better than that in the control group(P < 0.05). Ten days after treatment, IL-8 level was found to be significantly lower in the experimental group than in the control group, and the difference was statistically significant(P < 0.05). In addition, adverse events were significantly higher in the control group than in the experimental group, and the difference was statistically significant(χ~2 = 33.215, P = 0.000).CONCLUSION The application of stellate ganglion block effectively improves treatment efficacy in chronic ulcerative colitis, relieves clinical symptoms in patients, and reduces the level of inflammatory factors. Furthermore, this approach also had a positive impact on the disease to a certain extent. 展开更多
关键词 Stellate GANGLION BLOCK chronic ulcerATIVE COLITIS
下载PDF
Prevalence of Bacterial and Fungal Infected Chronic Leg Ulcers at a Teaching Hospital in Ghana
4
作者 Janet Pereko George Aryee +3 位作者 Warigbani Pieterson Albert Paintsil Zainab Nina Schumacher Japheth A. Opintan 《Modern Plastic Surgery》 2024年第4期87-98,共12页
Background: Chronic ulcers are responsible for considerable morbidity and significantly contribute to the escalation in the cost of health care. Chronic leg ulcers (CLUs) are susceptible to microbial infections and se... Background: Chronic ulcers are responsible for considerable morbidity and significantly contribute to the escalation in the cost of health care. Chronic leg ulcers (CLUs) are susceptible to microbial infections and serious complications such as tissue necrosis and osteomyelitis, can result without the timely control of infections. Recent studies have also reported an increase in the association of fungal infections with chronic non-healing ulcers. Aim: To determine the prevalence of bacterial and fungal infections among patients reporting with chronic leg ulcers in participants without co-morbidities. Methods: A prospective cross-sectional study was conducted among patients with chronic leg ulcers at the National Reconstructive Plastic Surgery and Burns Centre, Korle-Bu Teaching Hospital (NRPS/BC-KBTH) and those who consented were enrolled. Characteristics of the wound as well as micro-organisms cultured from wound swabs were recorded. Results: A total of 50 participants were enrolled for the study with the mean (SD) age of 40.7 (10.7) years. Eighty percent of the participants presented with post traumatic leg ulcers with 80% being artisans and traders in the age group 31 - 50 years. There was no statistically significant association between sex and the organism cultured for post traumatic and cellulitis (p-value > 0.05). The prevalence of bacterial and fungal infection was 79.3% and 20.7% respectively. Pseudomonas species was the most isolated bacteria (61.5%) while Aspergillus niger was the most isolated fungi (41%). Conclusion: From this study, fungal infections should be included in managing chronic leg ulcers, especially among artisans, famers and gardeners even though there was a significantly higher burden of bacterial infections. 展开更多
关键词 chronic Leg ulcers (CLUs) Microbial Infections Fungal Infections Pseudomonas Species Burn Surgery
下载PDF
Diabetic ulcer with cutaneous squamous cell carcinoma:A case report
5
作者 Yun Luo Chen-Ying Li +2 位作者 Yu-Qing Wang Sheng-Min Xiang Cheng Zhao 《World Journal of Clinical Oncology》 2024年第12期1514-1519,共6页
BACKGROUND Chronic skin ulcers are a risk factor for the development of skin tumors.In patients with diabetes,chronic refractory ulcers may also contribute to higher susceptibility to skin tumors.Timely surgical remov... BACKGROUND Chronic skin ulcers are a risk factor for the development of skin tumors.In patients with diabetes,chronic refractory ulcers may also contribute to higher susceptibility to skin tumors.Timely surgical removal of chronic and nonhealing diabetic foot ulcers can effectively prevent progression to squamous cell carcinoma.Such cases may be misdiagnosed owing to currently insufficient clinical evidence.However,in cases of chronic ulcer wounds,it is crucial to enhance clinical awareness regarding their potential progression into malignant lesions.CASE SUMMARY An 84-year-old male patient with diabetes presented with a significantly ulcerated area on his foot.The ulcer had been present to varying degrees since 1996.Between 2012 and July 2019,even after receiving treatments such as herbal medicines or heat clearance and detoxification complete healing of the wound was not achieved.In July 2020,histopathological analysis confirmed a well-differentiated cutaneous squamous cell carcinoma.After the treatments,the ulcer wound healed slowly and did not expand.CONCLUSION Potentially malignant lesions in chronic ulcer wounds should be identified and treated in a timely manner to prevent their progression. 展开更多
关键词 Diabetic ulcer chronic skin ulcers Skin cancer Squamous cell carcinoma Case report
下载PDF
Clinical outcome of ileal pouch-anal anastomosis for chronic ulcerative colitis in China 被引量:7
6
作者 Liu Gang Han Hongqiu Liu Tong Fu Qiang Lyu Yongcheng 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第8期1497-1503,共7页
Background The incidence of chronic ulcerative colitis (CUC) in China is remarkably increasing, while little information on surgical treatment has been reported. This study aimed to completely describe and analyze t... Background The incidence of chronic ulcerative colitis (CUC) in China is remarkably increasing, while little information on surgical treatment has been reported. This study aimed to completely describe and analyze the clinical outcome of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA)for CUC in China. Methods Ninety-five consecutive patients, who suffered CUC and had surgical indications, were carefully selected. All patients underwent IPAA. Data on patient characteristics, surgical indications, surgical details, postoperative complications, functional outcome, and quality of life were collected. Results The mean patient age at the time of the operation was 32 years. Twenty-nine (31%) patients underwent an emergency operation, and 66 (69%) underwent elective procedures. Four patients with severe dysplasia underwent operations, but no carcinoma was histologically confirmed. A two-stage operation was performed in 87 (92%) patients, and a hand-sewn technique was applied in 88 (93%) patients. Sixteen patients (17.0%) experienced early complications, and there was a significant difference between the emergency surgery group and the elective group (31.0% vs. 10.6%, respectively; P 〈0.01). Five (5.3%) patients developed pouchitis as a late complication. The mean stool frequency after the operation was 4.6 (2-11) during the first 24 hours and 1.5 (0-4) overnight. According to the Kirwan grading scale, 87 (91.8%) patients showed satisfactory anal continence function. The quality of life improved significantly from a preoperative mean value of 0.28-0.61 before ileostomy closure to 0.78 after ileostomy closure (P 〈0.01) according to the Cleveland Global Quality of Life index. Conclusions IPAA is an effective and safe surgical procedure for patients with CUC in China. However, some characteristics, such as the low incidence of pouchitis, require further study. 展开更多
关键词 chronic ulcerative colitis ileal pouch-anal anastomosis surgical indication postoperative complication CHINESE
原文传递
Strategies and challenges in the treatment of chronic venous leg ulcers 被引量:2
7
作者 Shi-Yan Ren Yong-Sheng Liu +5 位作者 Guo-Jian Zhu Meng Liu Shao-Hui Shi Xiao-Dong Ren Ya-Guang Hao Rong-Ding Gao 《World Journal of Clinical Cases》 SCIE 2020年第21期5070-5085,共16页
Evaluating patients with chronic venous leg ulcers(CVLUs)is essential to find the underlying etiology.The basic tenets in managing CVLUs are to remove the etiological causes,to address systemic and metabolic condition... Evaluating patients with chronic venous leg ulcers(CVLUs)is essential to find the underlying etiology.The basic tenets in managing CVLUs are to remove the etiological causes,to address systemic and metabolic conditions,to examine the ulcers and artery pulses,and to control wound infection with debridement and eliminating excessive pressure on the wound.The first-line treatments of CVLUs remain wound care,debridement,bed rest with leg elevation,and compression.Evidence to support the efficacy of silver-based dressings in healing CVLUs is unavailable.Hydrogen peroxide is harmful to the growth of granulation tissue in the wound.Surgery options include a high ligation with or without stripping or ablation of the GSVs depending on venous reflux or insufficiency.Yet,not all CVLUs are candidates for surgical treatment because of comorbidities.When standard care of wound for 4 wk failed to heal CVLUs effectively,use of advanced wound care should be considered based on the available evidence.Negative pressure wound therapy facilitates granulation tissue development,thereby helping closure of CVLUs.Autologous split-thickness skin grafting is still the gold standard approach to close huge CVLUs.Hair punch graft appears to have a better result than traditional hairless punch graft for CVLUs.Application of adipose tissue or placenta-derived mesenchymal stem cells is a promising therapy for wound healing.Autologous platelet-rich plasma provides an alternative strategy for surgery for safe and natural healing of the ulcer.The confirmative efficacy of current advanced ulcer therapies needs more robust evidence. 展开更多
关键词 chronic venous leg ulcers DEBRIDEMENT Compression Negative pressure wound therapy Autologous split-thickness skin grafting Hair punch graft Platelet-rich plasma Advanced wound care therapies
下载PDF
TREATMENT OF OBSTINATE PEPTIC ULCER AND CHRONIC GASTRITIS WITH A METAL RING EMBEDDED IN ZUSANLI ACUPOINT
8
作者 Chen Chunyuan Zhang Wanxing Cao Wensheng Wu Jinshan Luannan County Hospital,Hebei Province 063500,China 《World Journal of Acupuncture-Moxibustion》 1993年第2期11-13,6,共4页
We had treated 102 cases of obstinate peptic ulcer and chronic gastritis with ametal ring embedded in Zusanli acupoint since October 1989 to October 1992,and got satisfactorytherapeutic effects.The total effective rat... We had treated 102 cases of obstinate peptic ulcer and chronic gastritis with ametal ring embedded in Zusanli acupoint since October 1989 to October 1992,and got satisfactorytherapeutic effects.The total effective rate is 96.08%,the cure rate of peptic ulcer is 87.32%,therecurrence rate is significantly lower than that of control group(P【0.001),and it has no side-effect. 展开更多
关键词 PEPTIC ulcer chronic GASTRITIS ZUSANLI point Ring-embedding method METAL RING
下载PDF
以痈论治溃疡性结肠炎理论阐释及临床思路探析 被引量:1
9
作者 张斯瑶 于永铎 +2 位作者 柳越冬 陈萌 齐颖超 《吉林中医药》 2024年第4期387-391,共5页
于永铎认为,痈为火毒生,下利脓血为热毒本质,提出“病由毒起,热毒伤肠”为溃疡性结肠炎病机关键,“邪踞火毒”“湿热毒邪”“正虚伏毒”为溃疡性结肠炎的核心病机演变规律,体现热毒伤肠络,毒邪由实致虚,虚实夹杂的病邪转变过程。结合从... 于永铎认为,痈为火毒生,下利脓血为热毒本质,提出“病由毒起,热毒伤肠”为溃疡性结肠炎病机关键,“邪踞火毒”“湿热毒邪”“正虚伏毒”为溃疡性结肠炎的核心病机演变规律,体现热毒伤肠络,毒邪由实致虚,虚实夹杂的病邪转变过程。结合从肠黏膜屏障损伤、免疫功能紊乱、细胞自噬、凋亡、焦亡的病变特点及交叉转化的因果联系,提出以痈论治溃疡性结肠炎的核心治法,采用清热解毒、凉血消痈,清热利湿、解毒消痈,健脾益气、托毒消痈等辨治策略,并结合临床验案进行分析,以期为溃疡性结肠炎的治疗提供参考。 展开更多
关键词 久痢 溃疡性结肠炎 以痈论治
下载PDF
Intermittent Pneumatic Compression in Treatment of Chronic Venous Leg Ulcers: A Case Report and Review of Literature
10
作者 Ali Kordzadeh Attila Jonas Yiannis P. Panayiotopoulos 《Case Reports in Clinical Medicine》 2014年第9期513-517,共5页
Introduction: The benefit of intermittent pneumatic compression (IPC) for the prevention of venous thromboembolism and lymphedema has been well established in the literature. Recent evidence suggests that IPC plays a ... Introduction: The benefit of intermittent pneumatic compression (IPC) for the prevention of venous thromboembolism and lymphedema has been well established in the literature. Recent evidence suggests that IPC plays a beneficial role in circulation, hemodynamic peripheral pump, intravascular coagulation and arterial skin perfusion. Despite such evidence, the use of IPC in the treatment of resistant and chronic venous leg ulcers, has received little attention in practice. Case Presentation: We would like to report the case of successfully treated chronic and bilateral venous leg ulcer in an obese patient with IPC application and a review of the literature. Results: The use of IPC as an adjuvant therapy to the traditional multilayered compression therapy permitted significant resolution of the ulcers, reduced secondary infection incidence and prevented ulcer recurrence. Conclusion: In obese, minimally mobile patients with venous ulcers not responding to the traditional multilayered compression therapy application of IPC, an adjuvant therapy is recommended. 展开更多
关键词 Intermittent Pneumatic Compression (IPC) chronic VENOUS LEG ulcerS Bilateral VENOUS LEG ulcer Management Compression Therapy OBESE Patient Follow-Up
下载PDF
基于“玄府气液”理论治疗慢性难愈性溃疡 被引量:1
11
作者 祁林 刘丽芳 涂雅玲 《湖南中医药大学学报》 CAS 2024年第4期638-642,共5页
慢性难愈性溃疡是“虚”“瘀”两种致病因素相互交织、相互作用的结果,“虚”“瘀”贯穿疾病发展的始终。而“玄府开阖失司,气液代谢失调”是本病迁延难治的病机关键。刘丽芳教授综合运用煨脓生肌、阳和通玄、托里消毒诸法开玄府、调气... 慢性难愈性溃疡是“虚”“瘀”两种致病因素相互交织、相互作用的结果,“虚”“瘀”贯穿疾病发展的始终。而“玄府开阖失司,气液代谢失调”是本病迁延难治的病机关键。刘丽芳教授综合运用煨脓生肌、阳和通玄、托里消毒诸法开玄府、调气液,令玄府开阖有司,气液代谢调和,临床疗效满意,附验案一则加以阐明。 展开更多
关键词 慢性难愈性溃疡 “虚、瘀”致病 玄府气液学说 辨证施治 经验总结 刘丽芳
下载PDF
中医药调控胃干细胞对胃癌前疾病作用的研究进展
12
作者 王培 严展鹏 +1 位作者 肖雄 朱方石 《中华中医药学刊》 CAS 北大核心 2024年第5期52-56,共5页
胃干细胞是存在于胃组织中的成体干细胞,具有自我更新和定向分化潜能。最新研究表明,胃干细胞的增殖和分化影响胃癌前疾病的发病、病理改变及预后。近年来,中医药对胃干细胞调控作用的研究取得了进展,文献报道显示,胃干细胞功能特征与... 胃干细胞是存在于胃组织中的成体干细胞,具有自我更新和定向分化潜能。最新研究表明,胃干细胞的增殖和分化影响胃癌前疾病的发病、病理改变及预后。近年来,中医药对胃干细胞调控作用的研究取得了进展,文献报道显示,胃干细胞功能特征与中医理论存在一定的相关性,中医药能通过影响胃干细胞标志物表达、调控胃干细胞相关信号通路的异常以及对癌变胃干细胞增殖的影响而发挥对胃溃疡、慢性萎缩性胃炎(Chronic Atrophic Gastritis,CAG)等胃癌前疾病的生物学作用。就近10年上述内容的相关研究进展进行综述。 展开更多
关键词 胃干细胞 中医药 胃溃疡 慢性萎缩性胃炎 进展
下载PDF
Short term effect of Salvia miltiorrhiza in treating rat acetic acid chronic gastric ulcer and long term effect in preventing recurrence 被引量:8
13
作者 Wang, GZ Ru, X +1 位作者 Ding, LH Li, HQ 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期77-78,共2页
AIM To study the short term effect of Danshen ( Salvia miltiorrhiza ) on acetic acid induced chronic gastric ulcer in rats and its long term effect in preventing recurrence. METHODS Rats with acetic acid indu... AIM To study the short term effect of Danshen ( Salvia miltiorrhiza ) on acetic acid induced chronic gastric ulcer in rats and its long term effect in preventing recurrence. METHODS Rats with acetic acid induced gastric ulcer were treated with Danshen and cimetidine for 30 days. Traditional gastric mucosal auto radiography and 3H TdR incorporation into gastric mucosa in vitro were employed to study the effects of Danshen in rat acetic acid induced chronic gastric ulcer, including ulcer index (UI), ulcer inhibitory rate (IR) and label rate (LR). RESULTS On the day 5, 30 and 126 of ulcer making, the UI in the Danshen group was obviously lower than that in the cimetidine group and the control group (42 3±3 9, 3 6±1 2, 4 4±2 3; 49 1±3 6, 5 9±1 4, 9 2±1 3; 61 0±3 8, 8 9±2 5, 12 4±2 4, respectively, P <0 01), the IR (%) in the Danshen group was obviously higher than that in the cimetidine group (31, 59, 64 8; 19, 33, 26, respectively), and the LR in the Danshen group was obviously higher than that in the cimetidine group and the control group (10 0±0 5, 16 2±0 8, 15 0±0 6; 9 0±0 5, 13 9±0 6, 10 8±0 7; 6 5±0 7, 10 1±0 5, 8 0±0 7, respectively, P <0 01). There was no obvious difference in UI in the Danshen group on day 30 as compared with that on day 126. CONCLUSION Danshen is effective in promoting ulcer healing and preventing recurrence. The mechanism of action is to strengthen the gastric mucosal barrier and to promote the gastric mucosal cell proliferation along the edge of the ulcer. 展开更多
关键词 DANSHEN disease models animal SALVIA miltiorrhiza stomach ulcer acetic acid cimitidine gastric MUCOSA RECURRENCE rats Wistar chronic diseases
下载PDF
甲基莲心碱通过调节AMPK/mTOR/NLRP3信号通路减轻慢性皮肤溃疡大鼠的炎症反应
14
作者 齐淑静 付改霞 齐瑞霞 《东南大学学报(医学版)》 CAS 2024年第1期33-39,共7页
目的:探讨甲基莲心碱(Nef)调节AMP活化蛋白激酶(AMPK)/哺乳动物雷帕霉素靶蛋白(mTOR)/NOD样受体热蛋白结构域相关蛋白3(NLRP3)信号通路对慢性皮肤溃疡(CSU)大鼠炎症反应的影响。方法:将90只大鼠随机分为空白对照组(NC组)、CSU组、Nef组... 目的:探讨甲基莲心碱(Nef)调节AMP活化蛋白激酶(AMPK)/哺乳动物雷帕霉素靶蛋白(mTOR)/NOD样受体热蛋白结构域相关蛋白3(NLRP3)信号通路对慢性皮肤溃疡(CSU)大鼠炎症反应的影响。方法:将90只大鼠随机分为空白对照组(NC组)、CSU组、Nef组、AMPK抑制剂(Compound C)组、Nef+Compound C组,每组18只大鼠。除NC组外的其他各组大鼠通过剪开创口注射氢化可的松以及喷洒金黄色葡萄球菌构建CSU大鼠模型。造模完成后,Nef组和Compound C组分别将20%Nef、10μmol·L^(-1) Compound C与50 mL的20%高渗盐水凝胶混合敷在伤口处,Nef+Compound C组将20%Nef和10μmol·L^(-1) Compound C一起添加到20%高渗盐水凝胶中敷在伤口处,持续治疗2周,NC组、CSU组用等量盐水凝胶处理伤口。观察大鼠皮肤创面愈合情况;ELISA法检测血清白细胞介素(IL)-1β、IL-8、TNF-α水平;水解法检测创面肉芽组织中羟脯氨酸(HyP)水平;HE染色检测肉芽组织病理学变化;Western blotting检测CCL4、CCL2、CXCL12以及AMPK/mTOR/NLRP3信号通路蛋白表达水平。结果:CSU组大鼠可看到新生肉芽组织,并且有大量炎症细胞浸润现象,CSU组较NC组IL-1β、IL-8、TNF-α含量显著升高(P<0.05);与CSU组相比,Nef组创面愈合率、HyP含量、p-AMPK/AMPK蛋白水平显著增加(P<0.05),IL-1β、IL-8、TNF-α含量、CCL2、CXCL12、CCL4、mTOR、NLRP3蛋白水平显著下降(P<0.05),而Compound C组趋势相反(P<0.05);Compound C消除了Nef对CSU大鼠炎症反应的减轻作用。结论:Nef可能通过调控AMPK/mTOR/NLRP3信号通路减轻CSU大鼠炎症反应。 展开更多
关键词 甲基莲心碱 AMPK/mTOR/NLRP3信号通路 慢性皮肤溃疡 炎症反应 大鼠
下载PDF
儿童苔藓样肉芽肿性口炎1例报道及文献回顾
15
作者 徐婧 夏荣辉 +2 位作者 杨涟漪 沈雪敏 杜观环 《口腔疾病防治》 2024年第2期137-142,共6页
目的探讨口腔苔藓样损害的分类、临床表现、诊断、鉴别诊断及治疗,为临床提供参考。方法获得医院伦理审批及患者知情同意,报道1例儿童口腔苔藓样损害病例,结合文献对口腔苔藓样损害的诊疗进行回顾分析。结果患儿舌背反复破溃伴疼痛3年余... 目的探讨口腔苔藓样损害的分类、临床表现、诊断、鉴别诊断及治疗,为临床提供参考。方法获得医院伦理审批及患者知情同意,报道1例儿童口腔苔藓样损害病例,结合文献对口腔苔藓样损害的诊疗进行回顾分析。结果患儿舌背反复破溃伴疼痛3年余,舌背大面积糜烂面,形状不规则,糜烂周围见珠光白色纹,左侧糜烂区伴组织增生,约1.5 cm×2.0 cm,质地韧,宽蒂。舌背白色网纹组织切取活检病理诊断为苔藓样损害;舌背增生物切除活检病理诊断为苔藓样损害伴肉芽肿性炎。根据患者口内损害特征、系统病史、用药史、组织病理学检查结果,最终诊断为苔藓样肉芽肿性口炎。文献回顾表明,口腔苔藓样损害病因不明,临床上需与口腔扁平苔藓、口腔苔藓样药物反应、口腔苔藓样接触性损害、慢性溃疡性口炎等疾病鉴别。临床上治疗口腔苔藓样损害以糖皮质激素的局部和/或全身使用为主。结论目前口腔苔藓样损害的分类和诊断仍无统一标准,主要依靠病史询问、临床表现和组织病理学检查结果,治疗方法主要为糖皮质激素的局部和/或全身使用。 展开更多
关键词 口腔苔藓样损害 苔藓样肉芽肿性口炎 口腔扁平苔藓 口腔苔藓样药物反应 口腔苔藓样接触性损害 移植物抗宿主病相关性苔藓样损害 慢性溃疡性口炎 类天疱疮样扁平苔藓 儿童 糖皮质激素
下载PDF
从气虚毒滞论治慢性溃疡
16
作者 张秉睿 苏文全 +2 位作者 王可彬 杜雅薇 吴圣贤 《辽宁中医药大学学报》 CAS 2024年第11期61-65,共5页
慢性溃疡既包括体表皮肤溃疡,又包括消化道内的慢性胃溃疡、慢性十二指肠溃疡、溃疡性结肠炎和血管内的动脉粥样硬化斑块溃疡等。气虚毒滞证是慢性溃疡特有的核心证候,“气虚”为慢性溃疡发病之本,包括热盛耗气、脾胃气虚、肾气亏虚,“... 慢性溃疡既包括体表皮肤溃疡,又包括消化道内的慢性胃溃疡、慢性十二指肠溃疡、溃疡性结肠炎和血管内的动脉粥样硬化斑块溃疡等。气虚毒滞证是慢性溃疡特有的核心证候,“气虚”为慢性溃疡发病之本,包括热盛耗气、脾胃气虚、肾气亏虚,“毒滞”为慢性溃疡发病之标,包括热毒、痰毒、瘀毒之滞。临床见神疲、乏力等气虚的全身表现以及溃疡久不愈合、平坦塌陷的局部表现。治疗慢性溃疡气虚毒滞证以补气解毒为主,又根据脏腑归属、溃疡部位、溃疡形色的不同有所差异,其内服、外用方药各具特色。课题组提出以补气解毒作为治疗大法,自拟补气解毒汤为主方治疗,以期为临床治疗慢性溃疡气虚毒滞证提供系统思路和有效方法。 展开更多
关键词 慢性溃疡 气虚毒滞证 动脉粥样硬化 皮肤溃疡 补气解毒汤
下载PDF
基于氧化应激反应探讨慢性体表溃疡发病机理及象皮生肌膏联合托里消毒散的干预作用
17
作者 林雅思 孙之中 +4 位作者 刘朝红 陈其华 易倩 赵姣 何欢 《世界中西医结合杂志》 2024年第4期699-704,共6页
目的 探讨慢性体表溃疡发病机理以及象皮生肌膏联合托里消毒散的干预作用。方法 将30只SPF级雄性SD大鼠按随机数字表法分为空白对照组、模型组、象皮生肌膏组、托里消毒散组、象皮生肌膏联合托里消毒散组,每组各6只。采用金黄色葡萄球... 目的 探讨慢性体表溃疡发病机理以及象皮生肌膏联合托里消毒散的干预作用。方法 将30只SPF级雄性SD大鼠按随机数字表法分为空白对照组、模型组、象皮生肌膏组、托里消毒散组、象皮生肌膏联合托里消毒散组,每组各6只。采用金黄色葡萄球菌造模,连续给药1周后,检测创面组织中血管内皮生长因子(Vascular endothelial growth factor,VEGF)、血管内皮细胞生长因子受体2(Vascular endothelial growth factor receptor 2,VEGFR-2)、核因子E2相关因子2(Nuclear factor erythroid 2-related factor 2,Nrf2)、NAD(P)H醌氧化还原酶1[NAD(P)H quinone oxidoreductase1,NQO1)、血红素加氧酶1(Heme oxygenase-1,HO-1)]表达水平。结果 与空白对照组比较,模型组创面组织中VEGF、VEGFR-2表达均明显降低,差异有统计学意义(P<0.01);与模型组比较,象皮生肌膏组、托里消毒散组、象皮生肌膏联合托里消毒散组VEGF、VEGFR-2表达均明显升高,差异有统计学意义(P<0.01)。与对照组比较,模型组中Nrf2、NQO1、HO-1表达水平升高,差异有统计学意义(P<0.01);与模型组比较,象皮生肌膏组、托里消毒散组、象皮生肌膏联合托里消毒散组Nrf2表达水平均明显升高,NQO1和HO-1表达降低,差异有统计学意义(P<0.01)。结论 大鼠慢性溃疡的形成可能与氧化应激反应抑制了VEGF通路及Nrf2通路有关,而象皮生肌膏联合托里消毒散可能通过调节上述通路促进溃疡处血管新生和抗氧化应激,进而提高创面愈合能力。 展开更多
关键词 慢性皮肤溃疡 托里消毒散 象皮生肌膏 血管新生 氧化应激
下载PDF
从厥阴病机论乌梅丸现代临床证治思路 被引量:1
18
作者 宋雪 吕冠华 范颖 《中医药临床杂志》 2024年第1期31-35,共5页
从厥阴病寒热错杂,阴阳失和的病机入手,探析乌梅丸收敛气血,调和阴阳的作用及其临床应用范围。结合现代药理学研究及古今医家经验,总结出乌梅丸在治疗糖尿病性胃轻瘫、胃食管反流病、慢性顽固性腹泻、慢性胆囊炎、顽固性失眠和溃疡性结... 从厥阴病寒热错杂,阴阳失和的病机入手,探析乌梅丸收敛气血,调和阴阳的作用及其临床应用范围。结合现代药理学研究及古今医家经验,总结出乌梅丸在治疗糖尿病性胃轻瘫、胃食管反流病、慢性顽固性腹泻、慢性胆囊炎、顽固性失眠和溃疡性结肠炎上所取得的显著疗效,为经方临床应用提供思路。 展开更多
关键词 厥阴 乌梅丸 糖尿病性胃轻瘫 慢性顽固性腹泻 胃食管反流病 溃疡性结肠炎 慢性胆囊炎 顽固性失眠
下载PDF
In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy 被引量:3
19
作者 Giovanni D De Palma Stefania Staibano +4 位作者 Saverio Siciliano Francesco Maione Maria Siano Dario Esposito Giovanni Persico 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第5期677-680,共4页
Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was reported.In this brief report we aimed to assess the application of probe-based CLE to characterize coloni... Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was reported.In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC.The study involved a patient presenting long-standing CUC.Confocal imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images.Inflamed mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination. 展开更多
关键词 COLONOSCOPY Confocal laser endomicros-copy chronic ulcerative colitis Dysplasia-associatedlesional mass HISTOLOGY
下载PDF
中医外用药物治疗皮肤慢性溃疡的研究进展
20
作者 李毓欣 郑向龙 +2 位作者 李雪梦 杨丽娟 王万春 《中国民族民间医药》 2024年第12期60-63,共4页
皮肤慢性溃疡是伤口长期愈合困难所形成的创面。文章回顾了近十年来静脉曲张性溃疡、动脉性溃疡、糖尿病性溃疡、压力性溃疡等其他慢性溃疡的中医外用药物临床运用,分析得出中医外治药物具有分期辨证、直达病所、虚瘀为本、多元治疗等特... 皮肤慢性溃疡是伤口长期愈合困难所形成的创面。文章回顾了近十年来静脉曲张性溃疡、动脉性溃疡、糖尿病性溃疡、压力性溃疡等其他慢性溃疡的中医外用药物临床运用,分析得出中医外治药物具有分期辨证、直达病所、虚瘀为本、多元治疗等特点,以期为临床相关研究提供诊治思路与方法。 展开更多
关键词 皮肤慢性溃疡 臁疮 脱疽 中医外用药物
下载PDF
上一页 1 2 65 下一页 到第
使用帮助 返回顶部