Objective:To study and evaluate the clini1cal effect of plasma exchange in the adjuvant treatment of chronic and acute liver failure.Methods:Totally 60 patients with chronic and acute liver failure in our department w...Objective:To study and evaluate the clini1cal effect of plasma exchange in the adjuvant treatment of chronic and acute liver failure.Methods:Totally 60 patients with chronic and acute liver failure in our department were divided into two groups.The control group received comprehensive treatment and the plasma exchange group received plasma exchange.The changes of total bilirubin(TBIL),PT percentage activity(PTA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)were measured after treatment,and were assessed in terms of the degree of relief of clinical symptoms.Results:TBIL,ALB,Alt,AST,IL-6,PCT and CRP in the two groups decreased and PTA increased compared with those before treatment,but the curative effect of the treatment group was better than that of the control group(P<0.05).The total effective rate of the treatment group was 80.0%,which was higher than 46.6%of the treatment group(P<0.05).Conclusion:Plasma exchange can help to improve the liver function,remove a large number of inflammatory factors,promote the recovery of liver function and improve the prognosis of patients with chronic and acute liver failure.展开更多
基金Gansu Provincial Youth Fund Project(NO.20JR10RA016)。
文摘Objective:To study and evaluate the clini1cal effect of plasma exchange in the adjuvant treatment of chronic and acute liver failure.Methods:Totally 60 patients with chronic and acute liver failure in our department were divided into two groups.The control group received comprehensive treatment and the plasma exchange group received plasma exchange.The changes of total bilirubin(TBIL),PT percentage activity(PTA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)were measured after treatment,and were assessed in terms of the degree of relief of clinical symptoms.Results:TBIL,ALB,Alt,AST,IL-6,PCT and CRP in the two groups decreased and PTA increased compared with those before treatment,but the curative effect of the treatment group was better than that of the control group(P<0.05).The total effective rate of the treatment group was 80.0%,which was higher than 46.6%of the treatment group(P<0.05).Conclusion:Plasma exchange can help to improve the liver function,remove a large number of inflammatory factors,promote the recovery of liver function and improve the prognosis of patients with chronic and acute liver failure.
